Work in the Grainger group is centred on the development of new synthetic methods and strategies, and their application in the synthesis of organic molecules of biological or structural interest. Chemistry we are developing includes the use of reactive intermediates such as radicals and carbenes, photochemistry, cycloaddition reactions and organosulfur and other organochalcogen (Se, Te) chemistry. We also have an active interest in the use of 1,8-peri-substituted naphthalenes and related compounds for the generation and stabilization of reactive functionalities. As part of this research programme, we have recently developed a method for the 4,5-bay-functionalisation of carbazoles, of interest in organic materials.
We collaborate with University of Birmingham scientists within the School of Chemistry (Dr Paul Davies on gold-catalysed transformations of organosulfur compounds, Dr Sarah Horswell for electrochemistry measurements, Professor Jim Tucker on DNA and nitroxyl generation) and in the School of Pharmacy (Professor Nicholas Barnes, Dr Isolda Romero-Canelón, Dr Sam Butterworth (now at the University of Manchester)) on medicinal chemistry). Internationally we have collaborated with Professor Steve Bottle (Queensland University of Technology, Australia) on nitroxide radicals, and with Professor Antonella Capperucci and Dr Damiano Tanini (University of Florence, Italy) on glutathione peroxidase mimics.