Dr Angela E Taylor PhD

Institute of Metabolism and Systems Research
Senior Research Fellow
Academic Lead Steroid Metabolome Analysis Core

Contact details

Telephone: +44 (0) 121 415 58777
Email: a.taylor.5@bham.ac.uk
Twitter: @Angela_E_Taylor

Address: Steroid Metabolome Analysis Core (SMAC)
Institute of Metabolism and Systems Research
Medical School
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Angela is an analytical chemist who leads the research of the Steroid Metabolome Analysis Core (SMAC). SMAC is a team consisting of scientists, who develop, optimise and validate mass spectrometry methods which are applied to laboratory-based research, clinical research and clinical trials.

Angela’s research interest is the study of steroid metabolism in health and disease, including cancer, infertility, stress, trauma and metabolism. Investigating a number of different biological matrices such as urine, serum, plasma, cell culture media, tears, aqueous humour, micro-dialysis fluid, follicular fluid and bronchiolar fluid.

The Steroid Metabolome Analysis Core (SMAC) is an internationally recognised group investigating steroid metabolism in health and disease. SMAC has research collaborators in 15 countries. Over the last 10 years, SMAC has supported more than 140 different projects. The SMAC group has published high quality, high impact research papers all centred around steroid analysis by mass spectrometry.

ORCID ID: 0000-0002-5835-5643

Qualifications

PhD, Swansea University, 2009
MChem, Swansea University, 2009

Biography

Angela has an analytical chemistry master’s degree from Swansea University (2005). In 2009 she received her PhD from Swansea University investigating steroid metabolism in the human endometrium using mass spectrometry. This was followed by post-doctoral work at the University of Birmingham working for Prof Wiebke Arlt, which cumulated in setting up the SMAC facility in 2016. The SMAC lab now conducts steroid research from wet lab based projects to clinical trials.

Teaching

BMed Sci
MBChB
Yearly final year Biomedical scientist dissertations
Summer studentships
Lab visitor training

Research

Angela is interested in steroid metabolism in health and disease. Angela's role involves the development of highly sensitivity, high throughput, well validated mass spectrometry assays for steroid analysis. Her research applies these assays to answer important clinical questions.

Other activities

Angela is the deputy leader of the summer school which offers a unique opportunity to undergraduate students get hands-on experience on how metabolism and endocrinology affects disease-https://www.birmingham.ac.uk/research/metabolism-systems/work-study/index.aspx

Publications

Recent publications

Article

Sampson, OL, Jay, C, Adland, E, Csala, A, Lim, N, Ebbrecht, SM, Gilligan, LC, Taylor, AE, George, SS, Longet, S, Jones, LC, Barnes, E, Frater, J, Klenerman, P, Dunachie, S, Carrol, M, Hawley, J, Arlt, W, Groll, A & Goulder, P 2024, 'Gonadal androgens are associated with decreased type I interferon production by plasmacytoid dendritic cells and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents', Frontiers in immunology, vol. 15, 1329805. https://doi.org/10.3389/fimmu.2024.1329805

Schiffer, L, Oestlund, I, Snoep, JL, Gilligan, LC, Taylor, AE, Sinclair, AJ, Singhal, R, Freeman, A, Ajjan, R, Tiganescu, A, Arlt, W & Storbeck, KH 2024, 'Inhibition of the glucocorticoid‐activating enzyme 11β‐hydroxysteroid dehydrogenase type 1 drives concurrent 11‐oxygenated androgen excess', FASEB Journal, vol. 38, no. 7, e23574. https://doi.org/10.1096/fj.202302131r

Schiffer, L, Kempegowda, P, Sitch, AJ, Adaway, JE, Shaheen, F, Ebbehoj, A, Singh, S, Mctaggart, MP, O’reilly, MW, Prete, A, Hawley, JM, Keevil, BG, Bancos, I, Taylor, AE & Arlt, W 2023, 'Classic and 11-oxygenated androgens in serum and saliva across adulthood: a cross-sectional study analyzing the impact of age, body mass index, and diurnal and menstrual cycle variation', European Journal of Endocrinology, vol. 188, no. 1, lvac017. https://doi.org/10.1093/ejendo/lvac017

Bentley, C, Hazeldine, J, Bravo, L, Taylor, AE, Gilligan, LC, Shaheen, F, Acharjee, A, Gkoutos, G, Foster, MA, Arlt, W & Lord, JM 2023, 'The ultra-acute steroid response to traumatic injury: a cohort study', European Journal of Endocrinology. https://doi.org/10.1093/ejendo/lvad024

Dineen, RA, Martin-Grace, J, Ahmed, KMS, Taylor, AE, Shaheen, F, Schiffer, L, Gilligan, LC, Lavery, GG, Frizelle, I, Gunness, A, Garrahy, A, Hannon, AM, Methlie, P, Eystein, SH, Stewart, PM, Tomlinson, JW, Hawley, JM, Keevil, BG, O’reilly, MW, Smith, D, Mcdermott, J, Healy, M-L, Agha, A, Pazderska, A, Gibney, J, Behan, L-A, Thompson, CJ, Arlt, W & Sherlock, M 2023, 'Tissue Glucocorticoid Metabolism in Adrenal Insufficiency: A Prospective Study of Dual-release Hydrocortisone Therapy', Journal of Clinical Endocrinology and Metabolism, vol. 108, no. 12, pp. 3178–3189. https://doi.org/10.1210/clinem/dgad370

