Dr Marie-Christine Jones BPharm, PhD

Dr Marie-Christine Jones

School of Pharmacy
Lecturer in Pharmaceutics

Contact details

Address
Institute of Clinical Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Marie-Christine Jones has joined the Institute of Clinical Sciences as part of the team developing the new integrated MPharm degree.

Her research background is in pharmaceutical nanotechnology and her research interests are focussed on the development of new drug delivery systems and the evaluation of their behaviour in a physiological environment.

Qualifications

  • PhD Pharmaceutical sciences (option pharmaceutical technology) (2008)
  • Bachelor of Pharmacy (2000)

Biography

Marie-Christine obtained her Bachelor in Pharmacy from the Faculty of Pharmacy (Université de Montréal) in 2000. She then completed her PhD in Pharmaceutical Sciences working on polymeric  unimolecular micelles as oral delivery systems for Class II drugs and peptides.

After her PhD, Marie-Christine moved to London (UK) to join the School of Pharmacy (now University College London School of Pharmacy) where she furthered her expertise on polymeric drug delivery system, including their use in gene silencing therapy. In 2010, she joined King’s College London’s Institute of Pharmaceutical Science, where she studied the toxicity of inhaled nanoparticles made of ‘soft-materials’

Marie-Christine joined the College of Medical and Dental Science in 2012 as part of the team building the new MPharm curriculum at the University of Birmingham.

Teaching

  • MPharm undergraduate degree programme

Postgraduate supervision

Marie-Christine in interested in supervising projects in the following areas:

  • Drug delivery
  • Gene delivery
  • Nanotoxicology
  • Particokinetics

Research

Focussing mostly on the delivery of water-insoluble agents and labile macromolecules, Marie-Christine’s research platform aims at exploring novel polymeric drug delivery systems and providing a better understanding of their fate following administration.

More specifically, she is interested in identifying specific physico-chemical properties and pharmacological targets that can be exploited to provide higher therapeutic activity while limiting toxicity from both drug and carrier.

Publications

  1. Patel A, Woods A, Riffo-Vasquez Y, Babin-Morgan A, Jones MC, Jones S, Sunassee K,  Clarks ST, De Rosales TM, Page C, Spina D, Forbes B, Dailey LA. Lung inflammation does not affect the clearance kinetics of lipid nanocapsules following pulmonary administration. Journal of Controlled Release 2016; 235:24-33.
  2. Jones MC. Thinking outside the ‘block’: alternative polymer compositions for micellar drug delivery. Current Topics in Medicinal Chemistry 2015; 22:2254-2266.
  3. Khanbeigi A, Abelha TF, Woods A, Ratoin O, Harvey RD, Jones MC, Forbes B, Green MA, Collins H, Dailey LA. Biomacromolecules 2015; 16:733-742.
  4. de la Fuente M, Jones MC, Santander-Ortega MJ, Mirenska A, Marimuthu P, Uchegbu I, Schätzlein A. A nano-enabled cancer-specific ITCH RNAi chemotherapy booster for pancreatic cancer. Nanomedicine, Nanotechnology, Biology and Medicine 2015; 11:369-377.
  5. Dailey LA, Hernandez-Prieto R, Casas-Ferreira AM, Jones MC, Riffo-Vasquez Y, Rodriguez-Gonzalo E, Spina D, Jones SA, Smith NW, Forbes C, Page C, Legido-Quigley C. Adenosine monophosphate is elevated in the bronchoalveolar fluid of mice with acute respiratory toxicity induced by nanoparticles with high surface hydrophobicity. Nanotoxicology 2015; 9:106-115.
  6. Uchegbu, IF, Jones MC, Corrente F, Godfrey L, Laghezza D, Carafa M, Holm P, Schätzlein A. The oral and intranasal delivery of propofol using chitosan amphiphile nanoparticles. Pharmaceutical Nanotechnology 2014; 2:65-74.
  7. Jones MC, Jones SA, Riffo-Vasquez Y, Spina D, Hoffmann E, Morgan A, Patel A, Page C, Forbes B, Dailey LA. Quantitative assessment of nanoparticle surface hydrophobicity and its influence on pulmonary biocompatibility. Journal of Controlled Release 2014; 183:94-104.
  8. Jones MC, Kumar A, Spina D, Forbes B, Page C, Dailey LA. In vivo safety and particokinetics of inhaled nanomedicines. Journal of Drug Delivery Science and Technology 2011; 21:339-346.
  9. Jones MC, Leroux JC. Reverse micelles from amphiphilic branched polymers. Soft Matter 2010; 6:5850-5859.
  10. Gaucher G, Satturwar P, Jones MC, Furtos A, Leroux JC. Polymeric micelles for oral drug delivery. Journal of Controlled Release 2010; 76:147-158.
  11. Jones MC, Gao H, Leroux JC. Reverse polymeric micelles for pharmaceutical applications. Journal of Controlled Release 2008; 132: 208-215.
  12. Gao H, Jones MC, Chen J, Prud’homme RE, Leroux JC. Hydrophilic nanoreservoirs embedded into polymeric nanoparticules- An approach to compatibilize polar molecules with hydrophobic matrices. Chemistry of Materials 2008; 20:4191-4193.
  13. Gao H, Jones MC, Chen J, Prud’homme RE, Leroux JC. Core cross-linked reverse micelles from star-shaped polymers. Chemistry of Materials 2008; 20: 3063-3067.
  14. 14. Gao H, Jones MC, Tewari P, Ranger M, Leroux JC. Star-shaped poly(glycerol methacrylate) reverse micelles: synthesis and evaluation of their solubilization properties in organic media. Journal of Polymer Science Part A: Polymer Chemistry 2007; 45: 2425-2435.
  15. Jones MC, Tewari P, Blei C, Hales K, Pochan DJ, Leroux JC. Self-assembled nanocages for the encapsulation of hydrophilic guest molecules. Journal of the American Chemical Society 2006; 128:14599-14605.
  16. Jones MC, Ranger M and Leroux JC. pH-sensitive unimolecular polymeric micelles: synthesis and characterization of a novel drug carrier. Bioconjugate Chemistry 2003; 14:774-781.
  17. Ranger M, Jones MC, Yessine MA and Leroux JC. From well-defined diblock copolymers prepared by a versatile ATRP method to polymeric micelles for drug delivery. Journal of Polymer Science Part A: Polymer Chemistry 2001; 39:3861-3874.
  18. Taillefer J, Jones MC, Brasseur N, van Lier JE and Leroux JC. Preparation and characterization of pH-responsive polymeric micelles for the delivery of anticancer photosensitizing drugs. Journal of Pharmaceutical Sciences 2000; 89:52-62.
  19. Jones MC and Leroux JC. Polymeric micelles - A new generation of colloidal drug carriers. European Journal of Pharmaceutics and Biopharmaceutics 1999; 48: 101-111.

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