The Centre of Membrane Proteins and Receptors (COMPARE)

The Centre of Membrane Proteins and Receptors (COMPARE) is a unique collaboration between the Universities of Birmingham and Nottingham that formally started in August 2016 with a combined £10m investment over five years.

The Centre brings together world-leading experts across the two institutions in the study of G-protein-coupled receptors (GPCRs) and tyrosine kinase-linked receptors (TKRs) to develop new approaches to study these important cell surface proteins in health and disease. 

Our cutting-edge development in powerful imaging techniques enables researchers to visualise what happens when a drug binds to a cell surface receptor or protein in real-time and thereby identify new mechanisms of therapeutic intervention.

COMPARE COVID-19 Facility Access

Find out more at the COMPARE website

Why work with us?

Two women looking at a posterCOMPARE is a single institute across two universities which aims to achieve new insights into membrane proteins and drug development using cutting-edge technologies and through collaboration and career development. The cross-university collaboration, underpinned by infrastructure and cutting-edge technology, creates a critical mass of specialists with the breadth of knowledge and know-how for the study of GPCRs and TKRs.

COMPARE is positioned to produce significant research impacts in terms of publications, grant funding, recruitment and approaches to drug discovery.

Team Science is a fundamental part of COMPARE, enabling a collaborative approach to developing the next generation of internationally recognised research stars.

Who do we work with?

Male researcher presenting

The aim is to develop a state-of-the-art infrastructure in imaging and complementary technology to provide an environment that will attract leading research scientists and achieve international recognition for COMPARE. As part of this, we will form alliances with other centres of excellence in academia and with industrial partners.

COMPARE has a formal collaboration with the Centre for Research in Energy and Materials (CNPEM), Campinas, Brazil. This collaboration enables COMPARE to access very specialist equipment dedicated to the study of membrane proteins, as well as providing access to a library of natural products that is only available in Brazil. The specialist equipment includes one of the first fourth-generation synchrotron light sources in the world (Sirius) and two cyro-electron microscopes.

Resources and Services

Our technologies page details all microscopes and capabilities.

The diagram below shows the equipment that is available to researchers in the Universities of Birmingham and Nottingham, and to BHF-funded cardiovascular researchers across the UK.

compare 6Please contact compare@birmingham-nottingham.ac.uk for further information.

Our Imaging Team

Dr Deidre Kavanagh

Microscopy Officer
D.M.Kavanagh@bham.ac.uk

Deidre Kavanagh

Dr Jeremy Pike

Image Analyst
J.A.Pike@bham.ac.uk

Jeremy Pike

Dr Joao Correia

Microscopy Officer
J.N.Correia@bham.ac.uk

Joao Correia

Current Research

COMPARE is a Research Centre that has been initially funded for five years and research is ongoing.  See our latest news page for updates.

Researcher looking into a microscope

Recent Publications

All major COMPARE publications are listed on the web page.

Contact Us

For all initial enquiries about COMPARE, please contact: compare@contacts.bham.ac.uk 

You can also contact:

Sharmaine Afferion
COMPARE Administrator (Birmingham)
s.afferion@bham.ac.uk 
+44 (0)121 414 8739