Professor Gabriel Landini DrOdont, PhD

Professor Gabriel Landini

School of Dentistry
Professor of Analytical Pathology and Head of Oral Pathology Unit

Contact details

Telephone
+44 (0) 121 466 5519
Email
g.landini@bham.ac.uk
Address
The School of Dentistry
5 Mill Pool Way
Edgbaston
Birmingham
B5 7EG
United Kingdom

Gabriel Landini is Professor of Analytical Pathology and Head of the Oral Pathology Unit, at the School of Dentistry in the Institute of Clinical Sciences.

Director of Postgraduate Research Studies (Dentistry) since January 2017. 

Qualifications

  • PhD, 1991, Kagoshima University, Japan.
  • Doctor of Odontology, 1984, Universidad de la Republica, Uruguay.

Teaching

Postgraduate supervision

Gabriel is interested in supervising doctoral research students in the following areas:

  • Quantitative microscopy of oral cancer and oral mucosa ageing.
  • Development of intelligent imaging methods for histolgical image interpretation.
  • Biological object segmentation, image enhancement and digital staining.
  • Analysis and computer modeling of cell mixing in heterogeneous populations in vitro.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

RESEARCH THEMES

  • Tumour growth, image analysis in histopathology, tissue architecture, cell mixing.

RESEARCH ACTIVITY

  • Gabriel's research interests have been directed to the development of innovative quantitative markers of biological complexity. These include applications of fractal geometry and image analysis for the characterisation of biological shape to be able to understand and characterise morphological changes taking place in pathological conditions, in particular Oral Cancer.
  • Current research interests include the development evidence-based methods of morphological analysis which underpin the emerging discipline of Intelligent Microscopy. In this area, formal quantitative analyses are processed by machine-reasoning procedures, so testable algorithms can replace the subjective components of traditional observer-based microscopy and histopathology to create more reliable means of diagnosis.
  • Gabriel is also involved in the development of visualisation enhancements to histological imagery for dichromatic (colour blind) individuals.

Other activities

Gabriel is part of the international group of scientists contributing to the development of open source image processing modules for scientific imaging using the ImageJ and Fiji platforms.

Publications

Wang A, Jones IP, Landini G, Mei J, Tse YY, Li YX, Huang Y, Liu L, Wang C, Sammons RL. Backscattered electron imaging and electron backscattered diffraction in the study of bacterial attachment to titanium alloy structure. Journal of Microscopy 270(1):53-63, 2018.

Randell DA, Galton A, Fouad S, Mehanna H, Landini G. Mereotopological correction of segmentation errors in histological imaging. Journal of Imaging, 2017, 3, 63.

Fouad S, Randell D, Galton A, Mehanna H, Landini G. Epithelium and stroma identification in histopathological images using unsupervised and semi-supervised superpixel-based segmentation. Journal of Imaging, 2017, 3, 61.

Fouad S. Randell DA, Galton A, Mehanna H, Landini G. Unsupervised morphological segmentation of of tissue compartments in histopathological images. PLoS ONE 12(11): 2017.

Abdulkareem AA, Shelton RM, Landini G, Cooper PR, Milward MR. Periodontal pathogens promote epithelial mesenchymal transition in oral squamous cell carcinoma cells in vitro. Cell Adhesion and Migration, doi:10.1080/19336918.2017.1322253

Carella F, De Vico G, Landini G. Nuclear morphometry and ploidy of normal and neoplastic haemocytes in mussels. PloS One 12 (3):1-18, 2017

Florindo J, Bruno O, Landini G. Morphological classification of odontogenic keratocysts using Bouligand-Minkowski descriptors. Computers in Biology and Medicine 81:1-10, 2017.

Landini G, Randell DA, Fouad S, Galton A. Automatic thresholding from the gradients of region boundaries. Journal of Microscopy 265(2):185–195, 2017.

Sui T, Lunt AJG, Baimpas N, Li T, Zeng K, Landini G, Korsunsky AM. Understanding nature’s residual stress engineering at the human dentine-enamel junction interface. Acta Biomaterialia 32:256-263, 2016.

Mort RL, Ross R, Hainey KJ, Harrison O, Keighren MA, Landini G, Baker RE, Painter KJ, Jackson IJ, Yates CA. Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model. Nature Communications 7:10288, 2016.

Sui T, Ying S, Korsunsky AM, Landini G. X-ray study of human dental tissues affected by erythroblastosis fetalis. Journal of Dental Research 94(7):1004-1010, 2015.

Landini G, Mylonas P, Shah IZ, Hamburger J. The reported rates of transformation of oral lichen planus. Journal of Oral and Maxillofacial Surgery, Medicine and Pathology 26:213-220, 2014.

Sandholzer MA, Sui T, Korsunsky AM, Walmsley AD, Lumley PJ, Landini G. X-ray scattering evaluation of ultrastructural changes of human dental tissues with thermal treatment. Journal of Forensic Sciences 59(3):769-774, 2014,

Randell DA, Landini G, Galton A. Discrete mereotopology for spatial reasoning in automated histological image analysis. IEEE Transactions on Pattern Analysis and Machine Intelligence 35(3):568-581, 2013.

Iannaccone S, Zhou Y, Walterhouse D, Taborn G, Landini G, Iannaccone P. Three dimensional visualization of mosaic patches in rat chimeras: cell assortment in liver, adrenal cortex and cornea. PLoS ONE 7 (2):1-14, 2012.

Han, J. W., Breckon, T., Randell, D. A., Landini, G. (2011), The application of Support Vector Machine classification to detect cell nuclei for automated microscopy. Machine Vision & Applications DOI 10.1007/s00138-010-0275-y

Landini, G. (2011), Fractals in Microscopy. Journal of Microscopy 241, Pt1: 1-8, 2011. (Invited review) doi: 10.1111/j.1365-2818.2010.03454.x

Bloomfield, J. M., Sherratt, J. A., Painter, K. J., Landini, G. (2010), Cellular automata and integrodifferential equation models for cell proliferation in mosaic tissues. Journal of the Royal Society Interface 7: 1525–1535. doi: 10.1098/rsif.2010.0071.

Abu Eid, R., Landini, G. (2010), The complexity of the oral mucosa: a review of the use of fractal geometry. Journal of Control Engineering and Applied Informatics 12(1): 10-14.

Lea, S. C., Landini, G. (2010), Reconstruction of dental ultrasonic scaler 3D vibration patterns from phase-related data. Medical Engineering & Physics 32(6):673-677. doi:10.1016/j.medengphy.2010.02.010.

Landini, G., Randell, D. A., Breckon, T., Han, J. W. (2010), Morphologic characterization of cell neighborhoods in neoplastic and preneoplastic epithelium. Analytical and Quantitative Cytology & Histology 2: 30–38.

Landini, G., Perryer, D. G. (2009), Digital enhancement of Haematoxylin and Eosin stained histological images for red-green colour blind observers. Journal of Microscopy 234(3): 293-301. doi: 10.1111/j.1365-2818.2009.03174.

Stockholm, D., Benchaouir. R., Picot, J., Rameau, P., Neildez, T. M. A., Landini, G., Laplace-Builhe, C., Paldi, A. (2007), The origin of phenotypic heterogeneity in a clonal cell population in vitro. PLoS ONE 2(4): e394. doi:10.1371/journal.pone.0000394 .