Dr Dhruv Parekh MBBS (Hons), PhD, MRCP (UK), FFICM

Dhruv Parekh

Institute of Inflammation and Ageing
Associate Professor in Critical Care and Respiratory Medicine

Contact details

Address
Institute of Inflammation and Ageing
College of Medical and Dental Sciences
Centre for Translational and Inflammatory Research
1st Floor, New Queen Elizabeth Hospital
Mindelsohn Way
Birmingham, B15 2WB

Dr Dhruv Parekh is an Associate Professor in Critical Care and Respiratory Medicine at the University of Birmingham, Consultant in Intensive Care and Respiratory at the University Hospitals Birmingham NHS Foundation Trust. He is Deputy Theme lead for Acute Care Research and Programme Director of the Birmingham NIHR/Wellcome Clinical Research Facility.  His research interests are developing novel therapies in ARDS, lung fibrosis, perioperative inflammation, sepsis and critical care.

ORCID ID: 0000-0002-1508-8362

Qualifications

  • FFICM (Fellowship of the Faculty of Intensive Care Medicine) 2017
  • PhD (Health Sciences), University of Warwick, 2016
  • MRCP (UK), Royal College of Physicians, 2007
  • MBBS (Hons), St Bartholomew’s and the Royal London School of Medicine, 2003
  • BMedSci (Hons), St Bartholomew’s and the Royal London School of Medicine, 2002

Biography

Dhruv graduated from Bart’s and the London Medical School gaining a 1st class honours intercalated bachelor in medical sciences, winning numerous prizes and awards during his undergraduate training. He completed clinical training in London and higher specialist clinical training in Intensive Care Medicine, Respiratory and Internal Medicine in the West Midlands.

Dhruv was awarded a highly competitive MRC Clinical Research Training Fellowship and his PhD investigated if vitamin D deficiency is a mechanistic driver of ARDS, which was completed in collaboration with the Universities of Birmingham and Warwick and the West Midlands ARDS network. He was a Clinical Lecturer in Respiratory Medicine at the University and was founding member of the Birmingham Acute Care Research Group. He was awarded a West Midlands NIHR CRN Career Development Fellowship (Research Scholar).

He is currently an Associate Professor at the University of Birmingham and Consultant in Critical Care and Respiratory Medicine at University Hospitals Birmingham NHS Foundation Trust. As Programme Director of the Birmingham NIHR/Wellcome Clinical Research Facility and Deputy Theme Lead of the cross-cutting Acute Care Research Collaborative within the Birmingham Health Partnership he oversees a breadth of academic and industry led research.

His own programme of research from discovery science to clinical trials is based principally around improving the care and outcomes of acute and critically ill patients admitted to hospital. Dhruv has a keen interest in improving inequity in and access to research studies and is now with his leadership roles passionate about reducing health disparities by ensuring a cohesive cross-sector approach to research, so that every patient regardless of background, location, diversity, language or disability has equal access to innovation. He has recently been accepted onto the highly competitive Academy of Medical Sciences Future Leaders in Innovation and Research Programme Cohort 3.

He is the co-lead for post-graduate research for the institute and Clinical Academic Training Lead for Acute Care.

Teaching

Teaching Programmes

Postgraduate supervision

Dhruv is interested in supervising doctoral research students who are interested in research in the field of respiratory, peri-operative medicine and critical care.

If you are interesting in studying any of these subject areas please contact Dr Dhruv Parekh directly, or for any general doctoral research enquiries, please email mds-gradschool@contacts.bham.ac.uk.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

Dhruv’s programme of research is based principally around improving the care and outcomes of acute and critically ill patients admitted to hospital. To date this has focused on areas of sepsis and acute lung inflammation, and persistent inflammation post-acute injury, in particular innate immunity, macrophage biology and vitamin D in acute illness. His clinical experience allows him to bridge the gap and crosscut from acute and respiratory medicine, perioperative care, trauma to intensive care medicine with a central translational theme of acute inflammation and its resolution.

He also has an interest in the acute effect of vaping on lung health as well as growing area of work in mechanisms and treatment of lung fibrosis. His on-going research activity spans the breadth of discovery science, translation to phase 2 studies and design and delivery of large clinical and cost effectiveness trials in acute, respiratory, and critical care as well as big data, prognostic scoring and risk modelling: this includes funding from NIHR, MRC and collaboration with industry.

Publications

Recent publications

Article

Chotalia, M, Ali, M, Alderman, JE, Patel, JM, Parekh, D & Bangash, MN 2022, 'Cardiovascular subphenotypes in patients with COVID-19 pneumonitis whose lungs are mechanically ventilated: a single-centre retrospective observational study', Anaesthesia. https://doi.org/10.1111/anae.15700

Adderley, N, Taverner, T, Price, M, Sainsbury, C, Greenwood, D, Chandan, J, Takwoingi, Y, Haniffa, R, Hosier , I, Welch, C, Parekh, D, Gallier, S, Gokhale, K, Denniston, A, Sapey, E & Nirantharakumar, K 2022, 'Development and external validation of prognostic models for COVID-19 to support risk stratification in secondary care', BMJ open, vol. 12, no. 1, e049506. https://doi.org/10.1136/bmjopen-2021-049506

Mahida, RY, Scott, A, Parekh, D, Lugg, ST, Hardy, RS, Lavery, GG, Matthay, MA, Naidu, B, Perkins, GD & Thickett, DR 2021, 'Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis', The European respiratory journal, vol. 58, no. 3, 2100829. https://doi.org/10.1183/13993003.00829-2021

