Dr Paul Harrison BSc, PhD, FRCPath

Institute of Inflammation and Ageing
Senior Lecturer

Contact details

Telephone: +44(0)121 371 3251
Email: p.harrison.1@bham.ac.uk

Address: Institute of Inflammation and Ageing
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Paul Harrison is the Scar Free Foundation Senior Lecturer within the Institute of Inflammation and Ageing at the University of Birmingham in the UK. He is a Past- President of the British Society of Haemostasis & Thrombosis (BSHT) and a Past-chairman of the International Society of Thrombosis and Haemostasis (ISTH) Platelet Physiology Scientific and standardization committee. He has published over 180 papers and book chapters/reviews in his field. In 2010 Paul was featured as one of the top 100 healthcare scientists in the UK by the Department of Health.

Qualifications

Fellow of the Royal College of Pathologists (FRCPath)
Registered Clinical Scientist
PhD
BSc Biochemistry (Toxicology)

Biography

Paul Harrison is the Scar Free Foundation Senior Lecturer within the Institute of Inflammation and Ageing at the University of Birmingham. He is a Past-President of the British Society of Haemostasis and Thrombosis (BSHT), a Past-chairman of the International Society of Thrombosis and Haemostasis (ISTH) Platelet Physiology Scientific and standardization committee and co-editor in chief of the International Journal “Platelets”. He has published over 180 papers and book chapters/reviews. In 2010 Paul was featured as one of the top 100 healthcare scientists in the UK by the Department of Health.

Teaching

MBChB
- Personal Mentor for Medical Students
- Tutor for Infection, Immunology & Haematology (Year 2)
- Lecturer for SP1 - Clinical Aspects of Immunology, Haematology & Immunity
MPharm
- Lecturer and Tutor
BMedSc
- Lecturer - Vascular Biology and Pathology (Year 1)
- Lecturer - Immunity and Infection (Year 2)
- Lecturer - Immunity & inflammatory Disease (Year 3)
- Lecturer - Integrative Physiology and Pharmacology (Year 3)

Postgraduate supervision

Paul Harrison is the Scar free Foundation Senior Lecturer within the Institute of Inflammation and Ageing. Dr Harrison is researching into the influence of traumatic injury and burns on the systemic inflammatory response with a particular focus on haemostatic and thrombotic parameters. He is also a member of the Birmingham platelet group.

Current PhD projects include :-
1) Measurement of preplatelets in inherited and acquired thrombocytopenia
2) Neutrophil Extracellular Traps in Thermal and Traumatic Injury
3) Measurement of extracellular vesicles in cardiovascular disease by a novel interferometric imaging method

Research

Dr Harrison is researching into the influence of traumatic injury and burns on the systemic inflammatory response with a particular focus on haemostatic and thrombotic parameters. He is also a member of the Birmingham platelet group and the Genotyping and Phenotyping of Platelets Study (GAPP). His main interests are platelet biology, thrombopoeisis, platelet function testing, extracellular vesicles and regenerative medicine.

Other activities

Past-President of the British Society for Haemostasis and Thrombosis
Past-Chairman of the Platelet Physiology Scientific and Standardization committee of the International Society of Thrombosis and Haemostasis
Board member of the International Council for Standardization in Haematology (ICSH)
Co-editor in chief of Platelets (2015-2022) (Impact factor 3.106)
Member of the editorial board for the Journal of Thrombosis and Haemostasis
Winner of 2009 Sysmex Outstanding Science Award, Istanbul, May 2009
Featured in the publication “Extraordinary You” – as one of top 100 healthcare scientists within the UK by the Department of Health, 2009/2010

Publications

Recent publications

Article

Gasecka, A, Nieuwland, R, Budnik, M, Dignat-George, F, Eyileten, C, Harrison, P, Lacroix, R, Leroyer, A, Opolski, G, Pluta, K, van der Pol, E, Postula, M, Siljander, P, Siller-Matula, JM & Filipiak, K 2019, 'Ticagrelor attenuates the increase of extracellular vesicles concentrations in plasma after acute myocardial infarction compared to clopidogrel', Journal of thrombosis and haemostasis : JTH, pp. 1-15. https://doi.org/10.1111/jth.14689

Keene, D, Alsousou, J, Harrison, P, Hulley, P, Wagland, S, Parsons, S, Thompson, J, O'Connor, H, Schlussel, MM, Dutton, S, Lamb, S & Willett, K 2019, 'Platelet rich plasma injection for acute Achilles tendon rupture: PATH-2 randomised, placebo controlled, superiority trial', British Medical Journal, vol. 367, l6132. https://doi.org/10.1136/bmj.l6132

