Recent publications
Article
Bishop, EL, Gudgeon, NH, Mackie, GM, Chauss, D, Roberts, J, Tennant, DA, Maslowski, KM, Afzali, B, Hewison, M & Dimeloe, S 2022, '1,25-Dihydroxyvitamin D3 suppresses CD4+ T-cell effector functionality by inhibition of glycolysis', Immunology, vol. 166, no. 3, pp. 299-309. https://doi.org/10.1111/imm.13472
Fletcher, J, Bishop, E, Harrison, S, Williamson-Swift, A, Cooper, SC, Dimeloe, S, Raza, K & Hewison, M 2022, 'Autoimmune disease and interconnections with vitamin D', Endocrine Connections, vol. 11, no. 3, e210554. https://doi.org/10.1530/EC-21-0554
Gudgeon, N, Munford, H, Bishop, EL, Hill, J, Fulton-Ward, T, Bending, D, Roberts, J, Tennant, DA & Dimeloe, S 2022, 'Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation', Cell Reports, vol. 40, no. 7, 111193. https://doi.org/10.1016/j.celrep.2022.111193
Garcia, AM, Bishop, E, Li, D, Jeffery, L, Garten, A, Thakker, A, Certo, M, Mauro, C, Tennant, DA, Dimeloe, S, Evelo, CT, Coort, SL & Hewison, M 2021, 'Tolerogenic effects of 1,25-dihydroxyvitamin D on dendritic cells involve induction of fatty acid synthesis', The Journal of Steroid Biochemistry and Molecular Biology, vol. 211, 105891. https://doi.org/10.1016/j.jsbmb.2021.105891
Kolev, M, West, EE, Kunz, N, Chauss, D, Moseman, EA, Rahman, J, Freiwald, T, Balmer, ML, Lötscher, J, Dimeloe, S, Rosser, EC, Wedderburn, LR, Mayer-Barber, KD, Bohrer, A, Lavender, P, Cope, A, Wang, L, Kaplan, MJ, Moutsopoulos, NM, McGavern, D, Holland, SM, Hess, C, Kazemian, M, Afzali, B & Kemper, C 2020, 'Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells', Immunity, vol. 52, no. 3, pp. 513-527.e8. https://doi.org/10.1016/j.immuni.2020.02.006
Bishop, E, Ismailova, A, Dimeloe, SK, Hewison, M & White, JH 2020, 'Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory', JBMR Plus. https://doi.org/10.1002/jbm4.10405
Nageswara Rao, T, Hansen, N, Hilfiker, J, Rai, S, Majewska, JM, Lekovic, D, Gezer, D, Andina, N, Galli, S, Cassel, T, Geier, F, Delezie, J, Nienhold, R, Hao-Shen, H, Beisel, C, Di Palma, S, Dimeloe, S, Trebicka, J, Wolf, D, Gassmann, M, Fan, TW, Lane, AN, Handschin, C, Dirnhofer, S, Kroger, N, Hess, C, Radimerski, T, Koschmieder, S, Cokic, VP & Skoda, RC 2019, 'JAK2 mutant hematopoietic cells display metabolic alterations that can be targeted to treat myeloproliferative neoplasms', Blood, vol. 134, no. 21, pp. 1832-1846. https://doi.org/10.1182/blood.2019000162
Burgener, A-V, Bantug, G, Meyer, B, Higgins, R, Ghosh, A, Bignucolo, O, Ma, E, Loeliger, J, Unterstab, G, Geigges, M, Steiner, R, Enamorado, M, Ivanek, R, Hunziker, D, Schmidt, R, Muller_Durovic, B, Graehlert, J, Epple, R, Dimeloe, S, Lotscher, J, Sauder, U, Ebnother, M, Burger, B, Heijnen, I, Martinez-Cano, S, Cantoni, N, Brucker, R, Kahlert, CR, Sancho, D, Jones, RG, Navarini, A, Recher, M & Hess, C 2019, 'SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2', Nature Immunology, vol. 20, no. 10, pp. 1311–1321. https://doi.org/10.1038/s41590-019-0482-2
Dimeloe, S, Gubser, P, Loeliger, J, Frick, C, Develioglu, L, Fischer, M, Marquardsen, F, Bantug, GR, Thommen, DS, Lecoultre, Y, Zippelius, A, Langenkamp, A & Hess, C 2019, 'Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4+ T cells', Science signaling, vol. 12, no. 599, eaav3334. https://doi.org/10.1126/scisignal.aav3334
Dimeloe, S, Rice, L, Chen, H, Cheadle, C, Pfeffer, P, Lavender, P, Richards, D, Nyon, M, MacDonald, J, Kemper, C, Gooptu, B & Hawrylowicz, C 2019, 'Vitamin D (1,25(OH)2D3) induces α-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10.', The Journal of Steroid Biochemistry and Molecular Biology.
Thommen, DS, Koelzer, VH, Herzig, P, Roller, A, Trefny, M, Dimeloe, S, Kiialainen, A, Hanhart, J, Schill, C, Hess, C, Savic Prince, S, Wiese, M, Lardinois, D, Ho, P-C, Klein, C, Karanikas, V, Mertz, KD, Schumacher, TN & Zippelius, A 2018, 'A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade', Nature Medicine. https://doi.org/10.1038/s41591-018-0057-z
Editorial
Dimeloe, S & Mauro, C 2019, 'Translating immunometabolism: towards curing human diseases by targeting metabolic processes underpinning the immune response', Clinical & Experimental Immunology, vol. 197, no. 2, pp. 141-142. https://doi.org/10.1111/cei.13347
Review article
Pallett, LJ, Dimeloe, S, Sinclair, LV, Byrne, AJ & Schurich, A 2021, 'A glutamine 'tug-of-war': targets to manipulate glutamine metabolism for cancer immunotherapy', Immunotherapy Advances, vol. 1, no. 1, ltab010. https://doi.org/10.1093/immadv/ltab010
Bishop, EL, Gudgeon, N & Dimeloe, S 2021, 'Control of T Cell Metabolism by Cytokines and Hormones', Frontiers in immunology, vol. 12, 653605. https://doi.org/10.3389/fimmu.2021.653605
Munford, H & Dimeloe, S 2019, 'Intrinsic and Extrinsic Determinants of T Cell Metabolism in Health and Disease', Frontiers in Molecular Bioscience, vol. 6, pp. 118. https://doi.org/10.3389/fmolb.2019.00118
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