Professor Stefan Hübscher

Stefan Hübscher

Institute of Immunology and Immunotherapy
Leith Professor and Professor of Hepatic Pathology
Consultant Histopathologist

Contact details

Department of Cellular Pathology
Queen Elizabeth Hospital
B15 2WB

Professor Stefan G Hübscher is Leith Professor and Professor of Hepatic Pathology, University of Birmingham and Consultant Histopathologist at University Hospitals Birmingham NHS Foundation Trust.

Research and clinical activities are mainly in the field of liver pathology, including the pathology of liver transplantation and hepatobiliary neoplasia.


  • Fellow of the Royal College of Pathologists (FRCPath), 1995
  • Member of the Royal College of Pathologists (MRCPath), 1985
  • MBChB, University of Birmingham, 1979


Recent publications


Sheriff, L, Khan, RS, Saborano, R, Wilkin, R, Luu, N, Gunther, UL, Hubscher, SG, Newsome, PN & Lalor, PF 2020, 'Alcoholic hepatitis and metabolic disturbance in female mice: a more tractable model than Nrf2-/- animals', Disease Models & Mechanisms, vol. 13, no. 12, dmm046383.

Mergental, H, Laing, RW, Kirkham, AJ, Perera, MTPR, Boteon, YL, Attard, J, Barton, D, Curbishley, S, Wilkhu, M, Neil, DAH, Hübscher, SG, Muiesan, P, Isaac, JR, Roberts, KJ, Abradelo, M, Schlegel, A, Ferguson, J, Cilliers, H, Bion, J, Adams, DH, Morris, C, Friend, PJ, Yap, C, Afford, SC & Mirza, DF 2020, 'Transplantation of discarded livers following viability testing with normothermic machine perfusion', Nature Communications, vol. 11, no. 1, 2939.

Davies, SP, Reynolds, GM, Wilkinson, AL, Li, X, Rose, R, Leekha, M, Liu, YS, Gandhi, R, Buckroyd, E, Grove, J, Barnes, NM, May, RC, Hubscher, SG, Adams, DH, Huang, Y, Qureshi, O & Stamataki, Z 2019, 'Hepatocytes delete regulatory T cells by enclysis, a CD4+ T cell engulfment process', Cell Reports, vol. 29, no. 6, pp. 1610-1620.e4.

Jeffery, HC, Braitch, MK, Bagnall, C, Hodson, J, Jeffery, LE, Wawman, RE, Wong, LL, Birtwistle, J, Bartlett, H, Lohse, AW, Hirschfield, GM, Dyson, J, Jones, D, Hubscher, SG, Klenerman, P, Adams, DH & Oo, YH 2018, 'Changes in natural killer cells and exhausted memory regulatory T Cells with corticosteroid therapy in acute autoimmune hepatitis', Hepatology Communications, vol. 2, no. 4, pp. 421-436.

Mergental, H, Stephenson, BTF, Laing, RW, Kirkham, AJ, Neil, DAH, Wallace, LL, Boteon, YL, Widmer, J, Bhogal, RH, Perera, MTPR, Smith, A, Reynolds, GM, Yap, C, Hübscher, SG, Mirza, DF & Afford, SC 2018, 'Development of Clinical Criteria for Functional Assessment to Predict Primary Nonfunction of High-Risk Livers Using Normothermic Machine Perfusion', Liver Transplantation, vol. 24, no. 10, pp. 1453-1469.

Trivedi, PJ, Hubscher, SG, Heneghan, M, Gleeson, D & Hirschfield, GM 2018, 'Grand round: autoimmune hepatitis', Journal of Hepatology.

Hirschfield, G, Dyson, JK, Alexander, GJ, Chapman, MH, Collier, J, Hubscher, S, Patanwala, I, Pereira, SP, Thain, C, Thorburn, D, Tiniakos, D, Walmsley, M, Webster, G & Jones, DE 2018, 'The British Society of Gastroenterology/UK-PBC Primary Biliary Cholangitis Treatment and Management Guidelines', Gut.

