Dr Alessandro Prete MBBS, MD

Institute of Metabolism and Systems Research
Clinical Associate Professor in Endocrinology and Diabetes

Contact details

Telephone: +44 (0)121 414 2764
Email: a.prete@bham.ac.uk
Twitter: @AlePreteUoB

Address: University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Alessandro Prete completed his training in Endocrinology and Diabetes in Rome, Italy. In 2016, he joined the Institute of Metabolism and Systems Research at the University of Birmingham. Since 2018, he is a Diabetes UK Sir George Alberti Research Fellow and is currently working towards a PhD. The title of his PhD thesis is "Exploring the metabolic impact of mild autonomous cortisol excess (MACE), an underestimated cause of diabetes". His academic supervisors are Professor Wiebke Arlt and Dr Konstantinos Manolopoulos.

Dr Prete’s area of research interest focuses on the cardio-metabolic impact of autonomous cortisol secretion associated with adrenal tumours, as well as improving the therapeutic management of patients with adrenal insufficiency. See 'Stress hormones and risk of Type 2 diabetes' for more information about Dr Prete's area of research.

Qualifications

Associate member of the Royal College of Physicians, 2020
CCT in Endocrinology and Diabetes Mellitus (Catholic University of the Sacred Heart, Rome, Italy), 2016
Full registration with licence to practice, General Medical Council, UK, 2016
Full registration with licence to practice, General Medical Council, Italy, 2010
MBBS Summa Cum Laude (Catholic University of the Sacred Heart, Rome, Italy), 2010

Biography

In 2016, Dr Alessandro Prete successfully obtained funding from the European Society of Endocrinology, which allowed him to join the Institute of Metabolism and Systems Research at the University of Birmingham. Here, he gathered experiences in steroid mass spectrometry, human in vivo physiology studies and clinical trials guided by his supervisors, Professor Wiebke Arlt and Dr Konstantinos Manolopoulos.

In 2017, Dr Prete obtained a Birmingham Mayo Clinic Academic Exchange visiting fellowship and worked with Dr Irina Bancos at the Department of Endocrinology at the Mayo Clinic, Rochester, USA.

Diabetes UK awarded Dr Prete in 2018 with a Sir George Alberti Research Fellowship, which is allowing him to carry out his research and training project for his PhD. Dr Prete’s research focuses on the cardio-metabolic impact of mild autonomous cortisol excess (MACE) associated with incidentally discovered adrenal tumours, a very common condition also known as subclinical Cushing’s syndrome.

Other activities

Dr Alessandro Prete works as an Honorary Consultant in Endocrinology at the Queen Elizabeth Hospital Birmingham. He cares for patients suffering with adrenal tumours, Cushing’s syndrome, adrenal insufficiency, and congenital adrenal hyperplasia.

Since 2019, Dr Alessandro Prete is a member of the Scientific Advisory Committee of the NIHR/Wellcome Trust Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, where he also works as an investigator for several clinical trials recruiting patients with congenital adrenal hyperplasia, adrenal insufficiency, and adrenal tumours.

Dr Prete also serves as a member of the Editorial Board of Associazione Medici Endocrinology (AME, Italian Society of Endocrinology).

Publications

Recent publications

Article

Lippert, J, Smith, G, Appenzeller, S, Landwehr, L-S, Prete, A, Steinhauer, S, Asia, M, Urlaub, H, Elhassan, Y, Kircher, S, Arlt, W, Fassnacht, M, Altieri, B & Ronchi, C 2024, 'Circulating cell-free DNA-based biomarkers for prognostication and disease monitoring in adrenocortical carcinoma', European Journal of Endocrinology. https://doi.org/10.1093/ejendo/lvae022

Aggarwal, S, Prete, A, Chortis, V, Asia, M, Sutcliffe, R, Arlt, W, Ronchi, C, Karavitaki, N, Ayuk, J & Elhassan, Y 2024, 'Pheochromocytomas Most Commonly Present As Adrenal Incidentalomas: A Large Tertiary Center Experience', European Journal of Endocrinology, vol. 109, no. 1, pp. e389–e396. https://doi.org/10.1210/clinem/dgad401

