Mr Antonio Belli MD, FRCS, FRCS (SN)

Tony Belli

Institute of Inflammation and Ageing
Professor of Trauma Neurosurgery

Contact details

Address
Institute of Inflammation and Ageing
College of Medical and Dental Sciences
IBR West Building
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Mr Belli graduated from Tor Vergata University in Rome with a degree in Medicine and Surgery. He completed a doctoral degree (MD) on neurobiochemistry of brain ischaemia and reperfusion at Tor Vergata University and then moved to the UK in 1994.

He trained as a neurosurgeon at King’s College Hospital, Atkinson Morley’s Hospital, The National Hospital for Neurology and Neurosurgery, Great Ormond Street Hospital, The Royal Free Hospital and Charing Cross Hospital. Between 2001 and 2003 he carried out a research fellowship in neuromonitoring at the Institute of Neurology in London.

He is on the editorial board of several neurology journals and is an advisor to NICE and the Care Quality Commission.

Antonio Belli is Director of the NIHR SRMRC. Find out more about the work of the research centre on the SRMRC website.

Qualifications

  • Fellowship in Surgical Neurology (FRCS SN), 2004
  • Fellowship of the Royal College of Surgeons of Glasgow (FRCS), 1997
  • MD (Reactive Oxygen Species damage in brain ischaemia and reperfusion) – Department of Neurosciences, University of Rome ‘Tor Vergata’, 1992
  • Degree of Doctor of Medicine and Surgery (summa cum laude) – University of Rome ‘Tor Vergata’, 1990

Biography

Mr Belli is a Professor of Trauma Neurosurgery and Director of the Surgical Reconstruction and Microbiology Research Centre (SRMCR) based at the Queen Elizabeth Hospital Birmingham. The SRMRC is a leading centre for trauma research and was founded in 2011 with £20M grant from NIHR, MoD, the University of Birmingham and University Hospitals Birmingham. He heads the neurotrauma research theme, which carries out translational research on traumatic brain injury and spinal cord injury. He is also a practising neurosurgeon at the Queen Elizabeth Hospital where he leads the Neurotrauma service comprised of a formidable team of doctors, nurses and therapists.

Teaching

  • Tony has set up and leads the new MSc course in Trauma Sciences at the University of Birmingham. This is the first on-site MSc course in trauma in the UK and one of just a handful available in this field worldwide. In this programme he also leads the Neurotrauma module.
  • Tony also continues to be involved in the regular teaching of medical, BMedSc and Sports and Excercise Science students. He has contributed to teaching at other institutions by invitation; for example, the Nursing Degree at City University, the Neurotrauma Course at Royal College of Surgeons (where I am a regular faculty member) and MSc courses at Queen Mary University London.

Postgraduate supervision

Tony supervises a number of doctoral research students. If you are interested in studying with Tony please contact him on the contact details above, or for any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk or call +44 (0)121 414 5005.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

Mr Belli’s research interest is in neurobiochemistry and neuromonitoring of acute brain injury. A particular focus is brain metabolism following mild and severe traumatic brain injury and how this relates to the long-term outcome and the risk of early neurogenerative conditions. Many of his current studies involve cross-disciplinary collaborations with engineering, chemistry, computing science and IT.

Working with cerebral microdialysis, another area of interest is early markers of tissue damage for the prevention of secondary injury after trauma and subarachnoid haemorrhage, patient stratification and drug discovery.

He is the principal or chief investigator of several acute brain injury studies, including international multicentre trials.

Other activities

  • Director of NIHR Surgical Reconstruction and Microbiology Research Centre (Trauma Research)
  • Theme Lead of the NIHR Healthcare Technology Cooperative on Trauma Management
  • Module Editor for Neurosurgery for eLearning for Health Care (Royal College of Surgeons of England and Department of Health)
  • Member of the Leadership Committee for Trauma and Critical Care of the European Association of Neurosurgical Societies
  • Independent Member of the Expert Panel on Concussion and Head Injury of the Football Association and Rugby Football Union
  • Advisor on concussion to the England Cricket Board, British Basketball and GB Rowing
  • Trustee of Headway (Brain Injury charity) and of the Midlands Neuroscience Training and Research Fund
  • Member of the Trauma Group of the British Society of Neurological Surgeons
  • External Reviewer for the French National Research Agency
  • Ad hoc reviewer for the EPSRC, MRC, NIHR and Wellcome Trust

Publications

Recent publications

Article

Chimen, M, Evryviadou, A, Box, CL, Harrison, MJ, Hazeldine, J, Dib, LH, Kuravi, SJ, Payne, H, Price, JMJ, Kavanagh, D, Iqbal, AJ, Lax, S, Kalia, N, Brill, A, Thomas, SG, Belli, A, Crombie, N, Adams, RA, Evans, S-A, Deckmyn, H, Lord, JM, Harrison, P, Watson, SP, Nash, GB & Rainger, GE 2020, 'Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation', Haematologica, vol. 105, no. 5, pp. 1248-1261. https://doi.org/10.3324/haematol.2018.215145

McMullan, C, Retzer, A, Slade, A, Kyte, D, Jones, L, Belli, A, Calvert, M & Turner, GM 2020, 'Care providers' and patients' attitudes toward using electronic-patient reported outcomes to support patients with traumatic brain injury: a qualitative study (PRiORiTy)', Brain Injury, vol. 34, no. 6, pp. 723-731. https://doi.org/10.1080/02699052.2020.1740944

McMullan, C, Retzer, A, Slade, A, Kyte, D, Jones, L, Belli, T, Calvert, M & Turner, G 2020, 'Care providers’ and patients’ attitudes towards using electronic-patient reported outcomes to support patients with traumatic brain injury (PRiORiTy)', Brain Injury.

