Professor Neil Gittoes BSc (Hons), MBChB (Hons), FRCP, PhD

Professor Neil Gittoes

Institute of Metabolism and Systems Research
Consultant and Honorary Professor of Endocrinology

Contact details

Address
Centre for Endocrinology, Diabetes and Metabolism (CEDAM)
3rd Floor, Heritage Building
Queen Elizabeth Hospital
Edgbaston
Birmingham, B15 2TH

Professor Neil Gittoes is Consultant Endocrinologist in Birmingham and Honorary Professor of Endocrinology at the University of Birmingham. He is Head of the Centre of Endocrinology, Diabetes and Metabolism and Honorary Consultant at Birmingham Women’s and Children’s Hospital and the Royal Orthopaedic Hospital. He works within a large team of highly acclaimed endocrinologists who deliver the broadest array of endocrine services with embedded internationally recognised research portfolios. Neil leads the metabolic bone diseases unit in Birmingham and additionally leads a number of national work streams through the Royal Osteoporosis Society (ROS) as Trustee and Chair of the Clinical and Scientific Committee. He works closely with the Society for Endocrinology and Royal College of Physicians, leading on Genomics in Mainstream Medicine (endocrinology). He advises NICE and the BNF on endocrine and bone metabolism therapies and is Clinical Lead for the NICE Guideline on Primary Hyperparathyroidism. He has been honoured by award of the Goulstonian Lectureship, Royal College of Physicians. Neil is Chairman of the Clinical Reference Group (CRG) for Specialised Endocrinology. He is Vice-Chairman of Council of the West Midlands Clinical Senate, NHSE and Clinical Vice-Chair of the West Midlands Subcommittee of the Advisory Committee on Clinical Excellence Awards (ACCEA), Department of Health. He has published widely and has lectured at many national and international conferences. He sits on editorial boards of four journals; he has wide experience in multiple modalities of peer review. Neil’s main clinical and research interests focus on disorders of calcium homeostasis and rare causes of fracture susceptibility.

Qualifications

1987    BSc (Hons) Anatomical Studies (University of Birmingham)

1990    MBChB (Hons) Medicine (University of Birmingham)

1993    MRCP Member of the Royal College of Physicians, London

1997    PhD     University of Birmingham - “Nuclear thyroid/steroid hormone receptor expression in the normal human pituitary and pituitary adenomas”

2000    CCST  General Internal Medicine

2000    CCST  Endocrinology & Diabetes         

2004    FRCP  Fellow of the Royal College of Physicians, London

Biography

Professor Neil Gittoes graduated in 1990 from the University of Birmingham with BSc (Hons), MBChB (Hons), and was later awarded a PhD in Molecular Endocrinology and was supported by a prestigious MRC Career Establishment Grant. He is currently Consultant Endocrinologist in Birmingham and Honorary Professor of Endocrinology at the University of Birmingham; he is Head of the Centre of Endocrinology, Diabetes and Metabolism and Honorary Consultant at Birmingham Women’s and Children’s Hospital and the Royal Orthopaedic Hospital. He works within a large team of highly acclaimed endocrinologists who deliver the broadest array of endocrine services with embedded internationally recognised research portfolios. Neil leads the metabolic bone diseases unit in Birmingham and additionally leads a number of national work streams through the Royal Osteoporosis Society (ROS) as Trustee and Chair of the Clinical and Scientific Committee. He works closely with the Society for Endocrinology and Royal College of Physicians, leading on Genomics in Mainstream Medicine (endocrinology). He advises NICE and the BNF on endocrine and bone metabolism therapies and is Clinical Lead for the NICE Guideline on Primary Hyperparathyroidism. He has been honoured by award of the Goulstonian Lectureship, Royal College of Physicians. Neil is Chairman of the Clinical Reference Group (CRG) for Specialised Endocrinology, NHSE and has authored drug access policies and fostered cross-CRG working with other specialties. He is Vice-Chairman of Council of the West Midlands Clinical Senate, NHSE and Clinical Vice-Chair of the West Midlands Subcommittee of the Advisory Committee on Clinical Excellence Awards (ACCEA), Department of Health. He has published widely and has lectured at many national and international conferences. He sits on editorial boards of four journals; he has wide experience in multiple modalities of peer review. Neil’s main clinical and research interests focus on disorders of calcium homeostasis and rare causes of fracture susceptibility.

