Recent publications
Article
Webster, JM, Waaijenberg, K, van de Worp, WRPH, Kelders, MCJM, Lambrichts, S, Martin, C, Verhaegen, F, Van der Heyden, B, Smith, C, Lavery, GG, Schols, AMWJ, Hardy, RS & Langen, RCJ 2023, '11β-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD', American journal of physiology. Lung cellular and molecular physiology, vol. 324, no. 4, pp. L400-L412. https://doi.org/10.1152/ajplung.00009.2022
Chidomere, CI, Wahid, M, Kemble, S, Chadwick, C, Thomas, R, Hardy, RS, Mcgettrick, HM & Naylor, AJ 2023, 'Bench to Bedside: Modelling Inflammatory Arthritis', Discovery Immunology, vol. 2, no. 1, kyac010. https://doi.org/10.1093/discim/kyac010
Hansen, MS, Søe, K, Christensen, LL, Fernandez-Guerra, P, Hansen, NW, Wyatt, RA, Martin, C, Hardy, RS, Andersen, TL, Olesen, JB, Hartmann, B, Rosenkilde, MM, Kassem, M, Rauch, A, Gorvin, C & Frost, M 2023, 'GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells', European Journal of Endocrinology , vol. 188, no. 1, lvac004. https://doi.org/10.1093/ejendo/lvac004
Mahida, RY, Lax, S, Bassford, CR, Scott, A, Parekh, D, Hardy, RS, Naidu, B, Matthay, MA, Stewart, PM, Cooper, MC, Perkins, GD & Thickett, DR 2023, 'Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS', Frontiers in immunology, vol. 14, 1159831. https://doi.org/10.3389/fimmu.2023.1159831
Fenton, CG, Crastin, A, Martin, CS, Suresh, S, Montagna, I, Hussain, B, Naylor, AJ, Jones, SW, Hansen, MS, Gorvin, CM, Price, M, Filer, A, Cooper, MS, Lavery, GG, Raza, K & Hardy, RS 2022, '11β-hydroxysteroid dehydrogenase type 1 within osteoclasts mediates the bone protective properties of therapeutic corticosteroids in chronic inflammation', International Journal of Molecular Sciences, vol. 23, no. 13, 7334, pp. 7334. https://doi.org/10.3390/ijms23137334
Siddiqa, A, Tajammal, A, Irfan, A, Azam, M, Munawar, MA, Hardy, RS & Asim Raza Basra, M 2022, 'Synthesis, molecular docking, bio-evaluation and quantitative structure activity relationship of new chalcone derivatives as antioxidants', Journal of Molecular Structure. https://doi.org/10.1016/j.molstruc.2022.134814
Mahida, RY, Scott, A, Parekh, D, Lugg, ST, Hardy, RS, Lavery, GG, Matthay, MA, Naidu, B, Perkins, GD & Thickett, DR 2021, 'Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis', The European respiratory journal, vol. 58, no. 3, 2100829. https://doi.org/10.1183/13993003.00829-2021
Mahida, RY, Scott, A, Parekh, D, Lugg, ST, Belchamber, KBR, Hardy, RS, Matthay, MA, Naidu, B & Thickett, DR 2021, 'Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome', Frontiers in Medicine, vol. 8, 737859. https://doi.org/10.3389/fmed.2021.737859
Webster, JM, Sagmeister, MS, Fenton, CG, Seabright, AP, Lai, YC, Jones, SW, Filer, A, Cooper, MS, Lavery, GG, Raza, K, Langen, R & Hardy, RS 2021, 'Global deletion of 11β-HSD1 prevents muscle wasting associated with glucocorticoid therapy in polyarthritis', International Journal of Molecular Sciences, vol. 22, no. 15, 7828. https://doi.org/10.3390/ijms22157828
Fenton, C, Martin, C, Jones, R, Croft, A, Campos, J, Naylor, A, Taylor, A, Chimen, M, Cooper, M, Lavery, G, Raza, K & Hardy, R 2021, 'Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids', Annals of the Rheumatic Diseases, vol. 80, no. 2, pp. 250-260. https://doi.org/10.1136/annrheumdis-2020-218493
Review article
Sagmeister, M, Harper, L & Hardy, R 2023, 'Cortisol excess in chronic kidney disease: – a review of changes and impact on mortality', Frontiers in Endocrinology, vol. 13, 1075809. https://doi.org/10.3389/fendo.2022.1075809
Nicholson, TA, Sagmeister, M, Wijesinghe, SN, Farah, H, Hardy, RS & Jones, SW 2023, 'Oligonucleotide Therapeutics for Age-Related Musculoskeletal Disorders: Successes and Challenges', Pharmaceutics, vol. 15, no. 1, 237. https://doi.org/10.3390/pharmaceutics15010237
Hardy, R, Botfield, H, Markey, K, Mitchell, J, Alimajstorovic, Z, Westgate, C, Sagmeister, M, Fairclough, R, Ottridge, R, Yiangou, A, Storbeck, K-H, Taylor, A, Gilligan, L, Arlt, W, Stewart, P, Tomlinson, J, Mollan, S, Lavery, G & Sinclair, A 2021, '11βHSD1 inhibition with AZD4017 improves lipid profiles and lean muscle mass in Idiopathic intracranial hypertension', Journal of Clinical Endocrinology and Metabolism, vol. 106, no. 1, pp. 174-187. https://doi.org/10.1210/clinem/dgaa766
Martin, CS, Cooper, MS & Hardy, RS 2021, 'Endogenous Glucocorticoid Metabolism in Bone: Friend or Foe', Frontiers in Endocrinology, vol. 12, 733611. https://doi.org/10.3389/fendo.2021.733611
Webster, J, Kempen, L, Hardy, R & Langen, R 2020, 'Inflammation and skeletal muscle wasting during cachexia', Frontiers in Physiology, vol. 2020, 597675. https://doi.org/10.3389/fphys.2020.597675
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