Fenton, C, Martin, C, Jones, R, Croft, A, Campos, J, Naylor, A, Taylor, A, Chimen, M, Cooper, M, Lavery, G, Raza, K & Hardy, R 2020, 'Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids', Annals of the Rheumatic Diseases.
Fenton, C, Doig, C, Fareed, S, Naylor, A, Morrell, AP, Addison, O, Wehmeyer, C, Buckley, C, Cooper, MS, Lavery, G, Raza, K & Hardy, R 2019, '11β-HSD1 Plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy', Arthritis Research & Therapy, vol. 21, no. 1, 188. https://doi.org/10.1186/s13075-019-1972-1
Webster, J, Fenton, C, Langen, R & Hardy, R 2019, 'Exploring the interface between inflammatory and therapeutic glucocorticoid induced bone and muscle loss', International Journal of Molecular Sciences, vol. 20, no. 22, 5768. https://doi.org/10.3390/ijms20225768
Sagmeister, M, Taylor, A, Fenton, A, Wall, N, Chanouzas, D, Nightingale, P, Ferro, CJ, Arlt, W, Cockwell, P, Hardy, R & Harper, L 2019, 'Glucocorticoid activation by 11β-hydroxysteroid dehydrogenase enzymes in relation to inflammation and glycaemic control in chronic kidney disease: A cross-sectional study', Clinical Endocrinology, vol. 90, no. 1, pp. 241-249. https://doi.org/10.1111/cen.13889
Fenton, C, Webster, J, Martin, C, Fareed, S, Wehmeyer, C, Mackie, H, Jones, R, Seabright, A, Lewis, J, Lai, Y-C, Goodyear, CS, Jones, S, Cooper, MS, Lavery, G, Langen, R, Raza, K & Hardy, R 2019, 'Therapeutic glucocorticoids prevent bone loss but drive muscle wasting when administered in chronic polyarthritis', Arthritis Research & Therapy, vol. 21, no. 1, 182. https://doi.org/10.1186/s13075-019-1962-3
Hardy, R, Fenton, C, Croft, A, Naylor, A, Begum, R, Desanti, G, Buckley, C, Lavery, G, Cooper, MS & Raza, K 2018, '11beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis', Journal of Autoimmunity, vol. 92, pp. 104-113. https://doi.org/10.1016/j.jaut.2018.05.010, https://doi.org/10.1016/j.jaut.2018.05.010
Hardy, R, Zhou, H, Seibel, MJ & Cooper, MS 2018, 'Glucocorticoids and bone: consequences of endogenous and exogenous excess and replacement therapy', Endocrine Reviews. https://doi.org/10.1210/er.2018-00097
Hardy, R & Cooper, MS 2018, 'Unravelling how glucocorticoids work in rheumatoid arthritis', Nature Reviews Rheumatology, pp. 1759-4804. https://doi.org/10.1136/annrheumdis-2017-212762
Rokad, F, Moseley, R, Hardy, R, Chukkapalli, S, Crean, S, Kesavalu, L & Singhrao, S 2017, 'Cerebral Oxidative Stress and Microvasculature Defects in TNF-α Expressing Transgenic and Porphyromonas gingivalis-Infected ApoE-/- Mice', Journal of Alzheimer's Disease, vol. 60, no. 2, pp. 359-369. https://doi.org/10.3233/JAD-170304
Naylor, A, Desanti, G, Saghir, A & Hardy, R 2017, 'TNFα depleting therapy improves fertility and animal welfare in TNFα-driven transgenic models of polyarthritis when administered in their routine breeding', Laboratory Animals. https://doi.org/10.1177/0023677217707985
Hardy, RS, Doig, CL, Hussain, Z, O'Leary, M, Morgan, SA, Pearson, MJ, Naylor, A, Jones, S, Filer, A, Stewart, PM, Buckley, CD, Lavery, GG, Cooper, MS & Raza, K 2016, '11β-hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation', Journal of Pathology, vol. 240, no. 4, pp. 472-483. https://doi.org/10.1002/path.4806, https://doi.org/10.1002/path.4806
Juarez, M, McGettrick, HM, Scheel-Toellner, D, Yeo, L, Spengler, J, de Paz, B, Hardy, R, Cooper, M, Raza, K, Buckley, CD & Filer, A 2016, 'DKK1 expression by synovial fibroblasts in very early rheumatoid arthritis associates with lymphocyte adhesion in an in vitro flow co-culture system', Arthritis Research & Therapy, vol. 18, no. 1, 14. https://doi.org/10.1186/s13075-016-0915-3
Hardy, R, Botfield, H, Markey, K, Mitchell, J, Alimajstorovic, Z, Westgate, C, Sagmeister, M, Fairclough, R, Ottridge, R, Yiangou, A, Storbeck, K-H, Taylor, A, Gilligan, L, Arlt, W, Stewart, P, Tomlinson, J, Mollan, S, Lavery, G & Sinclair, A 2020, '11βHSD1 inhibition with AZD4017 improves lipid profiles and lean muscle mass in Idiopathic intracranial hypertension', Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/clinem/dgaa766
Webster, J, Kempen, L, Hardy, R & Langen, R 2020, 'Inflammation and skeletal muscle wasting during cachexia', Frontiers in Physiology.
Raza, K, Hardy, R & Cooper, MS 2020, 'Therapeutic glucocorticoids mechanisms of actions in rheumatic diseases', Nature Reviews Rheumatology, vol. 16, no. 3, pp. 133-144. https://doi.org/10.1038/s41584-020-0371-y, https://doi.org/https://www.nature.com/articles/s41584-020-0371-y#article-info
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