Prete, A, Lang, K, Pavlov, D, Rhayem, Y, Sitch, AJ, Franke, AS, Gilligan, LC, Shackleton, CHL, Hahner, S, Quinkler, M, Dekkers, T, Deinum, J, Reincke, M, Beuschlein, F, Biehl, M & Arlt, W 2024, 'Urine steroid metabolomics as a diagnostic tool in primary aldosteronism', The Journal of Steroid Biochemistry and Molecular Biology, vol. 237, 106445. https://doi.org/10.1016/j.jsbmb.2023.106445

Schiffer, L, Kempegowda, P, Sitch, AJ, Adaway, JE, Shaheen, F, Ebbehoj, A, Singh, S, Mctaggart, MP, O’reilly, MW, Prete, A, Hawley, JM, Keevil, BG, Bancos, I, Taylor, AE & Arlt, W 2023, 'Classic and 11-oxygenated androgens in serum and saliva across adulthood: a cross-sectional study analyzing the impact of age, body mass index, and diurnal and menstrual cycle variation', European Journal of Endocrinology, vol. 188, no. 1, lvac017. https://doi.org/10.1093/ejendo/lvac017

Knowles, G, Warmington, E, Shepherd, LM, Hazlehurst, JM, de Bray, A, Gleeson, H, Arlt, W & Prete, A 2023, 'Impact of coronavirus disease 2019 on patients with primary adrenal insufficiency: a cross-sectional study', Endocrine Connections, vol. 12, no. 8, e230122. https://doi.org/10.1530/EC-23-0122

Favero, V, Prete, A, Mangone, A, Elhassan, Y, Pucino, V, Asia, M, Hardy, R, Chiodini, I & Ronchi, C 2023, 'Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess: a retrospective single centre study', European Journal of Endocrinology, vol. 183, lvad151, pp. 517-526. https://doi.org/10.1093/ejendo/lvad151

Mangone, A, Altieri, B, Detomas, M, Prete, A, Abbas, H, Asia, M, Elhassan, Y, Mantovani, G & Ronchi, C 2023, 'Inflammation-based scores as predictors of treatment response in advanced adrenocortical carcinoma', Endocrine-related cancer, vol. 30, no. 4, e220372. https://doi.org/10.1530/ERC-22-0372

Lippert, J, Dischinger, U, Appenzeller, S, Prete, A, Kircher, S, Skordilis, K, Elhassan, YS, Altieri, B, Fassnacht, M & Ronchi, CL 2023, 'Performance of DNA-based biomarkers for classification of adrenocortical carcinoma: a prognostic study', European Journal of Endocrinology , vol. 189, no. 2, pp. 262-270. https://doi.org/10.1093/ejendo/lvad112

Prete, A, Taylor, A & Brown, MJ 2023, '[11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial', Nature Medicine, vol. 29, no. 1, pp. 190-202. https://doi.org/10.1038/s41591-022-02114-5

Mangone, A, Yousuf, Q, Arlt, W, Prete, A, Shaheen, F, Krishnasamy, S-K, Elhassan, Y & Ronchi, C 2022, 'A case of unilateral post-COVID-19 adrenal haemorrhage and follow-up during pregnancies', Endocrinology, diabetes & metabolism case reports, vol. 2022, no. 1, 22-0337. https://doi.org/10.1530/EDM-22-0337

