Dr Vasileios Chortis MD PhD MRCP

Dr Vasileios Chortis

Institute of Metabolism and Systems Research
Honorary Senior Research Fellow

Contact details

Email
v.chortis@bham.ac.uk
Twitter
@VChortis
View my research portal
Address
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Vasileios is an Honorary Senior Research Fellow. Dr Chortis’s research focuses on adrenal tumours, with a particular interest in adrenocortical carcinoma (ACC). His PhD work explored the role of antioxidant pathway targeting as  novel therapeutic approach for ACC. As a progression of this work, Dr Chortis is currently studying the therapeutic potential of mitochondrial NADPH synthesis inhibition in the same disease. He has also been studying the diagnostic role of mass spectrometry-based steroid profiling for ACC both at baseline tumour work-up and during post-operative follow-up, in integration with computational analytical approaches.

Qualifications

  • PhD in Endocrinology, University of Birmingham, 2017
  • Member of the Royal College of Physicians of London (MRCP), 2011
  • MBChB (Medicine and Surgery), National and Kapodistrian University of Athens, Greece, 2008

Biography

Vasileios completed his MBChB at the National and Kapodistrian University of Athens, Greece in 2008. He commenced his clinical training in the UK in the same year. In 2010, he started working as an NIHR Academic Clinical Fellow in Endocrinology and Diabetes, a post that allowed him to combine his clinical training (Birmingham City Hospital and University Hospitals Birmingham) with research experience in the University of Birmingham, supervised by Professor Wiebke Arlt. During this time, Vasileios developed an interest in Endocrine Oncology, with a focus on adrenocortical cancer. In 2013, he started a Doctoral Clinical Research Fellowship at the Institute of Metabolism and Systems Research (IMSR, University of Birmingham), supervised by Prof Arlt and Dr Paul Foster. His work explored the role of antioxidant pathway targeting as  novel therapeutic approach for adrenocortical cancer, as well as introducing a new diagnostic tool for the same disease based on urine steroid profiling. Since 2016, he has been working as a Clinical Lecturer in Endocrinology at the IMSR and University Hospitals Birmingham. His clinical training in Endocrinology and Diabetes will be completed in 2020. His current research work aims to dissect the metabolic pathways that support mitochondrial antioxidant pathways through NADPH synthesis in adrenocortical cancer using cutting edge metabolomic techniques, supervised by Dr Dan Tennant.

Teaching

  • Medicine and Surgery MBChB
  • Biomedical Science BSc

Postgraduate supervision

Vasileios has supervised 3 undergraduate students at the Institute of Metabolism and Systems Research.

Research

Cancer metabolism, steroid metabolism and redox balance in adrenal cancer, adrenal tumours

Research Groups and  Centres

Publications

Recent publications

Article

Majidi, F, Martino, S, Kondakci, M, Antke, C, Haase, M, Chortis, V, Arlt, W, Ronchi, C, Fassnacht, M, Laurent, C, Petit, J-M, Casasnovas, O, Habra, M, Kanji, A, Salvatori, R, Ho, ATN, Spyroglou, A, Beuschlein, F, Villa, D, Limvorapitak, W, Engelbrekt Wahlin, B, Gimm, O, Rudelius, M, Schott, M, Germing, U, Haas, R & Gattermann, N 2020, 'Clinical spectrum of primary adrenal lymphoma: results of a multicenter cohort study', European Journal of Endocrinology, vol. 183, no. 4, pp. 453–462. https://doi.org/10.1530/EJE-19-0506

Chortis, V, Bancos, I, Nijman, T, Gilligan, L, Taylor, A, Ronchi, C, O'Reilly, M, Schreiner, J, Asia, M, Riester, A, Perotti, P, Libe, R, Quinkler, M, Canu, L, Paiva, I, Bugalho, MJ, Kastelan, D, Dennedy, MC, Sherlock, M, Ambroziak, U, Vassiliadi, D, Bertherat, J, Beuschlein, F, Fassnacht, M, Deeks, J, Biehl, M & Arlt, W 2020, 'Urine steroid metabolomics as a novel tool for detection of recurrent adrenocortical carcinoma', Journal of Clinical Endocrinology and Metabolism, vol. 105, no. 3, pp. e303–e314. https://doi.org/10.1210/clinem/dgz141

ENSAT EURINE-ACT Investigators 2020, 'Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study', The Lancet Diabetes and Endocrinology, vol. 8, no. 9, pp. 773-781. https://doi.org/10.1016/S2213-8587(20)30218-7

Chortis, V, May, CJH, Skordilis, K, Ayuk, J, Arlt, W & Crowley, RK 2019, 'Double trouble: two cases of dual adrenal pathologies in one adrenal mass', Endocrinology, diabetes & metabolism case reports, vol. 2019, EDM180151. https://doi.org/10.1530/EDM-18-0151

