Dr Majid Malboubi PhD

Dr Majid Malboubi

Dubai Campus
Lecturer in Mechanical Engineering

Contact details

Address
University of Birmingham Dubai
Dubai International Academic City
PO Box 341799
Dubai, UAE

Dr Majid Malboubi a lecturer in Mechanical Engineering.

Inspired by the workings of nature, Dr Malboubi applies the principles of mechanics and design micro-tools to unravel the physics underlying cellular processes and to understand how cells interact with their surroundings. Dr Malboubi completed his PhD at the University of Birmingham and worked on the interaction of biological membranes with solid substrates, and published several articles on this subject, as well as a book (Gigaseal formation in patch clamping, Springer, 2014). Upon moving to the London Centre of Nanotechnology at UCL, Dr Malboubi worked on the poroelasticity and pressure propagation in cells to explain cells’ ability to sustain transient and prolonged pressure gradients across their cytoplasm in response to extrinsic and intrinsic mechanical stresses. Dr Malboubi also developed several microfluidic devices for cancer metastasis and drug screening. Subsequently, Dr Malboubi moved to the University of Oxford to investigate the effects of mechanical loadings, such as compression or stretch on neural electrophysiological responses and the ability of neurons to fire action potentials after trauma.

Biography

  • 2018 - Lecturer, Department of Mechanical Engineering, University of Birmingham  
  •  2014 – 2018 - Postdoctoral Researcher, Department of Engineering Science, University of Oxford
  •  2011 – 2014 - Postdoctoral Researcher, London Centre for Nanotechnology, University College London
  • 2007 – 2011 - PhD in Mechanical Engineering, University of Birmingham

Teaching

  • Mechanics
  • Fluid Mechanics
  • Energy Transfer and Thermodynamics
  • Mechanics Laboratory
  • Fluid Mechanics Laboratory  

Research

  • Cell and tissue mechanics
  • Microfluidics for life sciences
  • Patch clamp electrophysiology
  • Substrate-Membrane interactions

Publications

Book

  1. Malboubi M,and Jiang K. Gigaseal formation in patch clamping with applications of nanotechnology. 1st ed. Heidelberg: Springer, 2014 (Link to Book)

Book Chapter

  1. Malboubi M,Jayo A, Parsons M,Charras G. Microfluidic devices for examining the physical limits of migration in confined environments. Cell Migration Methods and Protocols, New York: Springer, 375-386 2018(Link to Book Chapter)
  2. Malboubi M, Gu Y, Jiang K. Study of the tip surface morphology of glass micropipettes and its effects on gigaseal formation. In: Electronic Engineering and Computing Technology. London: Springer, 609-619, 2010 (Link to Book Chapter)

Peer Reviewed Journal Articles

  1. Kwong M, Bianchi F, Malboubi M, García-Grajales J, Homsi L, Thompson M, Ye H, Noels L, Jérusalem A. 3D finite element formulation for mechanical–electrophysiological coupling in axonopathy, Computer Methods in Applied Mechanics and Engineering. 346, 1025-1050, 2019 (Link to Paper, Impact factor: 4.5 )
  2. Bianchi F, Malboubi M, Li Y, George J, Jerusalem A, Szele F, Thompson M, Ye H. Rapid and efficient differentiation of functional motor neurons from human iPSC for neural injury modelling. Stem cell research Elsevier, 32, 126-134, 2018 (Link to Paper, Impact factor: 1.8)
  3. Jayo A, Malboubi M, Antoku S, Chang W, Ortiz-Zapater E, Groen C, Tootle T, Charras G,  Gundersen G, Parsons M. Fascin regulates nuclear movement and plasticity in migrating cells, Developmental Cell, 38 (4), 371-383, 2016 (Link to Paper, Impact factor: 10.73)
  4. Malboubi M, Jayo A, Parsons M, Charras G. An open access microfluidic device for the study of the physical limits of cancer cell deformation during migration in confined environments, Microelectronic Engineering, 144, 42-45, 2015 (Link to Paper, Impact factor: 1.27)
  5. Malboubi M, Gu Y, Jiang K. Surface properties of glass micropipettes and their effect on biological studies. Nanoscale Research Letters, 6(401), 1-10, 2011 (Link to Paper, Impact factor: 2.58)
  6. Malboubi M, Gu Y, Jiang K. Characterization of surface properties of glass micropipettes using SEM stereoscopic technique. Microelectronic Engineering, 88, 2666–2670, 2011 (Link to Paper, Impact factor: 1.27)
  7. Mohammadkhani A, Malboubi M, Anthony C, Jiang K. Characterization of surface properties of ordered nanostructures using SEM stereoscopic technique. Microelectronic Engineering, 88: 2687–2690, 2011 (Link to Paper, Impact factor: 1.27)
  8. Malboubi M, Gu Y, Jiang K. Experimental and simulation study of the effect of pipette roughness on gigaseal formation in patch clamping. Microelectronic Engineering, 87, 778-781, 2011 (Link to Paper, Impact factor: 1.27)
  9. Malboubi M, Ostadi H, Wang S, Gu Y, Jiang K. Effects of the surface morphology of pipette tip on gigaseal formation. Engineering Letters, 17 (4), 281-285, 2009 (Link to Paper)
  10. Ostadi H, Malboubi M, Prewett P. D, Jiang K. 3D reconstruction of a micropipette tip. Microelectronic Engineering, 86, 868-870, 2008 (Link to Paper, Impact factor: 1.27)

