Dr Kevin Whitehead

School of Biomedical Sciences
Lecturer in Neuropharmacology

Contact details

Telephone: +44 (0)121 414 4521
Email: k.j.whitehead@bham.ac.uk

Address: Institute of Clinical Sciences
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Kevin Whitehead is a lecturer in the Neuropharmacology team, Institute of Clinical Sciences and principal investigator of the Pain Signalling Group.

Kevin has extensive experience of in vivo monitoring of neurochemistry and his current research is aimed towards an understanding the role of central neuroinflammatory processes in chronic pain. This is approached through whole animal studies for which he holds a Home Office project licence. His work has attracted funding from BBSRC and Arthritis Research Campaign as well as numerous collaborations with the pharmaceutical industry (GlaxoSmithKline, Pfizer, Organon, Parke Davis and NovoNordisk). He also leads the College Glia Special Interest Group.

He teaches pharmacology and neuroscience topics across all undergraduate degree programmes offered by the Medical School as well as other undergraduate and taught postgraduate courses across the University. Kevin has supervised five postgraduate research students towards their doctorate.

Kevin regularly speaks at schools on behalf of the national group Understanding Animal Research, presenting the facts about the use of animals for the advancement of scientific and medical research. For the last 3 years Kevin has acted as a Governor for a local Birmingham secondary school. He is a member of International Association for the Study of Pain; British Neuroscience Association; Understanding Animal Research (until 2008, Research Defence Society).

Qualifications

PhD Neuropharmacology (London)
GIBol Pharmacology (Surrey)
BSc Biological Science (Edinburgh)

Biography

Kevin Whitehead gained a BSc in Biological Science at the University of Edinburgh before completing his undergraduate education as a Graduate of the Institute of Biology (Pharmacology) at NESCOT (University of Surrey). He went on to study for a PhD in Neuropharmacology in the Movement Disorders Group, King’s College London under Prof Peter Jenner. After working in Prof Phil Moore’s lab in the Pharmacology Group, King’s College London, Kevin joined the University of Birmingham in 1997 as a Research Fellow working with Prof Norman Bowery in the Department of Pharmacology. This move was made possible through funding of a proposal investigating neurochemical plasticity in the spinal cord underlying chronic inflammatory pain awarded by the Arthritis Research Campaign. The proposal (written by Kevin) utilised his unique expertise in the UK in spinal microdialysis, an in vivo neurochemical monitoring technique applied to the spinal cord by only a few laboratories world-wide.

Kevin took up a teaching post in 2001 and was appointed Lecturer in 2006. He continues his research into the pathogenesis of chronic pain, focussing currently on the contribution of neuroinflammation and glial release of immune modulators (cytokines/chemokines) in the CNS to pathological pain conditions.

Teaching

BMedSc course modules (year): Pharmacology (1); Neuroscience (1); Systems Pharmacology (2); Neuroscience (2); Neuropharmacology (3); Molecular and Integrative Pharmacology (3)
BDS course modules (year): Introduction to Biomedical Sciences (1); Neuromusculoskeletal System (2); Basic & Applied Systemic Human Disease (3)
MB ChB course modules (year): Neurones and Synapses (1); Introduction to Respiratory Medicine (1); Brain and Behaviour (2)
BSc Chemistry with Pharmacology course modules (year): Pharmacology (1); Systems Pharmacology (2); Molecular and Integrative Pharmacology (3)
BSc MedBiochem course modules (year): Topics in Medical Biosciences (2)
Good Brain Bad Brain (MOMD) (2)
Physician Assistant Programme (1)
MSc Advanced Manipulative Physiotherapy
MRes In Vivo Skills

Research

Research is aimed at identifying critical pathological changes in nociceptive signalling underlying chronic pain states. Focus is on neurochemical plasticity, primarily utilising microdialysis for in vivo measurement of the release of neuroactive substances in rodent brain and spinal cord, the latter an approach unique in the UK. Development of ‘high flux’ microdialysis allied to multiplexed immunoassay (Luminex®) technology allows monitoring of cytokine/chemokine release and a novel window onto neuroinflammatory mechanisms.

Other activities

Module Coordinator BMedSc Neuroscience 1
Personal mentor, MB ChB course
Personal tutor, BMedSc
Personal mentor, graduate students (Neuropharmacology & Neurobiology)
Graduate Studies Assistant Coordinator (Neuropharmacology & Neurobiology)
College Lead for Glia Special Interest Group
Governor, Lordswood Girls’ School and Sixth Form Centre

Publications

Whitehead K.J., C.G.S. Smith, S-A. Delaney, S.J. Curnow, M. Salmon, J.P. Hughes, IP Chessell (2010) Dynamic regulation of spinal pro-inflammatory cytokine release in the rat in vivo following peripheral nerve injury. Brain Behav. Immun. 24, 569-576

Whitehead K.J., C.G.S. Smith, S-A. Delaney, S.J. Curnow, M. Salmon, J.P. Hughes, IP Chessell (2009)Neurone-glia signalling underlies spinal pro-inflammatory cytokine release evoked by primary afferent stimulation in the neuropathic rat.Eur. J. Pain 13 (Suppl. 1): 107.

Smith C.G.S., C.M. Taylor, W.J. Winchester, K. Lee, K.J. Whitehead (2008) Alosetron modulates central serotonergic visceral pain processing in the thalamus. 12^th World Congress on Pain, Glasgow, 17-22 August, 2008.

Devall A.J., K.J. Whitehead, Richards D.A. (2008) Assessment of thalamic 5-HT levels using microdialysis in a rat model of inflammatory pain. 12^th World Congress on Pain, Glasgow, 17-22 August, 2008.

Smith C.G., K.J. Whitehead (2007) GABA transporter type 1 (GAT-1) uptake inhibition reduces stimulated aspartate and glutamate release in the dorsal spinal cord in vivo via different GABAergic mechanisms. Neuropharmacology 53(8): 975-981.

Devall A.J., R. Blake, N. Langman, C.G.S. Smith, D.A. Richards, K.J. Whitehead (2007) A monolithic column-based reversed-phase liquid chromatography separation for amino acid assay in biological samples. Journal of Chromatography B 848(2): 323-328.

Langman N., C.G.S. Smith, K.J. Whitehead (2006) Selective serotonin re-uptake inhibition attenuates evoked glutamate release in the dorsal horn of the anaesthetised rat in vivo. Pharmacol. Res. 53: 149-155.

Whitehead K.J., C.G.S. Smith, B. Hoggart, S.J. Curnow and M. Salmon (2006) Primary afferent induced modulation of spinal pro-inflammatory cytokine release in the neuropathic rat in vivo. Eur. J. Pain 10 (Suppl. 1): 354. 10 (Suppl. 1): 354.

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