Recent publications
Article
Alzahrani, AA, Cao, LL, Aldossary, HS, Nathanael, D, Fu, J, Ray, CJ, Brain, KL, Kumar, P, Coney, AM & Holmes, AP 2021, 'β-Adrenoceptor blockade prevents carotid body hyperactivity and elevated vascular sympathetic nerve density induced by chronic intermittent hypoxia', Pfluegers Archiv: European journal of physiology , vol. 473, no. 1, pp. 37-51. https://doi.org/10.1007/s00424-020-02492-0
Holmes, AP, Ray, CJ, Kumar, P & Coney, AM 2020, 'A student practical to conceptualize the importance of Poiseuille's law and flow control in the cardiovascular system', American Journal of Physiology - Advances in Physiology Education, vol. 44, no. 3, pp. 436-443. https://doi.org/10.1152/advan.00004.2019
Holmes, A, Ray, C, Thompson, E, Alshehri, Z, Coney, A & Kumar, P 2018, 'Adrenaline activation of the carotid body: key to CO2 and pH homeostasis in hypoglycaemia and potential pathological implications in cardiovascular disease', Respiratory physiology & neurobiology. https://doi.org/10.1016/j.resp.2018.05.008
Holmes, A, Ray, C, Coney, A & Kumar, P 2018, 'Is carotid body physiological O2 sensitivity determined by a unique mitochondrial phenotype?', Frontiers in Physiology, vol. 9, 562. https://doi.org/10.3389/fphys.2018.00562
Holmes, AP, Ray, CJ, Pearson, SA, Coney, AM & Kumar, P 2017, 'Ecto-5'-nucleotidase (CD73) regulates peripheral chemoreceptor activity and cardiorespiratory responses to hypoxia', The Journal of Physiology. https://doi.org/10.1113/JP274498
Mahmoud, AD, Lewis, S, Juričić, L, Udoh, U-A, Hartmann, S, Jansen, MA, Ogunbayo, OA, Puggioni, P, Holmes, AP, Kumar, P, Navarro-Dorado, J, Foretz, M, Viollet, B, Dutia, MB, Marshall, I & Evans, AM 2016, 'AMPK deficiency blocks the hypoxic ventilatory response and thus precipitates hypoventilation and apnea', American Journal of Respiratory and Critical Care Medicine, vol. 193, no. 9. https://doi.org/10.1164/rccm.201508-1667OC
Thompson, EL, Ray, CJ, Holmes, AP, Pye, RL, Wyatt, CN, Coney, AM & Kumar, P 2016, 'Adrenaline release evokes hyperpnoea and an increase in ventilatory CO2 sensitivity during hypoglycaemia: a role for the carotid body', The Journal of Physiology, vol. 594, no. 15, pp. 4439-52. https://doi.org/10.1113/JP272191, https://doi.org/10.1113/JP272191
Elshafie, G, Acosta, J, Aliverti, A, Bradley, A, Kumar, P, Rajesh, P & Naidu, B 2016, 'Chest wall mechanics before and after diaphragm plication', Journal of Cardiothoracic Surgery, vol. 11, 25. https://doi.org/10.1186/s13019-016-0419-x
Naidu, B & Kumar, P 2016, 'Measuring changes in chest wall motion after lung resection using structured light plethysmography: a feasibility study', Interactive CardioVascular and Thoracic Surgery, vol. 23, no. 4, pp. 544-547. https://doi.org/10.1093/icvts/ivw185
Holmes, AP, Turner, PJ, Buckler, KJ & Kumar, P 2016, 'Moderate inhibition of mitochondrial function augments carotid body hypoxic sensitivity', Pfluegers Archiv: European journal of physiology , vol. 468, no. 1, pp. 143-155. https://doi.org/10.1007/s00424-015-1745-x
To, W, Kumar, P & Marshall, J 2015, 'Hypoxia is an effective stimulus for vesicular release of ATP from human umbilical vein endothelial cells', Placenta, vol. 36, no. 7, pp. 759-766. https://doi.org/10.1016/j.placenta.2015.04.005
Elshafie, G, Aliverti, A, Pippa, L, Kumar, P, Kalkat, M & Naidu, B 2015, 'Surgery corrects asynchrony of ribcage secondary to extra-thoracic tumor but leads to expiratory dysfunction during exercise', Journal of Cardiothoracic Surgery, vol. 10, no. 1, 187. https://doi.org/10.1186/s13019-015-0355-1
Chapter (peer-reviewed)
Holmes, AP, Nunes, AR, Cann, MJ & Kumar, P 2015, Ecto-5'-nucleotidase, adenosine and transmembrane adenylyl cyclase signalling regulate basal carotid body chemoafferent outflow and establish the sensitivity to hypercapnia. in C Peers, P Kumar, C Wyatt, E Gauda, CA Nurse & N Prabhakar (eds), Arterial Chemoreceptors in Physiology and Pathophysiology. vol. 860, Advances in Experimental Medicine and Biology, vol. 860, Springer, pp. 279-289. https://doi.org/10.1007/978-3-319-18440-1_32
Ray, CJ, Dow, B, Kumar, P & Coney, AM 2015, Mild chronic intermittent hypoxia in wistar rats evokes significant cardiovascular pathophysiology but no overt changes in carotid body-mediated respiratory responses. in C Peers, P Kumar, C Wyatt, E Gauda, CA Nurse & N Prabhakar (eds), Arterial Chemoreceptors in Physiology and Pathophysiology. vol. 860, Advances in Experimental Medicine and Biology, vol. 860, Springer, pp. 245-254. https://doi.org/10.1007/978-3-319-18440-1_28
Review article
Aldossary, HS, Alzahrani, AA, Nathanael, D, Alhuthail, EA, Ray, CJ, Batis, N, Kumar, P, Coney, AM & Holmes, AP 2020, 'G-protein-coupled receptor (GPCR) signaling in the carotid body: roles in hypoxia and cardiovascular and respiratory disease', International Journal of Molecular Sciences, vol. 21, no. 17, 6012. https://doi.org/10.3390/ijms21176012
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