Dr Chloe Thomas PhD, AF HEA

School of Biomedical Sciences
Post Doctoral Fellow

Contact details

Telephone: +44 (0)121 414 6620
Email: c.thomas.4@bham.ac.uk
Twitter: @ChloeThomas_Dr

Address: Institute of Clinical Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Chloe Thomas is a Post-Doctoral Researcher within the School of Biomedical Science, Institute of Clinical Sciences. Her research interests are in ocular injury and disease and the development of novel therapeutics and in the identification of biomarkers for traumatic brain injury. She completed her PhD research on cell death mechanisms in the retina and optic nerve after blunt impact and explosive blast ocular trauma (2015 – 2018). She then performed a post-doctoral research project researching topical therapies for the treatment of age-related macular degeneration (2018 – 2023). Dr Thomas has undertaken research placements at Vanderbilt University, TN USA and University of Bristol, UK. She is now a post-doctoral researcher on the mTBI-PREDICT project working on the biofluids workstream (2023 – present).

Dr Thomas is part of the Translational Brain Science Research Group, the Neuro-Ocular Inflammation and Matrix Research Group and Neuroscience, Trauma and Ophthalmology .

Qualifications

PhD in Inflammation and Ageing, 2019
BMedSc, 2015

Teaching

Supervisor for Year 3 projects
Undergraduate Tutor for Biomedical Science BSc

Other activities

Chloe is actively involved in public and patient events such as Brain Awareness Week and presenter at Macular Society patient groups. She is a Science, Technology, Engineering and Maths (STEM) ambassador and partakes in the Letters to a Pre-Scientist initiative.

Chloe is actively involved with the Association of Research in Vision and Ophthalmology (ARVO) (2015 – present).

Chloe was a mentee on ARVO Global Mentorship Programme (2018) and was an ARVO Science Communication training fellow (2018-2019) and was a member of the Members in Training Committee (2019 – 2022).

Chloe is the Institute of Clinical Sciences representative for Postdoctoral / Early Researcher Career Development and Training (PERCAT) committee at College of Medical and Dental Sciences, University of Birmingham.

Chloe’s post-doctoral research was featured in Fight for Sight funding campaign 2019.

Publications

Recent publications

Article

Hencz, A, Magony, A, Thomas, C, Kovacs, K, Szilagyi, G, Pal, J & Sik, A 2023, 'Mild hypoxia-induced structural and functional changes of the hippocampal network', Frontiers in Cellular Neuroscience, vol. 17, 1277375. https://doi.org/10.3389/fncel.2023.1277375

Thomas, C, Alfahad, N, Capewell, N, Cowley, J, Hickman, E, Fernandez, A, Harrison, N, Qureshi, O, Bennett, N, Barnes, N, Dick, A, Chu, C, Liu, X, Denniston, A, Vendrell, M & Hill, LJ 2022, 'Triazole-derivatized near-infrared cyanine dyes enable local functional fluorescent imaging of ocular inflammation', Biosensors and Bioelectronics , vol. 216, 114623. https://doi.org/10.1016/j.bios.2022.114623

Thomas, C, Bernardo-Colón, A, Courtie, E, Essex, G, Rex, TS, Blanch, R & Ahmed, Z 2021, 'Effects of intravitreal injection of siRNA against caspase‑2 on retinal and optic nerve degeneration in air blast induced ocular trauma', Scientific Reports, vol. 11, no. 1, 16839. https://doi.org/10.1038/s41598-021-96107-y

Thomas, CN, Courtie, E, Bernardo-Colón, A, Essex, G, Rex, TS, Ahmed, Z & Blanch, RJ 2020, 'Assessment of necroptosis in the retina in a repeated primary ocular blast injury mouse model', Experimental Eye Research, vol. 197, 108102. https://doi.org/10.1016/j.exer.2020.108102

Thomas, CN, Thompson, AM, Ahmed, Z & Blanch, RJ 2019, 'Retinal Ganglion Cells Die by Necroptotic Mechanisms in a Site-Specific Manner in a Rat Blunt Ocular Injury Model', Cells, vol. 8, no. 12, 1517. https://doi.org/10.3390/cells8121517

Thomas, C, Thompson, A, McCance, E, Berry, M, Logan, A, Blanch, R & Ahmed, Z 2018, 'Caspase-2 mediates site-specific retinal ganglion cell death after blunt ocular injury', Investigative Ophthalmology & Visual Science (IOVS), vol. 59, no. 11, pp. 4453-4462. https://doi.org/10.1167/iovs.18-24045

Hill, LJ, Mead, B, Thomas, CN, Foale, S, Feinstein, E, Berry, M, Blanch, RJ, Ahmed, Z & Logan, A 2018, 'TGF-β-induced IOP elevations are mediated by RhoA in the early but not the late fibrotic phase of open angle glaucoma', Molecular Vision, vol. 24, pp. 712-726. <http://www.molvis.org/molvis/v24/712/>

Review article

Thomas, CN, Sim, DA, Lee, WH, Alfahad, N, Dick, AD, Denniston, A & Hill, LJ 2022, 'Emerging therapies and their delivery for treating age-related macular degeneration', British Journal of Pharmacology, vol. 179, no. 9, pp. 1908-1937. https://doi.org/10.1111/bph.15459

Thomas, C, Berry, M, Logan, A, Blanch, R & Ahmed, Z 2017, 'Caspases in retinal ganglion cell death and axon regeneration', Cell Death Discovery, vol. 3, 17032. https://doi.org/10.1038/cddiscovery.2017.32

View all publications in research portal