Dr Richard D Horniblow MSci, PhD, AFHEA

Dr Richard D Horniblow

School of Biomedical Sciences
Lecturer – Teaching and Research

Contact details

Address
Institute of Clinical Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Richard is an early career researcher within the School of Biomedical Science in the Institute of Clinical Sciences. His research focusses on how different dietary components are implicated in the development and progression of intestinal diseases (particularly inflammatory bowel disease (IBD) and colorectal cancer). The majority of his work has focussed on dietary iron and how this key nutrient can modulate intestinal diseases. From this, he has developed novel therapies that can target toxic iron rendering it inert. Most recently he is developing new synbiotics that are able to deliver highly viable gut bacteria to the colon that may have therapeutic potential in treating IBD. Richard is an associate fellow of the Higher Education Academy and teaches on several modules in the Biomedical Science and MBChB programmes. He is also a co-lead for the Biomedical Birmingham International Summer School.

Qualifications

  • Associate Fellow of the Higher Education Academy, 2018
  • PhD in Medicinal Chemistry/Cancer, 2015
  • MSci in Chemistry with Pharmacology, Class I, University of Birmingham, 2011

Teaching

Other activities

Richard is involved in many public engagement events for Cancer Research UK, raising awareness of his research. His research is also showcased on chemBAM.com and assists in developing demonstrations suitable for use in schools with the aim of bringing university-research to students. He was previously a PhD tutor for The Brilliant Club, a charity that exists to increase the number of pupils from under-represented backgrounds progressing to highly-selective universities.

Publications

Recent publications

Article

Quraishi, MN, Acharjee, A, Beggs, AD, Horniblow, R, Tselepis, C, Gkoutos, G, Ghosh, S, Rossiter, A, Loman, N, van Schaik, W, Withers, D, Walters, JRF, Hirschfield, GM & Iqbal, TH 2020, 'A pilot integrative analysis of colonic gene expression, gut microbiota, and immune infiltration in primary sclerosing cholangitis-inflammatory bowel disease: association of disease with bile acid pathways', Journal of Crohn's & Colitis, vol. 14, no. 7, pp. 935-947. https://doi.org/10.1093/ecco-jcc/jjaa021

Horniblow, RD, Mistry, P, Quraishi, MN, Beggs, AD, Van de Wiele, T, Iqbal, TH & Tselepis, C 2019, 'The Safety and Tolerability of a Potential Alginate-Based Iron Chelator; Results of A Healthy Participant Study', Nutrients, vol. 11, no. 3. https://doi.org/10.3390/nu11030674

Horniblow, R, Mistry, P, Quraishi, MN, Beggs, A, van De Weile, T, Iqbal, T & Tselepis, C 2019, 'The safety and tolerability of a potential alginate-based iron chelator: results of a healthy participant study', Nutrients, vol. 11, no. 3, 674. https://doi.org/10.3390/nu11030674

Phillips, E, Horniblow, RD, Poole, V, Bedford, M, Ward, DG, Kirkham, AJ, Tomlinson, J, Iqbal, TH & Tselepis, C 2018, 'A potential role for hepcidin in obesity-driven colorectal tumourigenesis', Oncology reports, vol. 39, no. 1, pp. 392-400. https://doi.org/10.3892/or.2017.6062

Horniblow, RD, Bedford, M, Hollingworth, R, Evans, S, Sutton, E, Lal, N, Beggs, A, Iqbal, TH & Tselepis, C 2017, 'B-RAF mutations are associated with increased iron regulatory protein-2 expression in colorectal tumourigenesis', Cancer Science. https://doi.org/10.1111/cas.13234

Hollingworth, R, Horniblow, R, Forrest, C, Stewart, G & Grand, R 2017, 'Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus', Journal of virology, vol. 91, e00930-17. https://doi.org/10.1128/JVI.00930-17

Horniblow, RD, Henesy, D, Iqbal, TH & Tselepis, C 2016, 'Modulation of iron transport, metabolism and reactive oxygen status by quercetin-iron complexes in vitro', Molecular Nutrition & Food Research. https://doi.org/10.1002/mnfr.201600692

Jian, N, Dowle, M, Horniblow, RD, Tselepis, C & Palmer, RE 2016, 'Morphology of the ferritin iron core by aberration corrected scanning transmission electron microscopy', Nanotechnology, vol. 27, no. 46, 46LT02. https://doi.org/10.1088/0957-4484/27/46/46LT02

Horniblow, RD, Latunde-Dada, GO, Harding, SE, Schneider, M, Sahni, M, Bhatti, A, Ludwig, C, Norton, IT, Iqbal, TH & Tselepis, C 2016, 'The chelation of colonic luminal iron by a unique sodium alginate for the improvement of gastrointestinal health', Molecular Nutrition & Food Research. https://doi.org/10.1002/mnfr.201500882

Horniblow, RD, Dowle, M, Iqbal, TH, Latunde-dada, GO, Palmer, RE, Pikramenou, Z & Tselepis, C 2015, 'Alginate-iron speciation and its effect on in vitro cellular iron metabolism', PLoS ONE, vol. 10, no. 9, e0138240. https://doi.org/10.1371/journal.pone.0138240

Bedford, MR, Ford, SJ, Horniblow, RD, Iqbal, TH & Tselepis, C 2013, 'Iron chelation in the treatment of cancer: a new role for deferasirox?', Journal of Clinical Pharmacology, vol. 53, no. 9, pp. 885-91. https://doi.org/10.1002/jcph.113

Conference article

Horniblow, R, Radulescu, S, Schneider, M, Dowle, M, Iqbal, T, Palmer, R, Latunde-Dada, G, Pikramenou, Z & Tselepis, C 2014, 'Iron chelation by biopolymers for an anti-cancer therapy: binding up the 'ferrotoxicity' in the colon', European Journal of Cancer , vol. 50, no. supp 5, pp. S173. https://doi.org/10.1016/s0959-8049(14)50635-1

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