Dr Ye Htun Oo MBBS, MRCP, PhD

Image of Ye Oo

Institute of Immunology and Immunotherapy
Medical Research Council Clinician Scientist
Consultant Hepatologist

Contact details

Institute of Immunology and Immunotherapy
Institute of Biomedical Research
University of Birmingham
B15 2TT

Ye Htun Oo is a Medical Research Council Clinician Scientist at Centre for Liver Research, University of Birmingham and Honorary Consultant Hepatologist at UHB NHS Foundation Trust.

Ye is a clinical academic and his major clinical interest include liver transplantation, viral and autoimmune hepatitis. He conducts dedicated viral and autoimmune hepatitis clinics, involved in DAA clinical trials and hepatitis C vaccination trials.

He is an Honorary Consultant Hepatologist in Liver Transplant and Hepato-biliary Department at University Hospital Birmingham NHS Foundation Trust.

Ye’s major basic research interests are in hepatic tolerance, pathogenesis of liver inflammation and repair in autoimmune liver diseases, chronicity of HCV & HBV infection and operational tolerance.

He aims to translate understanding of scientific background for future cell and cytokine therapy for patients with autoimmune, viral hepatitis and in liver transplantation. His current focus is on understading the balance of effector immune cells and regulatory T/B cells in human liver inflammation.

He aim to restore immune homeostasis with GMP grade autologous regulatory T cells as part of his translational cell therapy programme.


  • MRC Clinician Scientist & Consultant Transplant Hepatologist (2012-
  • CCST General Internal Medicine/Gastroenterology 2011
  • PhD  (Regulatory T cells and Th17/Tc17 subsets) 2010
  • Member of Royal College of Physicians 2001
  • MBBS 1995


Ye qualify in Medicine in 1995 from Rangoon, Burma. He joined West Midlands Gastroenterology/Hepatology training programme in 2002 where he completed his clinical training in Gastroenterology/ General Internal Medicine and Transplant Hepatology. He studied PhD on Hepatic Immunology particularly focusing on hepatic tolerance and human Regulatory T cells and intrahepatic lymphocyte subsets balance in liver inflammation and repair under supervision of Pro VC and Dean, Professor David Adams. Following his PhD, he invested a year to develop GMP grade regulatory T cells with a vision to apply as new therapy in immune mediated liver diseases. He is also involved in HBV and HCV therapeutic vaccination and VIRGIL project on Hepatitis B.

He received a Clinician Scientist fellowship award from Medical Research Council in Jan 2012 to investigate both basic and preclinical study on Regulatory T cells homing with a subsequent plan to develop future translational Treg therapy. He joined his colleagues in Liver Medicine clinical team as a Consultant Transplant Hepatologist in Jan 2012.


Teaching Programmes

Postgraduate supervision

Ye is interested in supervising PhD or research fellows and students in the following areas:

  • Hepatic tolerance in relation to effector cells and regulatory T cells balance
  • Hepatic innate cells crosstalk with Treg in hepatic inflammation and fibrosis
  • Gut-Liver link with micro biome.
  • Role of IL-17 in hepatic repair.

If you are interesting in studying any of these subject areas please contact Ye on y.h.oo@bham.ac.uk or the contact details above, or for any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk or call +44 (0)121 414 5005.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.


Research theme (Basic Science)

  • Hepatic tolerance in relation to effector cells and regulatory T cells balance
  • Innate cell crosstalk with Treg in hepatic inflammation and fibrosis
  • Gut-Liver link with microbiome
  • Role of IL-17 in hepatic repair

Research theme (Translational)

  • GMP grade autologous human Regulatory T cells therapy in liver diseases
  • Cytokine therapy

Research team

Ye’s research team bridge both basic science and translational therapy exploring new immunological markers, predictors (CyTOF), OMIC profiles for patients’ stratification and developing new cell and cytokine therapies for his patients’ care. He leads an active research team with cross-collaboration nationally, across Europe, Asia and US.

