Dr Neil Morgan BSc, PhD

Dr Neil Morgan

Institute of Cardiovascular Sciences
Lecturer in Cardiovascular Genetics

Contact details

+44 (0)121 414 6820
+44 (0)121 415 8817
Institute of Cardiovascular Sciences
College of Medical and Dental Sciences
Institute of Biomedical Research
University of Birmingham
B15 2TT

Neil Morgan is a Lecturer in Cardiovascular Genetics within the Institute of Cardiovascular Sciences.

He has published over 75 research papers in high impact scientific journals in the field of human genetics. His research has primarily involved the identification and characterisation of novel genes for inherited diseases in the haematopoietic system.


  • PhD in Molecular Genetics 2005
  • BSc (Hons) Applied Biochemistry 1994


Neil Morgan qualified with a BSc (Hons) in Applied Biochemistry from Liverpool John Moores University in 1994. His first post was as Research Assistant at Guy’s Hospital until 2000 followed by a brief spell as a Research Associate at Leicester University. He joined the Medical and Molecular Genetics group at the University of Birmingham where he went onto study for a PhD in Molecular Genetics. In 2011 he was appointed as a lecturer in the Institute of Cardiovascular Sciences at the University of Birmingham.


Postgraduate supervision

Neil is interested in supervising doctoral research students in the following areas:

  • Gene identification of inherited bleeding disorders
  • Next generation sequencing technologies in human disease gene identification
  • Platelet and Megakaryocyte Biology of novel disease genes mutated in inherited thrombocytopenia

Current PhD students: Ben Johnson, Jane Futterer, Abdullah Khan, Annabel Maclachlan


His current research is focussing on the molecular genetics of patients with platelet bleeding disorders and low platelet counts (thrombocytopenia). The identification of novel gene defects provides clues to genes and proteins involved in normal platelet physiology and ultimately lead to devising new treatment strategies to minimise the risk of bleeding in such patients.

His past research has primarily involved identification of the novel genes for inherited diseases of the haematopoietic system. He has been extremely successful in his pursuit and key findings include: 

  • SLFN14 mutations causing an inherited bleeding disorder with thrombocytopenia and platelet secretion defects
  • TRAC mutations causing a novel immunodeficiency disorder  
  • SLC29A3 mutations causing familial Faisalabad histiocytosis/Rosai-Dorfman disease
  • BLOC1S3 mutations causing a novel form of Hermansky Pudlak disorder (HPS8)
  • CHRNG, RAPSN and DOK7 mutations causing multiple pterygia syndrome/foetal akinesia deformation sequence
  • PLA2G6 mutations causing a spectrum of childhood onset neurodegenerative disorders associated with brain iron accumulation


Fletcher SJ, Johnson B, Lowe GC, Bem D, Drake S, Lordkipanidzé M, Sánchez Guiú I, Dawood B, Rivera J, Simpson MA, Daly ME, Motwani J, Collins PW, Watson SP, Morgan NV (2015) SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects. J Clin Invest, 125 (9), 3600-05.

Lu W, Zhang Y, McDonald DO, Jing H, Carroll B, Robertson N, Zhang Q, Griffin H, Sanderson S, Lakey JH, Morgan NV, Reynard LN, Zheng L, Murdock HM, Turvey SE, Hackett SJ, Prestidge T, Hall JM, Cant AJ, Matthews HF, Koref MF, Simon AK, Korolchuk VI, Lenardo MJ, Hambleton S, Su HC (2014) Dual proteolytic pathways govern glycolysis and immune competence. Cell, 159, 1578-90.

Stockley J*, Morgan NV*, Bem D, Lowe GC, Lordkipanidzé M, Dawood B, Simpson MA, Macfarlane K, Horner K, Leo VC, Talks K, Motwani J, Wilde JT, Collins PW, Makris M, Watson SP, Daly ME: UK Genotyping and Phenotyping of Platelets Study Group (2013) Enrichment of FLI1 and RUNX1 mutations in families with excessive bleeding and platelet dense granule secretion defects. Blood, 122, 4090-3. * equal contribution

Hambleton S, Goodbourn S, Young DF, Dickinson P, Mohamad SM, Valappil M, McGovern N, Cant AJ, Hackett SJ, Ghazal P, Morgan NV, Randall RE. STAT2 deficiency and susceptibility to viral illness in humans. Proc Natl Acad Sci U S A. 2013; 110: 3053-8.

Morgan NV, Goddard S, Cardno TS, McDonald D, Rahman F, Barge D, Ciupek A, Straatman-Iwanowska A, Pasha S, Guckian M, Anderson G, Huissoon A, Cant A, Tate WP, Hambleton S, Maher ER (2011) Mutation in the TCR subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCR+ T cells. J Clin Invest 121(2):695-702

Morgan NV, Morris MR, Cangul H, Gleeson D, Straatman-Iwanowska A, Davies N, Keenan S, Pasha S, Rahman F, Gentle D,Vreeswijk MPG, Devilee P, Knowles MA, Ceylaner S, Trembath RC, Dalence C, Kismet E, Koseoglu V, Rossbach H-C, Gissen P, Tannanhill D, Maher ER (2010). Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial Histiocytosis syndrome (Faisalabad histiocytosis) and Familial Rosai-Dorfman disease. PLoS Genetics 6(2):e1000833

Morgan NV, Brueton LA, Cox P, Greally MT, Tolmie J, Pasha S, Aligianis IA, van Bokhoven H, Marton T, Al-Gazali L, Morton JE, Oley C, Johnson CA, Trembath RC, Brunner HG, Maher ER (2006) Mutations in the embryonal subunit of the acetylcholine receptor (CHRNG) cause lethal and Escobar variants of multiple pterygium syndrome. Am J Hum Genet 79:390-5.

Morgan NV, Westaway SK, Morton JE, Gregory A, Gissen P, Sonek S, Cangul H, Coryell J, Canham N, Nardocci N, Zorzi G, Pasha S, Rodriguez D, Desguerre I, Mubaidin A, Bertini E, Trembath RC, Simonati A, Schanen C, Johnson CA, Levinson B, Woods CG, Wilmot B, Kramer P, Gitschier J, Maher ER, Hayflick SJ (2006) PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron. Nat Genet 38:752-4.