Dr Vicki E. Smith PhD

Vicki Smith

Institute of Metabolism and Systems Research
Lecturer in Molecular Endocrinology, BBSRC New Investigator Award Holder

Contact details

Address
Centre for Endocrinology, Diabetes and Metabolism, 2nd Floor IBR
Institute of Metabolism and Systems Research
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Vicki is a Lecturer in Molecular Endocrinology in the Institute of Metabolism and Systems Research at the University of Birmingham. Her current research interests are focussed on enhancing radioiodine uptake in thyroid and breast cancer and investigating the molecular pathogenesis of thyroid disease, particularly the signalling pathways that contribute to thyroid cancer growth and progression.

 Vicki has authored a number of publications and has presented data at both national and international conferences on Endocrinology and Thyroidology. Her research has attracted funding from the MRC, Wellcome Trust, British Thyroid Foundation and Society for Endocrinology, and she has won a number of awards including the Society for Endocrinology Young Endocrinologist Prize Lecture and the Journal of Molecular Endocrinology Prize.

Qualifications

  • PhD in Medicine, University of Birmingham (2008)
  • BSc (Hons) in Medical Biochemistry, University of Leicester (2000)

Biography

Vicki qualified with a BSc (Hons) in Medical Biochemistry from the University of Leicester in 2000. She then spent over four years working for a biopharmaceutical company in Oxfordshire, identifying potential drug targets using genetic analyses of large patient cohorts.

 Vicki subsequently moved to Birmingham to study for a PhD in Medicine, under the supervision of Professors Chris McCabe and Jayne Franklyn, which she completed in 2008. She continued to work in the Centre for Endocrinology, Diabetes and Metabolism as an MRC Post-Doctoral Research Fellow with a brief visit to the lab of Professor James Fagin at the Memorial Sloan-Kettering Cancer Center in New York.

Vicki has a growing list of peer-reviewed research papers and reviews, and has presented her data at conferences both nationally and internationally. Her research has attracted a number of major grants and awards.

Following her recent appointment as Lecturer in the Institute of Metabolism and Systems Research Vicki is currently establishing her independent research group. She has an active teaching role within the University and sits on the Postdoctoral / Early Researcher Career Development And Training (PERCAT) committee. 

Externally, Vicki is an active member of the Society for Endocrinology and currently sits on the Science Committee.

Teaching

Postgraduate supervision

Vicki supervises PhD students on the following projects:

  • A New Therapeutic Target to Facilitate Radioiodide Treatment of Breast Cancer 
  • The Regulation of Sodium Iodide Symporter (NIS) Trafficking and Targeting in Differentiated Thyroid Cancer
Novel Functional Binding Partners of the Sodium Iodide Symporter

Research

Vicki’s research interests are centred on thyroid biology and the molecular pathogenesis of thyroid disease. She is particularly interested in the signalling pathways that mediate normal thyroid growth and function and are dysregulated in thyroid cancer and goitre. With a longstanding interest in investigating the repression of the iodide transporter NIS in thyroid cancer Vicki has recently identified a possible new therapeutic strategy to improve critical radioiodine treatment in thyroid tumours. She is currently interested in exploring the possibility of applying these strategies to induce radioiodine uptake in other tumour types such as breast cancer. These investigations include in vitro culture systems, animal models and human tissue to combine fundamental and translational research.

Other activities

Commitee Membership

  • Society for Endocrinology Science Committee member
  • Society for Endocrinology Programme Organising Committee member
  • British Thyroid Association Executive Committee

Society Membership

  • Society for Endocrinology                              
  • British Thyroid Association                             
  • American Thyroid Association           
  • European Society for Endocrinology              
  • British Thyroid Foundation

Peer Review

  • Endocrine-Related Cancer [I.F. = 5.3]           
  • Journal of Molecular Endocrinology [I.F. = 3.6]
  • Journal of Endocrinological Investigation [I.F. = 1.5] 
  • Oncogene [I.F. = 8.6] 
  • Journal of Endocrinology [I.F. = 3.9]  
  • Endocrine Connections
  • Oncotarget [I.F. = 6.4]

Publications

Recent publications

Article

Fletcher, A, Read, M, Thornton, C, Larner, D, Poole, V, Brookes, K, Nieto, H, Alshahrani, M, Thompson, R, Lavery, G, Landa, I, Fagin, JA, Campbell, MJ, Boelaert, K, Turnell, A, Smith, V & McCabe, C 2020, 'Targeting novel sodium iodide symporter interactors ADP-ribosylation factor 4 and valosin-containing protein enhances radioiodine uptake', Cancer Research, vol. 80, no. 1, pp. 102–115. https://doi.org/10.1158/0008-5472.CAN-19-1957

Thompson, RJ, Fletcher, A, Brookes, K, Nieto, H, Alshahrani, MM, Mueller, JW, Fine, NHF, Hodson, DJ, Boelaert, K, Read, ML, Smith, VE & McCabe, CJ 2019, 'Dimerization of the sodium/iodide symporter', Thyroid, vol. 29, no. 10, pp. 1485-1498. https://doi.org/10.1089/thy.2019.0034

Alshahrani, M, Fletcher, A, Thornton, C, Brookes, K, Nieto, H, Thompson, R, Read, M, Boelaert, K, McCabe, C & Smith, V 2018, 'Biochemical analysis of radioiodine uptake enhancement in endocrine cancer', Endocrine Abstracts, vol. 59, OC2.4. https://doi.org/10.1530/endoabs.59.OC2.4

