Dr Angela E Taylor PhD

Dr Angela Taylor

Department of Metabolism and Systems Science
Senior Research Fellow
Academic Lead Steroid Metabolome Analysis Core

Contact details

Address
Steroid Metabolome Analysis Core (SMAC)
Medical School
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Angela is an analytical chemist who leads the research of the Steroid Metabolome Analysis Core (SMAC). SMAC is a team consisting of scientists, who develop, optimise and validate mass spectrometry methods which are applied to laboratory-based research, clinical research and clinical trials.

Angela’s research interest is the study of steroid metabolism in health and disease, including cancer, infertility, stress, trauma and metabolism. Investigating a number of different biological matrices such as urine, serum, plasma, cell culture media, tears, aqueous humour, micro-dialysis fluid, follicular fluid and bronchiolar fluid.

SMAC logo

The Steroid Metabolome Analysis Core (SMAC) is an internationally recognised group investigating steroid metabolism in health and disease. SMAC has research collaborators in 15 countries. Over the last 10 years, SMAC has supported more than 140 different projects. The SMAC group has published high quality, high impact research papers all centred around steroid analysis by mass spectrometry.

ORCID ID: 0000-0002-5835-5643

Qualifications

  • PhD, Swansea University, 2009
  • MChem, Swansea University, 2009

Biography

Angela has an analytical chemistry master’s degree from Swansea University (2005). In 2009 she received her PhD from Swansea University investigating steroid metabolism in the human endometrium using mass spectrometry. This was followed by post-doctoral work at the University of Birmingham working for Prof Wiebke Arlt, which cumulated in setting up the SMAC facility in 2016. The SMAC lab now conducts steroid research from wet lab based projects to clinical trials.

Teaching

  • BMed Sci
  • MBChB
  • Yearly final year Biomedical scientist dissertations
  • Summer studentships
  • Lab visitor training

Research

Angela is interested in steroid metabolism in health and disease. Angela's role involves the development of highly sensitivity, high throughput, well validated mass spectrometry assays for steroid analysis. Her research applies these assays to answer important clinical questions.

Other activities

Publications

Recent publications

Article

Watson, AH, Gilligan, LC, Taylor, AE, Arlt, W & Syme, HM 2025, 'Determination of multi‐steroid profiles of cats with hyperaldosteronism or other diseases: A retrospective study', Journal of Veterinary Internal Medicine, vol. 39, no. 5, e70209. https://doi.org/10.1111/jvim.70209

Ng, E, Lee, Y-N, Taylor, A, Shaheen, F, Azizan, E, Drake, WM & Brown, MJ 2025, 'Evaluation of Aldosterone Suppression by Cinnarizine, a Putative Cav1.3 Inhibitor', Journal of Clinical Endocrinology and Metabolism, vol. 110, no. 10, pp. 2752-2761. https://doi.org/10.1210/clinem/dgaf081

McDonnell, T, Anthony, AV, Clarke, G, Schiffer, L, Taylor, AE, Cussen, L, Fan, Y, Hann, A, Mao, J, Shaheen, F, Miller, C, McIlroy, M, Jacob, B, Sherlock, M, Afford, SC, Storbeck, K-H, Arlt, W & O’Reilly, MW 2025, 'Hepatic metabolism of 11-oxygenated androgens in humans: an integrated in vivo and ex vivo approach', European Journal of Endocrinology , vol. 193, no. 3, pp. 340-347. https://doi.org/10.1093/ejendo/lvaf166

Turner, JD, Tsapparelli, J, Gilligan, LC, Pucino, V, Bandeira, M, Baranskaya, A, Rauz, S, Poveda-Gallego, A, Higham, J, Richards, A, Brown, RM, Bowman, SJ, Taylor, AE, Nayar, S & Fisher, BA 2025, 'Hormonal risk factors and androgen and glucocorticoid dysregulation in Sjogren’s disease and non-Sjogren's sicca', Rheumatology. https://doi.org/10.1093/rheumatology/keaf546

Lawrence, NR, Dawson, J, Lang, Z-Q, Prete, A, Baranowski, ES, Schiffer, L, Taylor, AE, Brac de la Perrière, A, Hirschberg, AL, Juul, A, Merke, DP, Newell-Price, J, Rees, DA, Reisch, N, Stikkelbroeck, N, Touraine, PA, Krone, N, Keevil, B, Collins, GS, Arlt, W & Ross, RJM 2025, 'Modelling adrenal steroid profiles to inform monitoring guidance in congenital adrenal hyperplasia', EBioMedicine, vol. 116, 105749. https://doi.org/10.1016/j.ebiom.2025.105749

Gjorgoska, M, Taylor, AE, Smrkolj, Š & Rižner, TL 2025, 'Multi-Steroid Profiling and Machine Learning Reveal Androgens as Candidate Biomarkers for Endometrial Cancer Diagnosis: A Case-Control Study', Cancers, vol. 17, no. 10, 1679. https://doi.org/10.3390/cancers17101679

Rate control Therapy Evaluation in permanent Atrial Fibrillation (RATE-AF) trial team, Akoumianakis, I, Gilligan, L, Bunting, K, Fobian, D, Kirchhof, P, Arlt, W, Taylor, AE, Pavlovic, D & Kotecha, D 2025, 'Quantification and impact of circulating cardiotonic steroids in the RATE-AF randomised trial of patients with atrial fibrillation and heart failure', BMC Medicine.

