Professor Larissa Fabritz

Professor Larissa Fabritz

Institute of Cardiovascular Sciences
Honorary Professor

Contact details

Institute of Cardiovascular Sciences
College of Medical and Dental Sciences
University of Birmingham
B15 2TT

Professor Larissa Fabritz studies novel mechanisms of heart disease and performs translational research towards mechanism-based therapies of cardiovascular diseases. As a clinical consultant, she sees patients in the Department of Cardiology at UHB. Larissa engages in research on molecular mechanisms of cardiomyopathies and arrhythmias as well as molecular cardiovascular imaging with her working group at the University of Birmingham and collaborations throughout Europe and North America.

Professor Fabritz is also Birmingham Principal Investigator for the Machine Learning and Artificial Intelligence (AI) for Early Detection of Stroke and Atrial Fibrillation (MAESTRIA) project. This is a major international research programme which will develop a precise method to diagnose atrial cardiomyopathy, thereby providing clinicians with individualised clinical patient data to predict a patient's likelihood of suffering from subclinical AF, their future risk of AF and their overall risk of ischemic stroke with an accuracy that surpasses any currently available instrument.


  • 2016 Fellow of the Royal College of Physicians London
  • 2012 Fellow of the European Society of Cardiology
  • 2012 Habilitation Internal Medicine “Towards molecular mechanism-based therapy of cardiomyopathies and arrhythmias”
  • 2011 GMC accreditation
  • 2010 Board Certification in Medicine
  • 1998 Thesis summa cum laude
  • 1997 Graduation from Medical School


Professor Fabritz is currently Cardiology Specialty Lead for Year 4 MBChB and Cardiology Specialty Lead for the Academic In Day (Year 5 MBChB)

Postgraduate supervision

  • PhD supervisor
  • MD supervisor

Current students are listed on the group webpage.

Professor Fabritz has supervised MD and PhD students in Germany and the UK and offers translational and interdisciplinary cardiovascular research projects on various topics of heart failure and arrhythmias, cardiomyopathies and sudden death with opportunities for engagement in international collaborations. If you are interested in an MD or PhD in these areas, please contact Professor Fabritz via email including your CV.

Research Associate and Postdoctoral positions are currently available. Please email your application to including your CV.


  • Molecular mechanisms of arrhythmias and cardiomyopathies
  • Molecular mechanisms of atrial fibrillation and atrial thrombosis
  • Sodium channel dysfunction
  • Desmosomal proteins
  • Effects of ageing and exercise on arrhythmia and cardiomyopathy
  • Translation of preclinical research into clinical trials
  • Personalised medicine and management of care in patients with atrial fibrillation using a variety of innovative tools and techniques
  • Biomarkers of cardiomyopathy and arrhythmia
  • Big data and machine learning techniques for cardiovascular data
  • Development of mobile apps for adherent therapy and patient engagement
  • Screening for atrial fibrillation including wearables


Professor Fabritz is also linked to the below research groups:

Other activities


Recent publications


Aljehani, A, Kew, T, Baig, S, Cox, H, Sommerfeld, LC, Ensam, B, Kalla, M, Steeds, RP & Fabritz, L 2023, 'Characterisation of patients referred to a tertiary-level inherited cardiac condition clinic with suspected arrhythmogenic right ventricular cardiomyopathy (ARVC)', BMC Cardiovascular Disorders, vol. 23, no. 1, 14.

Schnabel, RB, Marinelli, EA, Arbelo, E, Boriani, G, Boveda, S, Buckley, CM, Camm, AJ, Casadei, B, Chua, W, Dagres, N, de Melis, M, Desteghe, L, Diederichsen, SZ, Duncker, D, Eckardt, L, Eisert, C, Engler, D, Fabritz, L, Freedman, B, Gillet, L, Goette, A, Guasch, E, Svendsen, JH, Hatem, SN, Haeusler, KG, Healey, JS, Heidbuchel, H, Hindricks, G, Hobbs, FDR, Hübner, T, Kotecha, D, Krekler, M, Leclercq, C, Lewalter, T, Lin, H, Linz, D, Lip, GYH, Løchen, ML, Lucassen, W, Malaczynska-Rajpold, K, Massberg, S, Merino, JL, Meyer, R, Mont, L, Myers, MC, Neubeck, L, Niiranen, T, Oeff, M, Oldgren, J, Potpara, TS, Psaroudakis, G, Pürerfellner, H, Ravens, U, Rienstra, M, Rivard, L, Scherr, D, Schotten, U, Shah, D, Sinner, MF, Smolnik, R, Steinbeck, G, Steven, D, Svennberg, E, Thomas, D, True Hills, M, van Gelder, IC, Vardar, B, Palà, E, Wakili, R, Wegscheider, K, Wieloch, M, Willems, S, Witt, H, Ziegler, A, Daniel Zink, M, Willems, S, Witt, H, Ziegler, A, Daniel Zink, M & Kirchhof, P 2023, 'Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference', Europace, vol. 25, no. 1, pp. 6-27.

Kany, S, Cardoso, VR, Bravo, L, Williams, JA, Schnabel, R, Fabritz, L, Gkoutos, GV & Kirchhof, P 2022, 'Eligibility for early rhythm control in patients with atrial fibrillation in the UK Biobank', Heart.

O'Reilly, M, Sommerfeld, LC, O'Shea, C, Broadway-Stringer, S, Andaleeb, S, Reyat, JS, Kabir, SN, Stastny, D, Malinova, A, Delbue, D, Fortmueller, L, Gehmlich, K, Pavlovic, D, Skryabin, BV, Holmes, AP, Kirchhof, P & Fabritz, L 2022, 'Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide', EP Europace.

