Dr Dhruv Parekh BMedSci (Hons) MBBS(Hons) PhD MRCP

Dhruv Parekh

Institute of Inflammation and Ageing
Clinical Lecturer in Respiratory Medicine

Contact details

Address
Institute of Inflammation and Ageing
College of Medical and Dental Sciences
Centre for Translational and Inflammatory Research
1st Floor, New Queen Elizabeth Hospital
Mindelsohn Way
Birmingham, B15 2WB

Dr Dhruv Parekh is a Clinical Lecturer in Respiratory Medicine at the University of Birmingham and advanced trainee in Intensive Care Medicine in the final stages of clinical training within the West Midlands Deanery. His research interests are developing novel therapies in ARDS, perioperative inflammation, sepsis and critical care.

ORCID ID: 0000-0002-1508-8362

Qualifications

  • PhD (Health Sciences), University of Warwick, 2016
  • MRCP (UK), Royal College of Physicians, 2007
  • MBBS (Hons), St Bartholomew’s and the Royal London School of Medicine, 2003
  • BMedSci (Hons), St Bartholomew’s and the Royal London School of Medicine, 2002

Biography

Dr Dhruv Parekh completed his medical training at St Bartholomew’s and the Royal London School of Medicine in 2003. He gained a 1st class honours intercalated bachelor in medical sciences and won numerous prizes and award during his undergraduate training. After initial training and successful completion of his post-graduate exams he commenced clinical training in Respiratory, General Internal and Intensive Care Medicine.

Dhruv was awarded a highly competitive MRC Clinical Research Training Fellowship and his PhD investigated if vitamin D deficiency is a mechanistic driver of ARDS, which was completed in collaboration with the Universities of Birmingham and Warwick and the West Midlands ARDS network. 

He is currently a Clinical Lecturer in Respiratory Medicine at the University of Birmingham and also a member of the Perioperative, Anaesthesia, Critical Care and Trauma Trials (PACCT) group. He is currently in the final stages of his specialist training.

Dhruv has contributed to clinical trials and translational studies of vitamin D to prevent ARDS and statins in pneumonia and sepsis. He contributes to supervising BMedSci students and teaching respiratory modules on the MBChB course at the University. He has presented at many national and international meetings and has been the holder of the American Thoracic Society International Trainee Scholarship in 2014.

Teaching

Teaching Programmes

  • Medicine and Surgery MBChB
    • 1st Year MBChB Respiratory (IRM) Module
    • Tutor and Lecturer for the Written Professional Communication module year 5
    • Research tasters for students
  • Biomedical Materials Science BMedSc student supervision
  • Offers Personal Interest Projects: Respiratory and ICM

Postgraduate supervision

Dhruv is interested in supervising doctoral research students who are interested in research in the field of respiratory, peri-operative medicine and critical care.

If you are interested in studying any of these subject areas please contact Dhruv on the contact details above, or for any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk or call +44 (0)121 414 5005.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

Dhruv has translational research interests in respiratory, peri-operative and intensive care medicine. He is passionate about bringing the bench to bedside and his main research focuses on investigating novel therapeutic targets and increasing the understanding of the mechanisms of injury involved in sepsis and ARDS. His cellular interests have developed in the area of innate immunity and specifically macrophage and monocyte biology and function.

Publications

Recent publications

Article

Faqihi, BM, Trethewey, S, Morlet, J, Parekh, D & Turner, A 2021, 'Bilevel positive airway pressure ventilation for non-COPD acute hypercapnic respiratory failure patients: a systematic review and meta-analysis', Annals of Thoracic Medicine.

Haroon, S, Subramanian, A, Cooper, J, Anand, A, Gokhale, K, Byrne, N, Dhalla , S, Acosta-Mena , D, Taverner, T, Okoth, K, Wang, J, Chandan, J, Sainsbury, C, Zemedikun, D, Thomas, GN, Parekh, D, Marshall, T, Sapey, E, Adderley, N & Nirantharakumar, K 2021, 'Renin-angiotensin system inhibitors and susceptibility to COVID-19 in patients with hypertension: a propensity score-matched cohort study in primary care', BMC Infectious Diseases, vol. 21, no. 1, 262. https://doi.org/10.1186/s12879-021-05951-w

Mahida, RY, Chotalia, M, Alderman, J, Patel, C, Hayden, A, Desai, R, Beesley, E, Crowley, LE, Soltan, M, Bangash, M, Parekh, D, Patel, J & Thickett, DR 2020, 'Characterisation and outcomes of ARDS secondary to pneumonia in patients with and without SARS-CoV-2: a single-centre experience', BMJ Open Respiratory Research, vol. 7, no. 1, e000731. https://doi.org/10.1136/bmjresp-2020-000731

