Dr Benjamin Fisher MD(Res)

Image of Dr Benjamin Fisher

Institute of Inflammation and Ageing
Senior lecturer in Clinical Rheumatology

Contact details

Address
Institute of Inflammation and Ageing
Centre for Translational Inflammation Research
Research Laboratories
New Queen Elizabeth Hospital
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Ben Fisher is a Senior lecturer in Clinical Rheumatology. He has published research papers on Sjögren’s syndrome and inflammatory arthritis and has participated in many national and international collaborations.

Ben is part of a team who designed the recent COVID-19 drugs trial ‘CATALYST’, which rapidly tests new therapies for patients hospitalised due to COVID-19. It is hoped that by using drugs that target the most serious symptoms of the virus, the severity of the disease could be reduced leading to a reduction in the number of patients needing to be admitted to intensive care and ultimately, a reduction in virus related deaths.

Qualifications

  • MD(Res) Medicine 2011
  • MRCP 2002
  • MBBS 1999
  • BSc (Hons) Immunology 1996

Biography

Benjamin Fisher studied medicine at the United Medical and Dental Schools of Guy’s and St.Thomas’s Hospitals in London, obtaining a BSc(Hons) in Immunology in 1996 and his MBBS in 1999. He trained as a Rheumatologist in London with academic studies at the Kennedy Institute of Rheumatology, Imperial College London. Here he worked in the clinical trials unit and completed an MD(Res) on antibodies to citrullinated alpha enolase peptides in rheumatoid arthritis. Following this he was appointed as a Walport Clinical Lecturer at Imperial College. He joined Birmingham University as a Senior Clinical Lecturer in 2012.

Research

A key focus of Dr Fisher's current work is on clinical trials in inflammatory disease, especially Sjögren’s syndrome. Sjögren’s syndrome is an autoimmune condition resulting in dryness of the eyes and mouth, alongside a range of other complications that occur in a proportion of patients. Currently there are no existing disease-modifying therapies. However Ben's team have an active clinical trials programme and he presented data from a commercially sponsored trial of a novel agent blocking CD40 at the American College of Rheumatology annual congress in 2017. This was the first trial, to their knowledge, to show positive effects prospectively on a validated measure of systemic activity in a double-blind randomised controlled trial. Dr Fisher is chief investigator for the Optimising Assessments in Sjögren’s Syndrome (OASIS) cohort that has a number of objectives including to identify biomarkers of disease activity from blood, saliva and tissue, that may help inform future clinical trial design. He is a deputy clinical director at the Cancer Research UK clinical trials unit Birmingham, leading the Inflammation and Advanced Cellular Therapies (I-ACT) team.

Ben also has a longstanding interest in risk factors for autoimmune diseases such as rheumatoid arthritis and Sjögren’s syndrome, including autoantibodies and diet.

Lay summary

Sjögren’s syndrome is a disease where the body’s immune system causes inflammation in the glands that produce tears and saliva causing dryness. It is associated with profound fatigue in a large number of patients and together, these symptoms cause a large reduction in health-related quality of life. In a proportion of patients the disease also affects other body systems such as the joints and the lungs. There are no therapies proven to modify the underlying immune disease, but they have an active programme to study new drugs from industrial partners, including those blocking CD40 which in an early trial has shown some promise. CD40 has a role in how cells of the immune system activate each other. Dr Fisher also has an interest in how to measure how active a patient’s disease is, and to understand risk factors for disease such as diet; i.e. what makes a person more likely to develop Sjögren’s syndrome or rheumatoid arthritis, when others do not.

Publications

Recent publications

Article

Juarez, M, Diaz, N, Johnston, G, Nayar, S, Payne, A, Helmer, E, Cain, D, Williams, P, Devauchelle-Pensec, V, Fisher, B, Giacomelli, R, Gottenberg, J-E, Guggino, G, Kvarnstrom, M, Mariette, X, Ng, W-F, Rosas, J, Burson, J, Triolo, G, Barone, F & Bowman, S 2020, 'A phase 2 randomised, double-blind, placebo-controlled, proof-of-concept study of oral seletalisib in primary Sjögren’s syndrome', Rheumatology.

Fisher, B, Szanto, A, Ng, W-F, Bombardieri, M, Posch, M, Papas, A, Farag, A, Daikeler, T, Bannert, B, Kyburz, D, Kivitz, A, Carsons, S, Isenberg, D, Barone, F, Bowman, S, Espie, P, Floch, D, Dupuy, C, Ren, X, Faerber, P, Wright, A, Hockey, H-U, Rotte, M, Milojevic, J, Avrameas, A, Valentin, M-A, Rush, J & Gergely, P 2020, 'Assessment of the anti-CD40 antibody iscalimab in patients with primary Sjögren's syndrome: a multicentre, randomised, double-blind, placebo-controlled, parallel group proof-of-concept study', Lancet Rheumatology. https://doi.org/10.1016/S2665-9913(19)30135-3

ESSENTIAL (EULAR Sjögren's Syndrome Study Group), HarmonicSS (H2020), Colafrancesco, S, Priori, R, Smith, C, Minniti, A, Iannizzotto, V, Pipi, E, Lucchesi, D, Pontarini, E, Nayar, S, Campos, J, Arienzo, F, Fusconi, M, Cerbelli, B, Giordano, C, Valesini, G, Bombardieri, M, Fisher, B & Barone, F 2020, 'CXCL13 as biomarker for histological involvement in Sjögren’s Syndrome', Rheumatology (Oxford, England), vol. 59, no. 1, pp. 165-170. https://doi.org/10.1093/rheumatology/kez255

