Dr Angela E Taylor PhD

Dr Angela Taylor

Department of Metabolism and Systems Science
Senior Research Fellow
Technology Lead, Steroid Metabolome Analysis Core (SMAC)

Contact details

Telephone
+44 (0) 121 415 58777
Email
a.taylor.5@bham.ac.uk
Twitter
@Angela_E_Taylor
View my research portal
Address
Steroid Metabolome Analysis Core (SMAC)
Medical School
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Dr Angela Taylor is an analytical chemist and endocrine scientist who leads the Steroid Metabolome Analysis Core (SMAC). Her research focuses on hormone metabolomics, including steroid, thyroid and vitamin D metabolism, biomarker discovery, and translational endocrine research.

Qualifications

  • PhD in Chemistry, Swansea University, 2009
  • MChem in Chemistry, Swansea University, 2009

Biography

Dr Angela Taylor is a Senior Research Fellow and Technology Lead of the Steroid Metabolome Analysis Core (SMAC) within the Department of Metabolism and Systems Science at University of Birmingham.

Angela is an analytical chemist and endocrine scientist with over 17 years of experience in mass spectrometry-based metabolomics, hormone analysis and translational endocrine research. Following completion of her MChem and PhD in Chemistry at Swansea University, she joined the University of Birmingham in 2009 and has since played a key role in establishing SMAC as an internationally recognised facility supporting endocrine, metabolic and clinical research.

As Technology Lead of SMAC, Angela provides scientific and analytical leadership across laboratory-based research, clinical studies and multicentre clinical trials. Her expertise spans experimental design, assay development and validation, quality assurance, quantitative metabolomics and application of advanced liquid chromatography mass spectrometry and gas chromatography mass spectrometry (LC-MS/MS and GC-MS) technologies to human disease.

Her research focuses on understanding hormone metabolism in health and disease, with particular interests in steroid and androgen metabolism, thyroid hormone metabolism, adrenal diseases, reproductive endocrinology, congenital adrenal hyperplasia, poly metabolic ovary syndrome, hypertension and cardiometabolic disease.

Angela's work combines analytical innovation with clinical translation, contributing to major international studies aimed at improving diagnosis, patient stratification and treatment monitoring through novel biomarker approaches.

She currently contributes analytical leadership to research programmes investigating endocrine and metabolic disease and has authored more than 80 peer-reviewed publications and reviews and collaborates extensively with academic, clinical and industry partners nationally and internationally.

Under Angela's leadership, SMAC supports collaborations across academia, healthcare and industry, providing specialist expertise to national and international research programmes.

Alongside her research activities, Angela is committed to developing the next generation of scientists through teaching, supervision mentorship and specialist training in endocrinology, metabolomics and mass spectrometry.

Teaching

Module Lead, Endocrinology and Metabolism Stream, Biomedical Research MRes

Angela leads the Endocrinology and Metabolism stream of the Biomedical Research MRes programme, delivering teaching in endocrinology, steroid biology, metabolomics and translational biomedical research.

Angela contributes to undergraduate and postgraduate teaching in Biomedical Science and Medicine with a focus on:

  • Endocrinology
  • Steroid metabolism
  • Thyroid hormone metabolism
  • Metabolomics
  • Mass spectrometry
  • LC-MS/MS & GC-MS
  • Biomarker discovery
  • Analytical method development

She supervises undergraduate, MSc and PhD research projects and provides specialist analytical training through SMAC.

Metabolism and Systems Science Summer School

Angela also leads the Metabolism and Systems Science Summer School, which offers undergraduate research internships across the Department and provides students with hands-on laboratory research experience in metabolism and endocrinology.

Postgraduate supervision

Angela welcomes enquiries from prospective postgraduate students interested in postgraduate research. She has experience supervising undergraduate, MSc and PhD researchers working across analytical chemistry, pharmacy, medicine, biochemistry, endocrinology and metabolomics.

Research

Angela's research combines analytical chemistry, endocrinology and metabolomics to investigate hormone metabolism in health and disease.

As Technology Lead of the Steroid Metabolome Analysis Core (SMAC), she develops and applies highly sensitive and rigorously validated mass spectrometry methods for quantitative hormone profiling and biomarker discovery. Her work supports laboratory research, clinical studies and multicentre clinical trials across a broad range of disease areas from infertility to cancers, hormone excess to hypertension.

Steroid and Hormone Metabolomics

Development and application of LC-MS/MS methods for comprehensive profiling of hormone metabolic pathways.

Adrenal Disease

Investigation of novel biomarkers for the diagnosis, subtyping and treatment monitoring of adrenal disease, including primary aldosteronism.

Reproductive Endocrinology

Research into hormone metabolism in poly metabolic ovarian syndrome, infertility, recurrent pregnancy loss and endometriosis.