Peer Reviewed Conference Papers

  1. Malboubi M, Ostadi H, Wang S, Gu Y, Jiang K. The effect of pipette tip roughness on gigaseal formation. The 2009 International Conference of Systems Biology and Bioengineering, World Congress on Engineering. 1-3 July 2009 London. 1849-1852. (Link to Paper)
  2. Malboubi M, Shakeri M, Bakhshi M. Design and fabrication of a prototype two-component strain gauge based grinding dynamometer. International Conference on Advances in Materials and Processing Technologies, 30 July - 01 August 2006 Las Vegas
  3. Malboubi M, and Shakeri M. Machine tools with parallel structure and their calibration methods. The 13th International Conference on Mechanical Engineering, 17-19 May 2005 Esfahan
  4. Malboubi M, Jerusalem A. Experimental multi-physics measurement of neuronal responses under trauma, Biophysical Journal, 110(2), 149a, 2016 (Link to Paper , Impact factor: 3.66)
  5. Malboubi M, Jayo A, Parsons M, Charras M. An open access microfluidic device for the study of cancer cell deformation during migration. 40th International Conference on Micro Nano Engineering, 22 – 26 September 2014, Lausanne
  6. Bove A, Malboubi M, Lowe A, Charras G. A microfluidic device for studying cancer cells competition under controlled conditions. 40th International Conference on Micro Nano Engineering, 22 – 26 September 2014, Lausanne
  7. Davies J, Malboubi M, Ivetic A, Charras G. A microfluidic chip to model leukocyte inflammatory responses. 40th International Conference on Micro Nano Engineering, 22-26 September 2014, Lausanne
  8. Malboubi M, Behroozi M, Bowen J, Chizari M, Charras G, Jiang K. The effect of aperture size on gigaseal formation. Biophysical Journal, 104(2), 673a, 2013 (Link to Paper, Impact factor: 3.66)
  9. Malboubi M, Gu Y, Jiang K. Surface property characterization of glass micropipettes using SEM stereoscopic technique. 36th International Conference on Micro Nano Engineering, 19-22 September 2010 Genoa
  10. Mohammadkhani M, Malboubi M, Anthony C, Jiang K. 3D-reconstruction of nanostructures made by nanosphere lithography using SEM stereoscopic technique. 36th International Conference on Micro Nano Engineering, 19-22 September 2010 Genoa
  11. Malboubi M, Gu Y, Jiang K. Investigation of pipette roughness effects on seal formation in patch clamping. 35th International Conference on Micro Nano Engineering, 28 September - 01 October 2009 Ghent
  12. Ostadi H, Malboubi M, Jiang K, Prewett P. FIB/SEM Nano-Tomography of a micropipette. 34th International Conference on Micro Nano Engineering, 15-18 September 2008 Athens

View all publications in research portal