Professor Liam M Grover BMedSc(Hons), PhD, FIMMM

Professor Liam Grover

School of Chemical Engineering
Professor in Biomaterials Science
Deputy Head of School
Director of the Healthcare Technologies Institute (HTI)

Contact details

Address
Healthcare Technologies Institute
3rd Floor, Institute of Translational Medicine
Heritage Building (Old Queen Elizabeth Hospital)
Mindelsohn Way
Edgbaston, Birmingham
B15 2TH

Professor Liam Grover is a Professor in Biomaterials Science and the Director of the Healthcare Technologies Institute.

Professor Grover is a materials scientist by training, and completed his PhD at the University of Birmingham before moving to McGill University (Montreal) to work as a CIHR skeletal health scholar. He returned to Birmingham in 2006 to establish a research group within the School of Chemical Engineering.

He has published widely on the development of new materials to replace the function of tissues (more than 180 papers) and has filed more than ten patents to protect technologies that range from osteogenic cements through to scar reducing dressings. He has given well over 50 invited talks outside the UK.  Since starting his career, he has moved three technologies from concept through to clinical trial.  

Since returning to Birmingham, he has raised over £30m to fund his research on the development and translation of novel medical technologies (EPSRC, MRC, BBSRC, ERDF, EU, NC3Rs, NSFC – China, NIHR, RCDM, and industry) and is the Founder-Director of the Healthcare Technologies Institute, which works to help move novel technologies through the translational pipeline.  He sits on the EPSRC Healthcare Technologies SAT, the NIHR i4i panel and has sat on the MRC DPFS panel.

He was the youngest Professor in the history of the University of Birmingham (32) and the youngest ever Fellow of the Institute of Materials (30). 

Qualifications

  • PGCert in learning and teaching in higher education, 2011
  • PhD in Dentistry, School of Dentistry, University of Birmingham, 2004
  • BMedSc(Hons), Biomedical Materials Science, University of Birmingham, 2001

Teaching

Professor Grover has a PGCert in teaching in further education, his current teaching responsibilities include:

  •  Module coordinator and principle lecturer on Bioscience for Engineers (Level H and Level M)
  •  Coordinator for Bioscience for Engineers practical week.
  •  Module coordinator and principle lecturer on Modern Genome Based Bioscience/Frontier Interdisciplinary Bioscience (Level M)
  •  Module coordinator for MSc summer research projects (Level M)
  •  Lecturer on Sustainable Development module (Level H)

He has also given lectures at Keele University, the University of Wuerzburg and has been invited to lecture at the Technical University of Vienna.

Postgraduate supervision

Liam Grover’s research focuses on the development and characterisation of materials for the regeneration of diseased and damaged tissues, particularly bone and bone-interfacing tissues, but he has also published on the delivery of fibroblasts and keratinocytes for skin regeneration. Within this broader field, four of his principal areas of current research activity are:

Regenerating the hard-soft tissue interface: developing bone-to-bone ligament replacements using fibrin and ceramics; reinforcing ligament replacements

Polymer gel-encapsulation of cells: evaluating how cell encapsulation affects the mechanical properties of hydrogels; hydrogel matrices; cell responses to encapsulation; ultrasonic enhancement of matrix production

Calcium phosphate materials chemistry: involvement of amorphous materials in biomineralisation; developing calcium phosphate cement formulations

Controlling mineralisation: use of cheap proteins to adjust crystal habitats in industrial materials; stabilisation of amorphous minerals

Publications

Recent publications

Article

Hughes, EAB, Chipara, M, Hall, TJ, Williams, RL & Grover, LM 2020, 'Chemobrionic structures in tissue engineering: self-assembling calcium phosphate tubes as cellular scaffolds', Biomaterials Science, vol. 8, no. 3, pp. 812-822. https://doi.org/10.1039/c9bm01010f

Robinson, TE, Hughes, EAB, Bose, A, Cornish, EA, Teo, JY, Eisenstein, NM, Grover, LM & Cox, SC 2020, 'Filling the Gap: A Correlation between Objective and Subjective Measures of Injectability', Advanced Healthcare Materials, vol. 9, no. 5, 1901521. https://doi.org/10.1002/adhm.201901521

Robinson, TE, Hughes, EAB, Wiseman, OJ, Stapley, SA, Cox, SC & Grover, LM 2020, 'Hexametaphosphate as a potential therapy for the dissolution and prevention of kidney stones', Journal of Materials Chemistry B, vol. 8, no. 24, pp. 5215-5224. https://doi.org/10.1039/D0TB00343C

