Professor Warwick Dunn BSc (Hons), PhD

Professor Warwick Dunn

School of Biosciences
Professor of Analytical and Clinical Metabolomics
Director of the Birmingham Metabolomics Training Centre
Director of Mass Spectrometry, Phenome Centre Birmingham

Contact details

Address
School of Biosciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Professor Warwick (Rick) Dunn’s research group focuses on developing innovative chromatography, mass spectrometry, sample collection and computational resources and their application in the study of the complex role of metabolites in human ageing and diseases. Areas of biomedical study include endocrinology, inflammation and immunology including musculoskeletal health, cardio-renal diseases and complications of reproduction and pregnancy.

Qualifications

  • Fellow of the Higher Education Academy
  • PhD in Analytical Chemistry 1997
  • BSc(Hons) in Chemistry with Analytical Chemistry and Toxicology, University of Hull, 1993

Teaching

In the School of Biosciences:

Programme lead for Professional Placements in undergraduate degree programmes

Professor Dunn lectures on metabolism in the following undergraduate modules

  • BIO107 - Enzymes and metabolism
  • BIO139 - Human Biochemistry
  • BIO262 - Membrances, energy and metabolism

 Professor Dunn also lectures on metabolism in the following Masters course

  • Microbiology and Infection MSc

He also provides undergraduate and Masters research projects

Postgraduate supervision

Warwick (Rick) Dunn’s research group focuses on developing innovative chromatography, mass spectrometry, sample collection and computational resources and their application in the study of the complex role of metabolites in human ageing and diseases. Areas of biomedical study include endocrinology, inflammation and immunology including musculoskeletal health, cardio-renal diseases and complications of reproduction and pregnancy.

Dr Dunn’s research focuses on applying metabolomics techniques to translational biomedical research and stratified medicine as well as developing new tools to aid in the higher resolution study of complex samples and datasets.

Other activities

  • 2016-present: Reviews Editor, Metabolomics
  • 2015: Mass spectrometry committee for the Life Sciences review 2015
  • 2015-present: Midlands Analytical Division, Royal Society of Chemistry
  • 2011-2015: Conference and Training Committee, Metabolomics Society
  • 2013-present: Chair, Metabolite Identification Task Group, Metabolomics Society
  • 2014-present: Member of External Advisory Board, NIH Common Fund
  • Metabolomics Regional Metabolomics Cores
  • 2014-present: Member of the Metabolomics Society task group on data standards
  • 2010-2015: Director of the Metabolomics Society
  • 2011-2012: Organising Committee for MetaboMeeting 2012, Manchester, UK

Publications

Recent publications

Article

Fultang, L, Booth, S, Yogev, O, Costa, BMD, Tubb, V, Panetti, S, Stavrou, V, Scarpa, U, Jankevics, A, Lloyd, G, Southam, AD, Lee, SP, Dunn, W, Chesler, L, Mussai, FJ & Santo, CD 2020, 'Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity', Blood. https://doi.org/10.1182/blood.2019004500

Drury, N, Bi, R, Woolley, R, Stickley, J, Morris, KP, Montgomerie, J, Doorn, CV, Dunn, W, Madhani, M, Ives, N, Kirchhof, P & Jones, T 2020, 'The Bilateral Remote Ischaemic Conditioning in Children (BRICC) trial: protocol for a two-centre, double-blind, randomised controlled trial in young children undergoing cardiac surgery', BMJ open.

Thompson, JW, Adams, KJ, Adamski, J, Asad, Y, Borts, D, Bowden, JA, Byram, G, Dang, V, Dunn, W, Fernandez, F, Fiehn, O, Gaul, DA, Hühmer, AFR, Kalli, A, Koal, T, Koeniger, S, Mandal, R, Meier, F, Fuad J., N, O'Neil, D, Pal, A, Patti, GJ, Pham-Tuan, H, Prehn, C, Raynaud, FI, Shen, T, Southam, A, St. John-Williams, L, Sulek, K, Vasilopoulou, CG, Viant, M, Winder, C, Wishart, D, Zhang, L, Zheng, J & Moseley, MA 2019, 'International ring trial of a high resolution targeted metabolomics and lipidomics platform for serum and plasma analysis', Analytical Chemistry, vol. 91, no. 22, 9b02908, pp. 14407-14416. https://doi.org/10.1021/acs.analchem.9b02908

