Professor Larissa Fabritz

Professor Larissa Fabritz

Institute of Cardiovascular Sciences
Professor of Cardiovascular Sciences

Contact details

Address
Institute of Cardiovascular Sciences
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Professor Larissa Fabritz studies novel mechanisms of heart disease and performs translational research towards mechanism-based therapies of cardiovascular diseases. As a clinical consultant, she sees patients in the Department of Cardiology at UHB. Larissa engages in research on molecular mechanisms of cardiomyopathies and arrhythmias as well as molecular cardiovascular imaging with her working group at the University of Birmingham and collaborations throughout Europe and North America.

Qualifications

  • 2016 Fellow of the Royal College of Physicians London
  • 2012 Fellow of the European Society of Cardiology
  • 2012 Habilitation Internal Medicine “Towards molecular mechanism-based therapy of cardiomyopathies and arrhythmias”
  • 2011 GMC accreditation
  • 2010 Board Certification in Medicine
  • 1998 Thesis summa cum laude
  • 1997 Graduation from Medical School

Teaching

Professor Fabritz is currently Cardiology Specialty Lead for Year 4 MBChB and Cardiology Specialty Lead for the Academic In Day (Year 5 MBChB)

Postgraduate supervision

  • PhD supervisor
  • MD supervisor

Current students are listed on the group webpage.

Professor Fabritz has supervised MD and PhD students in Germany and the UK and offers translational and interdisciplinary cardiovascular research projects on various topics of heart failure and arrhythmias, cardiomyopathies and sudden death with opportunities for engagement in international collaborations. If you are interested in an MD or PhD in these areas, please contact Professor Fabritz via email including your CV.

Research Associate and Postdoctoral positions are currently available. Please email your application to L.Fabritz@bham.ac.uk including your CV.

Research

  • Molecular mechanisms of arrhythmias and cardiomyopathies
  • Molecular mechanisms of atrial fibrillation and atrial thrombosis
  • Sodium channel dysfunction
  • Desmosomal proteins
  • Effects of ageing and exercise on arrhythmia and cardiomyopathy
  • Translation of preclinical research into clinical trials
  • Personalised medicine and management of care in patients with atrial fibrillation using a variety of innovative tools and techniques
  • Biomarkers of cardiomyopathy and arrhythmia
  • Big data and machine learning techniques for cardiovascular data
  • Development of mobile apps for adherent therapy and patient engagement
  • Screening for atrial fibrillation including wearables

 

Professor Fabritz is also linked to the below research groups :-

Other activities

Publications

Recent publications

Article

Radhakrishnan, A, Pickup, L, Price, A, Law, J, McGee, K, Fabritz, L, Senior, R, Steeds, R, Ferro, C & Townend, J 2021, 'Coronary microvascular dysfunction is associated with degree of anaemia in end stage renal disease', BMC Cardiovascular Disorders, vol. 21, no. 1, 211. https://doi.org/10.1186/s12872-021-02025-2

Fabritz, L, Crijns, HJGM, Guasch, E, Goette, A, Hausler, K, Kotecha, D, Lewalter, T, Meyer, CG, Potpara, TS, Rienstra, M, B Schnabel, R, Willems, S, Breithardt, G, Camm, AJ, Chan, A, Chua, WWL, De Melis, M, Dimopoulou, C, Dobrev, D, Easter, C, Eckardt, L, Haase, D, Hatem, S, Healey, JS, Heijman, J, Hohnloser, SH, Huebner, T, Saeed Ilyas, B, Isaacs, A, Kutschka, I, Leclercq, C, Lip, GYH, Marinelli, EA, Merino, JL, Mont, L, Nabauer, M, Oldgren, J, Pürerfellner, H, Ravens, U, Savelieva, I, Sinner, MF, Sitch, A, Smolnik, R, Steffel, J, Stein, K, Stoll, M, Svennberg, E, Thomas, D, Van Gelder, IC, Vardar, B, Wakili, R, Wieloch, M, Zeemering, S, Ziegler, P, Heidbuchel, H, Hindricks, G, Schotten, U & Kirchhof, P 2021, 'Dynamic risk assessment to improve quality of care in patients with atrial fibrillation: the 7th AFNET/EHRAConsensus Conference', EP Europace, vol. 23, no. 3, pp. 329–344. https://doi.org/10.1093/europace/euaa279

Al-Arkee, S, Mason, J, Lane, D, Fabritz, L, Chua, WWL, Haque, S & Jalal, Z 2021, 'Mobile apps to improve medication adherence in cardiovascular disease: systematic review and meta-analysis', Journal of Medical Internet Research, vol. 23, no. 5, e24190. https://doi.org/10.2196/24190

Chua, W, Law, JP, Cardoso, VR, Purmah, Y, Neculau, G, Jawad-Ul-Qamar, M, Russell, K, Turner, A, Tull, SP, Nehaj, F, Brady, P, Kastner, P, Ziegler, A, Gkoutos, GV, Pavlovic, D, Ferro, CJ, Kirchhof, P & Fabritz, L 2021, 'Quantification of fibroblast growth factor 23 and N-terminal pro-B-type natriuretic peptide to identify patients with atrial fibrillation using a high-throughput platform: A validation study', PLoS Medicine, vol. 18, no. 2, e1003405. https://doi.org/10.1371/journal.pmed.1003405

Cao, L, Marshall, J, Fabritz, L & Brain, K 2021, 'Resting cardiac sympathetic firing frequencies suppress terminal norepinephrine transporter uptake', Autonomic Neuroscience, vol. 232, 102794. https://doi.org/10.1016/j.autneu.2021.102794

Phillips, K, Subramanian, A, Thomas, GN, Khan, N, Chandan, J, Brady, P, Marshall, T, Nirantharakumar, K, Fabritz, L & Adderley, N 2021, 'TRENDS IN THE PHARMACOLOGICAL MANAGEMENT OF ATRIAL FIBRILLATION IN UK GENERAL PRACTICE 2008-2018', Heart.