Teaching

CONFERENCE ORGANISATION

SOCIETY

CONFERENCE

DATE

FUNCTION

European Hypoparathyroidism

2nd Eurpoean Symposium on Hypoparathyroidism

October 2018, Prague

Scientific Steering Committe

National Osteoporosis Society

National Osteoporosis Society Clinical & Scientific Conference

2013 - present

Manchester 2012, Birmingham 2014, Birmingham 2016, Birmingham 2018

Programme Organising Committee (Chair from 2015)

Society for Endocrinology

British Endocrine Societies Annual Meeting

 

2013 - present

Member, Scientific Programme Organising Committee

Society for Endocrinology

Society for Endocrinology Annual Clinical Update Meeting

2012 - present

Convenor of Bone and Calcium stream

Society for Endocrinology

British Endocrine Societies Annual Meeting

2011 - 2013

Programme Recommendations Group to POC

Royal College of Physicians

General Medicine for the Physician – Annual 3 Day Conference

2007

Programme Organiser - sole

Midland Bone Club

Midland Bone Club Annual Update Conference

2006 - present

Chair, programme  and conference organiser

TEACHING AND EDUCATION ROLES

EXTERNAL EXAMINER

-           University of Sheffield, Masters of Research, Musculoskeletal Ageing (2017)

-           Doctor of Medical Sciences thesis – University of Sydney, Australia, 2018

-           PhD thesis – Occult rickets, Birmingham, 2018

-           Promotion work University of Uganda, 2018

-           Promotion referee Erasmus MC University, Netherlands

 

INTERNATIONAL

Scientific Steering Committee member, 2nd European Hypoparathyroidism Symposium, Prague, October (2018)

NATIONAL

Educational resource in genomics - educational video on Genomics in Medical Specialties - Endocrinology, 2018

Conference Organising Committee, National Osteoporosis Society, 700 delegates national and international (2018)

Chairman, Conference Organising Committee, National Osteoporosis Society, 700 delegates national and international (2016)

National Lead/Convenor for Clinical Update – Main National Endocrine Training Programme (200 endocrine trainees), Bone and Calcium, (2012 - 2018)

UK faculty member for HIV and Bone International Medical Education Programme (2009 - 2012)

Examiner Royal College of Physicians (UK) (2005 - 2011) PACES

Specialty Certificate Examination RCP – Question Writing Group Endocrinology (2007 - 2017)

Specialty Certificate Examination RCP – Endocrinology Lead for exit examination (2007 - 2012)

Specialty Certificate Examination RCP – Examining Board Member (2007 - 2016)

Lead for Education, Recruitment, and Retention of Endocrinologists, Society for Endocrinology (2005 - 2008)

National Essay Prize assessor SfE (2003 - 2008)

 

UNIVERSITY

Member of the Strategy Committee for Education within the School of Medicine to determine long-term strategy for education (2001 - 2006)

Lead and editor of endocrinology component of IVIMEDS (e-learning, 2001 - 2008)

New Undergraduate Curriculum Module Coordinator/Clinical Link – Cell Signaling and Communications (2003 - 2008)

Module coordinator (clinical) endocrinology module 2nd year MB (2001 - 2008)

3rd year Integrated Medicine and Surgery Planning Group member (Curriculum Development, 2003 - 2007)

Member E-learning Strategy Group (2007 - 2008)

MBChB 1 & 2 Biological Sciences Curriculum Committee (2007 - 2008)

Teach all levels of medical undergraduates MBChB - bedside, small group and tutorial formats

Lectures to large audiences of undergraduate students in medicine, biochemistry, and pharmacology

Set and mark examination questions for MB and BMedSci

Tutor medical students for Public Health projects

Organise revision courses in medicine and medical student clinical exams

Clinical examiner in 3rd, 4th, and final year medicine examinations

Completed the Development Programme for Lecturers in the University of Birmingham Staff Development Unit

3rd year coordinator of teaching Queen Elizabeth Hospital (2001 – 2003)

Undergraduate Executive committee UHB - 3rd year representative (2002 – )

3rd year coordinator of teaching University Hospital Birmingham (2003 – 2008)

3rd year curriculum development group

Module coordinator (clinical) endocrinology module 2nd year MB

Lead for preclinical teaching Year 1 module – Pituitary Module lead pituitary small group teaching