Ramos-Casals, M, Brito-Zeron, P, Bombardieri, S, Bootsma, H, De Vita, S, Dorner, T, Fisher, B, Gottenberg, J-E, Hernandez-Molina, G, Kocher, A, Kostov, B, Kruize, A, Mandl, T, Ng, W-F, Retamozo, S, Seror, R, Shoenfeld, Y, Siso-Almirall, A, Tzioufas, A, Vitali, C, Bowman, S & Mariette, X 2020, 'EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies', Annals of the Rheumatic Diseases, vol. 79, no. 1, 216114, pp. 3-18. https://doi.org/10.1136/annrheumdis-2019-216114, https://doi.org/10.1136/annrheumdis-2019-216114

Machowicz, A, Hall, I, De Pablo, P, Rauz, S, Richards, A, Higham, J, Poveda Gallego, A, Imamura, F, Bowman, S, Barone, F & Fisher, B 2020, 'Mediterranean diet and risk of Sjögren’s syndrome', Clinical and Experimental Rheumatology.

Posada, J, Valadkhan, S, Burge, D, Davies, K, Tarn, J, Casement, J, Jobling, K, Gallagher, P, Wilson, D, Barone, F, Fisher, B & Ng, W-F 2020, 'Nuclease Therapy Improves Severe Fatigue in Primary Sjögren’s Syndrome: A Randomized Clinical Trial', Arthritis and Rheumatology.

Yang, J, Zhang, C, Sparks, J, Malspeis, S, Tsoi, K, Kim, J, Fisher, B, Gao Smith, F, Sumerlin, T, Liu, Y, Liu, Y, Pan, Y, He, Y & Sung, J 2020, 'Regular use of proton pump inhibitor and risk of rheumatoid arthritis in women: a prospective cohort study', Alimentary Pharmacology & Therapeutics.

Nayar, S, Dias De Campos, J, Smith, C, Iannizzotto, V, Gardner, D, Mourcin, F, Roulois, D, Turner, J, Sylvestre, M, Asam, S, Glaysher, B, Bowman, SJ, Fearon, DT, Filer, A, Tarte, K, Luther, SA, Fisher, B, Buckley, C, Coles, MC & Barone, F 2019, 'Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology', Proc. Natl. Acad. Sci. (USA), vol. 116, no. 27, 201905301, pp. 13490-13497. https://doi.org/10.1073/pnas.1905301116

Nayar, S, Campos, J, Smith, CG, Iannizzotto, V, Gardner, DH, Colafrancesco, S, Pipi, E, Kollert, F, Hunter, KJ, Brewer, C, Buckley, CD, Bowman, SJ, Priori, R, Valesini, G, Juarez, M, Fahy, WA, Fisher, BA, Payne, A, Allen, RA & Barone, F 2019, 'Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren's syndrome', Annals of the Rheumatic Diseases, vol. 78, no. 2, pp. 249-260. https://doi.org/10.1136/annrheumdis-2017-212619

Ramos-Casals, M & Fisher, B 2019, 'Sicca/Sjögren Syndrome triggered by PD-1/PD-L1 checkpoint inhibitors: data from the International ImmunoCancer Registry (ICIR)', Clinical and Experimental Rheumatology, vol. 37, no. 3, Supplement 118, pp. 0114-0122. <https://www.clinexprheumatol.org/abstract.asp?a=14290>

Jousse-Joulin, S, Gatineau, F, Baldini, C, Baer, A, Barone, F, Bootsma, H, Bowman, S, Brito-Zeron, P, Cornec, D, Dorner, T, de Vita, S, Fisher, B, Hammenfors, D, Jonsson, M, Mariette, X, Milic, V, Nakamura, H, Ng, W-F, Nowak, E, Ramos-Casals, M, Rasmussen, A, Seror, R, Shiboski, C, Nakamura, T, Vissink, A, Saraux, A & Devauchelle-Pensec, V 2019, 'Weight of salivary-gland ultrasonography compared to other items of the 2016 ACR/EULAR classification criteria for Primary Sjögren’s Syndrome', Journal of Internal Medicine. https://doi.org/10.1111/joim.12992

Comment/debate

Fisher, B 2020, 'Is it the end of the road for abatacept treatment in Sjögren's syndrome?', Lancet Rheumatology. https://doi.org/10.1016/S2665-9913(20)30002-3

Review article

Kollert, F & Fisher, B 2020, 'Equal rights in autoimmunity: is Sjögren`s syndrome ever ‘secondary’?', Rheumatology. https://doi.org/10.1093/rheumatology/keaa009

Pucino, V, Gardner, D & Fisher, B 2020, 'Rationale for CD40 pathway blockade in autoimmune rheumatic disorders', Lancet Rheumatology, vol. 2, no. 5, pp. e292-e301. https://doi.org/10.1016/S2665-9913(20)30038-2

Miyamoto, S, Valim, V & Fisher, B 2019, 'Health-related Quality of Life and costs in Sjögren’s’ syndrome', Rheumatology (United Kingdom). https://doi.org/10.1093/rheumatology/key370

View all publications in research portal