Dr Angela E Taylor PhD

Dr Angela Taylor

Institute of Metabolism and Systems Research
Senior Research Fellow

Contact details

Address
Steroid Metabolome Analysis Core (SMAC)
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Angela is a steroid and analytical chemist who leads and manages the research work of the Steroid Metabolome Analysis Core (SMAC), under the supervision of Professor Wiebke Arlt. SMAC is a team consisting of scientists, who develop, optimise and validate mass spectrometry methods which are applied to laboratory based research, clinical research and clinical trials.

Angela’s research interest is the study of steroid metabolism in health and disease, including cancer, infertility, stress, trauma and metabolism. Investigating a number of different biological matrices such as urine, serum, plasma, cell culture media, tears, aqueous humour, micro-dialysis fluid, follicular fluid and bronchiolar fluid.

These optimised methods have become extremely useful tools for Angela and researchers at the University of Birmingham and beyond, resulting in more than 60 original research articles.

ORCID ID: 0000-0002-5835-5643

Biography

Angela has an analytical chemistry master’s degree from Swansea University (2005). In 2009 she received her PhD from Swansea University investigating steroid metabolism in the human endometrium using mass spectrometry. This was followed by post-doctoral work at the University of Birmingham working for Prof Wiebke Arlt, which cumulated in setting up the SMAC facility in 2016. The SMAC lab now conducts steroid research from wet lab based projects to clinical trials.

Teaching

  • BMed Sci
  • MBChB
  • Yearly final year Biomedical scientist dissertations
  • Summer studentships
  • Lab visitor training

Research

Angela is interested in steroid metabolism in health and disease. Angela's role involves the development of highly sensitivity, high throughput, well validated mass spectrometry assays for steroid analysis. Her research applies these assays to answer important clinical questions.

Other activities

  • Public engagement committee member for Society for Endocrinology 2019- present
  • Co-opted committee member for British Mass Spectrometry Society 2021- present

Publications

Recent publications

Article

Moll, JM, Hofland, J, Teubel, W, Ridder, CMAD, Taylor, A, Graeser, R, Arlt, W, Jenster, G & Van Weerden, W 2022, 'Abiraterone switches castration‐resistant prostate cancer dependency from adrenal androgens towards androgen receptor variants and glucocorticoid receptor signalling', The Prostate. https://doi.org/10.1002/pros.24297

Prete, A, Subramanian, A, Bancos, I, Chortis, V, Tsagarakis, S, Lang, K, Macech, M, Delivanis, D, Pupovac, I, Reimondo, G, Marina, L, Deutschbein, T, Balomenaki, M, O'reilly, M, Gilligan, L, Jenkinson, C, Bednarczuk, T, Zhang, C, Dusek, T, Diamantopoulos, A, Asia, M, Kondracka, A, Li, D, Masjkur, J, Quinkler, M, Ueland, G, Dennedy, C, Beuschlein, F, Tabarin, A, Fassnacht, M, Ivovic, M, Terzolo, M, Kastelan, D, Young Jr, W, Manolopoulos, K, Ambroziak, U, Vassiliadi, D, Taylor, A, Sitch, A, Nirantharakumar, K & Arlt, W 2022, 'Cardiometabolic disease burden and steroid excretion in benign adrenal tumors: a cross-sectional multicenter study', Annals of internal medicine, vol. 175, no. 3, pp. 325-334. https://doi.org/10.7326/M21-1737

Schiffer, L, Shaheen, F, Gilligan, LC, Storbeck, K-H, Hawley, JM, Keevil, BG, Arlt, W & Taylor, AE 2022, 'Multi-steroid profiling by UHPLC-MS/MS with post-column infusion of ammonium fluoride', Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, vol. 1209, 123413. https://doi.org/10.1016/j.jchromb.2022.123413

Snaterse, G, Van Dessel, L, Riet, JV, Taylor, A, Vlugt-Daane, MVD, Hamberg, P, Wit, PRD, Visser, JA, Arlt, W, Lolkema, M & Hofland, J 2021, '11-Ketotestosterone is the predominant active androgen in prostate cancer patients after castration: the resilience of a potent androgen in prostate cancer patients after castration', JCI Insight, vol. 6, no. 11, e148507. https://doi.org/10.1172/jci.insight.148507

Bentley, C, Potter, C, Yakoub, KM, Brock, K, Homer, V, Toman, E, Taylor, AE, Shaheen, F, Gilligan, LC, Athwal, A, Barton, D, Carrera, R, Young, K, Desai, A, McGee, K, Ermogenous, C, Sur, G, Greig, CA, Hazeldine, J, Arlt, W, Lord, JM & Foster, MA 2021, 'A prospective, phase II, single-centre, cross-sectional, randomised study investigating Dehydroepiandrosterone supplementation and its Profile in Trauma: ADaPT', BMJ open, vol. 11, no. 7, e040823. https://doi.org/10.1136/bmjopen-2020-040823

Grech, O, Clouter, A, Mitchell, J, Alimajstorovic, Z, Ottridge, R, Yiangou, A, Roque, M, Tahrani, A, Nicholls, M, Taylor, A, Shaheen, F, Arlt, W, Lavery, G, Shapiro, K, Mollan, S & Sinclair, A 2021, 'Cognitive performance in idiopathic intracranial hypertension and relevance of intracranial pressure', Brain Communications, vol. 3, no. 3, fcab202. https://doi.org/10.1093/braincomms/fcab202

