Professor Adam Croft BSc (Hons), MBChB, PhD, MRCP (UK)

Adam Croft

Institute of Inflammation and Ageing
Professor of Translational Rheumatology
Kennedy Trust for Rheumatology Research Senior Clinical Research Fellow

Contact details

Address
Rheumatology Research Group
Institute of Inflammation and Ageing (IIA)
University of Birmingham
Queen Elizabeth Hospital, Birmingham, B15 2WB

Adam is a Professor of Translational Rheumatology and an Honorary Consultant Rheumatologist at Sandwell and West Birmingham Hospitals and University Hospital of Birmingham NHS Trusts.

His main research interest is the development of novel immunotherapies for patients with autoimmune rheumatic and chronic inflammatory diseases, with a particular interest in the development of stromal cell (fibroblast) specific targets. He has received funding from the Wellcome Trust and NIHR.

His clinical interests include management of both early and treatment resistant inflammatory arthritis. His research is supported by the Kennedy Trust for Rheumatology Research, Versus Arthritis and Wellcome Trust

Video clip - Adam Croft talks about three exciting new posts available to join the team here in the Institute of Inflammation and Ageing.

Adam is a Professor of Translational Rheumatology and an Honorary Consultant Rheumatologist at Sandwell and West Birmingham Hospitals and University Hospital of Birmingham NHS Trusts.

His main research interest is the development of novel immunotherapies for patients with autoimmune rheumatic and chronic inflammatory diseases, with a particular interest in the development of stromal cell (fibroblast) specific targets. He has received funding from the Wellcome Trust and NIHR.

His clinical interests include management of both early and treatment resistant inflammatory arthritis. His research is supported by the Kennedy Trust for Rheumatology Research, Versus Arthritis and Wellcome Trust

Qualifications

  • PG Cert Medical education 2018
  • PG Cert in Clinical Research Methodology 2015
  • MRCP (UK) 2012
  • MBChB 2009
  • PhD 2005
  • BSc (Hons) 2002

Teaching

Postgraduate supervision

Dr Croft's main research interest is in the development of novel immunotherapies for patients with autoimmune rheumatic and chronic inflammatory diseases. He has a particular interest in the development of stromal cell specific targets. His clinical interests include management of both early and treatment resistant inflammatory arthritis. He is also interested in the management of rare systemic inflammatory diseases including vasculitis.

PhD opportunites are available within the Rheumatology Research Group

Other activities

Current

  • 2018- Member of Paediatric and adolescent rheumatology network
  • 2018- Member of Scientific Advisory Committee, NIHR Wellcome Trust Clinical Research facility, University of Birmingham
  • 2016- UK country liaison to EMUNET EULAR advisory group (by competitive national appointment)
  • 2016- Member of West Midlands regional vasculitis network

Previous

  • 2015-2018 Chair of British Rheumatologists in Training Advisory Group and West Midlands regional representative (by competitive national appointment)
  • Member of British Society of Rheumatology Council
  • Member of Joint Specialty Committee at Royal College of Physicians
  • Member of rheumatology JRCTPB speciality advisory group
  • Member of Education and training subcommittee
  • 2016-2018 Member of Clinical Care Quality committee, British Society of Rheumatology (trainee representative)
  • 2016-2018 Member of Peer Review working group, British Society of Rheumatology (trainee representative)
  • 2013-2017 Royal college of Physicians Associate Clinical Tutor, Queen Elizabeth Hospital, Birmingham
  • 2012-2014 Associate Clinical Teaching Fellow, Queen Elizabeth Hospital, Birmingham
  • 2009-2013 Advanced Life Support Instructor, Resuscitation Council UK     

Publications

Recent publications

Article

Fenton, C, Martin, C, Jones, R, Croft, A, Campos, J, Naylor, A, Taylor, A, Chimen, M, Cooper, M, Lavery, G, Raza, K & Hardy, R 2021, 'Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids', Annals of the Rheumatic Diseases, vol. 80, no. 2, pp. 250-260. https://doi.org/10.1136/annrheumdis-2020-218493

Friščić, J, Böttcher, M, Reinwald, C, Bruns, H, Writh, B, Popp, S-J, Walker, KI, Ackermann, JA, Chen, X, Turner, J, Zhu, H, Seyler, L, Euler, M, Kirchner, P, Krüger, R, Ekici, AB, Major, T, Aust, O, Weidner, D, Fischer, A, Andes, FT, Stanojevic, Z, Trajkovic, V, Hermann, M, Korb-Pap, A, Wank, I, Hess, A, Winter, J, Wixler, V, Distler, J, Steiner, G, Kiener, HP, Frey, B, Kling, L, Raza, K, Frey, S, Kleyer, A, Bäuerle, T, Grüneboom, A, Steffen, U, Krönke, G, Croft, A, Filer, A, Köhl, J, Klein, K, Buckley, CD, Schett, G, Mougiakakos, D & Hoffmann, MH 2021, 'The complement system drives local inflammatory tissue priming by metabolic reprogramming of articular fibroblasts', Immunity, vol. 2021, no. 00, pp. 1-31. https://doi.org/10.1016/j.immuni.2021.03.003