PRIDE Consortium Investigators, Venkatesan, S, Myles, PR, Bolton, KJ, Muthuri, SG, Al Khuwaitir, T, Anovadiya, AP, Azziz-Baumgartner, E, Bajjou, T, Bassetti, M, Beovic, B, Bertisch, B, Bonmarin, I, Booy, R, Borja-Aburto, VH, Burgmann, H, Cao, B, Carratala, J, Chinbayar, T, Cilloniz, C, Denholm, JT, Dominguez, SR, Duarte, PAD, Dubnov-Raz, G, Fanella, S, Gao, Z, Gérardin, P, Giannella, M, Gubbels, S, Herberg, J, Higuera Iglesias, AL, Hoeger, PH, Hu, XY, Islam, QT, Jiménez, MF, Keijzers, G, Khalili, H, Kusznierz, G, Kuzman, I, Langenegger, E, Lankarani, KB, Leo, Y-S, Libster, RP, Linko, R, Madanat, F, Maltezos, E, Mamun, A, Manabe, T, Metan, G, Mickiene, A & Parekh, D 2020, 'Neuraminidase inhibitors and hospital length of stay: a meta-analysis of individual participant data to determine treatment effectiveness among patients hospitalized with nonfatal 2009 pandemic influenza A(H1N1) virus infection', The Journal of Infectious Diseases, vol. 221, no. 3, pp. 356-366. https://doi.org/10.1093/infdis/jiz152

Zheng, S, Yang, J, Hu, X, Li, M, Wang, Q, Dancer, RCA, Parekh, D, Gao-Smith, F, Thickett, DR & Jin, S 2020, 'Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-β induced epithelial to mesenchymal transition', Biochemical Pharmacology, vol. 177, 113955. https://doi.org/10.1016/j.bcp.2020.113955

Lugg, ST, Alridge, KA, Howells, PA, Parekh, D, Scott, A, Mahida, RY, Park, D, Tucker, O, Gao, F, Perkins, GD, Thickett, DR & Dancer, RCA 2019, 'Dysregulated alveolar function and complications in smokers following oesophagectomy', ERJ Open Research, vol. 5, no. 1, 00089. https://doi.org/10.1183/23120541.00089-2018

Grudzinska, F, Aldridge, K, Hughes, S, Nightingale, P, Bangnash, M, Dancer, R, Parekh, D, Patel, J, Sapey, E & Thickett, D 2019, 'Early identification of severe community-acquired pneumonia: a retrospective observational study', BMJ Open Respiratory Research, vol. 6, no. 1, e000438. https://doi.org/10.1136/bmjresp-2019-000438

VITDALIZE Collaboration Group & Parekh, D 2019, 'Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency: a study protocol of a multicentre, placebo-controlled double-blind phase III RCT (the VITDALIZE study)', BMJ open, vol. 9, no. 11, pp. e031083. https://doi.org/10.1136/bmjopen-2019-031083

Thein, OS, Sutton, B, Thickett, DR & Parekh, D 2019, 'Mepolizumab rescue therapy for acute pneumonitis secondary to DRESS', BMJ case reports, vol. 12, no. 10. https://doi.org/10.1136/bcr-2019-231355

Sapey, E, Patel, JM, Greenwood, H, Walton, GM, Grudzinska, F, Parekh, D, Mahida, RY, Dancer, RC, Lugg, ST, Howells, PA, Hazeldine, J, Newby, P, Scott, A, Nightingale, P, Hill, AT & Thickett, DR 2019, 'Simvastatin improves neutrophil function and clinical outcomes in pneumonia: a pilot randomized controlled clinical trial', American Journal of Respiratory and Critical Care Medicine, vol. 200, no. 10, pp. 1282-1293. https://doi.org/10.1164/rccm.201812-2328OC

Martucci, G, McNally, D, Parekh, D, Zajic, P, Tuzzolino, F, Arcadipane, A, Christopher, KB, Dobnig, H & Amrein, K 2019, 'Trying to identify who may benefit most from future vitamin D intervention trials: a post hoc analysis from the VITDAL-ICU study excluding the early deaths', Critical care (London, England), vol. 23, no. 1, pp. 200. https://doi.org/10.1186/s13054-019-2472-z

Scott, A, Lugg, S, Aldridge, K, Lewis, K, Bowden, A, Mahida, R, Grudzinska, F, Dosanjh, D, Parekh, D, Foronjy, R, Sapey, E, Naidu, B & Thickett, D 2018, 'Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages', Thorax, vol. 73, no. 12, pp. 1161-1169. https://doi.org/10.1136/thoraxjnl-2018-211663

Patel, J, Sapey, E, Parekh, D, Scott, A, Dosanjh, D, Gao Smith, F & Thickett, D 2018, 'Sepsis induces a dysregulated neutrophil phenotype that is associated with increased mortality', Mediators of Inflammation, vol. 2018, 4065362. https://doi.org/10.1155/2018/4065362, https://doi.org/10.1155/2018/4065362

Comment/debate

Bangash, MN, Patel, J & Parekh, D 2020, 'COVID-19 and the liver: little cause for concern', The Lancet Gastroenterology and Hepatology. https://doi.org/10.1016/S2468-1253(20)30084-4

Review article

Amrein, K, Papinutti, A, Mathew, E, Vila, G & Parekh, D 2018, 'Vitamin D and critical illness: what endocrinology can learn from intensive care and vice versa.', Endocrine Connections, vol. 7, no. 12, pp. R304–R315. https://doi.org/10.1530/EC-18-0184

View all publications in research portal