Dr Punith Kempegowda MBBS MSc MD MRCP

Dr Punith Kempegowda

Institute of Metabolism and Systems Research
Wellcome Trust Clinical Research Fellow
Specialist Registrar in Endocrinology, Diabetes and General Internal Medicine

Contact details

Address
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Punith's research interests include impact of steroids on reproduction and metabolism, cancer therapy related endocrinopathies and improving the quality of care in diabetes and endocrinology. His current work focuses on how androgen activation in adipose tissue impacts on metabolic phenotype in Polycystic Ovary Syndrome (PCOS), and how modulation of these pathways might inform on new treatments for this disorder.

To find out more about Punith Kempegowda, please also see his personal website.

Punith Kempegowda from the Institute of Metabolism & System Research at the University of Birmingham shares his #WeAreIMSR story about his work on the DAISY-PCOS @daisypcos research project which focuses on polycystic ovary syndrome #PCOS. He also discusses his clinical work at Queen Elizabeth Hospital Birmingham @qehbham, including now caring for #covid19 patients during the first 24 hours of them being admitted into the hospital. He also talks about carrying on his teaching duties using innovative methods. Show you support research by helping us share these #WeAreIMSR stories far and wide.

 

Qualifications

MRCP, Royal College of Physicians London, 2015

MD, University of Buckingham, 2014

MSc, University of Buckingham, 2011

MBBS, Rajiv Gandhi University of Health Sciences, India, 2008

Biography

Polycystic Ovary Syndrome (PCOS) is a common amongst women of reproductive age affecting their metabolism and ability to conceive. Whilst insulin resistance and androgen excess form a cardinal part of the disease, the exact pathophysiology remains unclear. Recently, the discovery of ketosteroids and an enzyme that activates steroids has rejuvenated the hopes of discovering newer treatment modalities. He is currently dissecting the impact of these ketosteroids to better understand the pathophysiology.

Research

Reproductive endocrinology

Impact of steroids on metabolism in Polycystic Ovary Syndrome (PCOS)

  • DAISY PCOS - Dissecting Androgen excess and metabolic dysfunction – an Integrated Systems approach to PolyCystic Ovary Syndrome.
  • 11 OXO PCOS - The role of 11-oxygenated androgens in androgen excess and metabolic dysfunction of women with polycystic ovary syndrome

Long term Testorone Replacement Therapy (TRT)

Influence of ethnicity on TRT

Improving diabetes and endocrine clinical services through quality improvement programmes

  • DEKODE-DKA - Digital Evaluation of Ketosis and Other Diabetes Emergencies (DEKODE): diabetes-related ketoacidosis (DKA)
  • DEKODE-Hypoglycaemia
  • Improving management of patients with Cystic fibrosis related diabetes
  • Steroid induced diabetes Quality Improvement Programme (QIP)

Acute and chronic endocrinopathies associated with cancer therapy

  • Immune checkpoint inhibitors associated endocrinopathies

Medical Education

  • Simulation via Instant Messaging-Birmingham Advance (SIMBA)
  • Concise Medical Information Charts (CoMICs)

Other activities

Trainee Representative, Diabetes and Endocrinology, Health Education West Midlands, Since 2019

Trainee Representative, West Midlands Physician Association, UK, since 2018

Member of the Q community, the Health Foundation, since 2018

Former Trainee Representative, West Midlands Integrated Clinical Academic Training Group, 2015-2016

NIHR Academic Clinical Fellow in Endocrinology and Diabetes, 2013-2015

Punith has been awarded a public engagement grant from the Society for Endocrinology, for the second year. The award will enable him to work closely with the IMSR’s public engagement lead, Dr Caroline Gillett, to build on lessons learned from last year’s experience conducting endocrinology masterclasses for school students, whilst adding in new goals to create educational materials on endocrine themes created by and for young people. This will be done by co-creation workshops with medical students and young people who then present their work to the scientific community.

 

Society for Endocrinology logo

Publications

Recent publications

Article

Davitadze, M, Ooi, E, Ng, CY, Zhou, D, Thomas, L, Hanania, T, Blaggan, P, Evans, N, Chen, W, Melson, E, Arlt, W & Kempegowda, P 2022, 'SIMBA: using Kolb’s learning theory in simulation-based learning to improve participants’ confidence', BMC Medical Education, vol. 22, no. 1, 116 . https://doi.org/10.1186/s12909-022-03176-2

Melson, E, Chen, W, Zhou, D, Ooi, E, Evans, N, Delson, D, Davitadze, M & Kempegowda, P 2021, 'Adaptation and use of media in an innovative simulation-based clinician training programme', BMJ Simulation and Technology Enhanced Learning. https://doi.org/10.1136/bmjstel-2020-000808

Huynh, K, Kempegowda, P, Tamblyn, J, O'Reilly, M, Mueller, JW, Hewison, M & Jenkinson, C 2021, 'Development of a LC-MS/MS method to measure serum 3-sulfate and 3-glucuronide 25-hydroxyvitamin D3 metabolites; comparisons to unconjugated 25OHD in pregnancy and polycystic ovary syndrome', Steroids, vol. 169, 108812. https://doi.org/10.1016/j.steroids.2021.108812

