Dr Dhruv Parekh BMedSci (Hons) MBBS(Hons) PhD MRCP

Dhruv Parekh

Institute of Inflammation and Ageing
Clinical Lecturer in Respiratory Medicine

Contact details

Address
Institute of Inflammation and Ageing
College of Medical and Dental Sciences
Centre for Translational and Inflammatory Research
1st Floor, New Queen Elizabeth Hospital
Mindelsohn Way
Birmingham, B15 2WB

Dr Dhruv Parekh is a Clinical Lecturer in Respiratory Medicine at the University of Birmingham and advanced trainee in Intensive Care Medicine in the final stages of clinical training within the West Midlands Deanery. His research interests are developing novel therapies in ARDS, perioperative inflammation, sepsis and critical care.

ORCID ID: 0000-0002-1508-8362

Qualifications

  • PhD (Health Sciences), University of Warwick, 2016
  • MRCP (UK), Royal College of Physicians, 2007
  • MBBS (Hons), St Bartholomew’s and the Royal London School of Medicine, 2003
  • BMedSci (Hons), St Bartholomew’s and the Royal London School of Medicine, 2002

Biography

Dr Dhruv Parekh completed his medical training at St Bartholomew’s and the Royal London School of Medicine in 2003. He gained a 1st class honours intercalated bachelor in medical sciences and won numerous prizes and award during his undergraduate training. After initial training and successful completion of his post-graduate exams he commenced clinical training in Respiratory, General Internal and Intensive Care Medicine.

Dhruv was awarded a highly competitive MRC Clinical Research Training Fellowship and his PhD investigated if vitamin D deficiency is a mechanistic driver of ARDS, which was completed in collaboration with the Universities of Birmingham and Warwick and the West Midlands ARDS network. 

He is currently a Clinical Lecturer in Respiratory Medicine at the University of Birmingham and also a member of the Perioperative, Anaesthesia, Critical Care and Trauma Trials (PACCT) group. He is currently in the final stages of his specialist training.

Dhruv has contributed to clinical trials and translational studies of vitamin D to prevent ARDS and statins in pneumonia and sepsis. He contributes to supervising BMedSci students and teaching respiratory modules on the MBChB course at the University. He has presented at many national and international meetings and has been the holder of the American Thoracic Society International Trainee Scholarship in 2014.

Teaching

Teaching Programmes

Postgraduate supervision

Dhruv is interested in supervising doctoral research students who are interested in research in the field of respiratory, peri-operative medicine and critical care.

If you are interesting in studying any of these subject areas please contact Dr Dhruv Parekh directly, or for any general doctoral research enquiries, please email mds-gradschool@contacts.bham.ac.uk.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

Dhruv has translational research interests in respiratory, peri-operative and intensive care medicine. He is passionate about bringing the bench to bedside and his main research focuses on investigating novel therapeutic targets and increasing the understanding of the mechanisms of injury involved in sepsis and ARDS. His cellular interests have developed in the area of innate immunity and specifically macrophage and monocyte biology and function.

Publications

Recent publications

Article

Mahida, RY, Scott, A, Parekh, D, Lugg, ST, Belchamber, KBR, Hardy, RS, Matthay, MA, Naidu, B & Thickett, DR 2021, 'Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome', Frontiers in Medicine, vol. 8, 737859. https://doi.org/10.3389/fmed.2021.737859

Faqihi, BM, Trethewey, S, Morlet, J, Parekh, D & Turner, A 2021, 'Bilevel positive airway pressure ventilation for non-COPD acute hypercapnic respiratory failure patients: a systematic review and meta-analysis', Annals of Thoracic Medicine. <http://www.thoracicmedicine.org/>

Yip, KP, Gompertz, S, Snelson, C, Willson, J, Madathil, S, Huq, SS, Rauf, F, Salmon, N, Tengende, J, Tracey, J, Cooper, B, Filby, K, Ball, S, Parekh, D & Dosanjh, DPS 2021, 'Increase in recruitment upon integration of trial into a clinical care pathway: an observational study', BMJ Open Respiratory Research, vol. 8, no. 1, e000967. https://doi.org/10.1136/bmjresp-2021-000967

Stockley, JA, Alhuthail, EA, Coney, AM, Parekh, D, Geberhiwot, T, Gautum, N, Madathil, SC & Cooper, BG 2021, 'Lung function and breathing patterns in hospitalised COVID-19 survivors: a review of post-COVID-19 Clinics', Respiratory research, vol. 22, no. 1, 255. https://doi.org/10.1186/s12931-021-01834-5

CATALYST investigators, Fisher, B, Veenith, T, Slade, D, Gaskell, C, Rowland, M, Whitehouse, T, Scriven, J, Parekh, D, Balasubramaniam, M, Cooke, G, Morley, N, Gabriel, Z, Wise, M, Porter, J, McShane, H, Ho, L-P, Newsome, P, Rowe, A, Sharpe, R, Thickett, D, Bion, J, Gates, S, Richards, D & Kearns, P 2021, 'Namilumab or infliximab compared to standard of care in hospitalised patients with COVID-19 (CATALYST): a phase 2 randomised multicentre open adaptive multi-arm multi-stage trial', The Lancet Respiratory Medicine.

