Dr Carl Jenkinson MRSC, CChem

Dr Carl Jenkinson

Institute of Metabolism and Systems Research
EU Marie Skłodowska-Curie Actions Global Fellow

Contact details

Address
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Jenkinson is currently undertaking a 3 year EU Marie Skłodowska-Curie Actions Global Fellow at the IMSR University of Birmingham with a 2 year integrated outgoing phase at the ANZAC Research Institute (University of Sydney). The fellowship programme OPTIMAL-D aims to establish novel mass spectrometry methods to measure metabolic profiles of vitamin D in order to assess the actions of vitamin D in health.

Qualifications

PhD in steroid biochemistry 2014

Biography

Dr Jenkinson is an independent research fellow within the steroid metabolome analysis core in the IMSR at the University of Birmingham. He is an international figure in translational clinical chemistry applications for endocrine metabolism.

Dr Jenkinson is currently leading the OPTIMAL-D EU MSCA GF research programme. This incorporates research interests of mass spectrometry methods and their applications to investigate novel areas of vitamin D metabolism within diverse population groups. This research has led to many novel findings within vitamin D research, including alternative phase I vitamin D pathways and measurements of multiple phase II vitamin D metabolites in circulation.

Research

Research Themes

Dr Jenkinson’s research programme is based around clinical chemistry, vitamin D metabolism linked to human health. Other themes of research include analysis of steroid metabolism pathways by LC-MS/MS for translational approaches within sports antidoping and health research.

Research Activity

Dr Jenkinson’s research is focussed on the application of translational mass spectrometry research in the study of vitamin D metabolism for investigating optimal levels in human health (OPTIMAL-D).

This research has been funded by the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie Grant Agreement.

Further support has been provided through Society for Endocrinology Equipment and Early Career research grants.

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LC-MS/MS method development

These research projects aim to establish novel sample preparation and LC-MS/MS methods to quantify vitamin D metabolites across metabolic pathways in order to measure these metabolites in different biological samples including serum and tissues.

Vitamin D metabolism

There are multiple pathways for the activation and inactivation of vitamin D and these projects have aimed to explore these different pathways within circulation. This includes recent circulating measurements of alternative CYP11A1 pathway metabolites and phase II conjugated forms of vitamin D.

Biomarkers of vitamin D in health

The translational approach of LC-MS/MS analysis to clinical and observational studies have linked different metabolite forms beyond routinely measured 25OHD to outcomes in health. This includes 1,25-dihydroxyvitamin D measurements related to bone mineral density in elderly populations, and differences in metabolism during pregnancy.

Steroid metabolism

Other previous research projects have explored steroid metabolic profiles by LC-MS/MS for translational applications in sports antidoping tests and human health studies.

Research Groups and Centres

Other activities

  • Member of the Royal Society of Chemistry
  • Chartered Chemist
  • Griffith Hack Innovation Award Recipient

 

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