Crastin, A, Shanker, A, Sagmeister, MS, Taylor, A, Lavery, GG, Raza, K & Hardy, RS 2025, 'Vamorolone: a novel metabolism resistant steroid that suppresses joint destruction in chronic polyarthritis with reduced systemic side effects', Rheumatology, vol. 64, no. 7, pp. 4371-4381. https://doi.org/10.1093/rheumatology/keaf129

Wälchli-Popovic, M, Monnerat, S, Taylor, AE, Gilligan, LC, Schiffer, L, Arlt, W, Vogt, DR, De Geyter, C, Hutter, N, Donath, MY, Sartorius, G & Christ-Crain, M 2024, 'Effects of interleukin-1 receptor antagonism in women with polycystic ovary syndrome—the FertIL trial', Frontiers in Endocrinology, vol. 15, 1435698. https://doi.org/10.3389/fendo.2024.1435698

Sampson, OL, Jay, C, Adland, E, Csala, A, Lim, N, Ebbrecht, SM, Gilligan, LC, Taylor, AE, George, SS, Longet, S, Barnes, E, Frater, J, Klenerman, P, Dunachie, S, Carrol, M, Hawley, J, Arlt, W, Groll, A & Goulder, P 2024, 'Gonadal androgens are associated with decreased type I interferon production by plasmacytoid dendritic cells and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents', Frontiers in immunology, vol. 15, 1329805. https://doi.org/10.3389/fimmu.2024.1329805

Tomkins, M, McDonnell, T, Cussen, L, Sagmeister, M, Oestlund , I, Shaheen, F, Harper, L, Hardy, R, Taylor, A, Gilligan, L, Arlt, W, McIlroy , M, de Freitas , D, Conlon , P, Magee, C, Denton, M, O'Seaghdha, CM, Snoep, JL, Storbeck, K-H, Sherlock, M & O'Reilly, MW 2024, 'Impaired 11β-hydroxysteroid dehydrogenase type 2 activity in chronic kidney disease disrupts 11-oxygenated androgen biosynthesis', Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/clinem/dgae714

Martin, CS, Crastin, A, Sagmeister, MS, Kalirai, MS, Turner, JD, MacDonald, L, Kurowska-Stolarska, M, Scheel-Toellner, D, Taylor, AE, Gilligan, LC, Storbeck, K, Price, M, Gorvin, CM, Filer, A, Mahida, R, Clark, AR, Jones, SW, Raza, K, Hewison, M & Hardy, RS 2024, 'Inflammation Dynamically Regulates Steroid Hormone Metabolism and Action within Macrophages in Rheumatoid Arthritis  ', Journal of Autoimmunity, vol. 147, 103263. https://doi.org/10.1016/j.jaut.2024.103263

Abstract

Prete, A, Bain, JT, Karavitaki, N, Taylor, AE & Arlt, W 2025, 'OR18-04 Urine Steroid Metabolomics and Timed Urine Steroid Profiling: A Novel Test for the Diagnosis and Differential Diagnosis of Cushing’s Syndrome', Journal of the Endocrine Society, vol. 9, no. Supplement_1, bvaf149.276, pp. A148-A150. https://doi.org/10.1210/jendso/bvaf149.276

Tourigny, D, Tucci, L, Elhassan, Y, Skordilis, K, Asia, M, Prete, A, Crastin, A, David Onesimu, ELS, Taylor, AE, Chortis, V & Ronchi, CL 2025, 'OR32-07 Integrated liquid biopsy by ccfDNA and urinary steroid metabolomics for longitudinal monitoring of adrenocortical carcinoma', Journal of the Endocrine Society, vol. 9, no. Supplement_1, bvaf149.284, pp. A153-A154. https://doi.org/10.1210/jendso/bvaf149.284

Lawrence, NR, Krone, NP, Dawson, JF, Lang, ZQ, Arlt, W, Brac de la Perriere, A, Hirschberg, AL, Juul, A, Merke, DP, Newell-Price, JD, Prete, A, Taylor, AE, Rees, A, Reisch, N, Stikkelbroeck, M, Touraine, PA, Collins, G & Ross, RJ 2024, '6437 Analysis of 17-OH-Progesterone (17OHP) and Androstenedione (A4) Profiles To Rationalise Biochemical Monitoring Of CAH Patients', Journal of the Endocrine Society, vol. 8, no. Supplement_1, bvae163.111, pp. A59-A60. https://doi.org/10.1210/jendso/bvae163.111

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