Wright, WA, Crowley, LE, Parekh, D, Crawshaw, A, Dosanjh, DP, Nightingale, P & Thickett, DR 2021, 'Real-world retrospective observational study exploring the effectiveness and safety of antifibrotics in idiopathic pulmonary fibrosis', BMJ Open Respiratory Research, vol. 8, no. 1, e000782. https://doi.org/10.1136/bmjresp-2020-000782

Haroon, S, Subramanian, A, Cooper, J, Anand, A, Gokhale, K, Byrne, N, Dhalla , S, Acosta-Mena , D, Taverner, T, Okoth, K, Wang, J, Chandan, J, Sainsbury, C, Zemedikun, D, Thomas, GN, Parekh, D, Marshall, T, Sapey, E, Adderley, N & Nirantharakumar, K 2021, 'Renin-angiotensin system inhibitors and susceptibility to COVID-19 in patients with hypertension: a propensity score-matched cohort study in primary care', BMC Infectious Diseases, vol. 21, no. 1, 262. https://doi.org/10.1186/s12879-021-05951-w

Mahida, RY, Chotalia, M, Alderman, J, Patel, C, Hayden, A, Desai, R, Beesley, E, Crowley, LE, Soltan, M, Bangash, M, Parekh, D, Patel, J & Thickett, DR 2020, 'Characterisation and outcomes of ARDS secondary to pneumonia in patients with and without SARS-CoV-2: a single-centre experience', BMJ Open Respiratory Research, vol. 7, no. 1, e000731. https://doi.org/10.1136/bmjresp-2020-000731

PRIDE Consortium Investigators, Venkatesan, S, Myles, PR, Bolton, KJ, Muthuri, SG, Al Khuwaitir, T, Anovadiya, AP, Azziz-Baumgartner, E, Bajjou, T, Bassetti, M, Beovic, B, Bertisch, B, Bonmarin, I, Booy, R, Borja-Aburto, VH, Burgmann, H, Cao, B, Carratala, J, Chinbayar, T, Cilloniz, C, Denholm, JT, Dominguez, SR, Duarte, PAD, Dubnov-Raz, G, Fanella, S, Gao, Z, Gérardin, P, Giannella, M, Gubbels, S, Herberg, J, Higuera Iglesias, AL, Hoeger, PH, Hu, XY, Islam, QT, Jiménez, MF, Keijzers, G, Khalili, H, Kusznierz, G, Kuzman, I, Langenegger, E, Lankarani, KB, Leo, Y-S, Libster, RP, Linko, R, Madanat, F, Maltezos, E, Mamun, A, Manabe, T, Metan, G, Mickiene, A & Parekh, D 2020, 'Neuraminidase inhibitors and hospital length of stay: a meta-analysis of individual participant data to determine treatment effectiveness among patients hospitalized with nonfatal 2009 pandemic influenza A(H1N1) virus infection', The Journal of Infectious Diseases, vol. 221, no. 3, pp. 356-366. https://doi.org/10.1093/infdis/jiz152

Zheng, S, Yang, J, Hu, X, Li, M, Wang, Q, Dancer, RCA, Parekh, D, Gao-Smith, F, Thickett, DR & Jin, S 2020, 'Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-β induced epithelial to mesenchymal transition', Biochemical Pharmacology, vol. 177, 113955. https://doi.org/10.1016/j.bcp.2020.113955

Comment/debate

Bangash, MN, Patel, J & Parekh, D 2020, 'COVID-19 and the liver: little cause for concern', The Lancet Gastroenterology and Hepatology. https://doi.org/10.1016/S2468-1253(20)30084-4

Preprint

Veenith, T, Fisher, BA, Slade, D, Rowe, A, Sharpe, R, Thickett, DR, Whitehouse, T, Rowland, M, Scriven, J, Parekh, D, Bowden, SJ, Savage, JS, Richards, D, Bion, J, Kearns, P & Gates, S 2021 'CATALYST trial protocol: a multicentre, open-label, phase II, multi-arm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults' medRxiv, pp. 1-15. https://doi.org/10.1101/2021.02.10.21251478

Mahida, RY, Price, J, Lugg, ST, Li, H, Parekh, D, Scott, A, Harrison, P, Matthay, MA & Thickett, DR 2021 'CD14 positive extracellular vesicles in broncho-alveolar lavage fluid as a new biomarker of acute respiratory distress syndrome' medRxiv. https://doi.org/10.1101/2021.09.25.21264053

Fisher, BA, Veenith, T, Slade, D, Gaskell, C, Rowland, M, Whitehouse, T, Scriven, J, Parekh, D, Balasubramaniam, MS, Cooke, G, Morley, N, Gabriel, Z, Wise, MP, Porter, J, McShane, H, Ho, L-P, Newsome, PN, Rowe, A, Sharpe, R, Thickett, DR, Bion, J, Gates, S, Richards, D & Kearns, P 2021 'Namilumab or infliximab compared to standard of care in hospitalised patients with COVID-19 (CATALYST): a phase 2 randomised adaptive trial' medRxiv, pp. 1-26. https://doi.org/10.1101/2021.06.02.21258204

Review article

Lugg, ST, Scott, A, Parekh, D, Naidu, B & Thickett, DR 2021, 'Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease', Thorax. https://doi.org/10.1136/thoraxjnl-2020-216296

View all publications in research portal