Dr Hannah Trivett BSc PhD

Dr Hannah Trivett

Department of Microbes, Infection and Microbiomes
Postdoctoral Reseach Fellow

Contact details

Dr Hannah Trivett is a microbiologist whose research focuses on understanding how human microbiomes influence health and disease. She combines microbial genomics, metagenomics and bioinformatics to study antimicrobial resistance and develop methods for characterising complex microbial communities and their associated resistomes.

Qualifications

PhD Medical Microbiology, University of Liverpool, 2024
BSc Microbiology, University of Liverpool, 2020

Biography

Dr Hannah Trivett is a Research Fellow in the Department of Microbes, Infection and Microbiomes at the University of Birmingham, where she works within Prof Lindsay Hall's research group.

Hannah obtained her BSc in Microbiology from the University of Liverpool in 2020. Following a period working as a DNA Laboratory Scientist, she joined the Health Protection Research Unit in Gastrointestinal Infections (HPRU-GI) at the University of Liverpool to undertake a PhD focused on metagenomic sequencing for infectious disease diagnostics. During this time, she combined laboratory, bioinformatic and stakeholder-engagement approaches to explore how genomic technologies can be translated into routine clinical practice.

Her research has since evolved from pathogen-focused genomics to exploring the ecology of complex microbial communities and their impact on human health. She is particularly interested in how microorganisms interact, adapt and exchange genetic material within the human microbiome, and how these processes contribute to microbial function and antimicrobial resistance.

At the University of Birmingham, Hannah studies maternal and infant gut microbiomes using advanced sequencing technologies and bioinformatic approaches. Her research explores the microorganisms that colonise the gut during early life, the functions they perform, and the mobile genetic elements that shape their evolution. Through this work, she seeks to understand how microbial communities develop, how antimicrobial resistance emerges and spreads, and how these processes influence human health.

Alongside her research, Hannah is interested in making genomic technologies more accessible and clinically useful. She works closely with academic, clinical and public health partners and has contributed to public engagement activities, science communication initiatives and the development of resources that improve understanding of Microbiology, genomics, and antimicrobial resistance.

Research

Early-life microbiomes
Dr Trivett currently studies maternal and infant gut microbiomes using a combination of next-generation and third generation sequencing approaches, including long-read metagenomics, Hi-C and methylation-informed analyses. Her work aims to understand how antimicrobial resistance genes and mobile genetic elements are acquired, transmitted and maintained during early life, particularly focusing on the role of mobile genetic elements in shaping microbial function.

Microbiomes in chronic disease
Dr Trivett’s previous research focused on understanding how microbiome disruption contributes to disease progression and antimicrobial resistance (AMR) in advanced chronic liver disease (ACLD). Using long-read metagenomic sequencing, she characterised microbial community structure, resistome composition, and metagenome-assembled genomes across the spectrum of cirrhosis severity. This work demonstrated that disease progression is associated with profound shifts in microbial community composition, depletion of beneficial commensals, expansion of opportunistic pathogens, and enrichment of clinically relevant antimicrobial resistance genes.

Metagenomics for Infectious Disease Diagnostics
During her PhD, Dr Trivett investigated the application of metagenomic sequencing to gastrointestinal infections, combining laboratory, bioinformatic and stakeholder-engagement approaches to improve the translation of genomic technologies into clinical diagnostics. This work established her interest in antimicrobial resistance, microbial communities, and the clinical application of metagenomics.