O’Shea, C, Winter, J, Kabir, SN, O’Reilly, M, Wells, SP, Baines, O, Sommerfeld, LC, Correia, J, Lei, M, Kirchhof, P, Holmes, AP, Fabritz, L, Rajpoot, K & Pavlovic, D 2022, 'High resolution optical mapping of cardiac electrophysiology in pre-clinical models', Scientific Data, vol. 9, no. 1, 135.

O'Brien, S-M, Holmes, A, Johnson, D, Kabir, SN, O'Shea, C, O'Reilly, M, Avezzu, A, Reyat, J, Hall, AW, Apicella, C, Ellinor, PT, Niederer, S, Tucker, NR, Fabritz, L, Kirchhof, P & Pavlovic, D 2022, 'Increased atrial effectiveness of flecainide conferred by altered biophysical properties of sodium channels', Journal of Molecular and Cellular Cardiology, vol. 166, pp. 23-35.

Brady, PF, Chua, W, Nehaj, F, Connolly, DL, Khashaba, A, Purmah, YJV, Ul-Qamar, MJ, Thomas, MR, Varma, C, Schnabel, RB, Zeller, T, Fabritz, L & Kirchhof, PF 2022, 'Interactions Between Atrial Fibrillation and Natriuretic Peptide in Predicting Heart Failure Hospitalization or Cardiovascular Death', Journal of the American Heart Association, vol. 11, no. 4, e022833.

Fabritz, L, Connolly, DL, Czarnecki, E, Dudek, D, Guasch, E, Haase, D, Huebner, T, Zlahoda-Huzior, A, Jolly, K, Kirchhof, P, Obergassel, J, Schotten, U, Vettorazzi, E, Winkelmann, SJ, Zapf, A & Schnabel, RB 2022, 'Smartphone and wearable detected atrial arrhythmias in older adults: results of a fully digital European case finding study', European Heart Journal - Digital Health, vol. 3, no. 4, pp. 610–625.

Phillips, K, Subramanian, A, Thomas, GN, Khan, N, Chandan, J, Brady, P, Marshall, T, Nirantharakumar, K, Fabritz, L & Adderley, N 2022, 'Trends in the pharmacological management of atrial fibrillation in UK general practice 2008-2018', Heart, vol. 108, no. 7, 319338, pp. 517-522.

Holmes, AP, Saxena, P, Kabir, SN, O'Shea, C, Kuhlmann, SM, Gupta, S, Fobian, D, Apicella, C, O'Reilly, M, Syeda, F, Reyat, JS, Smith, GL, Workman, AJ, Pavlovic, D, Fabritz, L & Kirchhof, P 2021, 'Atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone', Heart Rhythm, vol. 18, no. 7, pp. 1212-1220.

Radhakrishnan, A, Pickup, L, Price, A, Law, J, McGee, K, Fabritz, L, Senior, R, Steeds, R, Ferro, C & Townend, J 2021, 'Coronary microvascular dysfunction is associated with degree of anaemia in end stage renal disease', BMC Cardiovascular Disorders, vol. 21, no. 1, 211.

Fabritz, L, Crijns, HJGM, Guasch, E, Goette, A, Hausler, K, Kotecha, D, Lewalter, T, Meyer, CG, Potpara, TS, Rienstra, M, B Schnabel, R, Willems, S, Breithardt, G, Camm, AJ, Chan, A, Chua, WWL, De Melis, M, Dimopoulou, C, Dobrev, D, Easter, C, Eckardt, L, Haase, D, Hatem, S, Healey, JS, Heijman, J, Hohnloser, SH, Huebner, T, Saeed Ilyas, B, Isaacs, A, Kutschka, I, Leclercq, C, Lip, G, Marinelli, EA, Merino, JL, Mont, L, Nabauer, M, Oldgren, J, Pürerfellner, H, Ravens, U, Savelieva, I, Sinner, MF, Sitch, A, Smolnik, R, Steffel, J, Stein, K, Stoll, M, Svennberg, E, Thomas, D, Van Gelder, IC, Vardar, B, Wakili, R, Wieloch, M, Zeemering, S, Ziegler, P, Heidbuchel, H, Hindricks, G, Schotten, U & Kirchhof, P 2021, 'Dynamic risk assessment to improve quality of care in patients with atrial fibrillation: the 7th AFNET/EHRA Consensus Conference', EP Europace, vol. 23, no. 3, pp. 329–344.

Chua, W, Law, JP, Cardoso, VR, Purmah, Y, Neculau, G, Jawad-Ul-Qamar, M, Russell, K, Turner, A, Tull, SP, Nehaj, F, Brady, P, Kastner, P, Ziegler, A, Gkoutos, GV, Pavlovic, D, Ferro, CJ, Kirchhof, P & Fabritz, L 2021, 'Quantification of fibroblast growth factor 23 and N-terminal pro-B-type natriuretic peptide to identify patients with atrial fibrillation using a high-throughput platform: a validation study', PLoS Medicine, vol. 18, no. 2, e1003405.


Chua, WWL & Fabritz, L 2021, 'Heart failure in patients with atrial fibrillation: why it matters now more than ever', Heart, vol. 107, no. 16, pp. 1278-1279.

Review article

Al-Arkee, S, Mason, J, Lane, D, Fabritz, L, Chua, WWL, Haque, S & Jalal, Z 2021, 'Mobile apps to improve medication adherence in cardiovascular disease: systematic review and meta-analysis', Journal of Medical Internet Research, vol. 23, no. 5, e24190.

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