Clinical Link for new pre-clinical curriculum development – Cell Signalling and Communication

Established new monthly regional training day for SpRs in endocrinology (2005 – 2007) 

Trust lead for endocrinology teaching UHB year IV (2012 – 2015)

Clinical teaching of clinical endocrinology 4th year – outpatient based – 3 clinics weekly

 

POSTGRADUATE EDUCATION DEVELOPMENT

Metabolic bone diseases – new teaching course for trainees, The ABC of Diabetes & Endocrinology, WM (2018)

Full GMC Accreditation as Named Clinical Supervisor (2016 - )

Nurse lecture updates (2016 - )

Regional Training Programme for DM/endo – Established consistent Midland Bone Club teaching contribution to cover bone and calcium disease (2011 - )

Doctors.net - Osteoporosis e-Learning resource on line (2007, 2009)

Doctors.net - How to Decide Who to Treat to Prevent Fractures (2010)

Orthopaedic, rheumatology and geriatric training programmes – Bone and calcium training (2011 - )

Acid-Base and Electrolyte Teaching Case for American Journal of Kidney Disease (2012)

Devised and delivered Endocrinology RCP study day at UHB (2012)

Advanced Education Supervision Course (2012)

CPD Course in Osteoporosis and Bone Disease for GPs, Initiated and Led, University of Birmingham (2012)

Motivational speaker for junior doctors entering DM & endocrinology (2012)

SHA and RCP Regional Specialty Advisor – endocrinology, (2013 – 2016)

Chair regional training days in endocrinology (2007 - 2017)

Postgraduate supervision

Year completed / due to complete

Source of support

Thesis

2010

United Birmingham Hospitals Endowment Fund

Pituitary radiotherapy as a risk factor for cerebrovascular disease and neurocognitive dysfunction

Planned for 2020

National Osteoporosis Society

Concurrent vitamin D and exercise intervention – effects on muscle and strength

 

  • External examiner for Doctor of Medical Sciences thesis – University of Sydney, Australia, 2018
  • Internal examiner for PhD, McCabe, NIS interacting factors and thyroid cancer, 2018

Research

Osteoporosis

Alternative bisphosphonate regimens for the prevention of osteoporotic fracture in adults, Blastoff Study, NIHR funded with multiple co-investigators, CI Prof Opinder Sahota, University of Nottingham

Role of screening older women for the prevention of osteoporosis and fractures, SCOOP Study, MRC funded with multiple co-investigators, CI Prof Lee Shepstone, University of East Anglia

 

Vitamin D and bone health

Concurrent vitamin D and exercise intervention – effects on muscle and strength – EXVITD Study, Royal Osteoporosis Society funded in collaboration with Dr Carolyn Greig, University of Birmingham

 

Rare bone and calcium diseases

Phase 4 Trial of PTH Therapy for Hypoparathyroidism; Shire Pharma

Osteogenesis imperfecta and potential links to valvular  heart disease, UHB Charities

Optimal treatment for adults with osteogenesis imperfecta, TOPAZ Study, MRC funded, CI Prof Stuart Ralston, University of Edinburgh

Rare disease registries in hypoparathyroidism, X-linked hypophosphataemic rickets and hypophosphatasia

Bone disease in Gaucher’s disease, Shire Pharma

 

Pituitary disease

Epidemiology, pathogenesis and prognosis of pituitary tumours, CI Dr Niki Karavitaki, University of Birmingham

 

Research groups and Centres

Rare endocrine ERN network lead for Birmingham Health Partners - https://endo-ern.eu/

CEDAM - https://www.birmingham.ac.uk/research/activity/mds/centres/cedam/index.aspx

SCOOP Study - http://www.scoopstudy.ac.uk/Homepage.htm

TOPAZ Study - https://www.ed.ac.uk/usher/edinburgh-clinical-trials/our-studies/ukcrc-studies/topaz

Other activities

MEMBERSHIP OF PROFESSIONAL SOCIETIES

 

1993    Member, Royal College of Physicians, London

1995    Member, Society for Endocrinology

1995 - 13   Member, British Thyroid Association

1998    Member, Endocrine Society USA

2001    Member, Pituitary Society

2003    Member, Royal (formerly National) Osteoporosis Society

2004    Fellow, Royal College of Physicians, London

2001-10   Member, European Neuroendocrine Tumor Society

2005    Member, Bone Research Society (formerly Bone & Tooth Society)

2005    Member, American Society for Bone and Mineral Research

 

