Dr Chris Mahony

Institute of Inflammation and Ageing
Postdoctoral Researcher

Contact details

Email: c.mahony@bham.ac.uk

Address: University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Mahony is a postdoctoral research fellow with an interest in studying the genetic and epi-genetic regulation of fibroblast sub-types to improve the treatment of rheumatoid arthritis.

Qualifications

PhD in Biomedical Sciences, 2013 (University of Aberdeen, UK)
BSc (Hons) in Biomedical Sciences, 2009 (University of Aberdeen, UK)

Biography

Chris completed his PhD at the University of Aberdeen in 2013 in Professor Vargesson’ s lab. He then moved to Geneva and worked in Professor Bertrand’s lab for his first postdoc. In 2019 he then moved to the University of Birmingham for his second postdoc positon in Dr Monteiro’s lab. In 2021 Chris moved to Prof. Croft’s lab where he is using a range of computational approaches to analyse scRNA-Seq/scATAC-Seq/CITE-Seq data along with functional validation to better understand the pathology of rheumatoid arthritis.

Publications

Mahony, CB*, Cacialli, P, Pasche, C and Bertrand, JY*, “Hapln1b, a central organizer of the extracellular matrix, modulates kit signalling to control developmental haematopoiesis”, Blood Adv (2021) 5 (23): 4935–4948. * Corresponding authors

Pena, OA, Lubin, A, Rowell, J, Hoade, Y, Khokhar, N, Mahony, C, Dace, P, Umamahesan and Payen EM. Differential Requirement of Gata2a and Gata2b for Primitive and Definitive Myeloid Development in Zebrafish. Front. Cell Dev. Biol., 13 September 2021.

Cacialli, P, Mahony, CB, Rougement-Pidoux, A, Bertrand JY. “The connexin/ifi30 pathway bridges HSCs with their niche to dampen oxidative stress”. Nature Communications, volume 12, Article number: 4484 (2021).

Gioacchino, E, Koyunlar, C, Peulen, J, de Looper, H, de Jong, M, Dobrzycki, T, Mahony, CB, Hoogenboezem. R, Bosch, D, van Strien, P, van Royen, M, French, P, Bindels, E, Monteiro, R, Gussinklo, E, Touw, I and de Pater, E, “Essential role for Gata2 in modulating lineage output from hematopoietic stem cells identified in zebrafish”, Blood advances, 2021.

Beedie, S, Harris, E, Strope, J, Mahony, CB, Chau, C, Vargesson, N, Figg, WD, “Cereblon in in vitro angiogenesis and the anti-angiogenic activity of thalidomide”, Jul 2020, The FASEB journal.

Dobrzycki T, Mahony CB, Krecsmarik M, et al. Deletion of a conserved Gata2 enhancer impairs haemogenic endothelium programming and adult Zebrafish haematopoiesis. Commun Biol. 2020;3(1):71. Published 2020 Feb 13.

Mahony, CB, Bertrand JY, “How HSCs colonize and expand in the fetal niche of the vertebrate embryo: an evolutionary perspective”. Front. Cell Dev. Biol. - Stem Cell Research. 2019 Mar 12;7:34.

Ghersi JJ, MahonyCB, Bertrand JY. “bif1, a new BMP signaling inhibitor, regulates embryonic hematopoiesis in the zebrafish. Development. 2019 Mar 5. Epub.

Ferrero, G, Mahony, CB, Dupuis, E, Yvernogeau, L, Di Ruggiero, E, Traver, D, Robin, C, Bertrand, JY and Wittamer, V. Temporally distinct populations of progenitors generate primitive and definitive microglia. Cell reports. 2018, July 3; 24(1):130-141.

Mahony, CB, Pasche, C, Bertrand JY. Oncostatin M and Kit-ligand control hematopoietic stem cell fate during zebrafish embryogenesis. Stem cell reports. 2018, Jun 5; 10(6): 1920–1934.

Mahony, CB, McMenemy, S, Rafipay, AJ, Beedie, S, Fraga, LR, Gutschow, M, Figg, WD, Erskine, L, and Vargesson, N. CPS49-induced neurotoxicity does not cause limb patterning anomalies in developing chicken embryos. J Anat., 2018, Apr 232(4):568-574.

Mahony, CB, Fish RJ., Pasche, C, and Bertrand JY. tfec controls the hematopoietic stem cell vascular niche during zebrafish embryogenesis. Blood. 2016 ;128(10):1336-13.

Beedie SL, Mahony, CB, Walker, H, Chau CH, Vargesson, N, Figg, WD. Shared mechanism of teratogenicity of anti-angiogenic drugs identified in the developing chicken embryo model. Scientific reports. 2016, Jul 22;6:30038.

Beedie SL, Peer CJ, Pisle S, Gardner ER, Mahony CB, Barnett S, Ambrozak A, Gütschow M, Chau CH, Vargesson N, Figg WD. Anticancer Properties of a Novel Class of Tetrafluorinated Thalidomide Analogues Mol Cancer Ther. 2015, Oct;14(10):2228-37.

Mahony, CB, Erskine, L, Niven, J, Greig, NH, Figg, WD, and Vargesson, N. Pomalidomide is nonteratogenic in chicken and zebrafish embryos and nonneurotoxic in vitro. PNAS. 2013, 110(31):12703-8.

Mahony, CB. and Vargesson, N. Molecular analysis of regulative events in the developing chick limb. J Anat. 2013, 223(1):1-13.

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