Dr Adam Devall BMedSc (Hons), PhD

Dr Adam Devall

Institute of Metabolism and Systems Research
Lecturer in Maternal Health Clinical Trials
Senior Clinical Trials Fellow, Tommy's National Centre for Miscarriage Research

Contact details

Address
Institute of Metabolism and Systems Research
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Adam's primary research focus is clinical trials in early pregnancy care, with a particular focus on miscarriage, infertility and global women’s health. As a lecturer, he collaborates with the Birmingham Clinical Trials Unit to manage a portfolio of national and international clinical trials. He is also a senior consortium member of the Tommy's National Centre for Miscarriage Research, led by Professor Arri Coomarasamy.

Qualifications

  • PhD in Neuropharmacology, University of Birmingham, 2007
  • BMedSc (Hons) Pharmacology, University of Birmingham, 2003

Biography

Adam Devall qualified with a BMedSc (Hons) in Medical Sciences from the University of Birmingham in 2003. He went on to study for a PhD in the Department of Pharmacology at Birmingham, which he was awarded in 2007. Following this, he took a position as a Research Fellow at the University of Birmingham in the Department of Neurobiology and Neuropharmacology before taking up the role of Trial Coordinator at the Cancer Research Clinical Trials Unit, University of Birmingham in 2011. In 2014, Adam moved to the Birmingham Clinical Trials Unit, working initially as a Senior Trial Manager for the PRISM trial. In 2016, Adam transitioned to the role of Trials Management Team Leader/Senior Clinical Trials Fellow, before moving to his current academic lecturer post in January 2021. 

Teaching

Adam teaches on the Clinical Trials MSc course.

Research

Adam Devall has a wide range of large research programs within his portfolio, which are listed below:

Principal Investigator 

Progestogens for preventing miscarriage: a network meta-analysis. £10,000. NIHR Incentive Awards Scheme. 2020-2022

Co-applicant

  • Tommy’s National Centre for Miscarriage Research. £2,500,000 plus institutional investment. Tommy’s. 2021-2026.
  • Development, Field-Testing and Piloting of a refractory postpartum haemorrhage management package: the PPH ReAct (PPH Refractory Action) study. £749,869.31. MRC 2020-2022.
  • Early detection and treatment of post-partum hemorrhage using the MOTIVE bundle: a World Health Organization cluster randomized trial with health economic analysis (the E-MOTIVE study). $10,915,588 USD. Bill & Melinda Gates Foundation. 2019-2022.
  • A 2x2 factorial design trial of letrozole versus clomiphene and metformin versus placebo for ovulation induction in women with polycystic ovary syndrome (LOCI). £2,100,000. NIHR. 2019-2023
  • Tommy's Reproductive Health Biobank. £1,445,074. MRC. 2017-2021.
  • Tommy’s National Centre for Miscarriage Research. £6,300,000 including institutional investment. Tommy’s. 2016-2021.
  • A randomised trial of mifepristone and misoprostol versus misoprostol alone for management of missed miscarriage (MifeMiso). £1,769,322. NIHR HTA. 2016-2020.
  • Progesterone in Spontaneous Miscarriage (PRISM). £1,756,618. NIHR HTA. 2014-2018.

Research groups and centres

Publications

Recent publications

Article

Okeke Ogwulu, D, Williams, E, Chu, J, Devall, A, Beeson, L, Hardy, P, Cheed, V, Sun, Y, Jones, L, La Fontaine, J, Bender Atik, R, Brewin, J, Hinshaw, K, Choudhary, M, Ahmed, A, Naflalin , J, Nunes, N, Oliver, A, Izzat, F, Bhatia, K, Hassan, I, Jeve, Y, Hamilton, J, Shilpa, D, Bottomley, C, Ross, J, Watkins, L, Underwood, M, Cheong, Y, Kumar, CS, Gupta, P, Small, R, Pringle, S, Hodge, F, Shahid, A, Horne, AW, Quenby, S, Gallos, I, Coomarasamy, A & Roberts, T 2021, 'Cost-effectiveness of mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage: an economic evaluation based on the MifeMiso Trial', BJOG: An International Journal of Obstetrics & Gynaecology. https://doi.org/10.1111/1471-0528.16737