Palmer, E, Cooper, H & Dunn, W 2019, 'Investigation of the 12-month stability and detectable metabolomes of dried blood and urine spots applying untargeted UHPLC-MS metabolomic assays', Analytical Chemistry, vol. 91, no. 22, pp. 14306−14313. https://doi.org/10.1021/acs.analchem.9b02577

D’Elia, R, Goodchild, S, Winder, CL, Southam, A, Weber, R, Stahl, F, Docx, C, Patel, V, Green, AC, Viant, M, Lukaszewski, R & Dunn, W 2019, 'Multiple metabolic pathways are predictive of ricin intoxication in a rat model', Metabolomics, vol. 15, no. 7, 102. https://doi.org/10.1007/s11306-019-1547-9

Sostare, J, Di Guida, R, Kirwan, J, Chalal, K, Palmer, E, Dunn, WB & Viant, MR 2018, 'Comparison of modified Matyash method to conventional solvent systems for polar metabolite and lipid extractions', Analytica Chimica Acta. https://doi.org/10.1016/j.aca.2018.03.019

Nash, W & Dunn, W 2018, 'From mass to metabolite in human untargeted metabolomics: recent advances in annotation of metabolites applying liquid chromatography-mass spectrometry data', Trends in Analytical Chemistry. https://doi.org/10.1016/j.trac.2018.11.022

Broadhurst, D, Goodacre, R, Reinke, SN, Kuligowski, J, Wilson, ID, Lewis, MR & Dunn, WB 2018, 'Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies', Metabolomics, vol. 14, no. 6, 72. https://doi.org/10.1007/s11306-018-1367-3

Dunn, W, Hulme, C, Stevens, A, Heazell, AEP, Begley, P, Hollywood, K, Westwood, M & Myers, J 2018, 'Identification of the functional pathways altered by placental cell exposure to high glucose: lessons from the transcript and metabolite interactome', Scientific Reports, vol. 8, 5270. https://doi.org/10.1038/s41598-018-22535-y

Lyall, M, Cartier, J, Thomson, JP, Cameron, K, Meseguer-Ripolles, J, O'Duibhir, E, Szkolnicka, D, Villarin, BL, Wang, Y, Rodriguez Blanco, G, Dunn, W, Meehan, RR, Hay, DC & Drake, AJ 2018, 'Modelling non-alcoholic fatty liver disease in human hepatocyte-like cells', Philosophical Transactions of the Royal Society of London Series B, vol. 373, no. 1750, 20170362. https://doi.org/10.1098/rstb.2017.0362

Chortis, V, Taylor, A, Doig, C, Ronchi, C, Arlt, W, Walsh, M, Meimaridou, E, Rodriguez Blanco, G, Jafri, A, Metherell, LA, Dunn, W, Hebenstreit, D & Foster, P 2018, 'Nicotinamide Nucleotide Transhydrogenase as a novel treatment target in adrenocortical carcinoma', Endocrinology, vol. 159, no. 8, pp. 2836–2849. https://doi.org/10.1210/en.2018-00014

O'Reilly, M, Kempegowda, P, Walsh, M, Taylor, A, Manolopoulos, K, Allwood, W, Semple, R, Hebenstreit, D, Dunn, W, Tomlinson, J & Arlt, W 2017, 'AKR1C3-mediated adipose androgen generation drives lipotoxicity in polycystic ovary syndrome', Endocrine Abstracts. https://doi.org/10.1530/endoabs.49.oc3.3

O'reilly, M, Kempegowda, P, Walsh, M, Taylor, A, Manolopoulos, K, Allwood, JW, Semple, RK, Hebenstreit, D, Dunn, W, Tomlinson, J & Arlt, W 2017, 'AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome', Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 9, pp. 3327–3339. https://doi.org/10.1210/jc.2017-00947

Haley, M, Mullard, G, Hollywood, K, Cooper, GJ, Dunn, W & Lawrence, C 2017, 'Adipose tissue, metabolic and inflammatory responses to stroke are altered in obese mice.', Disease Models & Mechanisms. https://doi.org/10.1242/dmm.030411

Comment/debate

Sostare, E, Di Guida, R, Kirwan, J, Chalal, K, Palmer, E, Dunn, WB & Viant, MR 2019, 'Erratum for “Comparison of modified Matyash method to conventional solvent systems for polar metabolite and lipid extractions” (Anal. Chim. Acta 1037 (2018), (301–315), (S0003267018303982), (10.1016/j.aca.2018.03.019))', Analytica Chimica Acta, vol. 1091. https://doi.org/10.1016/j.aca.2019.09.069

View all publications in research portal