Professor Martin Hewison

Martin Hewison

Institute of Metabolism and Systems Research
Professor of Molecular Endocrinology
IMSR Director of Education

Contact details

Address
Institute of Metabolism and Systems Research
IBR Building
University of Birmingham
Edgbaston
Birmingham
B15 2TT UK

Professor Hewison’s work focuses on different facets of vitamin D physiology, including classical skeletal effects and non-classical extra-skeletal effects. He has a particular interest in the interaction between vitamin D and the immune system, where antigen-presenting cells such as dendritic cells and macrophages synthesize active vitamin D (calcitriol) and also express the nuclear receptor for calcitriol (VDR). Vitamin D can therefore act as an endogenous regulator of both innate and adaptive immunity by enhancing antibacterial activity, and modulating antigen presentation and T lymphocyte function. Crucially these responses are highly dependent on the bioavailability of vitamin D, and Professor Hewison has hypothesized that immune function is influenced by vitamin D status in humans. His group is using a variety of models to test this hypothesis including basic molecular and cell analyses, and vitamin D supplementation trials in human cohorts. A key objective of his work is to increase awareness of vitamin D-deficiency in the UK population.

Qualifications

  • PhD (1987)
  • BSc (Hons) (1982)

Biography

Nutrient mechanisms in infection: Vitamin D-deficiency by Martin Hewison

Professor Hewison is currently Professor of Molecular Endocrinology in the Institute of Metabolism and Systems Research (IMSR) at The University of Birmingham. He gained his PhD in Biochemistry from Guy’s Hospital Medical School London and then spent nine years at University College London. He then moved to the University of Birmingham where he established the UK’s major vitamin D research group, leading to an appointment as Professor of Molecular Endocrinology in 2004. In 2005 he joined Cedars-Sinai Medical Center Los Angeles but was then recruited to neighbouring UCLA at the end of 2007 as Professor-in-Residence.In September 2014 Professor Hewison returned to The University of Birmingham to join the newly-established IMSR as Deputy Director.

Professor Hewison has published over 200 peer-reviewed manuscripts focused on various facets of steroid hormone endocrinology, and he is Chair of the Vitamin D Workshop (http://www.vitamindworkshop.org/). He currently has a team of two postdocs, four PhD students and a clinical fellow who are funded by US and UK research grants.

Teaching

  • BMedSc 3rd Year (Molecular Medicine)
  • MBChB 1st Year (Endocrinology)

Postgraduate supervision

  • Four PhD students and one Biological Sciences Integrated Masters student 

Research

Professor Hewison’s main research interest is vitamin D and its importance to human health.

Basic Biology of Vitamin D

Professor Hewison has published more than 200 research papers on classical (skeletal) and non-classical (extra-skeletal) actions of vitamin D. Prominent amongst these are newly published studies describing the impact of vitamin D binding protein (DBP) on vitamin D bioavailability and tissue-specific responses to vitamin D.

Vitamin D and the immune system

Professor Hewison’s group is at the forefront of research linking vitamin D and the immune system. This has implications for a wide range of clinical disorders including inflammatory and autoimmune disease, but more recently has been expanded to include studies of infection. Current studies include analysis of vitamin D insensitivity in T lymphocytes from the inflamed joints of patients with rheumatoid arthritis, and characterisation of the role of non-coding microRNAs in mediating the anti-inflammatory effects of vitamin D.  

Vitamin D and inflammatory bowel disease

Inflammatory bowel diseases (IBD) such as Crohn’s disease have been shown to be associated with vitamin D-insufficiency. Professor Hewison’s group have shown that abnormal vitamin D metabolism in IBD is key factor in the osteoporotic bone disease commonly associated with these patients. Conversely, studies using mouse models have shown that vitamin D-deficiency predisposes to IBD. Recent projects have explored the relationship between the gut microbiota, vitamin D and IBD. Current experiments are focused on the role of DBP as a determinant of vitamin D bioavailability and how this impacts IBD.

Vitamin D and pregnancy

Pregnant women are at high risk of vitamin D-insufficiency. Professor Hewison has shown that vitamin D plays a key role in several aspects of placental physiology, notably adequate immune activity, control of vascular/trophoblastic architecture and fetal programming of the skeleton. Studies are currently assessing the impact of vitamin D-deficiency on pre-term birth, as well as infection and inflammation during pregnancy, and how this may affect fetal development.

Vitamin D metabolism

Studies of the health impact of vitamin D-deficiency and vitamin D-supplementation are a prominent feature of modern vitamin D research. However, almost all of this work is dependent on the measurement of a single vitamin D metabolite, 25-hydroxyvitamin D (25OHD). Professor Hewison’s group has pioneered a range of studies to explore other markers of vitamin D ‘status’. This includes development of novel high throughput liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology to measure multiple metabolites of vitamin D – the vitamin D metabolome. The aim of this work is to provide a more accurate measurement of optimal vitamin D for current and future clinical trials.