Clinical Research Activities

  • Dedicated AIH clinic
  • Post transplant HCV clinic

Research grants

  1. Medical Research Council Intermediate Fellowship
  2. QEH Charity
  3. UK- Autoimmune Hepatitis (UK-AIH) deep immunophenotyping grant (NIHR Rare Disease Translational Research Collaboration)
  4. BDRF grant


Dr Oo has been awarded the 2016 Sir Francis Avery Jones Medal from the British Society for Gastroenterology in recognition of his T-cell research, and an innovative study he is due to lead starting in July.  Click here for full story.

Other activities

  • Honorary Consultant Hepatologist
  • British Association for Study of the Liver Disease member
  • European Association for Study of the Liver Disease member
  • American Association for Study of the Liver Disease member
  • Member of British Viral Hepatitis Group
  • Sutton Runners


van Wilgenburg B, Scherwitzl I, Hutchinson EC, Leng T, Kurioka A, Kulicke C, de Lara C, Cole S, Vasanawathana S, Limpitikul W, Malasit P, Young D, Denney L; STOP-HCV consortium, Moore MD, Fabris P, Giordani MT, Oo YH, Laidlaw SM, Dustin LB, Ho LP, Thompson FM, Ramamurthy N, Mongkolsapaya J, Willberg CB, Screaton GR and Klenerman P (2016) MAIT cells are activated during human viral infections. Nat Commun 7:11653

Chen YY, Jeffery HC, Hunter S, Bhogal R, Birtwistle J, Braitch MK, Roberts S, Ming M, Hannah J, Thomas C, Adali G, Hübscher SG, Syn WK, Afford S, Lalor PF, Adams DH and Oo YH (2016) Human intrahepatic regulatory T cells are functional, require IL-2 from effector cells for survival, and are susceptible to Fas ligand-mediated apoptosis. Hepatology 64(1):138-50

Jeffery HC, van Wilgenburg B, Kurioka A, Parekh K, Stirling K, Roberts S, Dutton EE, Hunter S, Geh D, Braitch MK, Rajanayagam J, Iqbal T, Pinkney T, Brown R, Withers DR, Adams DH, Klenerman P and Oo YH (2016) Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1. J Hepatol 64(5):1118-27

Krishnamoorthy TL, Miezynska-Kurtycz J, Hodson J, Gunson BK, Neuberger J, Milkiewicz P and Oo YH (2016) Longterm corticosteroid use after liver transplantation for autoimmune hepatitis is safe and associated with a lower incidence of recurrent disease. Liver Transpl 22(1):34-41

Oo YH and Adams DH (2014) Regulatory T cells and autoimmune hepatitis: what happens in the liver stays in the liver. J Hepatol 61(5):973-5

Oo YH and Sakaguchi S (2013) Regulatory T-cell directed therapies in liver diseases. J Hepatol 59(5):1127-34

Oo YH, Banz V, Kavanagh D, Liaskou E, Withers DR, Humphreys E, Reynolds GM, Lee-Turner L, Kalia N, Hubscher SG, Klenerman P, Eksteen B and Adams DH (2012) CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver. J Hepatol 57(5):1044-51

Oo YH, Hubscher SG and Adams DH (2010) Autoimmune hepatitis: new paradigms in the pathogenesis, diagnosis, and management. Hepatol Int 4(2):475-93

Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS and Adams DH (2010) Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. J Immunol 184(6):2886-98

Billerbeck E, Kang YH, Walker L, Lockstone H, Grafmueller S, Fleming V, Flint J, Willberg CB, Bengsch B, Seigel B, Ramamurthy N, Zitzmann N, Barnes EJ, Thevanayagam J, Bhagwanani A, Leslie A, Oo YH, Kollnberger S, Bowness P, Drognitz O, Adams DH, Blum HE, Thimme R and Klenerman P (2010) Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties. Proc Natl Acad Sci U S A 107(7):3006-11

Full list of publications

View all publications in research portal