Recent publications
Article
Hill, LJ, Botfield, H, Begum, G, Qureshi, O, Vigneswara, V, Masood, I, Barnes, N, Bruce, L & Logan, A 2021, 'ILB® resolves inflammatory scarring and promotes functional tissue repair', npj Regenerative Medicine, vol. 6, no. 1, 3. https://doi.org/10.1038/s41536-020-00110-2
Westgate, C, Botfield, H, Alimajstorovic, Z, Yiangou, A, Walsh, M, Smith, G, Singhal, R, Mitchell, J, Grech, O, Markey, K, Hebenstreit, D, Tennant, D, Tomlinson, J, Mollan, S, Ludwig, C, Akerman, I, Lavery, G & Sinclair, A 2021, 'Systemic and adipocyte transcriptional and metabolic dysregulation in idiopathic intracranial hypertension', JCI Insight, vol. 6, no. 10, e145346. https://doi.org/10.1172/jci.insight.145346
Markey, K, Mitchell, J, Botfield, H, Ottridge, R, Matthews, T, Krishnan, A, Woolley, R, Westgate, C, Yiangou, A, Alimajstorovic, Z, Shah, P, Rick, C, Ives, N, Taylor, A, Gilligan, L, Jenkinson, C, Arlt, W, Scotton, W, Fairclough, RJ, Singhal, R, Stewart, PM, Tomlinson, JW, Lavery, G, Mollan, S & Sinclair, A 2020, '11β-hydroxysteroid dehydrogenase type 1 inhibition in idiopathic intracranial hypertension: a double-blind randomized controlled trial', Brain Communications, vol. 2, no. 1, fcz050. https://doi.org/10.1093/braincomms/fcz050
OʼReilly, MW, Westgate, C, Hornby, C, Botfield, H, Taylor, A, Markey, K, Mitchell, J, Scotton, W, Mollan, S, Yiangou, A, Jenkinson, C, Gilligan, L, Sherlock, M, Gibney, J, Tomlinson, JW, Lavery, G, Hodson, D, Arlt, W & Sinclair, A 2019, 'A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics', JCI Insight, vol. 4, no. 6, e125348. https://doi.org/10.1172/jci.insight.125348
Scotton, WJ, Mollan, SP, Botfield, H, Yiangou, A, Markey, K, Sinclair, AJ, Walters, T, Doughty, S & Williamson, S 2018, 'Characterising the patient experience of diagnostic lumbar puncture in idiopathic intracranial hypertension: a cross-sectional online survey', BMJ open, vol. 8, no. 5, e020445. https://doi.org/10.1136/bmjopen-2017-020445
Hornby, C, Mollan, S, Botfield, H, OʼReilly, MW & Sinclair, A 2018, 'Metabolic Concepts in Idiopathic Intracranial Hypertension and Their Potential for Therapeutic Intervention', Journal of Neuro-Ophthalmology, vol. 38, no. 4, pp. 522–530. https://doi.org/10.1097/WNO.0000000000000684
Yiangou, A, Mitchell, J, Markey, KA, Scotton, W, Nightingale, P, Botfield, H, Ottridge, R, Mollan, SP & Sinclair, AJ 2018, 'Therapeutic lumbar puncture for headache in idiopathic intracranial hypertension: Minimal gain, is it worth the pain?', Cephalalgia. https://doi.org/10.1177/0333102418782192
Scotton, WJ, Botfield, HF, Westgate, CS, Mitchell, JL, Yiangou, A, Uldall, MS, Jensen, RH & Sinclair, AJ 2018, 'Topiramate is more effective than acetazolamide at lowering intracranial pressure', Cephalalgia. https://doi.org/10.1177/0333102418776455
Botfield, HF, Uldall, MS, Westgate, CSJ, Mitchell, JL, Hagen, SM, Gonzalez, AM, Hodson, DJ, Jensen, RH & Sinclair, AJ 2017, 'A glucagon-like peptide-1 receptor agonist reduces intracranial pressure in a rat model of hydrocephalus', Science Translational Medicine, vol. 9, no. 404, eaan0972. https://doi.org/10.1126/scitranslmed.aan0972
Ottridge, R, Mollan, S, Botfield, H, Frew, E, Ives, N, Matthews, T, Mitchell, J, Rick, C, Singhal, R, Woolley, R & Sinclair, A 2017, 'A randomised controlled trial of bariatric surgery versus a community weight loss programme for the sustained treatment of Idiopathic Intracranial Hypertension: the Idiopathic Intracranial Hypertension Weight Trial (IIH:WT) protocol', BMJ open, vol. 7, e017426. https://doi.org/10.1136/bmjopen-2017-017426
Uldall, M, Botfield, H, Jansen-Olesen, I, Sinclair, A & Jensen, R 2017, 'Acetazolamide Lowers Intracranial Pressure and Modulates the Cerebrospinal Fluid Secretion Pathway in Healthy Rats', Neuroscience Letters, vol. 645, pp. 33-39. https://doi.org/10.1016/j.neulet.2017.02.032
Hornby, C, Botfield, H, O'reilly, M, Westgate, C, Mitchell, J, Mollan, S, Manolopoulos, K, Tomlinson, J & Sinclair, A 2017, 'Evaluating the fat distribution in Idiopathic Intracranial Hypertension using Dual energy X-ray absorptiometry scanning', Neuro-Ophthalmology. https://doi.org/10.1080/01658107.2017.1334218
Aojula, A, Botfield, H, McAllister, JP, Gonzalez, A, Abdullah, O, Logan, A & Sinclair, A 2016, 'Diffusion tensor imaging with direct cytopathological validation: characterisation of decorin treatment in experimental juvenile communicating hydrocephalus', Fluids and barriers of the CNS, vol. 13, 9. https://doi.org/10.1186/s12987-016-0033-2
Mollan, S, Ali, F, Hassan-Smith, G, Botfield, H, Friedman, DI & Sinclair, A 2016, 'Evolving evidence in adult idiopathic intracranial hypertension: pathophysiology and management', Journal of Neurology Neurosurgery and Psychiatry, vol. 87, no. 9, pp. 982-992. https://doi.org/10.1136/jnnp-2015-311302
Review article
Hardy, R, Botfield, H, Markey, K, Mitchell, J, Alimajstorovic, Z, Westgate, C, Sagmeister, M, Fairclough, R, Ottridge, R, Yiangou, A, Storbeck, K-H, Taylor, A, Gilligan, L, Arlt, W, Stewart, P, Tomlinson, J, Mollan, S, Lavery, G & Sinclair, A 2021, '11βHSD1 inhibition with AZD4017 improves lipid profiles and lean muscle mass in Idiopathic intracranial hypertension', Journal of Clinical Endocrinology and Metabolism, vol. 106, no. 1, pp. 174-187. https://doi.org/10.1210/clinem/dgaa766
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