Dr Daniel Fulton

Dr Daniel Fulton

Institute of Inflammation and Ageing
Birmingham Fellow

Contact details

Address
Neuroscience and Ophthalmology
Institute of Inflammation and Ageing
College of Medical and Dental Sciences
IBR West
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Daniel Fulton is a Birmingham Fellow in the Neuroscience and Ophthalmology group of the Institute of Inflammation and Ageing. Dr Fulton also holds an honorary appointment at the School of Life Science at the University of Warwick through his role as a Senior Research Fellow in the Science Cities Research Alliance.

Qualifications

  • PhD Neuroscience, 2003
  • BSc Zoology, 1999

Biography

Daniel obtained his PhD in Neuroscience at the University of Sussex in 2003 where his thesis focused on the cellular mechanisms of learning and memory. Following his PhD he pursued postdoctoral research at the University of California Los Angeles (UCLA) where he continued to work on synaptic plasticity and learning and memory. In 2007 he joined the lab of Anthony Campagnoni (also at UCLA) where he begun his work on glial biology. Daniel’s work as a Research Neuroscientist in the Campagnoni lab focused on the physiological properties of oligodendrocytes and the expression of novel myelin proteins within striatal neurons. In 2010 Daniel was awarded a Senior Fellowship with the Science City Research Alliance and in 2011 he obtained a Marie Curie Career Integration Grant. Using these fellowships Daniel returned to the UK to pursue independent work at the University of Warwick investigating the role of neuronal activityin oligodendrocyte development and myelin formation. In July 2013 Daniel moved to the University of Birmingham to take up a Birmingham Fellowship, and more recently a Lectureship in Glial Biology, within the Institute of Inflammation and Age where he is leading the Oligodendrocyte and Myelin Research Group.

Teaching

Module lead for Neurotrauma: Degeneration & Regeneration (MDS BMedSc)

Neuroscience 2 (MDS BMedSc)

Cellular Neurobiology (LES Biological Sciences BSc)

Postgraduate supervision

  • Simon Foale, B.Sc., M.Sc. MRC funded Ph.D. Title ‘The role of amphoterin induced gene and open reading frame 3 (AMIGO3) in the pathogenesis of inflammatory demyelination’. Thesis to be submitted September 2018.
  • Sayed Muhammed Rassul, B.Sc., M.Sc. PSIBS Ph.D. title ‘Single molecule imaging of myelin proteins’. Thesis to be submitted September 2018.
  • Ahmad Aldahas, B.Sc., M.Sc., Ph.D. fellowship granted by the Kuwaiti Ministry of Health. ‘Investigating the role of nuclear factor Y (NFY) targets in oligodendrocyte development and injury’. Expected start date August 2018.
  • Majed Almutairi, B.Sc. M. Sc. PhD Fellowship funded by the Royal Embassy of Saudi Arabia. 'Exploring the role of amphoterin-induced gene and open reading frame (AMIGO) proteins in oligodendrocyte function'

Research

The following is a list of current projects in the Fulton lab. For more details please visit the Oligodendrocyte and Myelin Research Group pages.

1. Novel molecular targets for the protections of oligodendrocytes and myelin from glutamate-mediated excitotoxicity.

2. 3-D analysis of oligodendrocyte in health and disease

3. Investigating the role of amphoterin-induced gene and open reading frame (AMIGO) proteins in oligodendrocyte health and disease (in collaboration with Dr Zubair Ahmed and Professor Michael Douglas)

4. STEM-ZAP: Novel stem-cell derived models of early oligodendrocyte lineage cells

5. Canabinoid based protection of oligodendrocytes and myelin during ischemic excitotoxic injury.


Oligodendrocyte and Myelin Research Group

 

Neuroscience and Ophthalmology

Publications

Begum G, Otsu M, Ahmed U, Ahmed Z, Stevens A, Fulton D. (2018) NF-Y-dependent regulation of glutamate receptor 4 expression and cell survival in cells of the oligodendrocyte lineage. Glia. 66: 1896-1914. DOI: 10.1002/glia.23446.