Prete, A, Taylor, A & Brown, MJ 2023, '[11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial', Nature Medicine, vol. 29, no. 1, pp. 190-202. https://doi.org/10.1038/s41591-022-02114-5

Moll, JM, Hofland, J, Teubel, W, Ridder, CMAD, Taylor, A, Graeser, R, Arlt, W, Jenster, G & Van Weerden, W 2022, 'Abiraterone switches castration‐resistant prostate cancer dependency from adrenal androgens towards androgen receptor variants and glucocorticoid receptor signalling', The Prostate, vol. 82, no. 5, pp. 505-516. https://doi.org/10.1002/pros.24297

Prete, A, Subramanian, A, Bancos, I, Chortis, V, Tsagarakis, S, Lang, K, Macech, M, Delivanis, D, Pupovac, I, Reimondo, G, Marina, L, Deutschbein, T, Balomenaki, M, O'reilly, M, Gilligan, L, Jenkinson, C, Bednarczuk, T, Zhang, C, Dusek, T, Diamantopoulos, A, Asia, M, Kondracka, A, Li, D, Masjkur, J, Quinkler, M, Ueland, G, Dennedy, C, Beuschlein, F, Tabarin, A, Fassnacht, M, Ivovic, M, Terzolo, M, Kastelan, D, Young Jr, W, Manolopoulos, K, Ambroziak, U, Vassiliadi, D, Taylor, A, Sitch, A, Nirantharakumar, K & Arlt, W 2022, 'Cardiometabolic disease burden and steroid excretion in benign adrenal tumors: a cross-sectional multicenter study', Annals of internal medicine, vol. 175, no. 3, pp. 325-334. https://doi.org/10.7326/M21-1737

Schiffer, L, Shaheen, F, Gilligan, LC, Storbeck, K-H, Hawley, JM, Keevil, BG, Arlt, W & Taylor, AE 2022, 'Multi-steroid profiling by UHPLC-MS/MS with post-column infusion of ammonium fluoride', Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, vol. 1209, 123413. https://doi.org/10.1016/j.jchromb.2022.123413

Snaterse, G, Van Dessel, L, Riet, JV, Taylor, A, Vlugt-Daane, MVD, Hamberg, P, Wit, PRD, Visser, JA, Arlt, W, Lolkema, M & Hofland, J 2021, '11-Ketotestosterone is the predominant active androgen in prostate cancer patients after castration: the resilience of a potent androgen in prostate cancer patients after castration', JCI Insight, vol. 6, no. 11, e148507. https://doi.org/10.1172/jci.insight.148507

Bentley, C, Potter, C, Yakoub, KM, Brock, K, Homer, V, Toman, E, Taylor, AE, Shaheen, F, Gilligan, LC, Athwal, A, Barton, D, Carrera, R, Young, K, Desai, A, McGee, K, Ermogenous, C, Sur, G, Greig, CA, Hazeldine, J, Arlt, W, Lord, JM & Foster, MA 2021, 'A prospective, phase II, single-centre, cross-sectional, randomised study investigating Dehydroepiandrosterone supplementation and its Profile in Trauma: ADaPT', BMJ open, vol. 11, no. 7, e040823. https://doi.org/10.1136/bmjopen-2020-040823

Preprint

Jaulim, A, Cassidy, LD, Young, ARJ, Chan, ASL, Warren, AY, Taylor, AE, Arlt, W, Lan, G, Blayney, ML, Davidson, O, Barratt, CLR, Pacey, S & Narita, M 2023 'Autophagy maintains the homeostatic environment in the male reproductive accessory organs playing a key role in fertility' bioRxiv. https://doi.org/10.1101/2023.07.21.549845

Schiffer, L, Oestlund, I, Snoep, J, Gilligan, LC, Taylor, AE, Sinclair, AJ, Singhal, R, Freeman, A, Ajjan, R, Tiganescu, A, Arlt, W & Storbeck, K-H 2023 'Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 drives concurrent 11-oxygenated androgen excess' bioRxiv. https://doi.org/10.1101/2023.06.05.543687

Schiffer, L, Shaheen, F, Gilligan, LC, Storbeck, K-H, Hawley, J, Keevil, BG, Arlt, W & Taylor, AE 2022 'Multi-steroid profiling by uPLC-MS/MS with post-column infusion of ammonium fluoride' medRxiv. https://doi.org/10.1101/2022.03.08.22271681

Review article

Hardy, R, Botfield, H, Markey, K, Mitchell, J, Alimajstorovic, Z, Westgate, C, Sagmeister, M, Fairclough, R, Ottridge, R, Yiangou, A, Storbeck, K-H, Taylor, A, Gilligan, L, Arlt, W, Stewart, P, Tomlinson, J, Mollan, S, Lavery, G & Sinclair, A 2021, '11βHSD1 inhibition with AZD4017 improves lipid profiles and lean muscle mass in Idiopathic intracranial hypertension', Journal of Clinical Endocrinology and Metabolism, vol. 106, no. 1, pp. 174-187. https://doi.org/10.1210/clinem/dgaa766

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