Professor Iseult Lynch PhD, MBA

Professor Iseult Lynch

School of Geography, Earth and Environmental Sciences
Professor of Environmental Nanosciences
Theme lead for Environmental Sciences

Contact details

Address
School of Geography, Earth and Environmental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Professor Iseult Lynch, Chair of Environmental Nanosciences, joined the academic staff at the University of Birmingham in March 2013.

She is an Associate Editor for Environmental Science: Nano, and Deputy director for the Facility for Environmental Nanomaterials Analysis and Characterisation (FENAC) at the University of Birmingham.  Her research focuses on the environmental interactions of nanoparticles and nanostructured surfaces with biological entities from macromolecules to organisms.

She has a very broad overview of all aspects of nanomaterials safety assessment and the data requirements, having served as Chair of the EU Nanosafety Cluster Working Group (NSC WG) on databases for two years (and as co-Chair of the Hazed WG prior to that), as well as being theme editor for the Materials and classification section of the NSC Vision2020 research roadmap (under review for publication in June 2013). Prior to the University of Birmingham she was Strategic Research Manager at the Centre for BioNano Interactions in University College Dublin, where she was instrumental in the development and implementation of numerous large EU-funded projects.

Iseult is part of the Birmingham Plastics Network, an interdisciplinary team of more than 40 academics working together to shape the fate and sustainable future of plastics.  This unique team brings together chemists, environmental scientists, philosophers, linguists, economists, and experts in many other fields, to holistically address the global plastics problem.

Qualifications

BSc. (Hons) Chemistry (1995)

PhD (Chemistry, 2000)

MBA (2012)

Teaching

Professor Lynch is the undergraduate admissions tutor for Environmental Science.

Leads and contributes to undergraduate modules on the following topics:

  • molecules and materials
  • environmental protection
  • environmental pollution

Deputy director of the MRes in Biological and Environmental Nanoscience, and module leader for the MRes module 'Biological and Environmental Nanoscience'.

Postgraduate supervision

Dr Lynch’s research interests include:

Synthesis of novel composite polymeric materials for biomaterials and environmental applications
Nanoparticle interactions with biomolecules in the environment (natural organic matter, secreted proteins, organic pollutants, etc.) - the “eco-corona” and secondary pollutant effects
Determination of the fate and behavior of nanomaterials in the environment
Development of high throughput screening applications: nano(eco)toxicology, bionanointeractions and assessment of environmental fate of nanomaterials

Research

Understanding the role of the bio-nano interface, and interactions with biomolecules, in determining nanoparticle fate and behaviour in the environment and for human health.

Other activities

Publications

Recent publications

Article

Cai, R, Ren, J, Ji, Y, Wang, Y, Liu, Y, Chen, Z, Sabet, ZF, Wu, X, Lynch, I & Chen, C 2020, 'Corona of thorns: the surface chemistry-mediated protein corona perturbs the recognition and immune response of macrophages', ACS Applied Materials & Interfaces, vol. 12, no. 2, pp. 1997-2008. https://doi.org/10.1021/acsami.9b15910

Karatzas, P, Melagraki, G, Ellis, L-JA, Lynch, I, Varsou, D-D, Afantitis, A, Tsoumanis, A, Doganis, P & Sarimveis, H 2020, 'Development of Deep Learning Models for Predicting the Effects of Exposure to Engineered Nanomaterials on Daphnia magna', Small. https://doi.org/10.1002/smll.202001080

Ellis, L-JA, Valsami-Jones, E & Lynch, I 2020, 'Exposure medium and particle ageing moderate the toxicological effects of nanomaterials to Daphnia magna over multiple generations: a case for standard test review?', Environmental Science: Nano, vol. 7, no. 4, pp. 1136-1149. https://doi.org/10.1039/D0EN00049C

Billing, AM, Knudsen, KB, Chetwynd, AJ, Ellis, L-JA, Tang, SVY, Berthing, T, Wallin, H, Lynch, I, Vogel, U & Kjeldsen, F 2020, 'Fast and robust proteome screening platform identifies neutrophil extracellular trap formation in the lung in response to cobalt ferrite nanoparticles', ACS Nano, vol. 14, no. 4, pp. 4096-4110. https://doi.org/10.1021/acsnano.9b08818

Zhang, P, Guo, Z, Luo, W, Monikh, FA, Xie, C, Valsami-Jones, E, Lynch, I & Zhang, Z 2020, 'Graphene oxide induced pH alteration, iron overload and subsequent oxidative damage in rice (Oryza. sativa L.): a new mechanism of nanomaterial phytotoxicity', Environmental Science and Technology, vol. 54, no. 6, pp. 3181-3190. https://doi.org/10.1021/acs.est.9b05794

