Dr Neil Morgan

Dr Neil Morgan

Institute of Cardiovascular Sciences
Lecturer in Cardiovascular Genetics

Contact details

+44 (0)121 414 6820
+44 (0)121 415 8817
Institute of Cardiovascular Sciences
College of Medical and Dental Sciences
Institute of Biomedical Research
University of Birmingham
B15 2TT

Neil Morgan is a Lecturer in Cardiovascular Genetics within the Institute of Cardiovascular Sciences.

He has published over 50 research papers in high impact scientific journals in the field of human genetics. His research has primarily involved the identification of novel genes for autosomal recessive inherited diseases.


  • PhD in Molecular Genetics 2005
  • BSc (Hons) Applied Biochemistry 1994


Neil Morgan qualified with a BSc (Hons) in Applied Biochemistry from Liverpool John Moores University in 1994. His first post was as Research Assistant at Guy’s Hospital until 2000 followed by a brief spell as a Research Associate at Leicester University. He joined the Medical and Molecular Genetics group at the University of Birmingham where he went onto study for a PhD in Molecular Genetics. He has recently been appointed as a lecturer in the Centre for Cardiovascular Sciences.



His current research is focussing on the molecular genetics of patients with platelet bleeding disorders and low platelet counts (thrombocytopenia). The identification of novel gene defects will provide clues to genes and proteins involved in normal platelet physiology and ultimately lead to devising new treatment strategies to minimise the risk of bleeding in such patients.

His past research has primarily involved identification of the novel genes for autosomal recessive inherited diseases. He has been extremely successful in his pursuit and key findings include:

  • TRAC mutations causing a novel immunodeficiency disorder
  • SLC29A3 mutations causing familial Faisalabad histiocytosis/Rosai-Dorfman disease
  • BLOC1S3 mutations causing a novel form of Hermansky Pudlak disorder (HPS8)
  • CHRNG, RAPSN and DOK7 mutations causing multiple pterygia syndrome/foetal akinesia deformation sequence
  • PLA2G6 mutations causing a spectrum of childhood onset neurodegenerative disorders associated with brain iron accumulation


Morgan NV, Hartley JL, Setchell KDR,Simpson MA, Brown R, Tee L, Kirkham S,Pasha S, Trembath RC, Maher ER, Gissen P, Kelly DA (2013) A combination of mutations in AKR1D1 and SKIV2L in a family with severe infantile liver disease. Orphanet Journal Rare Diseases; 8: 74.

Watson SP, Lowe GC, Lordkipanidze M, Morgan NV (2013) Genotyping and phenotyping of platelet function disorders. J Thromb Haemost. 11 Suppl 1:351-63.

Hambleton S, Goodbourn S, Young DF, Dickinson P, Mohamad SM, Valappil M, McGovern N, Cant AJ, Hackett SJ, Ghazal P, Morgan NV, Randall RE (2013) STAT2 deficiency and susceptibility to viral illness in humans. Proc Natl Acad Sci U S A 110: 3053-8.

Lowe GC, Sanchez Guiu I, Chapman O, Rivera J, Lordkipanidze M, Dovlatova N, Wilde J, Watson SP, Morgan NV (2013) Microsatellite markers as a rapid approach for autozygosity mapping in Hermansky-Pudlak syndrome: Identification of the second HPS7 mutation in a patient presenting late in life. Thromb Haemost. 109: 766-8.

Nieminen P, Morgan NV, Fenwick AL, Parmanen S, Veistinen L, Mikkola ML, van der Spek PJ, Giraud A, Judd L, Arte S, Brueton LA, Wall SA, Mathijssen IMJ, Maher ER, Wilkie AOM, Kreiborg S, Thesleff I (2011) Inactivation of IL11 Signaling Causes Craniosynostosis, Delayed Tooth Eruption and Supernumerary Teeth. Am J Hum Genet July 7. [Epub ahead of print]

Morgan NV, Goddard S, Cardno TS, McDonald D, Rahman F, Barge D, Ciupek A, Straatman-Iwanowska A ,Pasha S, Guckian M, Anderson G, Huissoon A, Cant A, Tate WP, Hambleton S, Maher ER (2011) Mutation in the TCRa subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRab+ T cells. J Clin Invest 121(2):695-702

Bolze A, Byun M, McDonald D, Morgan NV, Abhyankar A, Premkumar L, Puel A, Bacon CM, Rieux-Laucat F, Pang K, Britland A, Abel L, Cant A, Maher ER, Riedl SJ, Hambleton S, Casanova JL (2010) Whole-exome-sequencing-based discovery of human FADD deficiency. Am J Hum Genet 87(6):873-81

Morgan NV, Morris MR, Cangul H, Gleeson D, Straatman-Iwanowska A, Davies N, Keenan S, Pasha S, Rahman F, Gentle D,Vreeswijk MPG, Devilee P, Knowles MA, Ceylaner S, Trembath RC, Dalence C, Kismet E, Koseoglu V, Rossbach H-C, Gissen P, Tannanhill D, Maher ER (2010). Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial Histiocytosis syndrome (Faisalabad histiocytosis) and Familial Rosai-Dorfman disease. PLoS Genetics 6(2):e1000833