Dr Alan McNally BSc PhD

Image of Alan McNally

Institute of Microbiology and Infection
Reader in Microbial Evolutionary Genomics
Interim Director of Institute of Microbiology and Infection within the College of Medical and Dental Sciences

Contact details

Address
Institute of Microbiology and Infection
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Alan McNally is a Reader in Microbial Genomics, a position he took up in September 2016. Alan works on the evolutionary genomics of pathogenesis and antimicrobial resistance in bacterial pathogens and has been funded by the European Union, Medical Research Council, and Royal Society.

Alan has a strong belief in the collaborative nature of genomics research with active collaborations in the UK, China, Germany, France, Vietnam, and the US.

Qualifications

  • PhD Molecular Microbiology, University of Edinburgh Royal (Dick) Vert Shool, 1999-2003
  • BSc Hons 2.i Molecular Microbiology with work placement, University of Glasgow, 1994-1999

Biography

Alan McNally began his scientific career studying molecular microbiology at University of Glasgow, including a year’s placement at SmithKline Beecham in Hertfordshire. He then went on to do a PhD studying gene regulation in E. coli O157 with Prof David Gally at University of Edinburgh. A short post-doc in microbial biochemistry at Bristol was followed by two post-doctoral projects at the Veterinary Laboratories Agency in Surrey. It was here whilst working on H5N1 avian influenza that Alan developed an interest in phylogenetics and evolution, which he developed in his first academic PI position at Nottingham Trent University. During 10 succesful years Alan established his group as an internationally renowned group studying microbial genomics and evolution, leading to him joining the IMI in September 2016.

For further information visit: www.alanmcnally.com

Teaching

Teaching Programmes

Postgraduate supervision

Alan has successfully supervised 9 PhD students. He is interested to hear from students interested in undertaking a PhD in the fields of:

  • Population genomics of multi-drug resistant E. coli
  • Evolution of antimicrobial resistance in gram negative pathogens
  • Evolution of pathogenesis in the Yersinia genus
  • Experimental evolution of MDR plasmid carriage in gram negative pathogens

If you are interested in studying any of these subject areas please contact Alan on the contact details above, or for any general doctoral research enquiries, please email: dr@contacts.bham.ac.uk or call +44 (0)121 414 5005.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

E. coli

We work on extra-intestinal pathogenic E. coli, or ExPEC. These are now the most common cause of drug-resistant infections worldwide, and the most common cause of hospital associated infections. 

ExPEC Genomics

We study population genomics of the predominant sequence types associated with extra-intestinal infections in humans, in particular ST131, ST73 and ST95. By doing this we hope to determine how these STs have become the dominant causative agents of human disease from the enormous population of E. coli. We also hope to be able to use this data to inform phylogenetic based epidemiology of these bacteria, better informing us how multi-drug resistant bacteria transmit in the hospital and community setting.

Classical bacterial pathogenesis

We also translate our genomic data into biological relevance, by attributing observations in our genome data to particular phenotypes. In particular we are interested in metabolic differences between ExPEC clades, and also differences in their transmission and environmental survival strategies.

Yersinia

We also work on the enteropathogenic members of the Yersinia genus. Again we use genomics data to investigate the evolution of pathogenesis in this model bacterial genus. We also have a keen interest in studying localised short term evolution in subsets of the enteropathogenic species.

As with ExPEC our goal is to marry the genomic data with differential phenotype data across population sets. To do this we heavily employ classical bacterial genetics techniques with surrogate infection models, in particular Galleria mellonella.

Other activities

  • Elected member of the Microbiology Society Prokaryotic Division since 2012
    Alan is now in his second elected term having organised several key symposia for the society annual conference
  • Editor for the society journal Microbial Genomics

Publications

Liu L, Feng Y, McNally A and Zong Z. 2018. blaNDM-21, a new variant of blaNDM in an Escherichia coli clinical isolate carrying blaCTX-M-55 and rmtB. J Antimicrob Chemother. doi: 10.1093/jac/dky226.

Zong Z, Fenn S, Connor C, Feng Y and McNally A. 2018. Complete genomic characterization of two Escherichia coli lineages responsible for a cluster of carbapenem-resistant infections in a Chinese hospital. J Antimicrob Chemother.  doi: 10.1093/jac/dky210.

Méric G, McNally A, Pessia A, Mourkas E, Pascoe B, Mageiros L, Corrander J and Sheppard SK. 2018. Convergent Amino Acid Signatures in Polyphyletic Campylobacter jejuni Subpopulations Suggest Human Niche Tropism. Genome biol Evol. 10 (3), 763-774   

Seecharran T, Kalin-Manttari L, Koskela K, Nikkari S, Dickins B, Corander J, Skurnik M and McNally A. 2017. Phylogeographic separation and formation of sexually discrete lineages in a global population of Yersinia pseudotuberculosis. Microb Genom. 3(10):e000133.

de Vos MGJ, Zagorski M, McNally A and Bollenbach T. (2017). Interaction networks, ecological stability, and collective antibiotic tolerance in polymicrobial infections. Proc Natl Acad Sci. 114:10666-10671.

Harrison F, McNally A, da Silva AC, Heeb S and Diggle SP. (2017). Optimised chronic infection models demonstrate that siderophore 'cheating' in Pseudomonas aeruginosa is context specific. ISME J. 11:2492-2509.

McInerney JO, McNally A and O'Connell MJ. 2017. Why prokaryotes have pangeomes. Nat Microbiol. 2:17040.

McNally A, Oren Y, Kelly D, Pascoe B, Dunn S, Sreecharan T, Vehkala M, Välimäki N, Prentice MB, Ashour A, Avram O, Pupko T, Dobrindt U, Literak I, Guenther S, Schaufler K, Wieler LH, Zhiyong Z, Sheppard SK, McInerney JO and Corander J. (2016). Combined analysis of variation in core, accessory and regulatory genome regions provides a super-resolution view into the evolution of bacterial populations. PLoS Genetics. 12: e1006280.

McNally A, Thomson NR, Reuter S and Wren BW (2016) 'Add, stir and reduce': Yersinia spp. as model bacteria for pathogen evolution. Nat Rev Microbiol 14(3):177-90

Alhashash F, Wang X, Paszkiewicz K, Diggle M, Zong Z and McNally A (2016) Increase in bacteraemia cases in the East Midlands region of the UK due to MDR Escherichia coli ST73: high levels of genomic and plasmid diversity in causative isolates. J Antimicrob Chemother 71(2):339-43

Reuter S, Corander J, de Been M, Harris S, Cheng L, Hall M, Thomson NR and McNally A (2015) Directional gene flow and ecological separation in Yersinia enterocolitica. Microbial Genomics 1

Reuter S, Connor TR, Barquist L, Walker D, Feltwell T, Harris S, Fookes M, Hall ME, Fuchs TM, DuFour M, Prentice M, Wren BW, Carniel E, Skurnik M, Falcão JP, Fukushima H, Scholz HC, Parkhill J, Achtman M, McNally A and Thomson NR.  (2014). Parallel independent evolution of pathogenicity within the genus Yersinia. Proc Nat Acad Sci USA. 111: 6768-73.

Zhao F, Feng Y, Lü X, McNally A and Zong Z. 2017. IncP Plasmid CarryingColistin Resistance Gene mcr-1 in Klebsiella pneumoniae from Hospital Sewage. Antimicrob Agents Chemother. 61:e02229-16.