Recent publications
Article
Cumberland, M, Riebel, LL, Roy, A, O'Shea, C, Holmes, A, Denning, C, Kirchhof, P, Rodriguez, B & Gehmlich, K 2022, 'Basic Research Approaches to Evaluate Cardiac Arrhythmia in Heart Failure and Beyond', Frontiers in Physiology, vol. 13, 806366. https://doi.org/10.3389/fphys.2022.806366
O'Reilly, M, Sommerfeld, LC, O'Shea, C, Broadway-Stringer, S, Andaleeb, S, Reyat, JS, Kabir, SN, Stastny, D, Malinova, A, Delbue, D, Fortmueller, L, Gehmlich, K, Pavlovic, D, Skryabin, BV, Holmes, AP, Kirchhof, P & Fabritz, L 2022, 'Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide', EP Europace. https://doi.org/10.1093/europace/euac218
Hall, C, Gehmlich, K, Denning, C & Pavlovic, D 2021, 'Complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease', Journal of the American Heart Association, vol. 10, no. 5, e019338. https://doi.org/10.1161/JAHA.120.019338
Jiang, H, Hooper, C, Kelly, M, Steeples, V, Simon, J, Beglov, J, Azad, A, Leinhos, L, Bennett, P, Ehler, E, Kalisch-Smith, J, Sparrow, D, Fischer, R, Heilig, R, Isackson, H, Ehsan, M, Patone, G, Huebner, N, Davies, B, Watkins, H & Gehmlich, K 2021, 'Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant', Basic research in cardiology, vol. 116, no. 1, 14, pp. 14. https://doi.org/10.1007/s00395-021-00853-z
Collier, MP, Alderson, TR, de Villiers, CP, Nicholls, D, Gastall, HY, Allison, TM, Degiacomi, MT, Jiang, H, Mlynek, G, Furst, DO, van der Ven, PFM, Djinovic-Carugo, K, Baldwin, AJ, Watkins, H, Gehmlich, K & Benesch, JLP 2019, 'HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C', Science Advances, vol. 5, no. 5, eaav8421. https://doi.org/10.1126/sciadv.aav8421
Azad, A, Poloni, G, Sontayananon, N, Jiang, H & Gehmlich, K 2019, 'The giant titin: how to evaluate its role in cardiomyopathies', Journal of Muscle Research and Cell Motility, vol. 40, no. 2, pp. 159-167. https://doi.org/10.1007/s10974-019-09518-w
Ehsan, M, Kelly, M, Hooper, C, Yavari, A, Beglov, J, Bellahcene, M, Ghataorhe, K, Poloni, G, Goel, A, Kyriakou, T, Fleischanderl, K, Ehler, E, Makeyev, E, Lange, S, Ashrafian, H, Redwood, C, Davies, B, Watkins, H & Gehmlich, K 2018, 'Mutant muscle LIM protein C58G causes cardiomyopathy through protein depletion', Journal of Molecular and Cellular Cardiology, vol. 121, pp. 287-296. https://doi.org/10.1016/j.yjmcc.2018.07.248
Gehmlich, K & Ehler, E 2018, 'Non-sarcomeric causes of heart failure', Biophysical Reviews, vol. 10, no. 4, pp. 943-947. https://doi.org/10.1007/s12551-018-0444-1
Smart, N, Riegler, J, Turtle, CW, Lygate, CA, McAndrew, DJ, Gehmlich, K, Dubé, KN, Price, AN, Muthurangu, V, Taylor, AM, Lythgoe, MF, Redwood, C & Riley, PR 2017, 'Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice', Journal of Molecular and Cellular Cardiology, vol. 102, pp. 94-107. https://doi.org/10.1016/j.yjmcc.2016.10.010
Rowlands, CT, Owen, T, Lawal, S, Cao, S, Pandey, SS, Yang, H-Y, Song, W, Wilkinson, R, Alvarez-Laviada, A, Gehmlich, K, Marston, SB & MacLeod, KT 2017, 'Age- and strain-related aberrant Ca2+ release is associated with sudden cardiac death in the ACTC E99K mouse model of hypertrophic cardiomyopathy', American Journal of Physiology Heart and Circulatory Physiology, vol. 313, no. 6, pp. H1213-H1226. https://doi.org/10.1152/ajpheart.00244.2017
Yavari, A, Bellahcene, M, Bucchi, A, Sirenko, S, Pinter, K, Herring, N, Jung, JJ, Tarasov, KV, Sharpe, EJ, Wolfien, M, Czibik, G, Steeples, V, Ghaffari, S, Nguyen, C, Stockenhuber, A, St Clair, JR, Rimmbach, C, Okamoto, Y, Yang, D, Wang, M, Ziman, BD, Moen, JM, Riordon, DR, Ramirez, C, Paina, M, Lee, J, Zhang, J, Ahmet, I, Matt, MG, Tarasova, YS, Baban, D, Sahgal, N, Lockstone, H, Puliyadi, R, de Bono, J, Siggs, OM, Gomes, J, Muskett, H, Maguire, ML, Beglov, Y, Kelly, M, Dos Santos, PPN, Bright, NJ, Woods, A, Gehmlich, K, Isackson, H, Douglas, G, Ferguson, DJP, Schneider, JE, Tinker, A, Wolkenhauer, O, Channon, KM, Cornall, RJ, Sternick, EB, Paterson, DJ, Redwood, CS, Carling, D, Proenza, C, David, R, Baruscotti, M, DiFrancesco, D, Lakatta, EG, Watkins, H & Ashrafian, H 2017, 'Mammalian γ2 AMPK regulates intrinsic heart rate', Nature Communications, vol. 8, no. 1, 1258. https://doi.org/10.1038/s41467-017-01342-5
Review article
Wadmore, K, Azad, A & Gehmlich, K 2021, 'The role of Z-disc proteins in myopathy and cardiomyopathy', International Journal of Molecular Sciences, vol. 22, no. 6, 3058. https://doi.org/10.3390/ijms22063058
Sontayananon, N, Redwood, C, Davies, B & Gehmlich, K 2020, 'Fluorescent PSC-derived cardiomyocyte reporter lines: generation approaches and their applications in cardiovascular medicine', Biology, vol. 9, no. 11, 402. https://doi.org/10.3390/biology9110402
Boycott, H, Nguyen, M, Vrellaku, B, Gehmlich, K & Robinson, P 2020, 'Nitric oxide and mechano-electrical transduction in cardiomyocytes', Frontiers in Physiology, vol. 11, 606740. https://doi.org/10.3389/fphys.2020.606740
Vimalanathan, AK, Ehler, E & Gehmlich, K 2018, 'Genetics of and pathogenic mechanisms in arrhythmogenic right ventricular cardiomyopathy', Biophysical Reviews, vol. 10, no. 4, pp. 973-982. https://doi.org/10.1007/s12551-018-0437-0
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