Royal Osteoporosis Society (formally NOS)

Trustee of the Charity

Chairman of the Clinical and Scientific Committee

Chairman Conference Organising Committee (2016, 2018)

National Lead for Peer Review of Metabolic Bone Diseases

Member, Fracture Liaison Service Implementation Group

2015-

2015-

2015-

2014-2018

2013-

Royal College of Physicians

National lead for Endocrine Genetics Services in Mainstream Medicine

Member, Fracture Liaison Service Database Group

Member, Specialist Certificate Examination RCP – Examining Board

Member, Specialist Certificate Examination RCP– Question Writing Group Endocrinology

2015-2018

 2015-

2007-2016

 2007-2016

Department of Health and Social Care      

 

Medical Vice-chair, Advisory Committee on Clinical Excellence Awards (ACCEA), West Midlands Subcommittee

Advisory Committee on Clinical Excellence Awards (ACCEA), West Midlands Subcommittee member

2018-

 2018-

National Osteoporosis Guideline Group (NOGG)

 

Advisory Board member

2016-

Society for Endocrinology

 

Member, Clinical Excellence Awards Panel

Member, Programme Organising Committee

Member, Public Engagement Committee

Member, National SpR Training Programme in Endocrinology (Clinical Update) - Lead for Metabolic Bone Disease

2018-

2013-2016

2010-2016

2012-2018

NHS England

 

Chairman, Specialised Endocrinology Clinical Reference group, NHS England

Vice Chairman, second stage assurance review, NHSE of MCP Vanguard model of revolutionary redesign of population health service provision, West Midlands

Clinical Lead for Drug Policy on Teriparatide for Osteoporosis in Men, NHSE – Approved by CPAG July 2018, positive impact on 4,000 osteoporosis sufferers in England

Vice Chairman, West Midlands and East of England Specialised Endocrinology Clinical Reference group, NHS England

West Midlands and East of England Member of Specialised Endocrinology Clinical Reference group, NHSE

Vice Chairman, West Midlands Clinical Senate Council

Vice Chairman, Stage 1 Assurance, Shropshire Future Fit

Member Task and Finish Group on Delivering 7 day Working West and East Midlands

Lead, Working Group to derive National Endocrinology Clinical Dashboards

Vice Chairman, Clinical Reference Group, Commissioning of Specialised Endocrinology Services, NHS England

West Midlands Clinical Senate Council member

Chairman, West Midlands Clinical Senate Urgent Care Workforce review group

Member, National Clinical Reference Group Member, Endocrinology Specialist Services, National Specialist Commissioning Group

2019

2019

2018

 

2016-

2016-

2016-

2016

2015-2017

2014-2016

2013-2016

2013-

2013-2014

2012-

NICE

 

Clinical Lead for NICE Guideline on Primary Hyperparathyroidism

Invited Clinical Adviser to NICE Multiple technology Appraisal of Non-Bisphosphonates (ID-901) in Osteoporosis, NICE and ScHARR

Invited Expert for NICE Scientific Advice – New Treatment for Osteogenesis Imperfecta in Children and Adults

Invited Expert for NICE Scientific Advice – New Treatment for Hypoparathyroidism (Natpar)

Invited Expert Advisor Medical Technologies Advisory Committee (MTAC) – Novel device for assessment of osteoporosis and fracture risk

Invited Clinical Advisor to NICE Multiple technology Appraisal of Bisphosphonates for Preventing Osteoporotic Fragility Fractures (with partial update of TA 160 and 161), NICE and ScHARR

2017-2019

2018 

2017

 2016

 

2014-2015

2015

Health Education England

 

Competency Framework  Development Group - Obtaining informed consent for genomic testing, HEE Genomic Education Programme

2019

Brittle Bone Society

 

Medical Advisory Board to charity for patients with osteogenesis imperfecta

2019

Miscellaneous

 

Scientific adviser - Improving uptake of fracture prevention treatments (iFraP): development of a consultation intervention – iFraP, a computerized decision support tool or us in FL Consultations, ROS and NIHR