Wei, K, Korsunsky, I, Marshall, JL, Gao, A, Watts, GFM, Major, T, Croft, AP, Watts, J, Blazar, PE, Lange, JK, Thornhill, TS, Filer, A, Raza, K, Donlin, LT, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Siebel, CW, Buckley, CD, Raychaudhuri, S & Brenner, MB 2020, 'Notch signalling drives synovial fibroblast identity and arthritis pathology', Nature, vol. 582, no. 7811, pp. 259–264. https://doi.org/10.1038/s41586-020-2222-z

Croft, AP, Campos, J, Jansen, K, Turner, JD, Marshall, J, Attar, M, Savary, L, Wehmeyer, C, Naylor, AJ, Kemble, S, Begum, J, Dürholz, K, Perlman, H, Barone, F, Mcgettrick, HM, Fearon, DT, Wei, K, Raychaudhuri, S, Korsunsky, I, Brenner, MB, Coles, M, Sansom, SN, Filer, A & Buckley, CD 2019, 'Distinct fibroblast subsets drive inflammation and damage in arthritis', Nature, vol. 570, no. 7760, pp. 246–251 . https://doi.org/10.1038/s41586-019-1263-7

Hardy, R, Fenton, C, Croft, A, Naylor, A, Begum, R, Desanti, G, Buckley, C, Lavery, G, Cooper, MS & Raza, K 2018, '11 beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis', Journal of Autoimmunity, vol. 92, pp. 104-113. https://doi.org/10.1016/j.jaut.2018.05.010

Bustamante, MF, Oliveira, PG, Garcia-Carbonell, R, Croft, A, Smith, JM, Serrano, RL, Sanchez-Lopez, E, Liu, X, Kisseleva, T, Hay, N, Buckley, C, Firestein, GS, Murphy, AN, Miyamoto, S & Guma, M 2018, 'Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis', Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2018-213103

Croft, A, Naylor, A, Marshall, J, Hardie, DL, Zimmermann, B, Turner, J, Desanti, G, Adams, H, Yemm, A, Müller-Ladner, U, Dayer, J-M, Neumann, E, Filer, A & Buckley, C 2016, 'Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage', Arthritis Research & Therapy, vol. 18, no. 1, 270. https://doi.org/10.1186/s13075-016-1156-1

Bartis, D, Crowley, LE, D'Souza, V, Borthwick, L, Fisher, AJ, Croft, AP, Pongrácz, JE, Thompson, R, Langman, G, Buckley, CD & Thickett, DR 2016, 'Role of CD248 as a potential severity marker in idiopathic pulmonary fibrosis', BMC Pulmonary Medicine, vol. 16, 51. https://doi.org/10.1186/s12890-016-0211-7

Wilhelm, A, Aldridge, V, Haldar, D, Naylor, AJ, Weston, CJ, Garg, A, Fear, J, Reynolds, GM, Croft, AP, Henderson, NC, Buckley, CD & Newsome, PN 2015, 'CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism', Gut. https://doi.org/10.1136/gutjnl-2014-308325

Croft, AP, Thompson, N, Duddy, MJ, Barton, C, Khattak, F, Mollan, SP & Jobanputra, P 2015, 'Cranial ultrasound for the diagnosis of giant cell arteritis. A retrospective cohort study', The journal of the Royal College of Physicians of Edinburgh, vol. 45, no. 4, pp. 268-272. https://doi.org/10.4997/JRCPE.2015.403

Editorial

Jani, M, Nikiphorou, E, Croft, AP & Bukhari, M 2017, 'Building the future of rheumatology: the role of national and international networks', Rheumatology. https://doi.org/10.1093/rheumatology/kew509

Letter

Jolobe, OM, Welsby, PD, Jawad, AS, Croft, AP & Jobanputra, P 2016, 'Letters to the editor', The journal of the Royal College of Physicians of Edinburgh, vol. 46, no. 1, pp. 68-70. https://doi.org/10.4997/JRCPE.2016.114

Croft, AP & Jobanputra, P 2016, 'Re: Giant cell or temporal arteritis?', Journal of the Royal College of Physicians of Edinburgh, vol. 46, no. 1, pp. 69-70. <http://www.rcpe.ac.uk/sites/default/files/jrcpe_46_1_letters.pdf>

Review article

Kemble, S & Croft, AP 2021, 'Critical Role of Synovial Tissue-Resident Macrophage and Fibroblast Subsets in the Persistence of Joint Inflammation', Frontiers in immunology, vol. 12, 715894. https://doi.org/10.3389/fimmu.2021.715894

Marsh, L-J, Kemble, S, Reis Nisa, P, Singh, R & Croft, AP 2021, 'Fibroblast pathology in inflammatory joint disease', Immunological Reviews. https://doi.org/10.1111/imr.12986

View all publications in research portal

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