Thyroid Hormone Metabolism

Investigation of thyroid hormone metabolism and action in human health and disease. Research focuses on the development of sensitive analytical approaches to characterise thyroid hormone pathways and identify biomarkers associated with endocrine and reproductive disorders.

Cardiometabolic Disease & Hypertension

Understanding the role of steroid metabolism in obesity, insulin resistance, hypertension and cardiovascular disease.

Vitamin D Metabolism

Application of mass spectrometry-based approaches to measure vitamin D metabolites and investigate their role in endocrine health, fertility, pregnancy outcomes and cardiometabolic disease.

Translational Endocrine Science

Application of hormone metabolomics to improve diagnosis, patient stratification and precision medicine approaches.

Collaborations

Through the Steroid Metabolome Analysis Core (SMAC), Angela collaborates with academic, clinical and industry partners in the UK and internationally. The facility supports a wide range of projects, from pilot studies and method development to lab based projects, large-scale clinical studies and multicentre clinical trials.

SMAC provides expertise in:

  • Steroid, thyroid hormone and vitamin D metabolomics
  • Assay development and validation
  • Biomarker discovery and translation
  • Endocrine and metabolic phenotyping
  • Clinical trial sample analysis
  • Study design and analytical strategy
  • Quantitative hormone profiling across diverse biological matrices

Angela welcomes opportunities for new research collaborations in endocrinology, metabolism, reproductive health, adrenal disease, cardiometabolic disease and biomarker development.

For more information see: Steroid Metabolome Analysis Core (SMAC) - University of Birmingham or email her directly a.taylor.5@bham.ac.uk

Publications

Recent publications

Article

Bain, JT, Shaheen, F, Prete, A, Gilligan, LC & Taylor, AE 2026, 'Comprehensive Quantitative Urinary Steroid Profiling of 29 Steroids Using Liquid Chromatography-Tandem Mass Spectrometry', Analytical Sciences Advances, vol. 7, no. 1, e70087. https://doi.org/10.1002/ansa.70087

Sagmeister, MS, Crastin, A, Welsh, B, Firkins, L, Cassidy, B, Nicholson, T, Hopkin, SJ, Wall, N, Taylor, AE, Kieswich, JE, Yaqoob, MM, Lavery, G, Chimen, M, McGettrick, HM, Iqbal, AJ, Breen, L, Jones, SW, Harper, L & Hardy, RS 2026, 'Divergent Roles of Skeletal Muscle 11β-HSD1 in Age-Related and Chronic Kidney Disease-Associated Sarcopenia', European Journal of Endocrinology . https://doi.org/10.1093/ejendo/lvag075

Prete, A, Abdi, L, Canducci, M, van den Brandhof, EL, Albors-Zumel, A, Jenkinson, C, Gilligan, LC, Zhang, Y, Visser, L, Chortis, V, Najdekr, L, Jankevics, A, Lloyd, GR, Winder, CL, Tsagarakis, S, Lang, K, Macech, M, Fell, V, Vodanovic, ID, Reimondo, G, Marina, LV, Deutschbein, T, Balomenaki, M, O'Reilly, MW, Bednarczuk, T, Dusek, T, Diamantopoulos, A, Asia, M, Kondracka, A, Yu, K, Masjkur, JR, Quinkler, M, Ueland, GÅ, Dennedy, MC, Beuschlein, F, Tabarin, A, Fassnacht, M, Ivovic, M, Terzolo, M, Kastelan, D, Young, Jr., WF, Manolopoulos, KN, Ambroziak, U, Vassiliadi, DA, Bancos, I, Sitch, AJ, Taylor, AE, Tino, P, Biehl, M, Dunn, WB, Arlt, W & ENSAT EURINE-ACT Investigators 2026, 'Endocrine and metabolic determinants of cardiometabolic risk in mild autonomous cortisol secretion', EBioMedicine, vol. 124, 106126. https://doi.org/10.1016/j.ebiom.2026.106126

Humby, T, Shepherd, FR, Elgie, T, Anderson-Watkins, L, Beevors, LI, Taylor, AE, Foster, PA & Davies, W 2026, 'Physiological and Behavioural Characterisation of a Novel Steroid Sulfatase-Deficient Mouse', Genes, Brain and Behavior, vol. 25, no. 4, e70061. https://doi.org/10.1111/gbb.70061

Simitsidellis, I, Ainslie, RJ, Taylor, AE, Gilligan, LC, Shaheen, F, Blanke, S, Anderson, C, Hapangama, D, Arlt, W, Horne, A, Saunders, PTK & Gibson, DA 2026, 'Steroid hormone profiling reveals altered adrenal androgen production in endometriosis', European Journal of Endocrinology, vol. 195, no. 1, pp. 22-34. https://doi.org/10.1093/ejendo/lvag109

Watson, AH, Gilligan, LC, Taylor, AE, Arlt, W & Syme, HM 2025, 'Determination of multi‐steroid profiles of cats with hyperaldosteronism or other diseases: A retrospective study', Journal of Veterinary Internal Medicine, vol. 39, no. 5, e70209. https://doi.org/10.1111/jvim.70209