Deutschbein, T, Reimondo, G, Di Dalmazi, G, Bancos, I, Patrova, J, Vassiliadi, DA, Nekić, AB, Debono, M, Lardo, P, Ceccato, F, Petramala, L, Prete, A, Chiodini, I, Ivović, M, Pazaitou-panayiotou, K, Alexandraki, KI, Hanzu, FA, Loli, P, Yener, S, Langton, K, Spyroglou, A, Kocjan, T, Zacharieva, S, Valdés, N, Ambroziak, U, Suzuki, M, Detomas, M, Puglisi, S, Tucci, L, Delivanis, DA, Margaritopoulos, D, Dusek, T, Maggio, R, Scaroni, C, Concistrè, A, Ronchi, CL, Altieri, B, Mosconi, C, Diamantopoulos, A, Iñiguez-ariza, NM, Vicennati, V, Pia, A, Kroiss, M, Kaltsas, G, Chrisoulidou, A, Marina, LV, Morelli, V, Arlt, W, Letizia, C, Boscaro, M, Stigliano, A, Kastelan, D, Tsagarakis, S, Athimulam, S, Pagotto, U, Maeder, U, Falhammar, H, Newell-price, J, Terzolo, M & Fassnacht, M 2022, 'Age-dependent and sex-dependent disparity in mortality in patients with adrenal incidentalomas and autonomous cortisol secretion: an international, retrospective, cohort study', The Lancet Diabetes and Endocrinology, vol. 10, no. 7, pp. 499-508. https://doi.org/10.1016/S2213-8587(22)00100-0

Prete, A, Subramanian, A, Bancos, I, Chortis, V, Tsagarakis, S, Lang, K, Macech, M, Delivanis, D, Pupovac, I, Reimondo, G, Marina, L, Deutschbein, T, Balomenaki, M, O'reilly, M, Gilligan, L, Jenkinson, C, Bednarczuk, T, Zhang, C, Dusek, T, Diamantopoulos, A, Asia, M, Kondracka, A, Li, D, Masjkur, J, Quinkler, M, Ueland, G, Dennedy, C, Beuschlein, F, Tabarin, A, Fassnacht, M, Ivovic, M, Terzolo, M, Kastelan, D, Young Jr, W, Manolopoulos, K, Ambroziak, U, Vassiliadi, D, Taylor, A, Sitch, A, Nirantharakumar, K & Arlt, W 2022, 'Cardiometabolic disease burden and steroid excretion in benign adrenal tumors: a cross-sectional multicenter study', Annals of internal medicine, vol. 175, no. 3, pp. 325-334. https://doi.org/10.7326/M21-1737

Merke, DP, Mallappa, A, Arlt, W, Perriere, ABDL, Hirschberg, AL, Juul, A, Newell-Price, J, Perry, CG, Prete, A, Rees, A, Reisch, N, Stikkelbroeck, N, Tourraine, P, Maltby, K, Treasure, P, Porter, J & Ross, RJ 2021, 'Modified-release hydrocortisone in congenital 1 adrenal hyperplasia', Journal of Clinical Endocrinology and Metabolism, vol. 2021, no. 00, pp. 1-15. https://doi.org/10.1210/clinem/dgab051

Prete, A, Taylor, AE, Bancos, I, Smith, DJ, Foster, MA, Kohler, S, Fazal-Sanderson, V, Komninos, J, O'Neil, DM, Vassiliadi, DA, Mowatt, CJ, Mihai, R, Fallowfield, JL, Annane, D, Lord, JM, Keevil, BG, Wass, JAH, Karavitaki, N & Arlt, W 2021, 'Response to Letter to the Editor from Chee et al: "Prevention of Adrenal Crisis: Cortisol Response to Major Stress Compared to Stress Dose Hydrocortisone Delivery"', The Journal of clinical endocrinology and metabolism, vol. 106, no. 1, pp. e407-e408. https://doi.org/10.1210/clinem/dgaa719

Comment/debate

Chortis, V, Sitch, AJ, Bancos, I, Prete, A, Taylor, AE, Biehl, M, Deeks, JJ & Arlt, W 2021, 'Comment on "A Modern Assessment of Cancer Risk in Adrenal Incidentalomas: Analysis of 2219 Patients" by Kahramangil B et al', Annals of surgery, vol. 274, no. 6, pp. e887-e888. https://doi.org/10.1097/SLA.0000000000004804

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