Professor Stefan Hübscher

Stefan Hübscher

Institute of Immunology and Immunotherapy
Leith Professor and Professor of Hepatic Pathology
Consultant Histopathologist

Contact details

Address
Department of Cellular Pathology
Queen Elizabeth Hospital
Birmingham
B15 2WB

Professor Stefan G Hübscher is Leith Professor and Professor of Hepatic Pathology, University of Birmingham and Consultant Histopathologist at University Hospitals Birmingham NHS Foundation Trust.

Research and clinical activities are mainly in the field of liver pathology, including the pathology of liver transplantation and hepatobiliary neoplasia.

Qualifications

  • Fellow of the Royal College of Pathologists (FRCPath), 1995
  • Member of the Royal College of Pathologists (MRCPath), 1985
  • MBChB, University of Birmingham, 1979

Publications

Recent publications

Article

Davies, SP, Reynolds, GM, Wilkinson, AL, Li, X, Rose, R, Leekha, M, Liu, YS, Gandhi, R, Buckroyd, E, Grove, J, Barnes, NM, May, RC, Hubscher, SG, Adams, DH, Huang, Y, Qureshi, O & Stamataki, Z 2019, 'Hepatocytes delete regulatory T cells by enclysis, a CD4+ T cell engulfment process', Cell Reports, vol. 29, no. 6, pp. 1610-1620.e4. https://doi.org/10.1016/j.celrep.2019.09.068

Trivedi, PJ, Hubscher, SG, Heneghan, M, Gleeson, D & Hirschfield, GM 2018, 'Grand round: autoimmune hepatitis', Journal of Hepatology. https://doi.org/10.1016/j.jhep.2018.11.006

Mergental, H, Stephenson, BTF, Laing, RW, Kirkham, AJ, Neil, DAH, Wallace, LL, Boteon, YL, Widmer, J, Bhogal, RH, Perera, MTPR, Smith, A, Reynolds, GM, Yap, C, Hübscher, SG, Mirza, DF & Afford, SC 2018, 'Development of Clinical Criteria for Functional Assessment to Predict Primary Nonfunction of High-Risk Livers Using Normothermic Machine Perfusion', Liver Transplantation, vol. 24, no. 10, pp. 1453-1469. https://doi.org/10.1002/lt.25291

Jeffery, HC, Braitch, MK, Bagnall, C, Hodson, J, Jeffery, LE, Wawman, RE, Wong, LL, Birtwistle, J, Bartlett, H, Lohse, AW, Hirschfield, GM, Dyson, J, Jones, D, Hubscher, SG, Klenerman, P, Adams, DH & Oo, YH 2018, 'Changes in natural killer cells and exhausted memory regulatory T Cells with corticosteroid therapy in acute autoimmune hepatitis', Hepatology Communications, vol. 2, no. 4, pp. 421-436. https://doi.org/10.1002/hep4.1163

Hirschfield, G, Dyson, JK, Alexander, GJ, Chapman, MH, Collier, J, Hubscher, S, Patanwala, I, Pereira, SP, Thain, C, Thorburn, D, Tiniakos, D, Walmsley, M, Webster, G & Jones, DE 2018, 'The British Society of Gastroenterology/UK-PBC Primary Biliary Cholangitis Treatment and Management Guidelines', Gut. https://doi.org/10.1136/gutjnl-2017-315259

Dah, N, Co, B, Smith, M, Haga, H, Zen, Y, Sebagh, M, Ruppert, K, Lunz, J, Hübscher, SG & Demetris, AJ 2017, 'Global quality assessment of liver allograft C4d staining during acute antibody mediated rejection in formalin-fixed paraffin-embedded tissue', Human Pathology. https://doi.org/10.1016/j.humpath.2017.12.007

Laing, RW, Mergental, H, Yap, C, Kirkham, A, Whilku, M, Barton, D, Curbishley, S, Boteon, YL, Neil, DA, Hübscher, SG, Perera, MTPR, Muiesan, P, Isaac, J, Roberts, KJ, Cilliers, H, Afford, SC & Mirza, DF 2017, 'Viability testing and transplantation of marginal livers (VITTAL) using normothermic machine perfusion: study protocol for an open-label, non-randomised, prospective, single-arm trial', BMJ open, vol. 7, no. 11, e017733. https://doi.org/10.1136/bmjopen-2017-017733