Mahida, RY, Scott, A, Parekh, D, Lugg, ST, Belchamber, KBR, Hardy, RS, Matthay, MA, Naidu, B & Thickett, DR 2021, 'Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome', Frontiers in Medicine, vol. 8, 737859. https://doi.org/10.3389/fmed.2021.737859

Faqihi, BM, Trethewey, S, Morlet, J, Parekh, D & Turner, A 2021, 'Bilevel positive airway pressure ventilation for non-COPD acute hypercapnic respiratory failure patients: a systematic review and meta-analysis', Annals of Thoracic Medicine, vol. 16, no. 4, pp. 306-322. https://doi.org/10.4103/atm.atm_683_20

Veenith, T, Fisher, BA, Slade, D, Rowe, A, Sharpe, R, Thickett, DR, Whitehouse, T, Rowland, M, Scriven, J, Parekh, D, Bowden, SJ, Savage, JS, Richards, D, Bion, J, Kearns, P, Gates, S & CATALYST Trial Investigators 2021, 'CATALYST trial protocol: a multicentre, open-label, phase II, multiarm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults', BMJ open, vol. 11, no. 11, e050202. https://doi.org/10.1136/bmjopen-2021-050202

Yip, KP, Gompertz, S, Snelson, C, Willson, J, Madathil, S, Huq, SS, Rauf, F, Salmon, N, Tengende, J, Tracey, J, Cooper, B, Filby, K, Ball, S, Parekh, D & Dosanjh, DPS 2021, 'Increase in recruitment upon integration of trial into a clinical care pathway: an observational study', BMJ Open Respiratory Research, vol. 8, no. 1, e000967. https://doi.org/10.1136/bmjresp-2021-000967

Stockley, JA, Alhuthail, EA, Coney, AM, Parekh, D, Geberhiwot, T, Gautum, N, Madathil, SC & Cooper, BG 2021, 'Lung function and breathing patterns in hospitalised COVID-19 survivors: a review of post-COVID-19 Clinics', Respiratory research, vol. 22, no. 1, 255. https://doi.org/10.1186/s12931-021-01834-5

CATALYST investigators, Fisher, B, Veenith, T, Slade, D, Gaskell, C, Rowland, M, Whitehouse, T, Scriven, J, Parekh, D, Balasubramaniam, M, Cooke, G, Morley, N, Gabriel, Z, Wise, M, Porter, J, McShane, H, Ho, L-P, Newsome, P, Rowe, A, Sharpe, R, Thickett, D, Bion, J, Gates, S, Richards, D & Kearns, P 2021, 'Namilumab or infliximab compared with standard of care in hospitalised patients with COVID-19 (CATALYST): a randomised, multicentre, multi-arm, multistage, open-label, adaptive, phase 2, proof-of-concept trial', The Lancet Respiratory Medicine. https://doi.org/10.1016/S2213-2600(21)00460-4

PHOSP-COVID Collaborative Group, Lord, J & Parekh, D 2021, 'Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study', The Lancet Respiratory Medicine, vol. 9, no. 11, pp. 1275-1287. https://doi.org/10.1016/S2213-2600(21)00383-0

Wright, WA, Crowley, LE, Parekh, D, Crawshaw, A, Dosanjh, DP, Nightingale, P & Thickett, DR 2021, 'Real-world retrospective observational study exploring the effectiveness and safety of antifibrotics in idiopathic pulmonary fibrosis', BMJ Open Respiratory Research, vol. 8, no. 1, e000782. https://doi.org/10.1136/bmjresp-2020-000782

Preprint

Veenith, T, Fisher, BA, Slade, D, Rowe, A, Sharpe, R, Thickett, DR, Whitehouse, T, Rowland, M, Scriven, J, Parekh, D, Bowden, SJ, Savage, JS, Richards, D, Bion, J, Kearns, P & Gates, S 2021 'CATALYST trial protocol: a multicentre, open-label, phase II, multi-arm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults' medRxiv, pp. 1-15. https://doi.org/10.1101/2021.02.10.21251478

Mahida, RY, Price, J, Lugg, ST, Li, H, Parekh, D, Scott, A, Harrison, P, Matthay, MA & Thickett, DR 2021 'CD14 positive extracellular vesicles in broncho-alveolar lavage fluid as a new biomarker of acute respiratory distress syndrome' medRxiv. https://doi.org/10.1101/2021.09.25.21264053

Fisher, BA, Veenith, T, Slade, D, Gaskell, C, Rowland, M, Whitehouse, T, Scriven, J, Parekh, D, Balasubramaniam, MS, Cooke, G, Morley, N, Gabriel, Z, Wise, MP, Porter, J, McShane, H, Ho, L-P, Newsome, PN, Rowe, A, Sharpe, R, Thickett, DR, Bion, J, Gates, S, Richards, D & Kearns, P 2021 'Namilumab or infliximab compared to standard of care in hospitalised patients with COVID-19 (CATALYST): a phase 2 randomised adaptive trial' medRxiv, pp. 1-26. https://doi.org/10.1101/2021.06.02.21258204

Review article

Lugg, ST, Scott, A, Parekh, D, Naidu, B & Thickett, DR 2021, 'Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease', Thorax. https://doi.org/10.1136/thoraxjnl-2020-216296

View all publications in research portal

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