Dr Daniel Fulton

Daniel Fulton

Institute of Inflammation and Ageing
Associate Professor in Glial Biology

Contact details

Telephone
+44 (0)1214148441
Email
d.fulton@bham.ac.uk
View my research portal
Address
Neuroscience and Ophthalmology
Institute of Inflammation and Ageing
College of Medical and Dental Sciences
IBR West
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Daniel Fulton is an Associate Professor in Glial Biology based in the Neuroscience, Trauma and Ophthalmology group of the Institute of Inflammation and Ageing. Dr Fulton leads the Oligodendrocyte & Myelin research group.

ORCID ID: 0000-0002-5712-2776

Qualifications

  • Postgraduate certificate in Higher Education (Distinction), 2020
  • Fellow of the Higher Education Academy
  • PhD Neuroscience, 2003
  • BSc Zoology, 1999

Biography

Daniel obtained his PhD in Neuroscience at the University of Sussex in 2003 where his thesis focused on the cellular mechanisms of learning and memory. Following his PhD he pursued postdoctoral research at the University of California Los Angeles (UCLA) where he continued to work on synaptic plasticity and learning and memory. In 2007 he joined the lab of Anthony Campagnoni (also at UCLA) where he begun his work on glial biology. Daniel’s work as a Research Neuroscientist in the Campagnoni lab focused on the physiological properties of oligodendrocytes and the expression of novel myelin proteins within striatal neurons.

In 2010 Daniel was awarded a Senior Fellowship with the Science City Research Alliance and in 2011 he obtained a Marie Curie Career Integration Grant. Using these fellowships Daniel returned to the UK to pursue independent work at the University of Warwick investigating the role of neuronal activityin oligodendrocyte development and myelin formation. In July 2013 Daniel moved to the University of Birmingham to take up a Birmingham Fellowship, and more recently a Lectureship in Glial Biology, within the Institute of Inflammation and Ageing where he is leading the Oligodendrocyte and Myelin Research Group.

Teaching

Postgraduate supervision

  • Simon Foale, B.Sc., M.Sc. MRC funded Ph.D. Title ‘The role of amphoterin induced gene and open reading frame 3 (AMIGO3) in the pathogenesis of inflammatory demyelination’. Graduated July 2019.
  • Sayed Muhammed Rassul, B.Sc., M.Sc. PSIBS Ph.D. title ‘Single molecule imaging of myelin proteins’. Graduated July 2019.
  • Majed Almutairi, B.Sc. M. Sc. PhD Fellowship funded by the Royal Embassy of Saudi Arabia. 'Exploring the role of amphoterin-induced gene and open reading frame (AMIGO) proteins in oligodendrocyte function' 
  • Natasha Bestall B.Sc. MRes project 'Investigating the influence of myelin integrity on neocortical circuit function'. Graduated July 2023. 
  • Narek Manukjan, B.Sc., M.Sc. (Research), Ph.D. Title 'White matter really matters in cerebral small vessel disease: role of hypoxia signalling in oligodendrocyte precursor cells and its cross-talk with endothelial cells'
  • Olivia Grech, B.Sc., M.Sc. (Research), Ph.D. Title 'Mechanisms and treatments for headache in raised intracranial pressure'
  • Rahatil Chowdhury, M.Sc., Ph.D. Title 'Investigating the metabolism of the microglia and its implications in glioblastoma'

Research

Research Interests

  • Oligodendrocyte and myelin plasticity
  • Live-imaging oligodendrocyte development and myelination
  • Single particle tracking of myelin proteins
  • Modelling oligodendrocyte development, injury and repair in brain slice culture models

Current Projects

  • Modelling complement-mediated myelin injury in the CNS

For further details, please visit the Oligodendrocyte and Myelin Research Group pages.