Robinson, T, Eisenstein, N, Cox, S, Moakes, R, Thompson, AM, Ahmed, Z, Hughes, E, Hill, LJ, Stapley, S & Grover, L 2020, 'Local injection of a hexametaphosphate formulation reduces heterotopic ossification in vivo', Materials today. Bio, vol. 7, 100059. https://doi.org/10.1016/j.mtbio.2020.100059

Carter, LN, Addison, O, Naji, N, Seres, P, Wilman, AH, Shepherd, DET, Grover, L & Cox, S 2020, 'Reducing MRI susceptibility artefacts in implants using additively manufactured porous Ti-6Al-4V structures', Acta Biomaterialia, vol. 107, pp. 338-348. https://doi.org/10.1016/j.actbio.2020.02.038

Wu, M, Downie, L, Grover, L, Moakes, R, Rauz, S, Logan, A, Jiao, H, Hill, LJ & Chinnery, HR 2020, 'The neuroregenerative effects of topical decorin on the injured mouse cornea', Journal of Neuroinflammation, vol. 17, no. 1, 142. https://doi.org/10.1186/s12974-020-01812-6, https://doi.org/10.1186/s12974-020-01812-6

ter Horst, B, Moakes, RJA, Chouhan, G, Williams, RL, Moiemen, NS & Grover, LM 2019, 'A gellan-based fluid gel carrier to enhance topical spray delivery', Acta Biomaterialia, vol. 89, pp. 166-179. https://doi.org/10.1016/j.actbio.2019.03.036

Chouhan, G, Moakes, RJA, Esmaeili, M, Hill, LJ, deCogan, F, Hardwicke, J, Rauz, S, Logan, A & Grover, LM 2019, 'A self-healing hydrogel eye drop for the sustained delivery of decorin to prevent corneal scarring', Biomaterials, vol. 210, pp. 41-50. https://doi.org/10.1016/j.biomaterials.2019.04.013

Hall, T, Blair, J, Moakes, R, Pelan, E, Grover, L & Cox, S 2019, 'Antimicrobial emulsions: formulation of a triggered release reactive oxygen delivery system', Materials Science and Engineering C, vol. 103, 109735. https://doi.org/10.1016/j.msec.2019.05.020

Davies, O, Cox, S, Azoidis, I, McGuinness, A, Cooke, M, Heaney, LM, Davis, E, Jones, S & Grover, L 2019, 'Corrigendum: Osteoblast-derived vesicle protein content Is temporally regulated during osteogenesis: implications for regenerative therapies', Frontiers in Bioengineering and Biotechnology, vol. 7, 392, pp. 1-2. https://doi.org/10.3389/fbioe.2019.00392

Hughes, EAB, Robinson, TE, Bassett, DB, Cox, SC & Grover, LM 2019, 'Critical and diverse roles of phosphates in human bone formation', Journal of Materials Chemistry B, vol. 7, no. 47, pp. 7460-7470. https://doi.org/10.1039/c9tb02011j

Pearson, M, Philip, AM, Nicholson, T, Cooke, M, Grover, L, Newton Ede, M & Jones, S 2019, 'Evidence of intrinsic impairment of osteoblast phenotype at the curve apex in girls with adolescent idiopathic scoliosis', Spine Deformity, vol. 7, no. 4, pp. 533-542. https://doi.org/10.1016/j.jspd.2018.11.016, https://doi.org/10.1016/j.jspd.2018.11.016

Conference article

Ginestra, P, Ceretti, E, Lobo, D, Lowther, M, Cruchley, S, Kuehne, S, Villapun, V, Cox, S, Grover, L, Shepherd, D, Attallah, M, Addison, O & Webber, M 2020, 'Post processing of 3D printed metal scaffolds: A preliminary study of antimicrobial efficiency', Procedia Manufacturing, vol. 47, pp. 1106-1112. https://doi.org/10.1016/j.promfg.2020.04.126

Review article

Bennett, N, Chinnery, HR, Downie, L, Hill, LJ & Grover, L 2020, 'Material, immunological, and practical perspectives on eye drop formulation', Advanced Functional Materials, vol. 30, no. 14, 1908476. https://doi.org/10.1002/adfm.201908476

Lowther, M, Louth, S, Davey, A, Hussain, A, Ginestra, P, Carter, L, Eisenstein, N, Grover, L & Cox, S 2019, 'Clinical, industrial, and research perspectives on powder bed fusion additively manufactured metal implants', Additive Manufacturing, vol. 28, pp. 565-584.

View all publications in research portal

Expertise

Tissue regeneration; new implant materials; growth of tissue in the lab that could be implanted or used as a biological model to study factors that may influence tissues in the body.

Expertise

Tissue regeneration; new implant materials; growth of tissue in the lab that could be implanted or used as a biological model to study factors that may influence tissues in the body.