Dr Tarekegn G Hiwot

Photograph of Dr Tarek Hiwot

Institute of Metabolism and Systems Research
Honorary Reader in Inherited Metabolic Disorders

Contact details

Institute of Metabolism and Systems Research

Career History

  • 2016                        Honorary Reader, Institute of Metabolism and Systems Research, UoB
  • 2012                       Honorary Senior Research Fellow, University of Birmingham
  • 2008                       Consultant in Inherited Metabolic Disorders, UHB NHS FT
  • 2000-7                   Chemical Pathology/Metabolic Medicine (SHO/Registrar), West midlands
  • 1995-2000             PhD , Molecular Immunology, Karolinska Institute, Sweden
  • 1994-95                 MSc, Biochemistry, Karolinska Institute, Sweden
  • 1990-93                 General practitioners, Addis Ababa, Ethiopia
  • 1989                       MD, Addis Ababa University, Ethiopia


Tarek's group focuses on the deep phenotyping of rare inherited metabolic disorders to provide the best available care for each patient based on stratification into disease subclasses with a common biological basis. They utilise metabolomics, exome sequencing, novel biomarkers and international patient registries to understand the heterogeneity of diseases caused by single gene defect. Their main disease research area of interests are; Niemann-Pick, Fabry, Gaucher, Mucopolysaccharidosis, Alstrom syndrome and Phenylketonuria. 

Group members  

  • Clinical Fellow: Shanat Baig      
  • PhD Students: Fahad Al-Harbi 
  • Research Nurse: Vishy Veeranna   
  • Research coordinator: Shaun Bolton


Major external collaborators

  • Jeremy Tomlinson (Oxford)
  • Paul Gissen (UCL)
  • Bruno Bembi (University of Udine, Italy)
  • Sandra Sirrs (Vancouver, Canada)
  • Derralynn Hughes (UCL)


Advanced non-alcoholic fatty liver disease and adipose tissue fibrosis in patients with Alström syndrome.

Gathercole LL, Hazlehurst JM, Armstrong MJ, Crowley R, Boocock S, O'Reilly MW, Round M, Brown R, Bolton S, Cramb R, Newsome PN, Semple RK, Paisey R, Tomlinson JW, Geberhiwot TLiver Int. 2016 Nov;36(11):1704-1712. doi: 10.1111/liv.13163.

A Novel Rapid MALDI-TOF-MS-Based Method for Measuring Urinary Globotriaosylceramide in Fabry Patients. Alharbi FJ, Geberhiwot T, Hughes DA, Ward DG. J Am Soc Mass Spectrom. 2016 Apr;27(4):719-25. doi: 10.1007/s13361-015-1318-4.

 High quality, patient centred and coordinated care for Alstrom syndrome: a model of care for an ultra-rare disease. Van Groenendael S, Giacovazzi L, Davison F, Holtkemper O, Huang Z, Wang Q, Parkinson K, Barrett T, Geberhiwot TOrphanet J Rare Dis. 2015 Nov 24;10:149. doi: 10.1186/s13023-015-0366-y.

 Diffuse left ventricular interstitial fibrosis is associated with sub-clinical myocardial dysfunction in Alström Syndrome: an observational study. Edwards NC, Moody WE, Yuan M, Warfield AT, Cramb R, Paisey RB, Geberhiwot T, Steeds RP.  Orphanet J Rare Dis. 2015 Jun 24;10:83. doi: 10.1186/s13023-015-0292-z.

 Duration of Diabetes Predicts Aortic Pulse Wave Velocity and Vascular Events in Alström Syndrome. Paisey RB, Smith J, Carey C, Barrett T, Campbell F, Maffei P, Marshall JD, Paisey C, Steeds RP, Edwards NC, Bunce S, Geberhiwot TJ Clin Endocrinol Metab. 2015 Aug;100(8):E1116-24. doi: 10.1210/jc.2015-1577.