Professor Christopher Buckley DPhil FRCP

Image of Chris Buckley

Institute of Inflammation and Ageing
Arthritis Research UK Professor of Rheumatology
Director of the Birmingham NIHR Wellcome Trust Clinical Research Facility

Contact details

Rheumatology Research Group
Institute of Inflammation and Ageing
College of Medical and Dental Sciences
University of Birmingham
Queen Elizabeth Hospital
Birmingham, B15 2WB

Chris has made major contributions to scientific administration through his roles with the arthritis research UK (Chair of the Fellowship Committee and Clinical Studies Group on early inflammatory arthritis) as well as EULAR (Scientific Programme organizing committee).   He is closely involved in the development of clinical academics and he is a strong and eloquent advocate for clinician scientists in several fora.


  • FRCP Medicine London 2006
  • DPhil Medicine Oxford 1996
  • BA Biochemistry (1st Class) Oxford 1985


Chris Buckley obtained his first degree (BA) in Biochemistry from the University of Oxford (1985) with subsequent undergraduate training in Medicine MBBS at the Royal Free Hospital, London (1990). Postgraduate Medical training MRCP (1993) in General Medicine at Hammersmith Hospital, London (Mark Walport, Dorian Haskard), and John Radcliffe Hospital, Oxford. DPhil (1996) arising from a Wellcome Training Fellowship with Professor J Bell and Dr D Simmons at the Institute Molecular Medicine, Oxford. In 1996, funded by a Wellcome Clinician Scientist Fellowship, he joined the Department of Rheumatology in Birmingham. In 2001 he was awarded an MRC Senior Clinical Fellowship and in October 2002 became ARUK Professor of Rheumatology, Division of Immunity and Infection in Birmingham.


Teaching Programmes

MBCHB - 2nd 3rd and 4th Year

Postgraduate supervision

Chris is interested in supervising doctoral research students in the following areas:

  • The role of stromal cells in inflammation.

He is particularly keen on mentoring and supporting medical doctors early in their academic careers. He sits on the College’s Integrated Clinical Academic Training committee.

If you are interested in studying any of these subject areas please contact Chris on the contact details above, or for any general doctoral research enquiries, please email: or call +44 (0)121 414 5005.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.


A characteristic feature of chronic inflammatory reactions is their persistence and predilection for certain sites. Our group investigates the role that tissue resident stromal cells (fibroblasts) play in determining both the switch to persistence as well as the site at which inflammation occurs. In chronic inflammation the resolution phase is prolonged and disordered leading to the persistent accumulation of the inflammatory infiltrate. Our work has allowed us to propose that a stromal area post code, predominantly defined by fibroblasts, exists within tissues. Our hypothesis predicts that components of this stromal area post code become disordered during inflammation, leading to the accumulation of lymphocytes in structures that resemble lymphoid tissues. We have proposed that inflammation is not generic but contextual and therefore differences in the response of different inflammatory diseases to therapy are likely to be due to intrinsic differences in the behavior of stromal cells within different environments. Ignoring the contribution of stromal cells to the pathogenesis of chronic inflammatory disease may account for the failure of current therapies to affect a permanent cure. We suggest that stromal cells in general and fibroblasts in particular offer a new family of organ specific targets to treat chronic immune mediated inflammatory diseases such as rheumatoid arthritis

For more information about Chris Buckley's research follow the links below:

BBC Radio 4 (2004) Inflammation 

BBC Radio 4 (2008) Inflamed Response


Barone F, Nayar S, Campos J, Cloake T, Withers DR, Toellner KM, Zhang Y, Fouser L, Fisher B, Bowman S, Rangel-Moreno J, Garcia-Hernandez M de L, Randall TD, Lucchesi D, Bombardieri M, Pitzalis C, Luther SA and Buckley CD (2015) IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs. Proc Natl Acad Sci U S A 112(35):11024-9

Chimen M, McGettrick HM, Apta B, Kuravi SJ, Yates CM, Kennedy A, Odedra A, Alassiri M, Harrison M, Martin A, Barone F, Nayar S, Hitchcock JR, Cunningham AF, Raza K, Filer A, Copland DA, Dick AD, Robinson J, Kalia N, Walker LS, Buckley CD, Nash GB, Narendran P and Rainger GE (2015) Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. Nat Med 21(5):467-75

Cheung K, Ma L, Wang G, Coe D, Ferro R, Falasca M, Buckley CD, Mauro C and Marelli-Berg FM (2015) CD31 signals confer immune privilege to the vascular endothelium. Proc Natl Acad Sci U S A 112(43):E5815-24

Bénézech C, Nayar S, Finney BA, Withers DR, Lowe K, Desanti GE, Marriott CL, Watson SP, Caamaño JH, Buckley CD and Barone F (2014) CLEC-2 is required for development and maintenance of lymph nodes. Blood 123(20):3200-7

Mittal S, Revell M, Barone F, Hardie DL, Matharu GS, Davenport AJ, Martin RA, Grant M, Mosselmans F, Pynsent P, Sumathi VP, Addison O, Revell PA and Buckley CD (2013) Lymphoid aggregates that resemble tertiary lymphoid organs define a specific pathological subset in metal-on-metal hip replacements. PLoS One 8(5):e63470

Sherlock JP, Joyce-Shaikh B, Turner SP, Chao CC, Sathe M, Grein J, Gorman DM, Bowman EP, McClanahan TK, Yearley JH, Eberl G, Buckley CD, Kastelein RA, Pierce RH, Laface DM and Cua DJ (2013) IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells. Nat Med 18(7):1069-76

Naylor AJ, Azzam E, Smith S, Croft A, Poyser C, Duffield JS, Huso DL, Gay S, Ospelt C, Cooper MS, Isacke C, Goodyear SR, Rogers MJ and Buckley CD (2012) The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice. Arthritis Rheum 64(10):3334-43

de Pablo P, Cooper MS and Buckley CD (2012) Association between bone mineral density and C-reactive protein in a large population-based sample. Arthritis Rheum 64(8):2624-31

Cader MZ, Filer A, Hazlehurst J, de Pablo P, Buckley CD and Raza K (2011) Performance of the 2010 ACR/EULAR criteria for rheumatoid arthritis: comparison with 1987 ACR criteria in a very early synovitis cohort. Ann Rheum Dis 70(6):949-55

Raza K, Stack R, Kumar K, Filer A, Detert J, Bastian H, Burmester GR, Sidiropoulos P, Kteniadaki E, Repa A, Saxne T, Turesson C, Mann H, Vencovsky J, Catrina A, Chatzidionysiou A, Hensvold A, Rantapää-Dahlqvist S, Binder A, Machold K, Kwiakowska B, Ciurea A, Tamborrini G, Kyburz D and Buckley CD (2011) Delays in assessment of patients with rheumatoid arthritis: variations across Europe. Ann Rheum Dis 70(10):1822-5


Factors involved in the triggering and perpetuation of chronic inflammatory arthritis, such as rheumatoid, reactive and juvenile arthritis; targets for effective future therapy; related systemic connective tissue diseases, particularly lupus.

Alternative contact number available for this expert: contact the press office