Dr Matt O'Shea MRCP, DPhil (Oxon), DTM&H

Image of Dr Matt O'Shea

Institute of Microbiology and Infection
Honorary Clinical Lecturer

Contact details

Institute of Microbiology & Infection
College of Medical and Dental Sciences
University of Birmingham
B15 2TT


  • DPhil (Oxon)
  • DTM&H (Distinction)
  •  MRCP
  •  MB ChB
  •  MPhil (Infection)
  •  BSc 1st Class (Hons) Medical Biochemistry


Matt received his BSc from the University of Birmingham in 1996 and then went on to study medicine there (1997-2003). Interested in academic medicine and Infectious Diseases and Tropical Medicine from an early stage, he completed a Master’s degree by research in Infection at NHRC in San Diego (2000-2001). After MB ChB he undertook clinical rotations in Birmingham and Worcester. He completed MRCP and was awarded a national training number in Infectious Diseases and Tropical Medicine in the West Midlands Deanery, undertaking clinical training at Heartlands Hospital. Matt completed the DTM&H at the Liverpool School of Tropical Medicine and Hygiene and has undertaken clinical work in resource-poor settings (Malawi and Sierra Leone). He completed his DPhil at the Jenner Institute, University of Oxford, having been awarded a Wellcome Trust Research Training Fellowship and Senior Scholarship (Corpus Christi College). He has returned to Birmingham to continue clinical training and to take up an Honorary Clinical Lectureship, with a broad portfolio of infection-related research projects but with a primary interest in Tuberculosis (TB).



  • Understanding the human host immune response to TB infection
  • Studying the influence of gastrointestinal parasite (helminth) co-infection
  • TB vaccine clinical trials
  • Anti-microbial resistance
  • Immunotherapy


A full list of publications can be found here.

Fletcher HA, Snowden MA, Landry B, Rida W, Satti I, Harris SA, Matsumiya M, Tanner R, O'Shea MK, Dheenadhayalan V, Bogardus L, Stockdale L, Marsay L, Chomka  A, Harrington-Kandt R, Manjaly-Thomas ZR, Naranbhai V, Stylianou E, Darboe F, Penn-Nicholson A, Nemes E, Hatheril M, Hussey G, Mahomed H, Tameris M, McClain JB, Evans TG, Hanekom WA, Scriba TJ and McShane H (2016) T-cell activation is an immune correlate of risk in BCG vaccinated infants. Nat Commun 7:11290

Whitehouse J, Flaxman A, Rollier C, O'Shea MK, Fallowfield J, Lindsay M, Gunner F, Knox K, Wyllie DH and Yamaguchi Y (2016) Population variation in anti-S. aureus  IgG isotypes influences surface protein A mediated immune subversion. Vaccine 34(15):1792-9

O'Shea MK, Clay KA, Craig DG, Moore AJ, Lewis S, Espina M, Praught J, Horne S, Kao R and Johnston AM (2016) A Health Care Worker with Ebola Virus Disease and Adverse Prognostic Factors Treated in Sierra Leone. Am J Trop Med Hyg 94(4):829-32

Naranbhai V, Fletcher HA, Tanner R, O'Shea MK, McShane H, Fairfax BP, Knight JC and Hill AV (2015) Distinct Transcriptional and Anti-Mycobacterial Profiles of Peripheral Blood Monocytes Dependent on the Ratio of Monocytes: Lymphocytes. EBioMedicine 2(11):1619-26

Quick J, Loman NJ, Duraffour S, Simpson JT, Severi E, Cowley L, Bore JA, Koundouno R, Dudas G, Mikhail A, Ouedraogo N, Afrough B, Bah A, Baum JH, Becker-Ziaja B, Boettcher JP, Cabeza-Cabrerizo M, Camino-Sanchez A, Carter LL, Doerrbecker J, Enkirch T, Garcia-Dorival I, Hetzelt N, Hinzmann J, Holm T, Kafetzopoulou LE, Koropogui M, Kosgey A, Kuisma E, Logue CH, Mazzarelli A, Meisel S, Mertens M, Michel J, Ngabo D, Nitzsche K, Pallasch E, Patrono LV, Portmann J,  Repits JG, Rickett NY, Sachse A, Singethan K, Vitoriano I, Yemanaberhan RL, Zekeng EG, Racine T, Bello A, Sall AA, Faye O, Faye O, Magassouba N, Williams CV, Amburgey V, Winona L, Davis E, Gerlach J, Washington F, Monteil V, Jourdain M, Bererd M, Camara A, Somlare H, Camara A, Gerard M, Bado G, Baillet B, Delaune D,  Nebie KY, Diarra A, Savane Y, Pallawo RB, Gutierrez GJ, Milhano N, Roger I, Williams CJ, Yattara F, Lewandowski K, Taylor J, Rachwal P, Turner DJ, Pollakis G, Hiscox JA, Matthews DA, O'Shea MK, Johnston AM, Wilson D, Hutley E, Smit E, Di Caro A, W√∂lfel R, Stoecker K, Fleischmann E, Gabriel M, Weller SA, Koivogui L, Diallo B, Keita S, Rambaut A, Formenty P, Gunther S and Carroll MW (2016) Real-time, portable genome sequencing for Ebola surveillanceNature 530(7589):228-32

O'Shea MK, Clay KA, Craig DG, Matthews SW, Kao RL, Fletcher TE, Bailey MS and Hutley E (2015) Diagnosis of Febrile Illnesses Other Than Ebola Virus Disease at an Ebola Treatment Unit in Sierra Leone. Clin Infect Dis 61(5):795-8

O'Shea MK, Koh GC, Munang M, Smith G, Banerjee A and Dedicoat M (2014) Time-to-detection in culture predicts risk of Mycobacterium tuberculosis transmission: a cohort studyClin Infect Dis 59(2):177-85

O'Shea MK, Fletcher TE, Beeching NJ, Dedicoat M, Spence D, McShane H, Cunningham AF and Wilson D (2014) Tuberculin skin testing and treatment modulates interferon-gamma release assay results for latent tuberculosis in migrants. PLoS One 9(5):e97366

Matsumiya M, Harris SA, Satti I, Stockdale L, Tanner R, O'Shea MK, Tameris M, Mahomed H, Hatherill M, Scriba TJ, Hanekom WA, McShane H and Fletcher HA (2014) Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response. BMC Infect Dis 14:314

Wells TJ, Whitters D, Sevastsyanovich YR, Heath JN, Pravin J, Goodall M, Browning DF, O'Shea MK, Cranston A, De Soyza A, Cunningham AF, MacLennan CA, Henderson IR and Stockley RA (2014) Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing. J Exp Med 211(9):1893-904