Dr John A Reynolds MRCP, PhD

Dr John Reynolds

Institute of Inflammation and Ageing
Clinical Senior Lecturer in Rheumatology

Contact details

University of Birmingham Research Labs
1st Floor
Queen Elizabeth Hospital
B15 2WB


PhD (Medicine), University of Manchester 2014

MRCP (UK) 2008

MBChB (with Honours), University of Birmingham 2005

BMedSc (Hons), University of Birmingham 2002


John Reynolds is a Clinical Senior Lecturer in Rheumatology at the University of Birmingham and an Honorary Consultant Rheumatologist at Sandwell and West Birmingham Hospitals NHS Trust.

John qualified from the University of Birmingham in 2005 and became a Member of the Royal College of Physicians in 2008.  After completing an Academic Foundation Programme in Birmingham in 2007 he moved to Manchester as an NIHR Academic Clinical Fellow and subsequently an NIHR Academic Clinical Lecturer.  Between 2010 and 2014 he completed a North West England MRC Clinical Pharmacology and Therapeutics Clinical Research Training Fellowship which included 3 months as a visiting scientist at the National Institutes of Health (NIH).  In 2018 he was awarded a Certificate in Human Pharmacology by the RCP Faculty of Pharmaceutical Medicine.


  • Clinical Senior Lecturer in Rheumatology and Honorary Consultant Rheumatologist
  • Consultant Rheumatologist


Recent publications


Chew, C, Reynolds, JA, Lertratanakul, A, Wu, P, Urowitz, M, Gladman, DD, Fortin, PR, Bae, S-C, Gordon, C, Clarke, AE, Bernatsky, S, Hanly, JG, Isenberg, D, Rahman, A, Sanchez-Guerrero, J, Romero-Diaz, J, Merrill, J, Wallace, D, Ginzler, E, Khamashta, M, Nived, O, Jönsen, A, Steinsson, K, Manzi, S, Kalunian, K, Dooley, MA, Petri, M, Aranow, C, Vollenhoven, RV, Stoll, T, Alarcón, GS, Lim, SS, Ruiz-Irastorza, G, Peschken, CA, Askanase, AD, Kamen, DL, İnanç, M, Ramsey-Goldman, R & Bruce, IN 2021, 'Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort', Rheumatology. https://doi.org/10.1093/rheumatology/keab090

Ubhi, M, Dubey, S, Gordon, C, Adizie, T, Sheeran, T, Allen, K, Jordan, R, Sadhra, S, Adams, J, Daji, R, Reynolds, J & Kumar, K 2021, 'Understanding the impact of Systemic Lupus Erythematosus on work amongst South Asian people in the UK: an explorative qualitative study', Lupus. https://doi.org/10.1177/09612033211022816

Reynolds, J, Tosounidou, S & Gordon, C 2019, 'Optimising the management of systemic lupus erythematosus', Practitioner, vol. 263, no. 1826. <https://www.thepractitioner.co.uk//Symposium/Musculoskeletal-Medicine/11233-/Optimising-the-management-of-systemic-lupus-erythematosus>

Reynolds, JA, Briggs, TA, Rice, GI, Darmalinggam, S, Bondet, V, Bruce, E, Khan, M, Haque, S, Chinoy, H, Herrick, AL, McCarthy, EM, Zeef, LAH, Hayes, A, Duffy, D, Parker, B & Bruce, IN 2019, 'Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles', Arthritis Research & Therapy, vol. 21, 147. https://doi.org/10.1186/s13075-019-1929-4

Reynolds, JA, McCarthy, EM, Haque, S, Ngamjanyaporn, P, Sergeant, JC, Lee, E, Lee, E, Kilfeather, SA, Parker, B & Bruce, IN 2018, 'Cytokine profiling in active and quiescent SLE reveals distinct patient subpopulations', Arthritis Research & Therapy, vol. 20, pp. 173. https://doi.org/10.1186/s13075-018-1666-0

