Professor Larissa Fabritz

Larissa Fabritz

Institute of Cardiovascular Sciences
Professor of Cardiovascular Sciences

Contact details

Address
Institute of Cardiovascular Sciences
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Professor Larissa Fabritz studies novel mechanisms of heart disease and performs translational research towards mechanism-based therapies of cardiovascular diseases. As a clinical consultant, she sees patients in the Department of Cardiology at UHB. Larissa engages in research on molecular mechanisms of cardiomyopathies and arrhythmias as well as molecular cardiovascular imaging with her working group at the University of Birmingham and collaborations throughout Europe and North America.

Qualifications

  • 2016 Fellow of the Royal College of Physicians London
  • 2012 Fellow of the European Society of Cardiology
  • 2012 Habilitation Internal Medicine “Towards molecular mechanism-based therapy of cardiomyopathies and arrhythmias”
  • 2011 GMC accreditation
  • 2010 Board Certification in Medicine
  • 1998 Thesis summa cum laude
  • 1997 Graduation from Medical School

Teaching

Professor Fabritz is currently Cardiology Specialty Lead for Year 4 MBChB and Cardiology Specialty Lead for the Academic In Day (Year 5 MBChB)

Postgraduate supervision

  • PhD supervisor
  • MD supervisor

Current students are listed on the group webpage.

Professor Fabritz has supervised MD and PhD students in Germany and the UK and offers translational and interdisciplinary cardiovascular research projects on various topics of heart failure and arrhythmias, cardiomyopathies and sudden death with opportunities for engagement in international collaborations. If you are interested in an MD or PhD in these areas, please contact Professor Fabritz via email including your CV.

Research Associate and Postdoctoral positions are currently available. Please email your application to L.Fabritz@bham.ac.uk including your CV.

Research

  • Molecular mechanisms of arrhythmias and cardiomyopathies
  • Molecular mechanisms of atrial fibrillation and atrial thrombosis
  • Sodium channel dysfunction
  • Desmosomal proteins
  • Effects of ageing and exercise on arrhythmia and cardiomyopathy
  • Translation of preclinical research into clinical trials
  • Personalised medicine and management of care in patients with atrial fibrillation using a variety of innovative tools and techniques

 

Professor Fabritz is also linked to the below research groups :-

Other activities

Publications

Recent publications

Article

Peeters, F, Dudink, EAMP, Weijs, B, Fabritz, L, Chua, WWL, Kietselaer, BL, Wildberger, J, Meex, S, Kirchhof, P, Crijns, HJGM & Schurgers, L 2020, 'Biomarkers associated with aortic valve calcification: should we focus on sex specific processes?', Frontiers in cell and developmental biology, vol. 8, 604. https://doi.org/10.3389/fcell.2020.00604

Law, JP, Price, AM, Pickup, L, Radhakrishnan, A, Weston, C, Jones, AM, McGettrick, HM, Chua, W, Steeds, RP, Fabritz, L, Kirchhof, P, Pavlovic, D, Townend, JN & Ferro, CJ 2020, 'Clinical potential of targeting fibroblast growth factor‐23 and αKlotho in the treatment of uremic cardiomyopathy', Journal of the American Heart Association, vol. 9, no. 7, e016041. https://doi.org/10.1161/JAHA.120.016041

Radhakrishnan, A, Price, A, Pickup, L, Law, J, McGee, K, Fabritz, L, Senior, R, Steeds, R, Ferro, C & Townend, J 2020, 'Coronary flow velocity reserve and inflammatory markers in living kidney donors', International Journal of Cardiology, vol. 320, pp. 141-147. https://doi.org/10.1016/j.ijcard.2020.08.013

Jawad-Ul-Qamar, M, Chua, WWL, Purmah, Y, Nawaz, M, Varma, C, Davis, R, Maher, A, Fabritz, L & Kirchhof, P 2020, 'Detection of unknown atrial fibrillation by prolonged ECG monitoring in an all-comer patient cohort and association with clinical and Holter variables', Open Heart, vol. 7, no. 1, e001151. https://doi.org/10.1136/openhrt-2019-001151

Cao, L, Holmes, A, Marshall, J, Fabritz, L & Brain, K 2020, 'Dynamic monitoring of single-terminal norepinephrine transporter rate in the rodent cardiovascular system: a novel fluorescence imaging method', Autonomic Neuroscience, vol. 223, 102611. https://doi.org/10.1016/j.autneu.2019.102611