Storbeck, K-H, Schiffer, L, Baranowski, E, Chortis, V, Prete, A, Barnard, L, Gilligan, L, Taylor, A, Idkowiak, J, Arlt, W & Shackleton, C 2019, 'Steroid metabolome analysis in disorders of adrenal steroid biosynthesis and metabolism', Endocrine Reviews, vol. 40, no. 6, pp. 1605-1625. https://doi.org/10.1210/er.2018-00262

Canu, L, Van Hemert, JAW, Kerstens, M, Hartman, R, Khanna, A, Kraljevic, I, Kastelan, D, Badiu, C, Ambroziak, U, Tabarin, A, Haissaguerre, M, Buitenwerf, E, Visser, A, Mannelli, M, Arlt, W, Chortis, V, Bourdeau, I, Gagnon, N, Buchy, M, Borson-Chazot, F, Deutschbein, T, Fassnacht, M, Hubalewska Dydejczyk, HA, Motyka, M, Rzepka, W, Casey, RT, Challis, B, Quinkler, M, Vroonen, L, Spyroglou, A, Beuschlein, F, Lamas, C, Young, WF, Bancos, I & Timmers, HJ 2018, 'CT characteristics of pheochromocytoma - Relevance for the evaluation of adrenal incidentaloma', Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/jc.2018-01532

Arlt, W & Chortis, V 2018, 'Human fetal adrenal cells retain age-related stem and endocrine-differentiation potential in culture: in vitro human fetal adrenal models', FASEB Journal.

Chortis, V, Johal, NJ, Bancos, I, Evans, M, Skordilis, K, Guest, P, Cullen, MH, Porfiri, E & Arlt, W 2018, 'Mitotane treatment in patients with metastatic testicular Leydig cell tutor associated with severe androgen excess', European Journal of Endocrinology. https://doi.org/10.1530/EJE-17-0542

Meimaridou, E, Goldsworthy, M, Chortis, V, Fragouli, E, Foster, PA, Arlt, W, Cox, R & Metherell, LA 2018, 'NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice', Journal of Endocrinology, vol. 236, pp. 13-28. https://doi.org/10.1530/JOE-16-0638

Chortis, V, Taylor, A, Doig, C, Walsh, M, Meimaridou, E, Jenkinson, C, Rodriguez Blanco, G, Ronchi, C, Jaffri, A, Metherell, LA, Hebenstreit, D, Dunn, W, Arlt, W & Foster, P 2018, 'Nicotinamide nucleotide transhydrogenase as a novel treatment target in adrenocortical carcinoma', Endocrinology, vol. 159, no. 8, pp. 2836–2849. https://doi.org/10.1210/en.2018-00014

Puar, T, Engels, M, van Herwaarden, A, Sweep, F, Hulsbergen-van de Kaa, C, Kamphuis-van Ulzen, K, Chortis, V, Arlt, W, Stikkelbroeck, N, Claahsen-van der Grinten, H & Hermus, A 2017, 'Bilateral testicular tumors resulting in recurrent Cushing's syndrome after bilateral adrenalectomy', Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 2, pp. 339-344. https://doi.org/10.1210/jc.2016-2702

Bancos, I, Hazeldine, J, Chortis, V, Hampson, P, Taylor, AE, Lord, J & Arlt, W 2017, 'Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality', European Journal of Endocrinology, vol. 176, no. 4, pp. 471-480. https://doi.org/10.1530/EJE-16-0969

Arlt, W, Lang, K, Sitch, A, Dietz, AS, Rhayem, Y, Bancos, I, Feuchtinger, A, Chortis, V, Gilligan, L, Ludwig, P, Riester, A, Asbach, E, Hughes, B, O'Neil, D, Bidlingmaier, M, Tomlinson, JW, Hassan-Smith, Z, Rees, DA, Adolf, C, Hahner, S, Quinkler, M, Dekkers, T, Deinum, J, Biehl, M, Keevil, B, Shackleton, C, Deeks, J, Walch, AK, Beuschlein, F & Reincke, M 2017, 'Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism', JCI Insight, vol. 2, no. 8, e93136. https://doi.org/10.1172/jci.insight.93136

Comment/debate

Chortis, V, Sitch, AJ, Bancos, I, Prete, A, Taylor, AE, Biehl, M, Deeks, JJ & Arlt, W 2021, 'Comment on "A Modern Assessment of Cancer Risk in Adrenal Incidentalomas: Analysis of 2219 Patients" by Kahramangil B et al', Annals of surgery. https://doi.org/10.1097/SLA.0000000000004804

Bancos, I, Taylor, A, Chortis, V, Sitch, A, Lang, K, Prete, A, Gilligan, L, Biehl, M, Deeks, J, Arlt, W & ENSAT EURINE-ACT Investigators 2020, 'Urine steroid metabolomic phenotyping for the detection of adrenocortical carcinoma: still a long way to go – Author’s reply', The Lancet Diabetes and Endocrinology, vol. 8, no. 11, pp. P877-878. https://doi.org/10.1016/S2213-8587(20)30345-4

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