Other activities

  • Endocrinology – Editorial Board
  • Journal of Bone and Mineral Research – Editorial Board
  • Cell Biochemistry and Function – Reviews Editor
  • Cell Biochemistry and Function – Editorial Board
  • NIH Study Group (Special Emphasis Panel) Ad-hoc reviewer
  • NIH Study Group (Skeletal Biology Development and Disease Section) Ad-hoc reviewer
  • Workshop on Vitamin D Executive Committee
  • Secretary Vitamin D Workshop
  • REF Output Lead IMSR

Publications

Recent publications

Article

Lanham-New, S, Webb, A, Cashman, K, Buttriss, J, Fallowfield, J, Masud, T, Hewison, M, Mathers, JC, Kiely, M, Welch, A, Ward, K, Magee, P, Darling, A, Hill, TR, Greig, C, Smith, CP, Murphy, RJ, Leyland, S, Bouillon, R, Ray, S & Kohlmeier, M 2020, 'Vitamin D and SARS-CoV-2 virus/COVID-19 disease', BMJ Nutrition, Prevention & Health. https://doi.org/10.1136/ bmjnph-2020-000089

Viloria, KM, Nasteska, D, Briant, LJB, Heising, S, Larner, D, Fine, N, Ashford, F, Da Silva Xavier, G, Jimenez-Gonzalez, M, Hasib, A, Cuozzo, F, Manning Fox, J, MacDonald, P, Akerman, I, Lavery, G, Flaxman, C, Morgan, N, Richardson, S, Hewison, M & Hodson, D 2020, 'Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion', Cell Reports, vol. 31, no. 11, 107761. https://doi.org/10.1016/j.celrep.2020.107761

Beentjes, CHL, Taylor-King, JP, Bayani, A, Davis, CN, Dunster, JL, Jabbari, S, Mirams, GR, Jenkinson, C, Kilby, M, Hewison, M & Tamblyn, JA 2019, 'Defining vitamin D status using multi-metabolite mathematical modelling: a pregnancy perspective', The Journal of Steroid Biochemistry and Molecular Biology, vol. 190, pp. 152-160. https://doi.org/10.1016/j.jsbmb.2019.03.024

Larner, DP, Jenkinson, C, Chun, RF, Westgate, CSJ, Adams, JS & Hewison, M 2019, 'Free versus total serum 25-hydroxyvitamin D in a murine model of colitis', The Journal of Steroid Biochemistry and Molecular Biology, vol. 189, pp. 204-209. https://doi.org/10.1016/j.jsbmb.2019.01.015

Crowe, F, Thayakaran, T, Gittoes, N, Hewison, M, Thomas, GN, Scragg, R & Nirantharakumar, K 2019, 'Non-linear associations of 25-hydroxyvitamin D concentrations with risk of cardiovascular disease and all-cause mortality: results from The Health Improvement Network (THIN) database', The Journal of Steroid Biochemistry and Molecular Biology, vol. 195, 105480. https://doi.org/10.1016/j.jsbmb.2019.105480

Li, D, Jeffery, LE, Jenkinson, C, Harrison, SR, Chun, RF, Adams, JS, Raza, K & Hewison, M 2019, 'Serum and synovial fluid vitamin D metabolites and rheumatoid arthritis', The Journal of Steroid Biochemistry and Molecular Biology, vol. 187, pp. 1-8. https://doi.org/10.1016/j.jsbmb.2018.10.008

Fletcher, J, Cooper, SC, Ghosh, S & Hewison, M 2019, 'The Role of Vitamin D in Inflammatory Bowel Disease: Mechanism to Management', Nutrients, vol. 11, no. 5, 1019. https://doi.org/10.3390/nu11051019

Tamblyn, J, Jeffery, L, Susarla, R, Lissauer, D, Coort, SL, Munoz Garcia, A, Knoblich, K, Fletcher, A, Bulmer, JN, Kilby, M & Hewison, M 2019, 'Transcriptomic analysis of vitamin D responses in uterine and peripheral NK cells', Reproduction, vol. 158, no. 2, pp. 211-221. https://doi.org/10.1530/REP-18-0509

Crowe, F, Jolly, K, MacArthur, C, Manaseki-Holland, S, Gittoes, N, Hewison, M, Scragg, R & Nirantharakumar, K 2019, 'Trends in the incidence of testing for vitamin D deficiency in primary care in the UK: a retrospective analysis of The Health Improvement Network (THIN), 2005-2015', BMJ open, vol. 9, no. 6, e028355. https://doi.org/10.1136/bmjopen-2018-028355

Taylor, A, Storbeck, K-H, Hewison, M & Jenkinson, C 2018, 'Analysis of multiple vitamin D metabolites by ultra-performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS)', Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, vol. 1087-1088, pp. 43-48. https://doi.org/10.1016/j.jchromb.2018.04.025

Jenkinson, C, Taylor, A, Storbeck, K-H & Hewison, M 2018, 'Data comparing the separation and elution of vitamin D metabolites on an ultra performance supercritical fluid chromatography tandem-mass spectrometer (UPSFC-MS/MS) compared to liquid chromatography (LC) and data presenting approaches to UPSFC method optimization', Data in Brief, vol. 20, pp. 426-435. https://doi.org/10.1016/j.dib.2018.08.027

Jeffery, L, Henley, P, Marium, N, Filer, A, Sansom, DM, Hewison, M & Raza, K 2018, 'Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint', Journal of Autoimmunity, vol. 88, pp. 50-60. https://doi.org/10.1016/j.jaut.2017.10.001

Tamblyn, J, Jenkinson, C, Larner, D, Hewison, M & Kilby, M 2018, 'Serum and urine vitamin D metabolite analysis in early preeclampsia', Endocrine Connections, vol. 7, no. 1, pp. 199-210. https://doi.org/10.1530/EC-17-0308

Other contribution

Viloria, K, Nasteska, D, Briant, LJB, Heising, S, Larner, D, Fine, NHF, Ashford, FB, Xavier, GDS, Ramos, MJ, Fox, JEM, MacDonald, PE, Akerman, I, Lavery, GG, Flaxman, C, Morgan, NG, Richardson, SJ, Hewison, M & Hodson, DJ 2019, Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretion.. https://doi.org/10.1101/2019.12.19.881185

Review article

Harrison, SR, Li, D, Jeffery, LE, Raza, K & Hewison, M 2019, 'Vitamin D, Autoimmune Disease and Rheumatoid Arthritis', Calcified Tissue International. https://doi.org/10.1007/s00223-019-00577-2

View all publications in research portal