Recent publications
Article
Clayton, SA, Daley, KK, Macdonald, L, Fernandez-vizarra, E, Bottegoni, G, O’Neil, JD, Major, T, Griffin, D, Zhuang, Q, Adewoye, AB, Woolcock, K, Jones, SW, Goodyear, C, Elmesmari, A, Filer, A, Tennant, DA, Alivernini, S, Buckley, CD, Pitceathly, RDS, Kurowska-stolarska, M & Clark, AR 2021, 'Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48', Science Advances, vol. 7, no. 50, eabl5182. https://doi.org/10.1126/sciadv.abl5182
Falconer, J, Pucino, V, Clayton, S, Marshall, JL, Raizada, S, Adams, H, Philp, A, Clark, AR, Filer, A, Raza, K, Young, S & Buckley, C 2021, 'Spontaneously resolving joint inflammation is characterised by metabolic agility of fibroblast-like synoviocytes', Frontiers in immunology, vol. 12, 725641. https://doi.org/10.3389/fimmu.2021.725641
Alivernini, S, MacDonald, L, Elmesmari, A, Finlay, S, Tolusso, B, Gigante, MR, Petricca, L, Di Mario, C, Bui, L, Perniola, S, Attar, M, Gessi, M, Fedele, AL, Chilaka, S, Somma, D, Sansom, SN, Filer, A, McSharry, C, Millar, NL, Kirschner, K, Nerviani, A, Lewis, MJ, Pitzalis, C, Clark, AR, Ferraccioli, G, Udalova, I, Buckley, C, Gremese, E, McInnes, IB, Otto, TD & Kurowska-Stolarska, M 2020, 'Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis', Nature Medicine, vol. 26, no. 8, pp. 1295-1306. https://doi.org/10.1038/s41591-020-0939-8
Clark, A 2019, 'Enhancing tristetraprolin activity reduces the severity of cigarette smoke-induced experimental chronic obstructive pulmonary disease.', Clinical and Translational Immunology. https://doi.org/10.1002/cti2.1084
Clark, AR & Ohlmeyer, M 2019, 'Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration', Pharmacology & Therapeutics, vol. 201, pp. 181-201. https://doi.org/10.1016/j.pharmthera.2019.05.016
Brown, JM, Ross, E, Desanti, G, Saghir, A, Clark, A, Buckley, C, Filer, A, Naylor, A & Claridge, E 2017, 'Detection and characterisation of bone destruction in murine rheumatoid arthritis using statistical shape models', Medical Image Analysis, vol. 40, pp. 30-43. https://doi.org/10.1016/j.media.2017.05.006
O'Neil, J, Ross, E, Ridley, M, Rosner, D, Crowley, T, Smallie, T, Buckley, C & Clark, A 2017, 'Gain-of-function mutation of tristetraprolin impairs negative feedback control of macrophages in vitro, yet has overwhelmingly anti-inflammatory consequences in vivo.', Molecular and Cellular Biology, vol. 37, no. 11, e00536-16. https://doi.org/10.1128/MCB.00536-16
Tang, T, Scambler, TE, Smallie, T, Cunliffe, HE, Ross, EA, Rosner, DR, O’neil, JD & Clark, AR 2017, 'Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin', Scientific Reports, vol. 7, no. 1, 4350. https://doi.org/10.1038/s41598-017-04100-1
Crowley, T, O’neil, JD, Adams, H, Thomas, AM, Filer, A, Buckley, CD & Clark, A 2017, 'Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts', Arthritis Research & Therapy, vol. 19, 35. https://doi.org/10.1186/s13075-017-1248-6
Ross, E, Naylor, A, O'Neil, J, Crowley, T, Ridley, M, Crowe, J, Smallie, T, Tang, JT, Turner, J, Norling, LV, Dominguez, S, Perlman, H, Verrills, NM, Kollias, G, Vitek, MP, Filer, A, Buckley, C, Dean, JL & Clark, A 2017, 'Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression', Annals of the Rheumatic Diseases, vol. 76, no. 3, pp. 612-619. https://doi.org/10.1136/annrheumdis-2016-209424
Bulbrook, D, Brazier, H, Mahajan, P, Kliszczak, M, Fedorov, O, Marchese, FP, Aubareda, A, Chalk, R, Picaud, S, Strain-Damerell, C, Filippakopoulos, P, Gileadi, O, Clark, AR, Yue, WW, Burgess-Brown, NA & Dean, JLE 2017, 'Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment', Journal of Molecular Biology. https://doi.org/10.1016/j.jmb.2017.12.018
Rahman, MM, Rumzhum, NN, Hansbro, PM, Morris, JC, Clark, A, Verrills, NM & Ammit, AJ 2016, 'Activating protein phosphatase 2A (PP2A) enhances tristetraprolin (TTP) anti-inflammatory function in A549 lung epithelial cells', Cellular Signalling. https://doi.org/10.1016/j.cellsig.2016.01.009
Review article
Clayton, SA, MacDonald, L, Kurowska-Stolarska, M & Clark, AR 2021, 'Mitochondria as key players in the pathogenesis and treatment of rheumatoid arthritis', Frontiers in immunology, vol. 12, 673916. https://doi.org/10.3389/fimmu.2021.673916
Crowley, T, Buckley, C & Clark, A 2018, 'Stroma: the forgotten cells of innate immune memory', Clinical & Experimental Immunology, vol. 193, no. 1, pp. 24-36. https://doi.org/10.1111/cei.13149
Falconer, J, Young, S, Clark, A & Buckley, C 2018, 'Synovial cell metabolism and chronic inflammation in rheumatoid arthritis', Arthritis and Rheumatology, vol. 70, no. 7, pp. 984-999. https://doi.org/10.1002/art.40504
View all publications in research portal