Edwards, N, Langford-Smith, AWW, Parker, BJ, Bruce, IN, Reynolds, JA, Alexander, MY, McCarthy, EM & Wilkinson, FL 2018, 'QRISK3 improves detection of cardiovascular disease risk in patients with systemic lupus erythematosus', Lupus Science and Medicine, vol. 5, no. 1, e000272. https://doi.org/10.1136/lupus-2018-000272

Ngamjanyaporn, P, McCarthy, EM, Sergeant, JC, Reynolds, J, Skeoch, S, Parker, BJ & Bruce, IN 2017, 'Clinicians approaches to management of background treatment in patients with SLE in clinical remission: results of an international observational survey', Lupus Science and Medicine, vol. 4, no. 1, e000173. https://doi.org/10.1136/lupus-2016-000173

Viatte, S, Lee, JC, Fu, B, Espéli, M, Lunt, M, De Wolf, JNE, Wheeler, L, Reynolds, JA, Castelino, M, Symmons, DPM, Lyons, PA, Barton, A & Smith, KGC 2016, 'Association between genetic variation in FOXO3 and reductions in inflammation and disease activity in inflammatory polyarthritis', Arthritis and Rheumatology, vol. 68, no. 11, pp. 2629-2636. https://doi.org/10.1002/art.39760

Reynolds, JA, Rosenberg, AZ, Smith, CK, Sergeant, JC, Rice, GI, Briggs, TA, Bruce, IN & Kaplan, MJ 2016, 'Brief Report: vitamin D deficiency is associated with endothelial dysfunction and increases type I interferon gene expression in a Murine model of systemic lupus erythematosus', Arthritis and Rheumatology, vol. 68, no. 12, pp. 2929-2935. https://doi.org/10.1002/art.39803

Reynolds, JA, Haque, S, Williamson, K, Ray, DW, Alexander, MY & Bruce, IN 2016, 'Vitamin D improves endothelial dysfunction and restores myeloid angiogenic cell function via reduced CXCL-10 expression in systemic lupus erythematosus', Scientific Reports. https://doi.org/10.1038/srep22341

Mohan, S, Barsalou, J, Bradley, TJ, Slorach, C, Reynolds, JA, Hasni, S, Thompson, B, Ng, L, Levy, D, Silverman, E & Kaplan, MJ 2015, 'Endothelial progenitor cell phenotype and function are impaired in childhood-onset systemic lupus erythematosus', Arthritis and Rheumatology, vol. 67, no. 8, pp. 2257-2262. https://doi.org/10.1002/art.39149

Reynolds, JA, Ray, DW, Zeef, LAH, O'Neill, T, Bruce, IN & Alexander, MY 2014, 'The effect of type 1 IFN on human aortic endothelial cell function in vitro: relevance to systemic lupus erythematosus', Journal of Interferon and Cytokine Research, vol. 34, no. 5, pp. 404-412. https://doi.org/10.1089/jir.2013.0016

Williamson, KA, Hamilton, A, Reynolds, JA, Sipos, P, Crocker, I, Stringer, SE & Alexander, YM 2013, 'Age-related impairment of endothelial progenitor cell migration correlates with structural alterations of heparan sulfate proteoglycans', Aging Cell, vol. 12, no. 1, pp. 139-147. https://doi.org/10.1111/acel.12031

Review article

Shoenfeld, Y, Giacomelli, R, Azrielant, S, Berardicurti, O, Reynolds, JA & Bruce, IN 2018, 'Vitamin D and systemic lupus erythematosus - the hype and the hope', Autoimmunity Reviews, vol. 17, no. 1, pp. 19-23. https://doi.org/10.1016/j.autrev.2017.11.004

Reynolds, JA & Bruce, IN 2017, 'Vitamin D treatment for connective tissue diseases: hope beyond the hype?', Rheumatology (Oxford, England), vol. 56, no. 2, pp. 178-186. https://doi.org/10.1093/rheumatology/kew212

View all publications in research portal