Dr Nikhil Desai PhD

Dr Nikhil Desai

School of Mathematics
Assistant Professor

Contact details

Address
Watson building
School of Mathematics
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Nikhil Desai is an interdisciplinary researcher interested in modelling and simulation of multi-physics problems involving viscous fluid flow, with applications in environmental technology, microfluidics, and physiology. 


Primarily, he works on modelling and simulation of “micro-swimmers” and small-scale biological fluid flows. His contributions in this field include: identification of physical mechanisms for experimentally observed bacterial swimming near interfaces, providing the first insights on near-wall propulsion of chemically powered "active drops", using fluid mechanics to resolve a controversy about the strength of cytoplasmic convection in eukaryotic cells, and developing a model for mucus transport in human sinuses. 


Nikhil likes communicating his research via clear and thorough presentations and is enthusiastic about teaching and developing effective pedagogical methods at all levels of education.

Dr Nikhil Desai's Google scholar page.

Qualifications

  • Bachelor of Technology in Mechanical Engineering, Indian Institute of Technology Kharagpur, 2014
  • Master of Technology in Thermal Science and Engineering, Indian Institute of Technology Kharagpur, 2014
  • PhD in Mechanical Engineering, Purdue University, 2019

Biography

Nikhil is originally from India, where he completed his B.Tech. and M.Tech. (Dual Degree) in 2014, at the Indian Institute of Technology Kharagpur. He majored in Mechanical Engineering with specialisation in Thermal Science and Engineering. He completed his PhD in 2019, in the School of Mechanical Engineering at Purdue University (USA). From 2020-2025, he did two post-docs: first in LadHyX, Ecole Polytechnique (France) and then in DAMTP, Cambridge (UK). In August 2025, Nikhil joined the School of Mathematics at the University of Birmingham as an Assistant Professor.

Postgraduate supervision

Nikhil Desai is interested in supervising PhD students in Continuum Mechanics (low Reynolds number flows, active matter hydrodynamics) and Mathematical Biology (biological fluid mechanics). If you are interested, please email him.

Research

Nikhil's research interests are in applied mathematics and continuum mechanics, particularly in micro-hydrodynamics. He uses analytical and computational methods to study micron-scale fluid flows relevant to engineering, biology and medicine e.g., locomotion of microscopic entities, flow of mucus films, intracellular flows, drug transport.

Research themes

  • Active matter hydrodynamics
  • Biological and physiological fluid mechanics
  • Micro-transport phenomena

Research activity

Nikhil's research focuses on theoretical and computational fluid mechanics, specifically low Reynolds number hydrodynamics in physico-chemical and biological systems.

In his PhD, advised by Professor Arezoo Ardekani, he developed mathematical models to explain the role played by fluid flow in helping bacteria colonise oil drops. He showed that, in addition to active nutrient-sensing called chemotaxis, bacteria benefit from a passive "hydrodynamic trapping" mechanism to populate nutrient sources like oil drops. He also offered hydrodynamics-based explanations for important experimentally observed swimming behaviour in bacteria, e.g., their motion near surfactant-laden interfaces and their varying affinity to surfaces based on their propulsion mechanisms. This research has applications in understanding the bioremediation of oil-spills by marine bacteria.

During his first post-doc, with Professor Sébastien Michelin, Nikhil studied the motion of chemical-reaction-driven "active" drops. In experiments, these drops are almost always confined near flat substrates, but theoretical understanding of their motion near boundaries was lacking. Nikhil performed numerical simulations to explain, for the first time, how confinement enhances the swimming speed of an active drop. For their work on confined propulsion of active drops, Dr Nikhil Desai and Professor Sébastien Michelin were awarded the 2022 Francois Frenkiel Award, by the American Physical Society, for significant contribution in fluid mechanics by early-career researchers. Nikhil is now interested in devising ways to control the motion of chemically active drops. This will help to exploit their ease of manufacturability toward performing useful microfluidic tasks.