Other activities

  • Local Group Representative (University of Birmingham) British Neuroscience Association
  • Academic Integrity Lead, BSc Biomedical Sciences programme
  • PGT Lead, Inflammation and Ageing

Publications

Recent publications

Article

Manukjan, N, Majcher, D, Leenders, P, Caiment, F, van Herwijnen, M, Smeets, HJ, Suidgeest, E, van der Weerd, L, Vanmierlo, T, Jansen, JFA, Backes, WH, van Oostenbrugge, RJ, Staals, J, Fulton, D, Ahmed, Z, Blankesteijn, WM & Foulquier, S 2023, 'Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood–brain barrier impairment', Acta Neuropathologica Communications, vol. 11, no. 1, 128. https://doi.org/10.1186/s40478-023-01627-5

Toth, E, Rassul, S, Berry, M & Fulton, D 2021, 'A morphological analysis of activity-dependent myelination and myelin injury in transitional oligodendrocytes', Scientific Reports, vol. 11, no. 1, 9588. https://doi.org/10.1038/s41598-021-88887-0

Otsu, M, Ahmed, Z & Fulton, D 2021, 'Generation of multipotential NG2 progenitors from mouse embryonic stem cell- derived neural stem cells', Frontiers in cell and developmental biology, vol. 9, 688283. https://doi.org/10.3389/fcell.2021.688283

Begum, G, Otsu, M, Ahmed, U, Ahmed, Z, Stevens, A & Fulton, D 2018, 'NF‐Y‐dependent regulation of glutamate receptor 4 expression and cell survival in cells of the oligodendrocyte lineage', GLIA. https://doi.org/10.1002/glia.23446

Fannon, J, Tamier, W & Fulton, D 2015, 'Neuronal activity and AMPA-type glutamate receptor activation regulates the morphological development of oligodendrocyte precursor cells', GLIA, vol. 63, no. 6, pp. 1021-1035. https://doi.org/10.1002/glia.22799

Leoni, G, Rattray, M, Fulton, D, Rivera, A & Butt, AM 2014, 'Immunoablation of cells expressing the NG2 chondroitin sulphate proteoglycan', Journal of Anatomy, vol. 224, no. 2, pp. 216-227. https://doi.org/10.1111/joa.12141

Paez, PM, Fulton, D, Spreuer, V, Handley, V & Campagnoni, AT 2011, 'Modulation of canonical transient receptor potential channel 1 in the proliferation of oligodendrocyte precursor cells by the golli products of the myelin basic protein gene', The Journal of Neuroscience, vol. 31, no. 10, pp. 3625-37. https://doi.org/10.1523/JNEUROSCI.4424-10.2011

Editorial

Ahmed, Z, Fulton, D & Douglas, M 2020, 'Opicinumab: is it a potential treatment for multiple sclerosis?', Annals of Translational Medicine. https://doi.org/10.21037/atm.2020.03.131

Other contribution

Toth, E, Rassul, SM, Berry, M & Fulton, D 2019, A morphological analysis of activity-dependent myelination and myelin injury in transitional oligodendrocytes.. https://doi.org/10.1101/750083

Review article

Grech, O, Mollan, S, Wakerley, B, Fulton, D, Lavery, G & Sinclair, A 2021, 'The role of metabolism in migraine pathophysiology and susceptibility', Life: Physiology and Pathology, vol. 11, no. 5, 415. https://doi.org/10.3390/life11050415

Manukjan, N, Ahmed, Z, Fulton, D, Blankesteijn, WM & Foulquier, S 2020, 'A Systematic Review of WNT Signaling in Endothelial Cell Oligodendrocyte Interactions: Potential Relevance to Cerebral Small Vessel Disease', Cells, vol. 9, no. 6, 1545. https://doi.org/10.3390/cells9061545

Ceprian, M & Fulton, D 2019, 'Glial Cell AMPA receptors in nervous system health, injury and disease', International Journal of Molecular Sciences, vol. 20, no. 10, 2450. https://doi.org/0.3390/ijms20102450

Foale, S, Berry, M, Logan, A, Fulton, D & Ahmed, Z 2017, 'LINGO-1 and AMIGO3, potential therapeutic targets for neurological and dysmyelinating disorders?', Neural Regeneration Research, vol. 12, no. 8, pp. 1247-1251. https://doi.org/10.4103/1673-5374.213538

Berry, M, Ahmed, Z, Morgan-Warren, P, Fulton, D & Logan, A 2016, 'Prospects for mTOR-mediated functional repair after central nervous system trauma', Neurobiology of Disease, vol. 85, pp. 99-110. https://doi.org/10.1016/j.nbd.2015.10.002

Rassul, S, Neely, R & Fulton, D 2015, 'Live-imaging in the CNS: new insights on oligodendrocytes, myelination, and their responses to inflammation', Neuropharmacology. https://doi.org/10.1016/j.neuropharm.2015.09.011

View all publications in research portal