Dah, N, Co, B, Smith, M, Haga, H, Zen, Y, Sebagh, M, Ruppert, K, Lunz, J, Hübscher, SG & Demetris, AJ 2017, 'Global quality assessment of liver allograft C4d staining during acute antibody mediated rejection in formalin-fixed paraffin-embedded tissue', Human Pathology.

Laing, RW, Bhogal, RH, Wallace, L, Boteon, Y, Neil, DAH, Smith, A, Stephenson, BTF, Schlegel, A, Hübscher, SG, Mirza, DF, Afford, SC, Mergental, H & Hubscher, S 2017, 'The Use of an Acellular Oxygen Carrier in a Human Liver Model of Normothermic Machine Perfusion', Transplantation, vol. 101, no. 11, pp. 2746-2756.

de Vries, EMG, de Krijger, M, Färkkilä, M, Arola, J, Schirmacher, P, Gotthardt, D, Goeppert, B, Trivedi, PJ, Hirschfield, GM, Ytting, H, Vainer, B, Buuren, HRV, Biermann, K, Harms, MH, Chazouilleres, O, Wendum, D, Kemgang, AD, Chapman, RW, Wang, LM, Williamson, KD, Gouw, ASH, Paradis, V, Sempoux, C, Beuers, U, Hübscher, SG, Verheij, J & Ponsioen, CY 2017, 'Validation of the prognostic value of histologic scoring systems in primary sclerosing cholangitis: An international cohort study', Hepatology, vol. 65, no. 3, pp. 907-919.

Trivedi, P, Tickle, J, Vesterhus, M, Eddowes, P, Bruns, T, Vainio, J, Parker, R, Smith, D, Liaskou, E, Thorbjornsen, LW, Hirschfield, G, Auvinen, K, Hubscher, S, Salmi, M, Adams, D & Weston, C 2017, 'Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome, and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner', Gut.

Laing, RW, Mergental, H, Yap, C, Kirkham, A, Whilku, M, Barton, D, Curbishley, S, Boteon, YL, Neil, DA, Hübscher, SG, Perera, MTPR, Muiesan, P, Isaac, J, Roberts, KJ, Cilliers, H, Afford, SC & Mirza, DF 2017, 'Viability testing and transplantation of marginal livers (VITTAL) using normothermic machine perfusion: study protocol for an open-label, non-randomised, prospective, single-arm trial', BMJ open, vol. 7, no. 11, e017733.

Dasari, BVM, Roberts, KJ, Hodson, J, Stevens, L, Smith, AM, Hubscher, SG, Isaac, J, Muiesan, P, Sutcliffe, RP, Marudanayagam, R & Mirza, DF 2016, 'A model to predict survival following pancreaticoduodenectomy for malignancy based on tumour site, stage and lymph node ratio', HPB : the official journal of the International Hepato Pancreato Biliary Association, vol. 18, no. 4, pp. 332-338.

Perera, T, Mergental, H, Stephenson, B, Roll, GR, Cilliers, H, Liang, R, Angelico, R, Hubscher, S, Neil, DA, Reynolds, G, Isaac, J, Adams, DA, Afford, S, Mirza, DF & Muiesan, P 2016, 'First human liver transplantation using a marginal allograft resuscitated by normothermic machine perfusion', Liver Transplantation, vol. 22, no. 1, LT-15-270R3, pp. 120-124.

Chen, Y-Y, Jeffery, HC, Hunter, S, Bhogal, R, Birtwistle, J, Kaur Braitch, M, Roberts, S, Ming, M, Hannah, J, Thomas, C, Adali, G, Hubscher, S, Syn, W-K, Afford, S, Lalor, PF, Adams, DH & Oo, YH 2016, 'Human intrahepatic tregs are functional, require IL-2 from effector cells for survival and are susceptible to fas ligand mediated apoptosis', Hepatology, vol. 64, no. 1, pp. 138–150.

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