Foale S, Berry M, Logan A, Fulton D, Ahmed Z. (2017) LINGO-1 and AMIGO3, potential therapeutic targets for neurological and dysmyelinating disorders?. Neural regeneration research.12:1247-1251.

Berry M, Ahmed Z, Morgan-Warren P, Fulton D, Logan A. (2015). Prospects for mTOR-mediated functional repair after central nervous system trauma. Neurobiology of Disease. 85, 99-110.

Rassul SM, Neely RK & Fulton D. (2015). Live-imaging in the CNS: Insights on oligodendrocytes, myelination, and their responses to inflammation. Neuropharmacology. In press.

Fanning, J., Tarmier, W & Fulton, D. (2015) Neuronal activity and AMPA-type glutamate receptor activation regulates the morphological development of oligodendrocyte precursor cells. Glia. 63, 1021-1035.

Leoni G., Rattray M., Fulton D., Butt A.M. (2014) Immunoablation of cells expressing the NG2 chondroitin sulphate proteoglycan. Journal of Anatomy. 224: 216-227. 

Fulton D, Paez P, Spreur V, Handley V, Colwell CS, Campagnoni A & Fisher R (2011). Developmental activation of the proteolipid protein (PLP) promoter transgene in neuronal and oligodendroglial cells of the neostriatum in mice. Developmental Neuroscience. 33: 170-184. *Selected for Editors Choice*.

Paez PM, Fulton D, Spreuer V, Handley V & Campagnoni AT (2011). Modulation of Canonical Transient Receptor Potential Channel 1 in the Proliferation of Oligodendrocyte Precursor Cells by the Golli Products of the Myelin Basic Protein Gene. Journal of Neuroscience. 31, 3625-3637.

Fulton D, Paez PM, Fisher R, Handley V, Colwell CS & Campagnoni AT (2010).  Regulation of L-type Ca++ Currents and process morphology in white matter oligodendrocyte precursor cells by golli-myelin proteins. Glia. 58, 1292-1303.

Paez PM, Fulton D, Spreuer V, Handley V & Campagnoni AT (2009). Multiple kinase pathways regulate voltage-dependent Ca++ influx & migration in oligodendrocyte precursor cells. Journal of Neuroscience. 30, 6422-643.

Paez PM, Fulton DJ, Spreuer V, Handley V, Campagnoni CW & Campagnoni AT (2009). Golli Myelin Basic Proteins Regulate Oligodendroglial Progenitor Cell Migration through Voltage-Gated Ca2+ Influx. Journal of Neuroscience. 29, 6663-6676.

Fulton D1, Paez PM1 & Campagnoni AT. (2009) The multiple roles of myelin protein genes during the development of the oligodendrocyte.  ASN NEURO. 1(1): doi:10.1042/AN20090051. 1Equal author contribution.

Paez PM, Fulton DJ, Spreuer V, Handley V, Campagnoni CW & Campagnoni AT (2009). Regulation of store-operated and voltage-operated calcium channels in the proliferation and death of oligodendrocyte precursor cells. ASN Neuro. Doi:10.1042/AN20090003.

Fulton D, Kemenes I, Andrew RJ & Benjamin PR (2008). Time-window for sensitivity to Cooling Distinguishes the Effects of Hypothermia and Protein Synthesis Inhibition on the Consolidation of Long-Term Memory. Neurobiology of Learning and Memory. 90, 651-654.

Fulton D, Condro MC, Pearce K & Glanzman DL (2008). The potential role of postsynaptic phospholipase C activity in synaptic facilitation and behavioral sensitization in Aplysia. Journal of Neurophysiology. 100, 108-116

Fulton D (2006) Reconsolidation: does the past linger on.

Journal of Neuroscience, 26 10935-10936.

Fulton D, Kemenes I, Andrew RJ & Benjamin PR. (2005). A single time-window for protein-synthesis-dependent long-term memory formation after one-trial appetitive conditioning. European Journal of Neuroscience, 21, 1347-1358.