The Centre of Membrane Proteins and Receptors (COMPARE)

The Centre of Membrane Proteins and Receptors (COMPARE) is a unique collaboration between the Universities of Birmingham and Nottingham that formally started in August 2016 with a combined £10m investment over five years.

The Centre brings together world-leading experts across the two institutions in the study of G-protein-coupled receptors (GPCRs) and tyrosine kinase-linked receptors (TKRs) to develop new approaches to study these important cell surface proteins in health and disease. 

Our cutting-edge development in powerful imaging techniques enables researchers to visualise what happens when a drug binds to a cell surface receptor or protein in real-time and thereby identify new mechanisms of therapeutic intervention.

Find out more at the COMPARE website

Why work with us?

compare 1COMPARE is a single institute across two universities which aims to achieve new insights into membrane proteins and drug development using cutting-edge technologies and through collaboration and career development. The cross-university collaboration, underpinned by infrastructure and cutting-edge technology, creates a critical mass of specialists with the breadth of knowledge and know-how for the study of GPCRs and TKRs.

COMPARE is positioned to produce significant research impacts in terms of publications, grant funding, recruitment and approaches to drug discovery.

Team Science is a fundamental part of COMPARE, enabling a collaborative approach to developing the next generation of internationally recognised research stars.

Who do we work with?

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The aim is to develop a state-of-the-art infrastructure in imaging and complementary technology to provide an environment that will attract leading research scientists and achieve international recognition for COMPARE. As part of this, we will form alliances with other centres of excellence in academia and with industrial partners.

COMPARE has a formal collaboration with the Centre for Research in Energy and Materials (CNPEM), Campinas, Brazil. This collaboration enables COMPARE to access very specialist equipment dedicated to the study of membrane proteins, as well as providing access to a library of natural products that is only available in Brazil. The specialist equipment includes one of the first fourth-generation synchrotron light sources in the world (Sirius) and two cyro-electron microscopes.

Resources and Services

Our technologies page details all microscopes and capabilities: http://www.birmingham-nottingham.ac.uk/compare/technologies/compare-technologies.aspx

The diagram below shows the equipment that is available to researchers in the Universities of Birmingham and Nottingham, and to BHF-funded cardiovascular researchers across the UK.

compare 6Please contact compare@birmingham-nottingham.ac.uk for further information.

Current Research

COMPARE is a Research Centre that has been initially funded for five years and research is ongoing.  See our latest news page for updates: http://www.birmingham-nottingham.ac.uk/compare/latest-news.aspx

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Recent Publications

All major COMPARE publications are listed on the web page below: http://www.birmingham-nottingham.ac.uk/compare/compare-publications.aspx

Contact Us

For all initial enquiries about COMPARE, please contact: compare@birmingham-nottingham.ac.uk

Sally Utton
Programme Operations Manager
s.utton@bham.ac.uk or sally.utton@nottingham.ac.uk 
+44 (0)121 414 4511 or +44 (0)115 823 0105

Sharmaine Afferion
COMPARE Administrator (Birmingham)
s.afferion@bham.ac.uk 
+44 (0)121 414 8739

Christine McGrath
COMPARE Research Assistant (Nottingham) 
christine.mcgrath@nottingham.ac.uk
+44 (0)115 82 30398

COMPARE
Institute of Cardiovascular Sciences
IBR Building
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
0121 414 4511

COMPARE 
Room C101
School of Life Sciences
University of Nottingham Medical School
Queens Medical Centre
Nottingham
NG7 2UH
0115 82 30398