Forcione, M, Chiarelli, AM, Davies, DJ, Perpetuini, D, Sawosz, P, Merla, A & Belli, A 2020, 'Cerebral perfusion and blood-brain barrier assessment in brain trauma using contrast-enhanced near-infrared spectroscopy with indocyanine green: A review', Journal of Cerebral Blood Flow and Metabolism, vol. 40, no. 8, pp. 1586-1598. https://doi.org/10.1177/0271678X20921973

Begum, G, Reddy, R, Yakoub, KM, Belli, A, Davies, DJ & Di Pietro, V 2020, 'Differential expression of circulating inflammatory proteins following sport-related traumatic brain injury', International Journal of Molecular Sciences, vol. 21, no. 4, 1216. https://doi.org/10.3390/ijms21041216

Forcione, M, Yakoub, KM, Chiarelli, AM, Perpetuini, D, Merla, A, Sun, R, Sawosz, P, Belli, A & Davies, DJ 2020, 'Dynamic contrast-enhanced near-infrared spectroscopy using indocyanine green on moderate and severe traumatic brain injury: a prospective observational study', Quantitative Imaging in Medicine and Surgery, vol. 10, no. 11, pp. 2085-2097. https://doi.org/10.21037/qims-20-742

Lazzarino, G, Amorini, AM, Barnes, NM, Bruce, L, Mordente, A, Lazzarino, G, Pietro, VD, Tavazzi, B, Belli, A, Logan, A & Nagy, Z 2020, 'Low molecular weight dextran sulfate (ILB®) administration restores brain energy metabolism following severe traumatic brain injury in the rat', Antioxidants, vol. 9, no. 9, 850. https://doi.org/10.3390/antiox9090850

Gittins, A, Talbott, N, Gilani, AA, Packer, G, Mullhi, R, Whitehouse, T, Belli, A, Mehta, RL, Gao-Smith, F & Veenith, T 2020, 'Outcomes following acute poor-grade aneurysmal subarachnoid bleed – Is early definitive treatment better than delayed management?', Journal of the Intensive Care Society. https://doi.org/10.1177/1751143720946562

Rickard, J, Di Pietro, V, Smith, D, Davies, D, Belli, T & Goldberg Oppenheimer, P 2020, 'Rapid optofluidic detection of biomarkers for traumatic brain injury via surface-enhanced Raman spectroscopy', Nature Biomedical Engineering. https://doi.org/10.1038/s41551-019-0510-4

Rickard, JJS, Di-Pietro, V, Smith, DJ, Davies, DJ, Belli, A & Oppenheimer, PG 2020, 'Rapid optofluidic detection of biomarkers for traumatic brain injury via surface-enhanced Raman spectroscopy', Nature Biomedical Engineering, vol. 4, no. 6, pp. 610-623. https://doi.org/10.1038/s41551-019-0510-4

Davies, DJ, Yakoub, KM, Su, Z, Clancy, M, Forcione, M, Lucas, SJE, Dehghani, H & Belli, A 2020, 'The Valsalva maneuver: an indispensable physiological tool to differentiate intra versus extracranial near-infrared signal', Biomedical Optics Express, vol. 11, no. 4, pp. 1712-1724. https://doi.org/10.1364/BOE.11.001712

Forcione, M, Chiarelli, AM, Perpetuini, D, Davies, DJ, O'Halloran, P, Hacker, D, Merla, A & Belli, A 2020, 'Tomographic Task-Related Functional Near-Infrared Spectroscopy in Acute Sport-Related Concussion: An Observational Case Study', International Journal of Molecular Sciences, vol. 21, no. 17. https://doi.org/10.3390/ijms21176273

Comment/debate

NOSTRA Investigators 2020, 'Correction to: Ronopterin (VAS203) in patients with moderate and severe traumatic brain injury (NOSTRA phase III trial): study protocol of a confirmatory, placebocontrolled, randomised, double blind, multi-centre study', Trials, vol. 21, no. 1, 172. https://doi.org/10.1186/s13063-020-4107-8

Review article

Di Pietro, V, Yakoub, KM, Caruso, G, Lazzarino, G, Signoretti, S, Barbey, AK, Tavazzi, B, Lazzarino, G, Belli, A & Amorini, AM 2020, 'Antioxidant Therapies in Traumatic Brain Injury', Antioxidants, vol. 9, no. 3. https://doi.org/10.3390/antiox9030260

Beedham, W, Belli, A, Ingaralingam, S, Haque, S & Upthegrove, R 2020, 'The management of depression following traumatic brain injury: A systematic review with meta-analysis', Brain Injury, vol. 34, no. 10, pp. 1287-1304. https://doi.org/10.1080/02699052.2020.1797169

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