Dr James Coverdale MChem PhD CChem MRSC

Dr James Coverdale

School of Pharmacy
Lecturer in Pharmaceutical Biology

Dr James Coverdale is a Lecturer in Pharmaceutical Biology. His previous experience within industry and academia has provided him with analytical expertise in the field of bioinorganic chemistry. He lectures on medicinal chemistry to students on the MPharm course.

James’s research focuses on the role of metals in medicine, and the development of new experimental techniques. James has a specific interest in how metal dyshomeostasis can contribute to various pathological states, and how metal-based therapies can provide new opportunities for the treatment of diseases.

James was awarded Chartered Chemist status in 2021, in recognition of his on-going professional practice.

ORCID: 0000-0002-7779-6620

https://www.researchgate.net/profile/James-Coverdale

Qualifications

  • PhD in Chemistry, University of Warwick, 2017
  • MChem in Chemistry, University of Warwick,  2014

Teaching

MPharm: Chemistry for Pharmacists

Postgraduate supervision

Dr Coverdale is interested in supervising doctoral research in the following areas:

  • Inorganic medicinal chemistry
  • Metalloproteomics

Development of inorganic analytical techniques

If you are interesting in studying any of these subject areas please contact Dr Coverdale directly, or for any general doctoral research enquiries, please email mdsgradschool@contacts.bham.ac.uk

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings  

Other activities

  • Chartered Chemist (CChem)
  • Member of the Royal Society of Chemistry (MRSC)
  • Winner: 2019 Best Paper Awards – Inorganics (MDPI, Basel)
  • Winner: Research Publication Prize 2019 – University of Warwick
  • Postgraduate Award in Transferable Skills – University of Warwick
  • “Osmium Catalysis & Methods of Synthesis” – UK Patent Application No. GB 1504281

Publications

Recent publications

Article

Mikhaylina, A, Ksibe, AZ, Wilkinson, RC, Smith, D, Marks, E, Coverdale, JPC, Fülöp, V, Scanlan, DJ & Blindauer, CA 2022, 'A single sensor controls large variations in zinc quotas in a marine cyanobacterium', Nature Chemical Biology, vol. 18, no. 8, pp. 869–877 . https://doi.org/10.1038/s41589-022-01051-1

Coverdale, JPC, Berg, HAVD, Khazaipoul, S, Bridgewater, HE, Stewart, AJ & Blindauer, CA 2022, 'Albumin-mediated extracellular zinc speciation drives cellular zinc uptake', Chemical Communications, vol. 58, no. 53, pp. 7384-7387. https://doi.org/10.1039/D2CC02278H

Bolitho, EM, Coverdale, J, Wolny, JA, Schunemann, V & Sadler, PJ 2022, 'Density functional theory investigation of Ru(II) and Os(II) asymmetric transfer hydrogenation catalysts', Faraday Discussions. https://doi.org/10.1039/d1fd00075f

Bolitho, EM, Bridgewater, HE, Needham, RJ, Coverdale, JPC, Quinn, PD, Sanchez-Cano, C & Sadler, PJ 2021, 'Elemental mapping of half-sandwich azopyridine osmium arene complexes in cancer cells', Inorganic Chemistry Frontiers, vol. 8, no. 15, pp. 3675-3685. https://doi.org/10.1039/D1QI00512J

Kladnik, J, Coverdale, JPC, Kljun, J, Burmeister, H, Lippman, P, Ellis, FG, Jones, AM, Ott, I, Romero-Canelón, I & Turel, I 2021, 'Organoruthenium complexes with benzo-fused pyrithiones overcome platinum resistance in ovarian cancer cells', Cancers, vol. 13, no. 10, 2493. https://doi.org/10.3390/cancers13102493

Coverdale, JPC, Guy, CS, Bridgewater, HE, Needham, RJ, Fullam, E & Sadler, PJ 2021, 'Osmium–arene complexes with high potency towards Mycobacterium tuberculosis', Metallomics, vol. 13, no. 4, mfab007, pp. 1-8. https://doi.org/10.1093/mtomcs/mfab007

Bolitho, EM, Worby, NG, Coverdale, J, Wolny, JA, Schunemann, V & Sadler, PJ 2021, 'Quinone reduction by organo-osmium half-sandwich transfer hydrogenation catalysts', Organometallics. https://doi.org/10.1021/acs.organomet.1c00358

Bolitho, EM, Coverdale, JPC, Bridgewater, HE, Clarkson, GJ, Quinn, PD, Sanchez‐Cano, C & Sadler, PJ 2021, 'Tracking reactions of asymmetric organo‐osmium transfer hydrogenation catalysts in cancer cells', Angewandte Chemie, vol. 60, no. 12, pp. 6462-6472. https://doi.org/10.1002/ange.202016456, https://doi.org/10.1002/anie.202016456

Zhang, W-Y, Banerjee, S, Hughes, GM, Bridgewater, HE, Song, J-I, Breeze, BG, Clarkson, GJ, Coverdale, JPC, Sanchez-Cano, C, Ponte, F, Sicilia, E & Sadler, PJ 2020, 'Ligand-centred redox activation of inert organoiridium anticancer catalysts', Chemical Science, no. 21. https://doi.org/10.1039/D0SC00897D

Oliveira, CG, Romero-Canelón, I, Coverdale, JPC, Maia, PIS, Clarkson, GJ, Deflon, VM & Sadler, PJ 2020, 'Novel tetranuclear PdII and PtII anticancer complexes derived from pyrene thiosemicarbazones', Dalton Transactions, no. 28, pp. 9595-9604. https://doi.org/10.1039/D0DT01133A

Song, H, Rogers, NJ, Brabec, V, Clarkson, GJ, Coverdale, JPC, Kostrhunova, H, Phillips, RM, Postings, M, Shepherd, SL & Scott, P 2020, 'Triazole-based, optically-pure metallosupramolecules; highly potent and selective anticancer compounds', Chemical Communications, vol. 47. https://doi.org/10.1039/D0CC02429E

Coverdale, JPC, Barnett, JP, Adamu, AH, Griffiths, EJ, Stewart, AJ & Blindauer, CA 2019, 'A metalloproteomic analysis of interactions between plasma proteins and zinc: elevated fatty acid levels affect zinc distribution', Metallomics, vol. 11, no. 11, pp. 1805-1819. https://doi.org/10.1039/C9MT00177H

Coverdale, J, Khazaipoul, S, Arya, S, Stewart, AJ & Blindauer, CA 2019, 'Crosstalk between zinc and free fatty acids in plasma', Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. https://doi.org/10.1016/j.bbalip.2018.09.007

Review article

Coverdale, JPC, Harrington, CF & Solovyev, N 2022, 'Review: advances in the accuracy and traceability of metalloprotein measurements using isotope dilution inductively coupled plasma mass spectrometry', Critical Reviews in Analytical Chemistry. https://doi.org/10.1080/10408347.2022.2162811

Coverdale, J, Laroiya-McCarron, T & Romero-Canelón, I 2019, 'Designing ruthenium anticancer drugs: what have we learnt from the key drug candidates?', Inorganics, vol. 7, no. 3, 31. https://doi.org/10.3390/inorganics7030031

View all publications in research portal