Member, Trial Steering Committee “Risks and benefits of bisphosphonate use in patients with chronic kidney disease: a population-based cohort study” Health Technology Appraisal (NDORMS, University of Oxford), Prof Daniel Prieto-Alhambra

SHA and RCP Regional Specialty Advisor – endocrinology

Clinical Advisor to the National Association for the Relief of Paget’s Disease

Member, National Falls and Fracture Alliance Executive Board, Advising National Commissioning Board

Member, Medical Advisory Board for the Brittle Bone Society

Inaugural Chairman and developer of the Midland Bone Club

Member, National Advisory Boards for major pharmaceutical companies related to bone and endocrine diseases (Roche/GSK, Lilly, Amgen, Internis, Prostrakan, Proctor & Gamble, Stirling Anglia, Servier; not all active)

Endocrine Advisor to the British National Formulary

2019-2020

 

2015-2017

2013-2017

2005-2015

2012-2015

2011-

2006-2018

2006-2014

2002-

Publications

Santharam S, Fountas A, Tampourlou M, Arlt W, Ayuk J, Gittoes N, Toogood A, Karavitaki N (2018) Impact of menopause on outcomes in prolactinomas after dopamine agonist treatment withdrawal. Clin Endocrinol (Oxf).89(3): 346-353. PMID: 30072564

Turner DA, Khioe RFS, Shepstone L, Lenaghan E, Cooper C, Gittoes N, Harvey NC, Holland R, Howe A, McCloskey E, O'Neill TW, Torgerson D, Fordham R; SCOOP Study Team (2018) The Cost-Effectiveness of Screening in the Community to Reduce Osteoporotic Fractures in Older Women in the UK: Economic Evaluation of the SCOOP Study. J Bone Miner Res. 33(5):845-851. PMID:29470854

Shepstone L, Lenaghan E, Cooper C, Clarke S, Fong-Soe-Khioe R, Fordham R, Gittoes N, Harvey I, Harvey N, Heawood A, Holland R, Howe A, Kanis J, Marshall T, O'Neill T, Peters T, Redmond N, Torgerson D, Turner D, McCloskey E; SCOOP Study Team (2018) Screening in the community to reduce fractures in older women (SCOOP): a randomised controlled trial. Lancet Feb 24;391(10122):741-747. PMID: 29254858

 Santharam S, Tampourlou M, Arlt W, Ayuk J, Gittoes N, Toogood A, Webster R, Karavitaki N (2017) Prolactinomas diagnosed in the postmenopausal period: Clinical phenotype and outcomes. Clin Endocrinol (Oxf).87(5):508-514. PMID: 28626987

Compston J, Cooper A, Cooper C, Gittoes N, Gregson C, Harvey N, Hope S, Kanis JA, McCloskey EV, Poole KES, Reid DM, Selby P, Thompson F, Thurston A, Vine N; National Osteoporosis Guideline Group (NOGG) (2017) UK clinical guideline for the prevention and treatment of osteoporosis. Arch Osteoporos. 12(1):43. PMID:28425085

Hassan-Smith ZK, Hewison M, Gittoes N (2017) Effect of vitamin D deficiency in developed countries. Br Med Bull. 1;122(1):79-89. PMID: 28334220

Tampourlou M, Ntali G, Ahmed S, Arlt W, Ayuk J, Byrne JV, Chavda S, Cudlip S, Gittoes N, Grossman A, Mitchell R, O'Reilly MW, Paluzzi A, Toogood A, Wass JAH, Karavitaki N. (2017)Outcome of Nonfunctioning Pituitary Adenomas That Regrow After Primary Treatment: A Study From Two Large UK Centers. J Clin Endocrinol Metab. 102(6):1889-1897. PMID: 28323946

Hassan-Smith ZK, Jenkinson C, Smith DJ, Hernandez I, Morgan SA, Crabtree NJ, Gittoes N, Keevil BG, Stewart PM, Hewison M. (2017) 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression. PLoS One. 12(2) PMID: 28199350

Davis S, Martyn-St James M, Sanderson J, Stevens J, Goka E, Rawdin A, Sadler S, Wong R, Campbell F, Stevenson M, Strong M, Selby P, Gittoes N. (2016) A systematic review and economic evaluation of bisphosphonates for the prevention of fragility fractures. Health Technol Assess. 20(78):1-406. Erratum in: Health Technol Assess. 2018 Mar;20(78):407-424. PMID:27801641

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