Holmes, AP, Saxena, P, Kabir, SN, O'Shea, C, Kuhlmann, SM, Gupta, S, Fobian, D, Apicella, C, O'Reilly, M, Syeda, F, Reyat, JS, Smith, GL, Workman, AJ, Pavlovic, D, Fabritz, L & Kirchhof, P 2021, 'The atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone', Heart Rhythm, vol. 2021, no. 00, pp. 1-37. https://doi.org/10.1016/j.hrthm.2021.03.016

Peeters, F, Dudink, EAMP, Weijs, B, Fabritz, L, Chua, WWL, Kietselaer, BL, Wildberger, J, Meex, S, Kirchhof, P, Crijns, HJGM & Schurgers, L 2020, 'Biomarkers associated with aortic valve calcification: should we focus on sex specific processes?', Frontiers in cell and developmental biology, vol. 8, 604. https://doi.org/10.3389/fcell.2020.00604

Law, JP, Price, AM, Pickup, L, Radhakrishnan, A, Weston, C, Jones, AM, McGettrick, HM, Chua, W, Steeds, RP, Fabritz, L, Kirchhof, P, Pavlovic, D, Townend, JN & Ferro, CJ 2020, 'Clinical potential of targeting fibroblast growth factor‐23 and αKlotho in the treatment of uremic cardiomyopathy', Journal of the American Heart Association, vol. 9, no. 7, e016041. https://doi.org/10.1161/JAHA.120.016041

Radhakrishnan, A, Price, A, Pickup, L, Law, J, McGee, K, Fabritz, L, Senior, R, Steeds, R, Ferro, C & Townend, J 2020, 'Coronary flow velocity reserve and inflammatory markers in living kidney donors', International Journal of Cardiology, vol. 320, pp. 141-147. https://doi.org/10.1016/j.ijcard.2020.08.013

Jawad-Ul-Qamar, M, Chua, WWL, Purmah, Y, Nawaz, M, Varma, C, Davis, R, Maher, A, Fabritz, L & Kirchhof, P 2020, 'Detection of unknown atrial fibrillation by prolonged ECG monitoring in an all-comer patient cohort and association with clinical and Holter variables', Open Heart, vol. 7, no. 1, e001151. https://doi.org/10.1136/openhrt-2019-001151

Cao, L, Holmes, A, Marshall, J, Fabritz, L & Brain, K 2020, 'Dynamic monitoring of single-terminal norepinephrine transporter rate in the rodent cardiovascular system: a novel fluorescence imaging method', Autonomic Neuroscience, vol. 223, 102611. https://doi.org/10.1016/j.autneu.2019.102611

Abstract

Fabritz, L, Crijns, HJGM, Guasch, E, Goette, A, Häusler, KG, Kotecha, D, Lewalter, T, Meyer, CG, Potpara, TS, Rienstra, M, Schnabel, RB, Willems, S, Breithardt, G, Camm, AJ, Chan, A, Chua, WWL, De Melis, M, Dimopoulou, C, Dobrev, D, Easter, C, Eckardt, L, Hatem, S, Haase, D, Healey, JS, Heijman, J, Hohnloser, SH, Huebner, T, Saeed Ilyas, B, Isaacs, A, Kutschka, I, Leclercq, C, Lip, GYH, Marinelli, EA, Merino, JL, Mont, L, Nabauer, M, Oldgren, J, Pürerfellner, H, Ravens, U, Savelieva, I, Sinner, MF, Stitch, A, Smolnik, R, Steffel, J, Stein, K, Stoll, M, Thomas, D, Svennberg, E, Van Gelder, IC, Vardar, B, Wakili, R, Wieloch, M, Zeemering, S, Ziegler, P, Heidbuchel, H, Hindricks, G, Schotten, U & Kirchhof, P 2021, 'Dynamic risk assessment to improve quality of care in patients with atrial fibrillation: the 7th AFNET/EHRA Consensus Conference', Europace. https://doi.org/10.1093/europace/euaa279

Editorial

Chua, WWL & Fabritz, L 2021, 'Heart failure in patients with atrial fibrillation: why it matters now more than ever', Heart. https://doi.org/10.1136/heartjnl-2021-319145

Short survey

O'Shea, C, Kabir, SN, Holmes, AP, Lei, M, Fabritz, L, Rajpoot, K & Pavlovic, D 2020, 'Cardiac optical mapping – state-of-the-art and future challenges', International Journal of Biochemistry and Cell Biology, vol. 126, 105804. https://doi.org/10.1016/j.biocel.2020.105804

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