Taiwo, BG, Frettsome-Hook, RL, Taylor, AE, Correia, JN, Lefievre, L, Publicover, SJ, Conner, SJ & Kirkman-Brown, JC 2021, 'Complex combined steroid mix of the female tract modulates human sperm', Reproductive biology, vol. 21, no. 4, 100561. https://doi.org/10.1016/j.repbio.2021.100561

Fenton, C, Martin, C, Jones, R, Croft, A, Campos, J, Naylor, A, Taylor, A, Chimen, M, Cooper, M, Lavery, G, Raza, K & Hardy, R 2021, 'Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids', Annals of the Rheumatic Diseases, vol. 80, no. 2, pp. 250-260. https://doi.org/10.1136/annrheumdis-2020-218493

Schiffer, L, Bossey, A, Kempegowda, P, Taylor, A, Akerman, I, Scheel-Toellner, D, Storbeck, K-H & Arlt, W 2021, 'Peripheral blood mononuclear cells preferentially activate 11-oxygenated androgens', European Journal of Endocrinology, vol. 184, no. 3, pp. 353–363. https://doi.org/10.1530/EJE-20-1077

Prete, A, Taylor, AE, Bancos, I, Smith, DJ, Foster, MA, Kohler, S, Fazal-Sanderson, V, Komninos, J, O'Neil, DM, Vassiliadi, DA, Mowatt, CJ, Mihai, R, Fallowfield, JL, Annane, D, Lord, JM, Keevil, BG, Wass, JAH, Karavitaki, N & Arlt, W 2021, 'Response to Letter to the Editor from Chee et al: "Prevention of Adrenal Crisis: Cortisol Response to Major Stress Compared to Stress Dose Hydrocortisone Delivery"', The Journal of clinical endocrinology and metabolism, vol. 106, no. 1, pp. e407-e408. https://doi.org/10.1210/clinem/dgaa719

Prete, A, Taylor, AE, Bancos, I, Smith, DJ, Foster, MA, Kohler, S, Fazal-Sanderson, V, Komninos, J, O'Neil, DM, Vassiliadi, DA, Mowatt, CJ, Mihai, R, Fallowfield, JL, Annane, D, Lord, JM, Keevil, BG, Wass, JAH, Karavitaki, N & Arlt, W 2021, 'Response to Letter to the Editor: "Prevention of Adrenal Crisis: Cortisol Response to Major Stress Compared to Stress Dose Hydrocortisone Delivery"', The Journal of clinical endocrinology and metabolism, vol. 106, no. 1, pp. e404-e406. https://doi.org/10.1210/clinem/dgaa712

Sun, M, Mueller, JW, Gilligan, LC, Taylor, AE, Shaheen, F, Noczyńska, A, T'Sjoen, G, Denvir, L, Shenoy, S, Fulton, P, Cheetham, TD, Gleeson, H, Rahman, M, Krone, NP, Taylor, NF, Shackleton, CHL, Arlt, W & Idkowiak, J 2021, 'The broad phenotypic spectrum of 17α-hydroxylase/17,20-lyase (CYP17A1) deficiency: a case series', European Journal of Endocrinology , vol. 185, no. 5, pp. 729-741. https://doi.org/10.1530/EJE-21-0152

Markey, K, Mitchell, J, Botfield, H, Ottridge, R, Matthews, T, Krishnan, A, Woolley, R, Westgate, C, Yiangou, A, Alimajstorovic, Z, Shah, P, Rick, C, Ives, N, Taylor, A, Gilligan, L, Jenkinson, C, Arlt, W, Scotton, W, Fairclough, RJ, Singhal, R, Stewart, PM, Tomlinson, JW, Lavery, G, Mollan, S & Sinclair, A 2020, '11β-hydroxysteroid dehydrogenase type 1 inhibition in idiopathic intracranial hypertension: a double-blind randomized controlled trial', Brain Communications, vol. 2, no. 1, fcz050. https://doi.org/10.1093/braincomms/fcz050

Comment/debate

Chortis, V, Sitch, AJ, Bancos, I, Prete, A, Taylor, AE, Biehl, M, Deeks, JJ & Arlt, W 2021, 'Comment on "A Modern Assessment of Cancer Risk in Adrenal Incidentalomas: Analysis of 2219 Patients" by Kahramangil B et al', Annals of surgery. https://doi.org/10.1097/SLA.0000000000004804

Review article

Hardy, R, Botfield, H, Markey, K, Mitchell, J, Alimajstorovic, Z, Westgate, C, Sagmeister, M, Fairclough, R, Ottridge, R, Yiangou, A, Storbeck, K-H, Taylor, A, Gilligan, L, Arlt, W, Stewart, P, Tomlinson, J, Mollan, S, Lavery, G & Sinclair, A 2021, '11βHSD1 inhibition with AZD4017 improves lipid profiles and lean muscle mass in Idiopathic intracranial hypertension', Journal of Clinical Endocrinology and Metabolism, vol. 106, no. 1, pp. 174-187. https://doi.org/10.1210/clinem/dgaa766

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