Kempegowda, P, Melson, E, Johnson, A, Wallett, L, Thomas, L, Zhou, D, Holmes, C, Juszczak, A, Karamat, MA, Ghosh, S, Hanif, W, Narendran, P & Bellary, S 2021, 'Effect of COVID-19 on the clinical course of diabetic ketoacidosis (DKA) in people with type 1 and type 2 diabetes', Endocrine Connections, vol. 10, no. 4, pp. 371–377. https://doi.org/10.1530/EC-20-0567

Kempegowda, P, Chen, W, Melson, E, Leong, A, Amrelia, P & Syed, A 2021, 'Incidental finding of lipaemia retinalis on diabetic retinal screening', Endocrinology, diabetes & metabolism case reports, vol. 2021. https://doi.org/10.1530/EDM-21-0051

Schiffer, L, Bossey, A, Kempegowda, P, Taylor, A, Akerman, I, Scheel-Toellner, D, Storbeck, K-H & Arlt, W 2021, 'Peripheral blood mononuclear cells preferentially activate 11-oxygenated androgens', European Journal of Endocrinology, vol. 184, no. 3, pp. 353–363. https://doi.org/10.1530/EJE-20-1077

Kempegowda, P, Sunsoa, H, Chandan, J, Quinn, L, Amrelia, P, Atta, S, Amir, S, Teh, Y, Chaudhry, S, De Bray, A, Rashid, R, Whitehouse, J, Nash, E & Syed, A 2021, 'Retinopathy and microalbuminuria are common microvascular complications in cystic fibrosis-related diabetes', Therapeutic Advances in Endocrinology and Metabolism, vol. 11, pp. 1-10. https://doi.org/10.1177/2042018820966428

Morgan, G, Melson, E, Davitadze, M, Ooi, E, Zhou, D, Hanania, T, Chen, W, Thomas, L, Allison, I, Ding, M, Blaggan, P, Ng, CY, Evans, N, Warmington, E, Radcliffe, E, Soran, V, Nirmal, R, Boelaert, K, Cooney, R, Reddy-Kolanu, V, Karavitaki, N, Pathmakanthan, S, Arlt, W & Kempegowda, P 2021, 'Utility of Simulation via Instant Messaging - Birmingham Advance (SIMBA) in medical education during COVID-19 pandemic', Journal of the Royal College of Physicians of Edinburgh, vol. 51, no. 2, pp. 168–172. https://doi.org/10.4997/JRCPE.2021.218

Kempegowda, P, Melson, E, Manolopoulos, K, Arlt, W & O'reilly, M 2020, 'Implicating androgen excess in propagating metabolic disease in polycystic ovary syndrome', Therapeutic Advances in Endocrinology and Metabolism. https://doi.org/10.1177/2042018820934319

Kyriacou, A, Melson, E, Chen, W & Kempegowda, P 2020, 'Is immune checkpoint inhibitor-associated diabetes the same as fulminant type 1 diabetes mellitus?', Clinical Medicine. https://doi.org/10.7861/clinmed.2020-0054

Kempegowda, P, Quinn, LM, Chandan, JS, Shepherd, L, Kauser, S, Rahim, A & Bates, A 2020, 'Long‐term testosterone undecanoate replacement therapy: Impact of ethnicity', Clinical Endocrinology, vol. 92, no. 5, pp. 428-433. https://doi.org/10.1111/cen.14157

Thomas, L, Kolenysk, A, Melson, E, Johnson, A, Chandan, JS, Ghosh, S, Narendran, P & Kempegowda, P 2020, 'Retrospective validation of digital evaluation of Ketosis and other Diabetes emergencies (DEKODE) algorithm: automated auditing system for diabetic ketoacidosis (DKA) management', Future Healthcare Journal, vol. 7, no. Suppl 1, pp. s75-s76. https://doi.org/10.7861/fhj.7.1.s75

Chen, W, Kempegowda, P, Melson, E, Davitadze, M, Aftab, M, Ooi, E, Ng, CY, Blaggan, P, Hanania, T, Thomas, L, Zhou, D, Sankar, S, Ayuk, J & Karamat, MA 2020, 'Simulation training using WhatsApp (Sim-thru-WhatsApp) improves doctors' confidence in endocrine and diabetes case management', Clinical Medicine, vol. 20, no. Suppl 2, pp. s62-s63. https://doi.org/10.7861/clinmed.20-2-s62

Melson, E, Davitadze, M, Aftab, M, Ng, CY, Ooi, E, Blaggan, P, Chen, W, Hanania, T, Thomas, L, Zhou, D, Chandan, J, Senthil, L, Arlt, W, Sankar, S, Ayuk, J, Karamat, M & Kempegowda, P 2020, 'Simulation via Instant Messaging-Birmingham Advance (SIMBA) model helped improve clinicians’ confidence to manage cases in diabetes and endocrinology', BMC Medical Education, vol. 20, 274. https://doi.org/10.1186/s12909-020-02190-6

Abstract

Evans, N, Davitadze, M, Narendran, A, Evans, S, Thomas, L, Blaggan, P, Melson, E & Kempegowda, P 2020, 'The use of SIMBA as an alternative and/or adjunct to pre-medical work experience during COVID-19 Pandemic', Future Healthcare Journal. https://doi.org/10.7861/fhj.2020-0219

View all publications in research portal

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