Geitner, NK, Hendren, CO, Cornelis, G, Kaegi, R, Lead, JR, Lowry, GV, Lynch, I, Nowack, B, Petersen, E, Bernhardt, E, Brown, S, Garidel-Thoron, CD, Hanson, J, Harper, S, Jones, K, Kammer, FVD, Kennedy, A, Kidd, J, Matson, C, Metcalfe, CD, Pedersen, J, Peijnenburg, WJGM, Quik, JTK, Rodrigues, SM, Rose, J, Sayre, P, Simonin, M, Svendsen, C, Tanguay, R, Tefenkji, N, Teunenbroek, TV, Thies, G, Tian, Y, Rice, J, Turner, A, Liu, J, Unrine, J, Vance, M, White, JC & Wiesner, MR 2020, 'Harmonizing across environmental nanomaterial testing media for increased comparability of nanomaterial datasets', Environmental Science: Nano, vol. 7, no. 1, pp. 13-36. https://doi.org/10.1039/C9EN00448C

Guggenheim, E, Rappoport, J & Lynch, I 2020, 'Mechanisms for cellular uptake of nanosized clinical MRI contrast agents', Nanotoxicology, vol. 14, no. 4, pp. 504-532. https://doi.org/10.1080/17435390.2019.1698779, https://doi.org/10.1080/17435390.2019.1698779

Ellis, L, Kissane, S, Hoffman, E, Brown, J, Valsami-Jones, E, Colbourne, J & Lynch, I 2020, 'Multigenerational exposures of Daphnia magna to pristine and aged silver nanoparticles: epigenetic changes and phenotypical ageing related effects', Small. https://doi.org/10.1002/smll.202000301

Chen, C, Leong, DT & Lynch, I 2020, 'Rethinking Nanosafety: Harnessing Progress and Driving Innovation', Small, vol. 16, no. 21, pp. e2002503. https://doi.org/10.1002/smll.202002503, https://doi.org/10.1002/smll.202002503

Khan, AO, Maio, AD, Guggenheim, EJ, Chetwynd, AJ, Pencross, D, Tang, S, Belinga-Desaunay, M-FA, Thomas, SG, Rappoport, JZ & Lynch, I 2020, 'Surface chemistry-dependent evolution of the nanomaterial corona on TiO2 nanomaterials following uptake and sub-cellular localization', Nanomaterials, vol. 10, no. 3, 401. https://doi.org/10.3390/nano10030401

Chetwynd, AJ, Zhang, W, Thorn, JA, Lynch, I & Ramautar, R 2020, 'The Nanomaterial Metabolite Corona Determined Using a Quantitative Metabolomics Approach: A Pilot Study', Small, pp. e2000295. https://doi.org/10.1002/smll.202000295

Chetwynd, AJ & Lynch, I 2020, 'The rise of the nanomaterial metabolite corona, and emergence of the complete corona', Environmental Science: Nano, vol. 7, no. 4, pp. 1041-1060. https://doi.org/10.1039/c9en00938h

Letter

Guo, Z, Zhang, P, Xie, HQ, Zhao, B & Lynch, I 2020, 'First in vivo evidence for compromised brain energy metabolism upon intranasal exposure to ZnO nanoparticles', Environmental Science and Technology Letters, vol. 7, no. 5, pp. 315–322. https://doi.org/10.1021/acs.estlett.0c00176

Review article

Antreas Afantitis; Georgia Melagraki; Panagiotis Isigonis; Andreas Tsoumanis; Dimitra Danai Varsou; Eugenia Valsami-Jones; Anastasios Papadiamantis; Laura-Jayne A. Ellis, Haralambos Sarimveis; Philip Doganis; Pantelis Karatzas; Periklis Tsiros; Irene Liampa; Vladimir Lobaskin; Dario Greco; Angela Serra; Pia Anneli Sofia Kinaret; Laura Aliisa Saarimäki; Roland Grafström; Pekka Kohonen; Penny Nymark; Egon Willighagen; Tomasz Puzyn; Anna Rybinska-Fryca; Alexander Lyubartsev; Keld Alstrup Jensen; Jan Gerit Brandenburg; Stephen Lofts; Claus Svendsen; Samuel Harrisono; Dieter Maier; Kaido Tamm; Jaak Jänes; Lauri Sikk; Maria Dusinska; Eleonora Longhin; Elise Rundén-Pran; Espen Mariussen; Naouale El Yamani; Wolfgang Unger; Jörg Radnik; Alexander Tropsha; Yoram Cohen; Jerzy Leszczynski; Christine Ogilvie Hendren; Mark Wiesner; David Winkler; Noriyuki Suzuki; Tae Hyun Yoon; Jang-Sik Choi, Natasha Sanabria; Mary Gulumian, Iseult Lynch 2020, 'NanoSolveIT Project: Driving nanoinformatics research to develop innovative and integrated tools for in silico nanosafety assessment', Computational and Structural Biotechnology Journal, vol. 18, pp. 583-602. https://doi.org/10.1016/j.csbj.2020.02.023

Zhang, P, Guo, Z, Zhang, Z, Fu, H, White, JC & Lynch, I 2020, 'Nanomaterial Transformation in the Soil-Plant System: Implications for Food Safety and Application in Agriculture', Small, vol. 16, no. 21, pp. e2000705. https://doi.org/10.1002/smll.202000705

View all publications in research portal

Expertise

Nanomaterials in the environment (as well as food, cosmetics, consumer products, nanomedicines, nanopesticides etc.); nanomaterials transformations; nanomaterials fate and behaviour; nanomaterials eco/toxicology; Nanosafety assessment; nanoregulation; nanogovernance; Microplastics; nanoplastics; Open data