Read, M, Modasia, B, Fletcher, A, Thompson, R, Brookes, K, Rae, P, Nieto, H, Poole, V, Roberts, S, Campbell, M, Boelaert, K, Turnell, A, Smith, V, Mehanna, H & McCabe, C 2018, 'PTTG and PBF functionally interact with p53 and predict overall survival in head and neck cancer', Cancer Research, vol. 78, no. 20, pp. 5863-5876. https://doi.org/10.1158/0008-5472.CAN-18-0855

Read, M, Fong, J, Modasia, B, Fletcher, A, Imruetaicharoenchoke, W, Thompson, R, Nieto, H, Reynolds, J, Bacon, A, Mallick, U, Hackshaw, A, Watkinson, J, Boelaert, K, Turnell, A, Smith, V & McCabe, C 2017, 'Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer', Oncogene, vol. 36, pp. 5296–5308. https://doi.org/10.1038/onc.2017.154

Imruetaicharoenchoke, W, Fletcher, A, Lu, W, Watkins, RJ, Modasia, B, Poole, V, Nieto, H, Thompson, R, Boelaert, K, Read, M, Smith, V & McCabe, C 2017, 'Functional consequences of the first reported mutations of the proto-oncogene PTTG1IP/PBF', Endocrine-related cancer, vol. 24, no. 9, pp. 459-474. https://doi.org/10.1530/ERC-16-0340

Abstract

Read, M, Brookes, K, Fletcher, A, Thornton, C, Alshahrani, M, Khan, R, Nieto, H, Adcock, H, Webster, J, Cox, L, Alderwick, L, Boelaert, K, Smith, V & McCabe, C 2020, 'Drug repurposing identifies inhibitors of the proteostasis network to augment radioiodine uptake in combinatorial approaches targeting thyroid cancer', Journal of the Endocrine Society, vol. 4, no. Issue Supplement 1, OR28-03. https://doi.org/10.1210/jendso/bvaa046.2135

Read, M, Brookes, K, Fletcher, A, Thornton, C, Alshahrani, M, Nieto, H, Khan, R, Webster, J, Haggie, P, Verkman, A, Alderwick, L, Boelaert, K, Smith, V & McCabe, C 2019, 'A high-throughput yellow fluorescent protein (YFP) cell-based screen identifies autophagy modulators to increase the effectiveness of radioiodine therapy', Endocrine Abstracts, vol. 65, OC4.1. https://doi.org/10.1530/endoabs.65.OC4.1

Fletcher, A, Thompson, R, Read, M, Turnell, A, Smith, V & McCabe, C 2018, 'Abstract LB-327: Identification of novel sodium iodide symporter (NIS) interactors which modulate iodide uptake', Cancer Research, vol. 78, no. 13 Supplement, pp. LB327-LB327. https://doi.org/10.1158/1538-7445.AM2018-LB-327

Read, M, Modasia, B, Fletcher, A, Thompson, R, Brookes, K, Nieto, H, Campbell, M, Boelaert, K, Turnell, A, Smith, V, Mehanna, H & McCabe, C 2018, 'Oncogenic action of pituitary-tumor transforming gene (PBF) in head and neck cancer is associated with poorer overall survival', Endocrine Abstracts, vol. 59, P119. https://doi.org/10.1530/endoabs.59.P119

Read, M, Modasia, B, Fletcher, A, Thompson, R, Baker, K, Boelaert, K, Turnell, A, Smith, V, Mehanna, H & McCabe, C 2018, 'PO-124 PTTG and PBF functionally interact with P53 and predict overall survival in head and neck cancer', ESMO Open, vol. 3, no. Suppl. 2, pp. A69-A69. https://doi.org/10.1136/esmoopen-2018-EACR25.165

Read, M, Baker, K, Thornton, C, Alshahrani, M, Fletcher, A, Thompson, R, Haggie, P, Verkman, A, Boelaert, K, Smith, V & McCabe, C 2018, 'Yellow fluorescent protein (YFP) as a biosensor for intracellular iodide in thyroid cancer cells', The 66th British Thyroid Association Annual Meeting, Birmingham, United Kingdom, 14/05/18 - 15/05/18.

Read, M, Smith, J, Hoffman, J, Smith, V, Morgan, N, Campbell, C, Wake, N, Watkinson, J, Wallis, Y, Maher, E, McCabe, C & Woodward, E 2017, 'A novel ESR2 frameshift mutation predisposes to medullary thyroid carcinoma and causes inappropriate RET expression', Thyroid Research, vol. 10(Suppl 1), no. 2, P4, pp. 5. https://doi.org/10.1186/s13044-016-0036-8

Read, M, Fong, J, Imruetaicharoenchoke, W, Modasia, B, Nieto, H, Fletcher, A, Thompson, R, Sharma, N, Watkinson, J, Turnell, A, Boelaert, K, Smith, V & McCabe, C 2017, 'Comparative analysis of human and mouse expression data identifies proto-oncogene PTTG- and PBF-associated genes in thyroid cancer', Thyroid Research, vol. 10(Suppl 1), no. 2. https://doi.org/10.1186/s13044-016-0036-8

Poole, V, Fletcher, A, Modasia, B, Sharma, N, Thompson, R, Imruetaicharoenchoke, W, Read, M, Boelaert, K, McCabe, C & Smith, V 2017, 'Pharmacological enhancement of radioiodine uptake using Src kinase inhibitors', Thyroid Research, vol. 10(Suppl 1), no. 2, O2, pp. 2. https://doi.org/10.1186/s13044-016-0036-8

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