Recent publications
Article
Swiderska, A, Coney, AM, Alzahrani, AA, Aldossary, HS, Batis, N, Ray, CJ, Kumar, P & Holmes, AP 2021, 'Mitochondrial succinate metabolism and reactive oxygen species are important but not essential for eliciting carotid body and ventilatory responses to hypoxia in the rat', Antioxidants, vol. 10, no. 6, 840. https://doi.org/10.3390/antiox10060840
Alzahrani, AA, Cao, LL, Aldossary, HS, Nathanael, D, Fu, J, Ray, CJ, Brain, KL, Kumar, P, Coney, AM & Holmes, AP 2021, 'β-Adrenoceptor blockade prevents carotid body hyperactivity and elevated vascular sympathetic nerve density induced by chronic intermittent hypoxia', Pfluegers Archiv: European journal of physiology , vol. 473, no. 1, pp. 37-51. https://doi.org/10.1007/s00424-020-02492-0
Holmes, AP, Ray, CJ, Kumar, P & Coney, AM 2020, 'A student practical to conceptualize the importance of Poiseuille's law and flow control in the cardiovascular system', American Journal of Physiology - Advances in Physiology Education, vol. 44, no. 3, pp. 436-443. https://doi.org/10.1152/advan.00004.2019
Holmes, A, Ray, C, Thompson, E, Alshehri, Z, Coney, A & Kumar, P 2018, 'Adrenaline activation of the carotid body: key to CO2 and pH homeostasis in hypoglycaemia and potential pathological implications in cardiovascular disease', Respiratory physiology & neurobiology. https://doi.org/10.1016/j.resp.2018.05.008
Holmes, A, Ray, C, Coney, A & Kumar, P 2018, 'Is carotid body physiological O2 sensitivity determined by a unique mitochondrial phenotype?', Frontiers in Physiology, vol. 9, 562. https://doi.org/10.3389/fphys.2018.00562
Holmes, AP, Ray, CJ, Pearson, SA, Coney, AM & Kumar, P 2017, 'Ecto-5'-nucleotidase (CD73) regulates peripheral chemoreceptor activity and cardiorespiratory responses to hypoxia', The Journal of Physiology. https://doi.org/10.1113/JP274498
Mahmoud, AD, Lewis, S, Juričić, L, Udoh, U-A, Hartmann, S, Jansen, MA, Ogunbayo, OA, Puggioni, P, Holmes, AP, Kumar, P, Navarro-Dorado, J, Foretz, M, Viollet, B, Dutia, MB, Marshall, I & Evans, AM 2016, 'AMPK deficiency blocks the hypoxic ventilatory response and thus precipitates hypoventilation and apnea', American Journal of Respiratory and Critical Care Medicine, vol. 193, no. 9. https://doi.org/10.1164/rccm.201508-1667OC
Thompson, EL, Ray, CJ, Holmes, AP, Pye, RL, Wyatt, CN, Coney, AM & Kumar, P 2016, 'Adrenaline release evokes hyperpnoea and an increase in ventilatory CO2 sensitivity during hypoglycaemia: a role for the carotid body', The Journal of Physiology, vol. 594, no. 15, pp. 4439-52. https://doi.org/10.1113/JP272191, https://doi.org/10.1113/JP272191
Elshafie, G, Acosta, J, Aliverti, A, Bradley, A, Kumar, P, Rajesh, P & Naidu, B 2016, 'Chest wall mechanics before and after diaphragm plication', Journal of Cardiothoracic Surgery, vol. 11, 25. https://doi.org/10.1186/s13019-016-0419-x
Naidu, B & Kumar, P 2016, 'Measuring changes in chest wall motion after lung resection using structured light plethysmography: a feasibility study', Interactive CardioVascular and Thoracic Surgery, vol. 23, no. 4, pp. 544-547. https://doi.org/10.1093/icvts/ivw185
Holmes, AP, Turner, PJ, Buckler, KJ & Kumar, P 2016, 'Moderate inhibition of mitochondrial function augments carotid body hypoxic sensitivity', Pfluegers Archiv: European journal of physiology , vol. 468, no. 1, pp. 143-155. https://doi.org/10.1007/s00424-015-1745-x
To, W, Kumar, P & Marshall, J 2015, 'Hypoxia is an effective stimulus for vesicular release of ATP from human umbilical vein endothelial cells', Placenta, vol. 36, no. 7, pp. 759-766. https://doi.org/10.1016/j.placenta.2015.04.005
Chapter (peer-reviewed)
Holmes, AP, Nunes, AR, Cann, MJ & Kumar, P 2015, Ecto-5'-nucleotidase, adenosine and transmembrane adenylyl cyclase signalling regulate basal carotid body chemoafferent outflow and establish the sensitivity to hypercapnia. in C Peers, P Kumar, C Wyatt, E Gauda, CA Nurse & N Prabhakar (eds), Arterial Chemoreceptors in Physiology and Pathophysiology. vol. 860, Advances in Experimental Medicine and Biology, vol. 860, Springer, pp. 279-289. https://doi.org/10.1007/978-3-319-18440-1_32
Ray, CJ, Dow, B, Kumar, P & Coney, AM 2015, Mild chronic intermittent hypoxia in wistar rats evokes significant cardiovascular pathophysiology but no overt changes in carotid body-mediated respiratory responses. in C Peers, P Kumar, C Wyatt, E Gauda, CA Nurse & N Prabhakar (eds), Arterial Chemoreceptors in Physiology and Pathophysiology. vol. 860, Advances in Experimental Medicine and Biology, vol. 860, Springer, pp. 245-254. https://doi.org/10.1007/978-3-319-18440-1_28
Review article
Aldossary, HS, Alzahrani, AA, Nathanael, D, Alhuthail, EA, Ray, CJ, Batis, N, Kumar, P, Coney, AM & Holmes, AP 2020, 'G-protein-coupled receptor (GPCR) signaling in the carotid body: roles in hypoxia and cardiovascular and respiratory disease', International Journal of Molecular Sciences, vol. 21, no. 17, 6012. https://doi.org/10.3390/ijms21176012
View all publications in research portal