Dr Paul Harrison BSc, PhD, FRCPath

Paul Harrison

Institute of Inflammation and Ageing
Senior Lecturer

Contact details

Telephone
+44(0)121 371 3251
Email
p.harrison.1@bham.ac.uk
View my research portal
Address
Institute of Inflammation and Ageing
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Paul Harrison is the Scar Free Foundation Senior Lecturer within the Institute of Inflammation and Ageing at the University of Birmingham in the UK. He is a Past- President of the British Society of Haemostasis & Thrombosis (BSHT) and a Past-chairman of the International Society of Thrombosis and Haemostasis (ISTH) Platelet Physiology Scientific and standardization committee. He has published over 180 papers and book chapters/reviews in his field. In 2010 Paul was featured as one of the top 100 healthcare scientists in the UK by the Department of Health.

Qualifications

  • Fellow of the Royal College of Pathologists (FRCPath)
  • Registered Clinical Scientist
  • PhD
  • BSc Biochemistry (Toxicology)

Biography

Paul Harrison is the Scar Free Foundation Senior Lecturer within the Institute of Inflammation and Ageing at the University of Birmingham. He is a Past-President of the British Society of Haemostasis and Thrombosis (BSHT), a Past-chairman of the International Society of Thrombosis and Haemostasis (ISTH) Platelet Physiology Scientific and standardization committee and co-editor in chief of the International Journal “Platelets”. He has published over 180 papers and book chapters/reviews. In 2010 Paul was featured as one of the top 100 healthcare scientists in the UK by the Department of Health.

Teaching

  • MBChB
    • Personal Mentor for Medical Students
    • Tutor for Infection, Immunology & Haematology (Year 2)
    • Lecturer for SP1 - Clinical Aspects of Immunology, Haematology & Immunity
  • MPharm
    • Lecturer and Tutor
  • BMedSc
    • Lecturer - Vascular Biology and Pathology (Year 1)
    • Lecturer - Immunity and Infection (Year 2)
    • Lecturer - Immunity & inflammatory Disease (Year 3)
    • Lecturer - Integrative Physiology and Pharmacology (Year 3)

Postgraduate supervision

Paul Harrison is the Scar free Foundation Senior Lecturer within the Institute of Inflammation and Ageing. Dr Harrison is researching into the influence of traumatic injury and burns on the systemic inflammatory response with a particular focus on haemostatic and thrombotic parameters. He is also a member of the Birmingham platelet group.

Current PhD projects include :-
1) Measurement of preplatelets in inherited and acquired thrombocytopenia
2) Neutrophil Extracellular Traps in Thermal and Traumatic Injury
3) Measurement of extracellular vesicles in cardiovascular disease by a novel interferometric imaging method

If you are interesting in studying any of these subject areas please contact Dr Paul Harrison directly, or for any general doctoral research enquiries, please email mds-gradschool@contacts.bham.ac.uk.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

Dr Harrison is researching into the influence of traumatic injury and burns on the systemic inflammatory response with a particular focus on haemostatic and thrombotic parameters. He is also a member of the Birmingham platelet group and the Genotyping and Phenotyping of Platelets Study (GAPP). His main interests are platelet biology, thrombopoeisis, platelet function testing, extracellular vesicles and regenerative medicine.

Other activities

  • Past-President of the British Society for Haemostasis and Thrombosis
  • Past-Chairman of the Platelet Physiology Scientific and Standardization committee of the International Society of Thrombosis and Haemostasis
  • Board member of the International Council for Standardization in Haematology (ICSH)
  • Co-editor in chief of Platelets (2015-2022) (Impact factor 3.106) 
  • Member of the editorial board for the Journal of Thrombosis and Haemostasis
  • Winner of 2009 Sysmex Outstanding Science Award, Istanbul, May 2009
  • Featured in the publication “Extraordinary You” – as one of top 100 healthcare scientists within the UK by the Department of Health, 2009/2010

Publications

Recent publications

Article

Kemble, S, Dalby, A, Lowe, G, Nicolson, P, Watson, S, Senis, Y, Thomas, S & Harrison, P 2022, 'Analysis of preplatelets and their barbell platelet derivatives by imaging flow cytometry', Blood Advances, vol. 6, no. 9, pp. 2932–2946. https://doi.org/10.1182/bloodadvances.2021006073

Mahida, RY, Price, J, Lugg, ST, Li, H, Parekh, D, Scott, A, Harrison, P, Matthay, MA & Thickett, DR 2022, 'CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome', American journal of physiology. Lung cellular and molecular physiology, vol. 322, no. 4, pp. L617-L624. https://doi.org/10.1152/ajplung.00052.2022

Mezzano, D, Harrison, P, Andrew L. Frelinger, III, Mumford, AD, Noris, P, Lordkipanidzé, M & Gresele, P 2022, 'Expert opinion on the use of platelet secretion assay for the diagnosis of inherited platelet function disorders: communication from the ISTH SSC Subcommittee on platelet physiology', Journal of Thrombosis and Haemostasis. https://doi.org/10.1111/jth.15781