Rinné, S, Ortiz-Bonnin, B, Stallmeyer, B, Kiper, AK, Fortmüller, L, Schindler, RFR, Herbort-Brand, U, Kabir, N, Dittmann, S, Friedrich, C, Zumhagen, S, Gualandi, F, Selvatici, R, Rapezzi, C, Arbustini, E, Ferlini, A, Fabritz, L, Schulze-Bahr, E, Brand, T & Decher, N 2020, 'POPDC2 a novel susceptibility gene for conduction disorders', Journal of Molecular and Cellular Cardiology, vol. 145, pp. 74-83. https://doi.org/10.1016/j.yjmcc.2020.06.005

Dretzke, J, Chuchu, N, Agarwal, R, Herd, C, Chua, WWL, Fabritz, L, Bayliss, S, Kotecha, D, Deeks, J, Kirchhof, P & Takwoingi, Y 2020, 'Predicting recurrent atrial fibrillation after catheter ablation: a systematic review of prognostic models', Europace, vol. 22, no. 5, pp. 748–760. https://doi.org/10.1093/europace/euaa041

Baig, S, Dowd, R, Edwards, NC, Hodson, J, Fabritz, L, Vijapurapu, R, Liu, B, Geberhiwot, T & Steeds, RP 2020, 'Prospective cardiovascular magnetic resonance imaging in adults with Alström syndrome: silent progression of diffuse interstitial fibrosis', Orphanet Journal of Rare Diseases, vol. 15, 139. https://doi.org/10.1186/s13023-020-01426-4

Reyat, JS, Chua, W, Cardoso, VR, Witten, A, Kastner, PM, Kabir, SN, Sinner, MF, Wesselink, R, Holmes, AP, Pavlovic, D, Stoll, M, Kääb, S, Gkoutos, GV, de Groot, JR, Kirchhof, P & Fabritz, L 2020, 'Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation', JCI Insight, vol. 5, no. 16, e139179. https://doi.org/10.1172/jci.insight.139179

Kloosterman, M, Chua, WWL, Fabritz, L, Al-Khalidi, HR, Schotten, U, Nielsen, JC, Piccini, , JP, Di Biase, L, Häusler, KG, Todd, D, Mont, L, Van Gelder, IC & Kirchhof, P 2020, 'Sex differences in catheter ablation of atrial fibrillation: results from AXAFA-AFNET 5', Europace. https://doi.org/10.1093/europace/euaa015

O’shea, C, Holmes, AP, Winter, J, Correia, J, Ou, X, Dong, R, He, S, Kirchhof, P, Fabritz, L, Rajpoot, K & Pavlovic, D 2019, 'Cardiac optogenetics and optical mapping – overcoming spectral congestion in all-optical cardiac electrophysiology', Frontiers in Physiology, vol. 10, 182. https://doi.org/10.3389/fphys.2019.00182

Chua, WL, Purmah, Y, Roth Cardoso, V, Gkoutos, G, Tull, S, Neculau, G, Thomas, MR, Kotecha, D, Lip, G, Kirchhof, P & Fabritz, L 2019, 'Data-driven discovery and validation of circulating blood-based biomarkers associated with prevalent atrial fibrillation.', European Heart Journal, vol. 40, no. 16, ehy815, pp. 1268-1276. https://doi.org/10.1093/eurheartj/ehy815

Comment/debate

Hendriks, J & Fabritz, L 2019, 'AI can now identify atrial fibrillation through sinus rhythm', The Lancet, vol. 394, no. 10201, pp. 812-813. https://doi.org/10.1016/S0140-6736(19)31719-2

Conference contribution

Cao, L, Marshall, J, Fabritz, L & Brain, K 2020, Norepinephrine transporter saturation at physiological sympathetic firing rates in the murine heart. in Proceedings of the American Autonomic Society., 21.

Short survey

O'Shea, C, Kabir, SN, Holmes, AP, Lei, M, Fabritz, L, Rajpoot, K & Pavlovic, D 2020, 'Cardiac optical mapping – state-of-the-art and future challenges', International Journal of Biochemistry and Cell Biology, vol. 126, 105804. https://doi.org/10.1016/j.biocel.2020.105804

View all publications in research portal