Dr Shishir Shetty MRCP PhD

Image of Shishir Shetty

Institute of Immunology and Immunotherapy
Wellcome Trust Intermediate Clinical Fellow
Honorary Consultant Hepatologist

Contact details

Address
Centre for Liver Research/Institute of Immunology and Immunotherapy/ MRC Centre for Immune Regulation/ Institute of Biomedical Research
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Shishir Shetty is a clinician scientist in the Centre for Liver Research/ National Institute for Health Research (NIHR) Birmingham Liver Biomedical Research Unit and honorary consultant hepatologist at the Queen Elizabeth Liver Transplant Unit, Birmingham. He has received grant funding from the Wellcome Trust, the Core Charity, The Bardhan Research and Education Trust and the Rosetrees charity

Shishir’s research focus is the regulation of leucocyte recruitment to the liver and the role of novel adhesion molecules including scavenger receptors. He is also studying how scavenger receptors influence the tissue microenvironment in fibrosis and cancer. The overall aim is to identify new targets of therapy for inflammatory liver disease and primary liver cancer. His clinical interests include the management of hepatocellular cancer and co-existing liver disease.

Qualifications

  • CCT, 2011
  • PhD Immunology, 2011
  • Membership of the Royal College of Physicians, 2002
  • MbChB, 1999

Teaching

Postgraduate supervision

Dr Shetty is interested in supervising doctoral research in the following areas:

Lymphocyte adhesion and migration via hepatic endothelium.
Lymphocyte subset recruitment to the inflamed liver.
The role of C-type lectins in chronic liver disease and primary liver cancer.

Research

Dr Shishir Shetty on CLEVER-1

Other activities

  • Member of the Royal College of Physicians
  • Member of British Gastroenterology Society
  • Member of British Association for the Study of the Liver

Publications

Recent publications

Article

Patten, DA, Shepherd, EL, Weston, CJ & Shetty, S 2019, 'Novel targets in the immune microenvironment of the hepatic sinusoids for treating liver diseases', Seminars in Liver Disease, vol. 39, no. 2, pp. 111-123. https://doi.org/10.1055/s-0039-1678727

Patten, DA, Kamarajah, SK, Rose, JM, Tickle, J, Shepherd, EL, Adams, DH, Weston, CJ & Shetty, S 2017, 'SCARF-1 promotes adhesion of CD4+ T cells to human hepatic sinusoidal endothelium under conditions of shear stress', Scientific Reports, vol. 7, 17600. https://doi.org/10.1038/s41598-017-17928-4

Wadkin, JCR, Patten, DA, Kamarajah, S, Shepherd, EL, Novitskaia, V, Berditchevski, F, Adams, DH, Weston, CJ & Shetty, S 2017, 'CD151 supports VCAM-1 mediated lymphocyte adhesion to liver endothelium and is upregulated in chronic liver diseases and hepatocellular carcinoma', American journal of physiology. Gastrointestinal and liver physiology, vol. 313, no. 2, pp. G138-G149. https://doi.org/10.1152/ajpgi.00411.2016

Atkin, C, Earwaker, P, Pallan, A, Shetty, S, Punia, P & Ma, Y 2017, 'Exceptional serological and radiological response to sorafenib in 2 patients with advanced hepatocellular carcinoma and chronic hepatitis C viral infection: case report and review of the literature', BMC Gastroenterology, vol. 17, 30. https://doi.org/10.1186/s12876-017-0585-x

Than, NN, Ghazanfar, A, Hodson, J, Tehami, N, Coldham, C, Mergental, H, Manas, D, Shah, T, Newsome, P, Reeves, H & Shetty, S 2017, 'Comparing clinical presentations, treatments and outcomes in hepatocellular carcinoma due to Hepatitis C and Non Alcoholic Fatty Liver Disease', QJM: An International Journal of Medicine, vol. 110, no. 2, pp. 73-81. https://doi.org/10.1093/qjmed/hcw151

Patten, D, Wilson, G, Bailey, D, Shaw, R, Jalkanen, S, Salmi, M, Rot, A, Weston, C, Adams, D & Shetty, S 2016, 'Human liver sinusoidal endothelial cells promote intracellular crawling of lymphocytes during recruitment - a new step in migration', Hepatology. https://doi.org/10.1002/hep.28879

Hoare, M, Ito, Y, Kang, T-W, Weekes, MP, Matheson, NJ, Patten, D, Shetty, S, Parry, AJ, Menon, S, Salama, R, Antrobus, R, Tomimatsu, K, Howat, W, Lehner, PJ, Zender, L & Narita, M 2016, 'NOTCH1 mediates a switch between two distinct secretomes during senescence', Nature Cell Biology, vol. 18, no. 9, pp. 979-92. https://doi.org/10.1038/ncb3397

Rantakari, P, Patten, D, Valtonen, J, Karikoski, M, Gerke, H, Dawes, H, Laurila, J, Ohlmeier, S, Elima, K, Hubscher, S, Weston, C, Jalkanen, S, Adams, D, Salmi, M & Shetty, S 2016, 'Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury', National Academy of Sciences. Proceedings, vol. 113, no. 33, pp. 9298–9303. https://doi.org/10.1073/pnas.1604780113, https://doi.org/10.1073/pnas.1604780113

Coombes, JD, Swiderska-Syn, M, Dollé, L, Reid, D, Eksteen, B, Claridge, L, Briones-Orta, MA, Shetty, S, Oo, YH, Riva, A, Chokshi, S, Papa, S, Mi, Z, Kuo, PC, Williams, R, Canbay, A, Adams, DH, Diehl, AM, van Grunsven, LA, Choi, SS & Syn, WK 2015, 'Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice', Gut, vol. 64, no. 7, pp. 1120-31. https://doi.org/10.1136/gutjnl-2013-306484

Shetty, S, Weston, CJ, Adams, DH & Lalor, PF 2014, 'A flow adhesion assay to study leucocyte recruitment to human hepatic sinusoidal endothelium under conditions of shear stress', Journal of Visualized Experiments, no. 85, e51330. https://doi.org/10.3791/51330

Shetty, S, Bruns, T, Weston, C, Stamataki, Z, Oo, YH, Long, H, Reynolds, G, Pratt, G, Moss, P, Jalkanen, S, Hubscher, S, Lalor, P & Adams, D 2012, 'Recruitment mechanisms of primary and malignant B cells to the human liver.', Hepatology, vol. 56, no. 4, pp. 1521-1531. https://doi.org/10.1002/hep.25790

Shetty, S, Adams, DH, Hubscher, SG & Shetty, S 2012, 'Post-transplant liver biopsy and the immune response: lessons for the clinician', Expert Review of Clinical Immunology, vol. 8, no. 7, pp. 645-61. https://doi.org/10.1586/eci.12.65

Editorial

O'Rourke, J, Patten, D & Shetty, S 2019, 'Tumour-associated macrophages in hepatocellular carcinoma: pressing the metabolic switch to prevent T cell responses', Journal of Hepatology. https://doi.org/10.1016/j.jhep.2019.05.019

Review article

Patten, DA & Shetty, S 2018, 'More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking', Frontiers in immunology, vol. 9, 2904. https://doi.org/10.3389/fimmu.2018.02904

Shetty, S, Lalor, PF & Adams, DH 2018, 'Liver sinusoidal endothelial cells - gatekeepers of hepatic immunity', Nature Reviews. Gastroenterology & Hepatology. https://doi.org/10.1038/s41575-018-0020-y

View all publications in research portal