Quenby, S, Gallos, I, Dhillon-smith, R, Podesek, M, Stephenson, MD, Fisher, J, Brosens, JJ, Brewin, J, Ramhorst, R, Lucas, ES, McCoy, RC, Anderson, R, Daher, S, Regan, L, Al-Memar, M, Bourne, T, MacIntyre, DA, Rai, R, Christiansen, OB, Sugiura-Ogasawara, M, Odendaal, J, Devall, A, Bennett, PR, Petrou, S & Coomarasamy, A 2021, 'Miscarriage matters: the epidemiological, physical, psychological and economic burden of early pregnancy loss', The Lancet, vol. 397, pp. 1658–1667. https://doi.org/10.1016/S0140-6736(21)00682-6

Devall, A, Papadopoulou, A, Podesek, M, Haas , DM, Price, MJ, Coomarasamy, A & Gallos, I 2021, 'Progestogens for preventing miscarriage: a network meta-analysis (Review)', Cochrane Database of Systematic Reviews, vol. 2021, no. 4, CD013792. https://doi.org/10.1002/14651858.CD013792.pub2

Coomarasamy, A, Dhillon-smith, R, Papadopoulou, A, Al-Memar, M, Brewin, J, Abrahams, VM, Maheshwari, A, Christiansen, OB, Stephenson, MD, Goddijn, M, Oladapo, OT, Wijeyaratne, CN, Bick, D, Shehata, H, Small, R, Bennett, PR, Regan, L, Rai, R, Bourne, T, Kaur, R, Pickering, O, Brosens, JJ, Devall, A, Gallos, I & Quenby, S 2021, 'Recurrent miscarriage: evidence to accelerate action', The Lancet, vol. 397, no. 10285, pp. 1675-1682. https://doi.org/10.1016/S0140-6736(21)00681-4

Melo, P, Chung, Y, Pickering, O, Price, M, Fishel, S, Khairy, M, Kingsland, C, Lowe, P, Petsas, G, Rajkhowa, M, Sephton, V, Tozer, A, Wood, S, Labarta, E, Wilcox, M, Devall, A, Gallos, I & Coomarasamy, A 2021, 'Serum luteal phase progesterone in women undergoing frozen embryo transfer in assisted conception: a systematic review and meta-analysis', Fertility and Sterility. https://doi.org/10.1016/j.fertnstert.2021.07.002

Coomarasamy, A, Gallos, I, Papadopoulou, A, Dhillon-smith, R, Al-Memar, M, Brewin, J, Christiansen, OB, Stephenson, MD, Oladapo, OT, Wijeyaratne, CN, Small, R, Bennett, PR, Regan, L, Goddijn, M, Devall, A, Bourne, T, Brosens, JJ & Quenby, S 2021, 'Sporadic miscarriage: evidence to provide effective care', The Lancet, vol. 397, no. 10285, pp. 1668-1674. https://doi.org/10.1016/S0140-6736(21)00683-8

Cheshire, J, Jones, L, Munthali, L, Kamphinga, C, Liyaya, H, Phiri, T, Parry‐Smith, W, Dunlop, C, Makwenda, C, Devall, AJ, Tobias, A, Nambiar, B, Merriel, A, Williams, H, Gallos, I, Wilson, A, Coomarasamy, A & Lissauer, D 2021, 'The FAST‐M complex intervention for the detection and management of maternal sepsis in low‐resource settings: a multi‐site evaluation', BJOG: An International Journal of Obstetrics & Gynaecology. https://doi.org/10.1111/1471-0528.16658

Chu, J, Devall, A, Beeson, L, Hardy, P, Cheed, V, Sun, Y, Roberts, T, Okeke Ogwulu, D, Williams, E, Jones, L, La Fontaine, J, Bender Atik, R, Brewin, J, Hinshaw, K, Choudhary, M, Ahmed, A, Naftalin, J, Nunes, N, Oliver, A, Izzat, F, Bhatia, K, Hassan, I, Jeve, Y, Hamilton, J, Deb, S, Bottomley, C, Ross, J, Watkins, L, Underwood, M, Cheong, Y, Kumar, CS, Gupta, P, Small, R, Pringle, S, Hodge, F, Shahid, A, Gallos, I, Horne, AW, Quenby, S & Coomarasamy, A 2020, 'Mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage (MifeMiso): a randomised, double-blind, placebo-controlled trial', The Lancet, vol. 396, no. 10253, pp. 770-778. https://doi.org/10.1016/S0140-6736(20)31788-8