Harrison, P, Price, J, Didembourg, M, Johnstone, A, Baldwin, S, Veronneau, M, Baertlein, D, Shi, X & Machin, S 2022, 'Feasibility of a mean platelet volume standard: an international council for standardization in hematology (ICSH) inter-laboratory study', Platelets, pp. 1-9. https://doi.org/10.1080/09537104.2022.2060956

PATH-2 trial group 2022, 'Platelet-rich plasma injection for acute Achilles tendon rupture: two-year follow-up of the PATH-2 randomized, placebo-controlled, superiority trial', Bone and Joint Journal, vol. 104-B, no. 11, pp. 1256-1265. https://doi.org/10.1302/0301-620X.104B11.BJJ-2022-0653.R1

Colicchia, M, Schrottmaier, WC, Perrella, G, Reyat, JS, Begum, J, Slater, A, Price, J, Clark, JC, Zhi, Z, Simpson, M, Bourne, J, Poulter, NS, Khan, AO, Nicolson, PLR, Pugh, MR, Harrison, P, Iqbal, AJ, Rainger, GE, Watson, SP, Thomas, MR, Mutch, NJ, Assinger, A & Rayes, J 2022, 'S100A8/A9 drives the formation of procoagulant platelets through GPIbα', Blood. https://doi.org/10.1182/blood.2021014966

Couch, Y, Buzas, E, Di Vizio, D, Gho, YS, Harrison, P, Hill, A, Lötvall , J, Raposo, G, Stahl , P, Théry , C, Witwer, K & Carter, D 2021, 'A brief history of nearly EV-erything – the rise and rise of extracellular vesicles', Journal of Extracellular Vesicles, vol. 10, no. 14, e12144. https://doi.org/10.1002/jev2.12144

Andrew L. Frelinger, III, Rivera, J, Connor, DE, Freson, K, Greinacher, A, Harrison, P, Kunishima, S, Lordkipanidzé, M, Michelson, AD, Ramström, S & Gresele, P 2021, 'Consensus recommendations on flow cytometry for the assessment of inherited and acquired disorders of platelet number and function: communication from the ISTH SSC Subcommittee on Platelet Physiology', Journal of Thrombosis and Haemostasis. https://doi.org/10.1111/jth.15526

Kearney, R, Ji, C, Warwick, J, Parsons, N, Brown, J, Harrison, P, Young, J & Costa, M 2021, 'Effect of platelet-rich plasma injection vs sham injection on tendon dysfunction in patients with chronic midportion achilles tendinopathy: a randomized clinical trial', JAMA The Journal of the American Medical Association, vol. 326, no. 2, pp. 137-144. https://doi.org/10.1001/jama.2021.6986.

Cato, L, Bailiff, B, Price, J, Ermogenous, C, Hazeldine, J, Lester, W, Lowe, G, Wearn, C, Bishop, J, Lord, J, Moiemen, N & Harrison, P 2021, 'Heparin resistance in severe thermal injury: a prospective cohort study', Burns & Trauma, vol. 9, tkab032. https://doi.org/10.1093/burnst/tkab032

Hazeldine, J, McGee, KC, Al-Tarrah, K, Hassouna, T, Patel, K, Imran, R, Bishop, JRB, Bamford, A, Barnes, D, Wilson, Y, Harrison, P, Lord, JM & Moiemen, NS 2021, 'Multicentre, longitudinal, observational cohort study to examine the relationship between neutrophil function and sepsis in adults and children with severe thermal injuries: a protocol for the Scientific Investigation of the Biological Pathways Following Thermal Injury-2 (SIFTI-2) study', BMJ open, vol. 11, no. 10, e052035. https://doi.org/10.1136/bmjopen-2021-052035

Price, J, Gardiner, C & Harrison, P 2021, 'Platelet‐enhanced plasma: characterization of a novel candidate resuscitation fluid's extracellular vesicle content, clotting parameters, and thrombin generation capacity', Transfusion. https://doi.org/10.1111/trf.16423

Hazeldine, J, Dinsdale, R, Naumann, D, Acharjee, A, Bishop, J, Lord, J & Harrison, P 2021, 'Traumatic injury is associated with reduced deoxyribonuclease activity and dysregulation of the actin scavenging system', Burns & Trauma, vol. 9, tkab001. https://doi.org/10.1093/burnst/tkab001

Preprint

Kemble, S, Dalby, A, Lowe, GC, Nicolson, PLR, Watson, SP, Senis, Y, Thomas, SG & Harrison, P 2021 'Analysis of preplatelets and their barbell platelet derivatives by imaging flow cytometry' bioRxiv, pp. 1-36. https://doi.org/10.1101/2021.07.30.454421

Mahida, RY, Price, J, Lugg, ST, Li, H, Parekh, D, Scott, A, Harrison, P, Matthay, MA & Thickett, DR 2021 'CD14 positive extracellular vesicles in broncho-alveolar lavage fluid as a new biomarker of acute respiratory distress syndrome' medRxiv. https://doi.org/10.1101/2021.09.25.21264053

View all publications in research portal