Laing, RW, Bhogal, RH, Wallace, L, Boteon, Y, Neil, DAH, Smith, A, Stephenson, BTF, Schlegel, A, Hübscher, SG, Mirza, DF, Afford, SC, Mergental, H & Hubscher, S 2017, 'The Use of an Acellular Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion', Transplantation, vol. 101, no. 11, pp. 2746-2756. https://doi.org/10.1097/TP.0000000000001821

Trivedi, P, Tickle, J, Vesterhus, M, Eddowes, P, Bruns, T, Vainio, J, Parker, R, Smith, D, Liaskou, E, Thorbjornsen, LW, Hirschfield, G, Auvinen, K, Hubscher, S, Salmi, M, Adams, D & Weston, C 2017, 'Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome, and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner', Gut. https://doi.org/10.1136/gutjnl-2016-312354

de Vries, EMG, de Krijger, M, Färkkilä, M, Arola, J, Schirmacher, P, Gotthardt, D, Goeppert, B, Trivedi, PJ, Hirschfield, GM, Ytting, H, Vainer, B, Buuren, HRV, Biermann, K, Harms, MH, Chazouilleres, O, Wendum, D, Kemgang, AD, Chapman, RW, Wang, LM, Williamson, KD, Gouw, ASH, Paradis, V, Sempoux, C, Beuers, U, Hübscher, SG, Verheij, J & Ponsioen, CY 2017, 'Validation of the prognostic value of histologic scoring systems in primary sclerosing cholangitis: An international cohort study', Hepatology, vol. 65, no. 3, pp. 907-919. https://doi.org/10.1002/hep.28963

Rantakari, P, Patten, D, Valtonen, J, Karikoski, M, Gerke, H, Dawes, H, Laurila, J, Ohlmeier, S, Elima, K, Hubscher, S, Weston, C, Jalkanen, S, Adams, D, Salmi, M & Shetty, S 2016, 'Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury', National Academy of Sciences. Proceedings, vol. 113, no. 33, pp. 9298–9303. https://doi.org/10.1073/pnas.1604780113, https://doi.org/10.1073/pnas.1604780113

Chen, Y-Y, Jeffery, HC, Hunter, S, Bhogal, R, Birtwistle, J, Kaur Braitch, M, Roberts, S, Ming, M, Hannah, J, Thomas, C, Adali, G, Hubscher, S, Syn, W-K, Afford, S, Lalor, PF, Adams, DH & Oo, YH 2016, 'Human intrahepatic tregs are functional, require IL-2 from effector cells for survival and are susceptible to fas ligand mediated apoptosis', Hepatology, vol. 64, no. 1, pp. 138–150. https://doi.org/10.1002/hep.28517

Mergental, H, Afford, S, Mirza, D, Laing, R, Hubscher, S, Perera, MT, Muiesan, P, Isaac, JR, Smith, A, Stephenson, B, Cilliers, H & Neil, DAH 2016, 'Transplantation of rejected high risk liver allografts following normothermic ex-situ evaluation', American Journal of Transplantation. https://doi.org/10.1111/ajt.13875

Wilhelm, A, Shepherd, E, Amatucci, A, Munir, M, Reynolds, G, Humphreys, E, Resheq, Y, Adams, DH, Hubscher, S, Burkly, LC, Weston, C & Afford, S 2016, 'Interaction of TWEAK with Fn14 leads to the progression of fibrotic liver disease by directly modulating hepatic stellate cell proliferation', Journal of Pathology, vol. 239, no. 1, pp. 109–121. https://doi.org/10.1002/path.4707

Dasari, BVM, Roberts, KJ, Hodson, J, Stevens, L, Smith, AM, Hubscher, SG, Isaac, J, Muiesan, P, Sutcliffe, RP, Marudanayagam, R & Mirza, DF 2016, 'A model to predict survival following pancreaticoduodenectomy for malignancy based on tumour site, stage and lymph node ratio', HPB : the official journal of the International Hepato Pancreato Biliary Association, vol. 18, no. 4, pp. 332-338. https://doi.org/10.1016/j.hpb.2015.11.008

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