Coomarasamy, A, Harb, HM, Devall, AJ, Cheed, V, Roberts, TE, Goranitis, I, Ogwulu, CB, Williams, HM, Gallos, ID, Eapen, A, Daniels, JP, Ahmed, A, Bender-Atik, R, Bhatia, K, Bottomley, C, Brewin, J, Choudhary, M, Crosfill, F, Deb, S, Duncan, WC, Ewer, A, Hinshaw, K, Holland, T, Izzat, F, Johns, J, Lumsden, MA, Manda, P, Norman, JE, Nunes, N, Overton, CE, Kriedt, K, Quenby, S, Rao, S, Ross, J, Shahid, A, Underwood, M, Vaithilingham, N, Watkins, L, Wykes, C, Horne, AW, Jurkovic, D & Middleton, LJ 2020, 'Progesterone to prevent miscarriage in women with early pregnancy bleeding: The PRISM RCT', Health Technology Assessment, vol. 24, no. 33, pp. 1-70. https://doi.org/10.3310/hta24330

Devall, AJ, Papadopoulou, A, Haas, DM, Price, MJ, Coomarasamy, A & Gallos, ID 2020, 'Progestogens for preventing miscarriage: a network meta-analysis', Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD013792

Roberts, T, Okeke Ogwulu, D, Goranitis, I, Devall, A, Cheed, V, Gallos, I, Middleton, L, Harb, H, Williams, H, Eapen, A, Daniels, J, Ahmed, A, Bender atik, R, Bhatia, K, bottomley, C, Ewer, A & Coomarasamy, A 2020, 'The cost-effectiveness of progesterone in preventing miscarriages in women with early pregnancy bleeding: an economic evaluation based on the PRISM Trial', BJOG: An International Journal of Obstetrics & Gynaecology. https://doi.org/DOI: 10.1111/1471-0528.16068

Coomarasamy, A, Devall, AJ, Cheed, V, Harb, H, Middleton, LJ, Gallos, ID, Williams, H, Eapen, AK, Roberts, T, Ogwulu, CC, Goranitis, I, Daniels, JP, Ahmed, A, Bender-Atik, R, Bhatia, K, Bottomley, C, Brewin, J, Choudhary, M, Crosfill, F, Deb, S, Duncan, WC, Ewer, A, Hinshaw, K, Holland, T, Izzat, F, Johns, J, Kriedt, K, Lumsden, M-A, Manda, P, Norman, JE, Nunes, N, Overton, CE, Quenby, S, Rao, S, Ross, J, Shahid, A, Underwood, M, Vaithilingam, N, Watkins, L, Wykes, C, Horne, A & Jurkovic, D 2019, 'A randomized trial of progesterone in women with bleeding in early pregnancy', The New England Journal of Medicine, vol. 380, no. 19, pp. 1815-1824. https://doi.org/10.1056/NEJMoa1813730

Tan, WS, Panchal, A, Buckley, L, Devall, AJ, Loubière, LS, Pope, AM, Feneley, MR, Cresswell, J, Issa, R, Mostafid, H, Madaan, S, Bhatt, R, McGrath, J, Sangar, V, Griffiths, TRL, Page, T, Hodgson, D, Datta, SN, Billingham, LJ & Kelly, JD 2018, 'Radiofrequency-induced thermo-chemotherapy effect versus a second course of Bacillus Calmette-Guérin or institutional standard in patients with recurrence of non–muscle-invasive bladder cancer following induction or maintenance Bacillus Calmette-Guérin therapy (HYMN): a phase III, open-label, randomised controlled trial', European urology. https://doi.org/10.1016/j.eururo.2018.09.005

Review article

Ghosh, J, Papadopoulou, A, Devall, AJ, Jeffery, HC, Beeson, LE, Do, V, Price, MJ, Tobias, A, Tunçalp, Ö, Lavelanet, A, Gülmezoglu, AM, Coomarasamy, A & Gallos, ID 2021, 'Methods for managing miscarriage: a network meta-analysis', Cochrane Database of Systematic Reviews, vol. 2021, no. 6, CD012602. https://doi.org/10.1002/14651858.CD012602.pub2

Coomarasamy, A, Devall, AJ, Brosens, JJ, Quenby, S, Stephenson, MD, Sierra, S, Christiansen, OB, Small, R, Brewin, J, Roberts, TE, Dhillon-Smith, R, Harb, H, Noordali, H, Papadopoulou, A, Eapen, A, Prior, M, Di Renzo, GC, Hinshaw, K, Mol, BW, Lumsden, MA, Khalaf, Y, Shennan, A, Goddijn, M, van Wely, M, Al-Memar, M, Bennett, P, Bourne, T, Rai, R, Regan, L & Gallos, ID 2020, 'Micronized vaginal progesterone to prevent miscarriage: a critical evaluation of randomized evidence', American journal of obstetrics and gynecology, vol. 223, no. 2, pp. 167-176. https://doi.org/10.1016/j.ajog.2019.12.006

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