Dinsdale, R, Hazeldine, J, Al-Tarrah, K, Hampson, P, Devi, A, Ermogenous, C, Bamford, A, Bishop, J, Watts, S, Kirkman, E, Dalle Lucca, JJ, Midwinter, M, Woolley, T, Foster, M, Lord, J, Moiemen, N & Harrison, P 2019, 'Dysregulation of the actin scavenging system and inhibition of DNase activity following severe thermal injury', British Journal of Surgery. https://doi.org/10.1002/bjs.11310

Noy, PJ, Gavin, RL, Colombo, D, Haining, EJ, Reyat, JS, Payne, H, Thielmann, I, Lokman, AB, Neag, G, Yang, J, Lloyd, T, Harrison, N, Heath, VL, Gardiner, C, Whitworth, KM, Robinson, J, Koo, CZ, Di Maio, A, Harrison, P, Lee, SP, Michelangeli, F, Kalia, N, Rainger, GE, Nieswandt, B, Brill, A, Watson, SP & Tomlinson, MG 2019, 'Tspan18 is a novel regulator of the Ca2+ channel Orai1 and von Willebrand factor release in endothelial cells', Haematologica, vol. 104, no. 9, pp. 1892-1905. https://doi.org/10.3324/haematol.2018.194241

Chimen, M, Evryviadou, A, Box, CL, Harrison, MJ, Hazeldine, J, Dib, LH, Kuravi, SJ, Payne, H, Price, JMJ, Kavanagh, D, Iqbal, AJ, Lax, S, Kalia, N, Brill, A, Thomas, SG, Belli, A, Crombie, N, Adams, RA, Evans, S-A, Deckmyn, H, Lord, JM, Harrison, P, Watson, SP, Nash, GB & Rainger, GE 2019, 'Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation', Haematologica. https://doi.org/10.3324/haematol.2018.215145

Hazeldine, J, Harrison, P, Dinsdale, R & Lord, J 2019, 'Traumatic injury and exposure to mitochondrial-derived damage associated molecular patterns suppresses neutrophil extracellular trap formation', Frontiers in immunology. https://doi.org/10.3389/fimmu.2019.00685

Alsousou, J, Keene, D, Harrison, P, Hulley, P, Wagland, S, Thompson, J, Byrne, C, Schlussel, MM, O'Connor, H, Dutton, S, Lamb, S & Willett, K 2019, 'Platelet Rich Plasma injection versus placebo injection in adults with acute Achilles tendon ruptures: the PATH-2 multicentre randomised controlled trial', Efficacy and Mechanism Evaluation.

Gasecka, A, Nieuwland, R, Budnick, M, Dignat-George, F, Eyileten, C, Harrison, P, Huczek, Z, Kaplon-Cieslicka, A, Lacroix, R, Opolski, G, Pluta, K, van der Pol, E, Postula, M, Leroyer, A, Siljander, P, Starke, A & Filipiak, K 2018, 'Randomized controlled trial protocol to investigate the antiplatelet therapy effect on extracellular vesicles in acute myocardial infarction (AFFECT EV)', Platelets. https://doi.org/10.1080/09537104.2018.1557616

Lowe, G, Fickowska, R, Al Ghaithi, RHR, Maclachlan, A, Harrison, P, Lester, W, Watson, S, Myers, B, Clark, TJ & Morgan, N 2018, 'Investigation of the contribution of an underlying platelet defect in women with unexplained heavy menstrual bleeding', Platelets. https://doi.org/10.1080/09537104.2018.1543865

Al Ghaithi, RHR, Mori, J, Nagy, Z, Maclachlan, A, Hardy, L, Philippou, H, Hethershaw, E, Morgan, N, Senis, Y & Harrison, P 2018, 'Evaluation of the Total Thrombus-Formation System (T-TAS): application to human and mouse blood analysis: evaluation of T-TAS in assessing clot formation ', Platelets. https://doi.org/10.1080/09537104.2018.1535704

Chapter

Lordkipanidze, M, Hvas, A-M & Harrison, P 2019, Clinical Tests of Platelet Function. in A Michelson, M Cattaneo, A Frelinger & P Newman (eds), Platelets. 4th edition edn, Academic Press (Elsevier), London, pp. 593-608.

Kemble, S, Briggs, C & Harrison, P 2019, Platelet Counting. in A Michelson, M Cattaneo, L Frelinger & P Newman (eds), Platelets. 4th edition edn, Academic Press (Elsevier), London, pp. 582-591.

Alsousou, J & Harrison, P 2019, Therapeutic Platelet-Rich Plasma in Wound Healing. in A Michelson, M Cattaneo, L Frelinger & P Newman (eds), Platelets. 4th edition edn, Academic Press (Elsevier), London, pp. 1161-1171.