Dr Punith Kempegowda MBBS MSc MD MRCP

Dr Punith Kempegowda

Institute of Metabolism and Systems Research
Wellcome Trust Clinical Research Fellow
Specialist Registrar in Endocrinology, Diabetes and General Internal Medicine

Contact details

Address
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

My research interests include impact of steroids on reproduction and metabolism, cancer therapy related endocrinopathies and improving the quality of care in diabetes and endocrinology. My current work focuses on how androgen activation in adipose tissue impacts on metabolic phenotype in PCOS, and how modulation of these pathways might inform on new treatments for this disorder.

Qualifications

MRCP, Royal College of Physicians London

MD, University of Buckingham, 2014

MSc, University of Buckingham, 2011

MBBS, Rajiv Gandhi University of Health Sciences, India

Biography

PCOS is a common amongst women of reproductive age affecting their metabolism and ability to conceive. Whilst insulin resistance and androgen excess form a cardinal part of the disease, the exact pathophysiology remains unclear. Recently, the discovery of ketosteroids and an enzyme that activates steroids has rejuvenated the hopes of discovering newer treatment modalities. I am currently dissecting the impact of these ketosteroids to better understand the pathophysiology.

Research

  • Reproductive endocrinology
    • Impact of steroids on metabolism in PCOS
      • DAISY PCOS
      • 11 OXO PCOS
    • Long term testosterone replacement therapy (TRT)
      • Comparing effects of various testosterone replacement preparations
      • Influence of ethnicity on TRT
  • Improving diabetes and endocrine clinical services through quality improvement programmes
    • Improving diabetic ketoacidosis management through frequent feedbacks
    • Improving management of patients with Cystic fibrosis related diabetes
    • Steroid induced diabetes QIP
  • Acute and chronic endocrinopathies associated with cancer therapy
    • Immune checkpoint inhibitors associated endocrinopathies

Other activities

Trainee Representative, Diabetes and Endocrinology, Health Education West Midlands, Since 2019

Trainee Representative, West Midlands Physician Association, UK, since 2018

Member of the Q community, the Health Foundation, since 2018

Former Trainee Representative, West Midlands Integrated Clinical Academic Training Group, 2015-2016

NIHR Academic Clinical Fellow in Endocrinology and Diabetes, 2013-2015

Publications

Kempegowda P, Chandan JS, Abdulrahman S, Chauhan A and Saeed MA (2019) Managing hypertension in people of African origin with diabetes: Evaluation of adherence to NICE Guidelines. Prim Care Diabetes. Jan 28

Kempegowda P, Livesey AC, McFarlane-Majeed L, Chandan JS, Smyth T, Stewart M, Blackwood K, McMahon M, Melapatte AV, Salahuddin S, Webber J and Ghosh S (2018) Are they high on steroids? Tailored interventions help improve screening for steroid-induced hyperglycaemia in hospitalised patients. BMJ Open Qual. Mar 14 7(1):e000238.

Kempegowda P, Chandan J.S, Hutton R, Brown L, Madden W, Webb J, Doyle A and Treml J (2018) Focused educational intervention improves but may not sustain knowledge regarding falls management. BMJ Open Qual. Jul 23;7(3):e000222.

Kempegowda P, Coombs B, Nightingale P, Chandan JS, Al-Sheikhli J, Shyamanur B,  Theivendran K, Melapatte AV, Salanke U, Akber M, Ghosh S and Narendran P (2017) Regular and frequent feedback of specific clinical criteria delivers a sustained improvement in the management of diabetic ketoacidosis. Clin Med (Northfield Il) Oct 3;17(5):389–94.

O’Reilly M.W, Kempegowda P, Walsh M, Taylor A.E, Manolopoulos K.N, Allwood J.W, Semple R, Hebenstreit D, Dunn, Warwick, Tomlinson J and Arlt W (2017) AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 102(9).

O’Reilly MW, Kempegowda P, Jenkinson C, Taylor A.E, Quanson J.L, Storbeck K-H and Arlt, W (2017) 11-oxygenated C19 steroids are the predominant androgens in polycystic ovary syndrome. J Clin Endocrinol Metab; 102(3).