During his second post-doc, with Professor Eric Lauga, Nikhil worked on modelling mucus transport in human maxillary sinuses. He developed a mathematical model that explained the physical mechanisms responsible for the maintenance of a thin mucus film inside healthy sinuses. He also studied intracellular fluid flow, using analytical calculations supported by numerical simulations to accurately quantify the strength of naturally occurring temperature-gradient-driven flows inside eukaryotic cells. Nikhil's current interests in biological and bio-medical fluid mechanics include utilising our knowledge of mucosal flows to enhance bioavailability of administered drugs.

Publications

Recent publications

Article

Desai, N & Lauga, E 2024, 'Modelling Mucus Clearance in Sinuses: Thin-Film Flow Inside a Fluid-Producing Cavity Lined with an Active Surface', Bulletin of Mathematical Biology, vol. 86, no. 11, 134. https://doi.org/10.1007/s11538-024-01360-7

Desai, N, Liao, W & Lauga, E 2024, 'Natural convection in the cytoplasm: Theoretical predictions of buoyancy-driven flows inside a cell', PLOS One, vol. 19, no. 7, e0307765. https://doi.org/10.1371/journal.pone.0307765

Desai, N & Michelin, S 2022, 'Steady state propulsion of isotropic active colloids along a wall', Physical Review Fluids, vol. 7, no. 10, 100501. https://doi.org/10.1103/PhysRevFluids.7.100501

Desai, N & Michelin, S 2021, 'Instability and self-propulsion of active droplets along a wall', Physical Review Fluids, vol. 6, no. 11, 114103. https://doi.org/10.1103/PhysRevFluids.6.114103

Desai, N & Ardekani, AM 2020, 'Biofilms at interfaces: Microbial distribution in floating films', Soft Matter, vol. 16, no. 7, pp. 1731-1750. https://doi.org/10.1039/c9sm02038a

Desai, N, Shaik, VA & Ardekani, AM 2019, 'Hydrodynamic interaction enhances colonization of sinking nutrient sources by motile microorganisms', Frontiers in Microbiology, vol. 10, no. MAR, 289. https://doi.org/10.3389/fmicb.2019.00289

Desai, N & Ardekani, AM 2018, 'Combined influence of hydrodynamics and chemotaxis in the distribution of microorganisms around spherical nutrient sources', Physical Review E, vol. 98, no. 1, 012419. https://doi.org/10.1103/PhysRevE.98.012419

Desai, N, Shaik, VA & Ardekani, AM 2018, 'Hydrodynamics-mediated trapping of micro-swimmers near drops', Soft Matter, vol. 14, no. 2, pp. 264-278. https://doi.org/10.1039/c7sm01615h

Desai, N, Dabiri, S & Ardekani, AM 2018, 'Nutrient uptake by chemotactic bacteria in presence of rising oil drops', International Journal of Multiphase Flow, vol. 108, pp. 156-168. https://doi.org/10.1016/j.ijmultiphaseflow.2018.06.016

Ardekani, AM, Doostmohammadi, A & Desai, N 2017, 'Transport of particles, drops, and small organisms in density stratified fluids', Physical Review Fluids, vol. 2, no. 10, 100503. https://doi.org/10.1103/PhysRevFluids.2.100503

Desai, N, Ghosh, U & Chakraborty, S 2014, 'Capillary filling under electro-osmotic effects in the presence of electromagneto-hydrodynamic effects', Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, vol. 89, no. 6, 063017. https://doi.org/10.1103/PhysRevE.89.063017

Other

Ardekani, AM, Desai, N & Shaik, VA 2018, 'Oil-microbe interactions: Role of chemotaxis and hydrodynamics', 2018 IUTAM Symposium on Motile Cells in Complex Environments, MCCE 2018, Udine, Italy, 15/05/18 - 18/05/18 pp. 33-34.

Review article

Desai, N & Ardekani, AM 2017, 'Modeling of active swimmer suspensions and their interactions with the environment', Soft Matter, vol. 13, no. 36, pp. 6033-6050. https://doi.org/10.1039/c7sm00766c

View all publications in research portal