Metabolomics in Toxicology

School of Biosciences - University of Birmingham
Event cost
Monday 7 October (09:15) - Wednesday 9 October 2024 (16:00)

Delegates in lab again

Metabolomics in Toxicology

7th - 9th October 2024 | Register via our online shop


Course Overview

This 3-day course introduces the use of LC-MS based metabolomics to study toxicological processes and toxicological risk. Metabolomics is an increasingly popular tool within the field of toxicology, with significant investment being made from both regulators and the industry working in the development of sophisticated next-generation toxicity testing. This course provides delegates with hands-on experience for both the Q Exactive™ Plus (QE+) and Orbitrap ID-X™ Tribrid™ mass spectrometers, using a single toxicological case-study to guide delegates through an introduction to metabolomics in toxicology, from experimental design to metabolite identification. It is an intensive course designed to provide foundational knowledge for delegates to develop further skills and undertake their own metabolomics experiments. 

This course is led and delivered by five experts in the field of metabolomics and includes lectures, laboratory sessions, and computer workshops to provide a detailed overview of how metabolomics can be used in toxicological research. 

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Topics Covered

  • An introduction to metabolomics in toxicology
  • Experimental design for toxicological research
  • Sample preparation in metabolomics
  • An introduction to LC and HRMS/MS
  • UHPLC-MS set up and calibration
  • Biphasic sample prep and reconstitution of pre-prepared samples
  • Method configuration on QE+ and ID-X instruments
  • Hands-on sequencing setup (Excel, Xcalibur™)
  • Overview of instrument capabilities for metabolite identification inclusion/exclusion limits
  • XCMS data processing and statistics (univariate and multivariate analysis)
  • Statistics workshop covering fold-changes/PCCB/trend test
  • Basic concepts of metabolite identification (Compound Discoverer™, mzCloud™)

Preview the course programme



This course is aimed at PhD, Post-Doctorate and Early Career Researchers who work within the metabolomics community and ideally have minimal previous experience of applying LC-MS in toxicological studies. A basic working knowledge of LC-MS and metabolomics would be highly advantageous.


Early-bird: £1,299

Register via our online shop

Rate available until 7th September 2024 (terms and availability apply)


Standard: £1,499

Rate pending

Rate opening 7th September 2024 (terms and availability apply)


Please read the Birmingham Metabolomics Training Centre's Conditions and Cancellation Policy prior to registering.