Schiffer L, Kempegowda P, Arlt W, O’Reilly MW. MECHANISMS IN ENDOCRINOLOGY: The sexually dimorphic role of androgens in human metabolic disease (2017) Eur J Endocrinol ;177(3).

Kempegowda P, O’Reilly MW, Hassan-Smith Z, Storbeck K-H, Taylor AE and Arlt W (2016) Impaired DHEA sulfation defines androgen excess in women with polycystic ovarian syndrome (PCOS). Endocr Abstr. May 13 

Kempegowda P, Saeed M. Foot (2016) STAMP (Short-burst Teaching Aimed at Medical Professionals): impact of ‘short-burst’ teaching on the knowledge regarding the Ipswich Touch Test. Diabet Med;33(S1):134.

Kempegowda P, Quinn L, Vijayan MA, Jain A, Steven N, Gleeson H and Toogood A (2017) Ipilimumab induced hypophysitis - an insight from a case series in the United Kingdom. Endocr Abstr. May 3

 

For a full list of Dr Kempegowda’s publications 

 

 

1.       Kempegowda P, Chandan JS, Abdulrahman S, Chauhan A and Saeed MA (2019) Managing hypertension in people of African origin with diabetes: Evaluation of adherence to NICE Guidelines. Prim Care Diabetes. Jan 28

2.       Kempegowda P, Livesey AC, McFarlane-Majeed L, Chandan JS, Smyth T, Stewart M, Blackwood K, McMahon M, Melapatte AV, Salahuddin S, Webber J and Ghosh S (2018) Are they high on steroids? Tailored interventions help improve screening for steroid-induced hyperglycaemia in hospitalised patients. BMJ Open Qual. Mar 14 7(1):e000238.

3.       Kempegowda P, Chandan J.S, Hutton R, Brown L, Madden W, Webb J, Doyle A and Treml J (2018) Focused educational intervention improves but may not sustain knowledge regarding falls management. BMJ Open Qual. Jul 23;7(3):e000222.

4.       Kempegowda P, Coombs B, Nightingale P, Chandan JS, Al-Sheikhli J, Shyamanur B,  Theivendran K, Melapatte AV, Salanke U, Akber M, Ghosh S and Narendran P (2017) Regular and frequent feedback of specific clinical criteria delivers a sustained improvement in the management of diabetic ketoacidosis. Clin Med (Northfield Il) Oct 3;17(5):389–94.

5.       O’Reilly M.W, Kempegowda P, Walsh M, Taylor A.E, Manolopoulos K.N, Allwood J.W, Semple R, Hebenstreit D, Dunn, Warwick, Tomlinson J and Arlt W (2017) AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 102(9).

6.       O’Reilly MW, Kempegowda P, Jenkinson C, Taylor A.E, Quanson J.L, Storbeck K-H and Arlt, W (2017) 11-oxygenated C19 steroids are the predominant androgens in polycystic ovary syndrome. J Clin Endocrinol Metab; 102(3).

7.       Schiffer L, Kempegowda P, Arlt W, O’Reilly MW. MECHANISMS IN ENDOCRINOLOGY: The sexually dimorphic role of androgens in human metabolic disease (2017) Eur J Endocrinol ;177(3).

8.       Kempegowda P, O’Reilly MW, Hassan-Smith Z, Storbeck K-H, Taylor AE and Arlt W (2016) Impaired DHEA sulfation defines androgen excess in women with polycystic ovarian syndrome (PCOS). Endocr Abstr. May 13  

9.       Kempegowda P, Saeed M. Foot (2016) STAMP (Short-burst Teaching Aimed at Medical Professionals): impact of ‘short-burst’ teaching on the knowledge regarding the Ipswich Touch Test. Diabet Med;33(S1):134.

10.   Kempegowda P, Quinn L, Vijayan MA, Jain A, Steven N, Gleeson H and Toogood A. Ipilimumab induced hypophysitis - an insight from a case series in the United Kingdom. Endocr Abstr. 2017 May 3;

For a full list of Dr Kempegowda’s publications

View all publications in research portal