Ng, E, Lee, Y-N, Taylor, A, Shaheen, F, Azizan, E, Drake, WM & Brown, MJ 2025, 'Evaluation of Aldosterone Suppression by Cinnarizine, a Putative Cav1.3 Inhibitor', Journal of Clinical Endocrinology and Metabolism, vol. 110, no. 10, pp. 2752-2761. https://doi.org/10.1210/clinem/dgaf081

McDonnell, T, Anthony, AV, Clarke, G, Schiffer, L, Taylor, AE, Cussen, L, Fan, Y, Hann, A, Mao, J, Shaheen, F, Miller, C, McIlroy, M, Jacob, B, Sherlock, M, Afford, SC, Storbeck, K-H, Arlt, W & O’Reilly, MW 2025, 'Hepatic metabolism of 11-oxygenated androgens in humans: an integrated in vivo and ex vivo approach', European Journal of Endocrinology , vol. 193, no. 3, pp. 340-347. https://doi.org/10.1093/ejendo/lvaf166

Turner, JD, Tsapparelli, J, Gilligan, LC, Pucino, V, Bandeira, M, Baranskaya, A, Rauz, S, Poveda-Gallego, A, Higham, J, Richards, A, Brown, RM, Bowman, SJ, Taylor, AE, Nayar, S & Fisher, BA 2025, 'Hormonal risk factors and androgen and glucocorticoid dysregulation in Sjogren’s disease and non-Sjogren's sicca', Rheumatology. https://doi.org/10.1093/rheumatology/keaf546

Lawrence, NR, Dawson, J, Lang, Z-Q, Prete, A, Baranowski, ES, Schiffer, L, Taylor, AE, Brac de la Perrière, A, Hirschberg, AL, Juul, A, Merke, DP, Newell-Price, J, Rees, DA, Reisch, N, Stikkelbroeck, N, Touraine, PA, Krone, N, Keevil, B, Collins, GS, Arlt, W & Ross, RJM 2025, 'Modelling adrenal steroid profiles to inform monitoring guidance in congenital adrenal hyperplasia', EBioMedicine, vol. 116, 105749. https://doi.org/10.1016/j.ebiom.2025.105749

Gjorgoska, M, Taylor, AE, Smrkolj, Š & Rižner, TL 2025, 'Multi-Steroid Profiling and Machine Learning Reveal Androgens as Candidate Biomarkers for Endometrial Cancer Diagnosis: A Case-Control Study', Cancers, vol. 17, no. 10, 1679. https://doi.org/10.3390/cancers17101679

Rate control Therapy Evaluation in permanent Atrial Fibrillation (RATE-AF) trial team, Akoumianakis, I, Gilligan, LC, Bunting, KV, Fobian, D, Kirchhof, P, Arlt, W, Taylor, AE, Pavlovic, D & Kotecha, D 2025, 'Quantification and impact of circulating cardiotonic steroids in the RATE-AF randomised trial of patients with atrial fibrillation and heart failure', BMC Medicine, vol. 23, no. 1, 694. https://doi.org/10.1186/s12916-025-04476-2

Crastin, A, Shanker, A, Sagmeister, MS, Taylor, A, Lavery, GG, Raza, K & Hardy, RS 2025, 'Vamorolone: a novel metabolism resistant steroid that suppresses joint destruction in chronic polyarthritis with reduced systemic side effects', Rheumatology, vol. 64, no. 7, pp. 4371-4381. https://doi.org/10.1093/rheumatology/keaf129

Abstract

Prete, A, Bain, JT, Karavitaki, N, Taylor, AE & Arlt, W 2025, 'OR18-04 Urine Steroid Metabolomics and Timed Urine Steroid Profiling: A Novel Test for the Diagnosis and Differential Diagnosis of Cushing’s Syndrome', Journal of the Endocrine Society, vol. 9, no. Supplement_1, bvaf149.276, pp. A148-A150. https://doi.org/10.1210/jendso/bvaf149.276

Tourigny, D, Tucci, L, Elhassan, Y, Skordilis, K, Asia, M, Prete, A, Crastin, A, David Onesimu, ELS, Taylor, AE, Chortis, V & Ronchi, CL 2025, 'OR32-07 Integrated liquid biopsy by ccfDNA and urinary steroid metabolomics for longitudinal monitoring of adrenocortical carcinoma', Journal of the Endocrine Society, vol. 9, no. Supplement_1, bvaf149.284, pp. A153-A154. https://doi.org/10.1210/jendso/bvaf149.284

View all publications in research portal

Media experience

Angela has contributed expert commentary and scientific content for the national media and through public engagement activities. She has provided expert input for Which? magazine and the i Paper and is on the Science Media Centre Expert Database. She has experience communicating complex scientific and medical topics to public, patient and professional audiences.