Professor Warwick Dunn BSc (Hons), PhD

Professor Warwick Dunn

School of Biosciences
Professor of Analytical and Clinical Metabolomics
Director of the Birmingham Metabolomics Training Centre
Director of Mass Spectrometry, Phenome Centre Birmingham

Contact details

Address
School of Biosciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Professor Warwick (Rick) Dunn’s research group focuses on developing innovative chromatography, mass spectrometry, sample collection and computational resources and their application in the study of the complex role of metabolites in human ageing and diseases. Areas of biomedical study include endocrinology, inflammation and immunology including musculoskeletal health, cardio-renal diseases and complications of reproduction and pregnancy.

Qualifications

  • Fellow of the Higher Education Academy
  • PhD in Analytical Chemistry 1997
  • BSc(Hons) in Chemistry with Analytical Chemistry and Toxicology, University of Hull, 1993

Teaching

In the School of Biosciences:

Programme lead for Professional Placements in undergraduate degree programmes

Professor Dunn lectures on metabolism in the following undergraduate modules

  • BIO107 - Enzymes and metabolism
  • BIO139 - Human Biochemistry
  • BIO262 - Membrances, energy and metabolism

 Professor Dunn also lectures on metabolism in the following Masters course

  • Microbiology and Infection MSc

He also provides undergraduate and Masters research projects

Postgraduate supervision

Warwick (Rick) Dunn’s research group focuses on developing innovative chromatography, mass spectrometry, sample collection and computational resources and their application in the study of the complex role of metabolites in human ageing and diseases. Areas of biomedical study include endocrinology, inflammation and immunology including musculoskeletal health, cardio-renal diseases and complications of reproduction and pregnancy.

Dr Dunn’s research focuses on applying metabolomics techniques to translational biomedical research and stratified medicine as well as developing new tools to aid in the higher resolution study of complex samples and datasets.

Other activities

  • 2016-present: Reviews Editor, Metabolomics
  • 2015: Mass spectrometry committee for the Life Sciences review 2015
  • 2015-present: Midlands Analytical Division, Royal Society of Chemistry
  • 2011-2015: Conference and Training Committee, Metabolomics Society
  • 2013-present: Chair, Metabolite Identification Task Group, Metabolomics Society
  • 2014-present: Member of External Advisory Board, NIH Common Fund
  • Metabolomics Regional Metabolomics Cores
  • 2014-present: Member of the Metabolomics Society task group on data standards
  • 2010-2015: Director of the Metabolomics Society
  • 2011-2012: Organising Committee for MetaboMeeting 2012, Manchester, UK

Publications

Recent publications

Article

Thorne, LS, Rochford, G, Williams, TD, Southam, AD, Rodriguez-Blanco, G, Dunn, WB & Hodges, NJ 2021, 'Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin', Scientific Reports, vol. 11, no. 1, 985. https://doi.org/10.1038/s41598-020-79830-w

Southam, AD, Haglington, LD, Najdekr, L, Jankevics, A, Weber, RJM & Dunn, WB 2020, 'Assessment of human plasma and urine sample preparation for reproducible and high-throughput UHPLC-MS clinical metabolic phenotyping', The Analyst, vol. 145, no. 20, pp. 6511-6523. https://doi.org/10.1039/D0AN01319F

Tipple, C, Moiemen, NS, Ioannou, C, Paglione, M, Goodson, S, Mcgee, K, O'neil, D, Winder, CL, Barnett, C, Wolf, AI, Bamford, AL, Dunn, WB, Lord, JM & Berger, S 2020, 'Intestinal permeability in participants with thermal injury: A case series from a prospective, longitudinal study (HESTIA)', Burns Open, vol. 4, no. 3, pp. 94-102. https://doi.org/10.1016/j.burnso.2020.05.005

Fultang, L, Booth, S, Yogev, O, Costa, BMD, Tubb, V, Panetti, S, Stavrou, V, Scarpa, U, Jankevics, A, Lloyd, G, Southam, AD, Lee, SP, Dunn, W, Chesler, L, Mussai, FJ & Santo, CD 2020, 'Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity', Blood. https://doi.org/10.1182/blood.2019004500

Drury, N, Bi, R, Woolley, R, Stickley, J, Morris, KP, Montgomerie, J, Doorn, CV, Dunn, W, Madhani, M, Ives, N, Kirchhof, P & Jones, T 2020, 'The Bilateral Remote Ischaemic Conditioning in Children (BRICC) trial: protocol for a two-centre, double-blind, randomised controlled trial in young children undergoing cardiac surgery', BMJ open, vol. 10, no. 10, :e042176. https://doi.org/10.1136/bmjopen-2020-042176

Wilkinson, DJ, Rodriguez-blanco, G, Dunn, WB, Phillips, BE, Williams, JP, Greenhaff, PL, Smith, K, Gallagher, IJ & Atherton, PJ 2020, 'Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing', Aging, vol. 12, no. 13, pp. 12517-12533. https://doi.org/10.18632/aging.103513, https://doi.org/10.18632/aging.v12i13

Jeffery, HC, Hunter, S, Humphreys, EH, Bhogal, R, Wawman, RE, Birtwistle, J, Atif, M, Bagnal, CJ, Rodriguez Blanco, G, Richardson, N, Warner, S, Dunn, WB, Afford, SC, Adams, DH & Oo, YH 2019, 'Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases', Journal of Immunology, vol. 203, no. 5, pp. 1151-1159. https://doi.org/10.4049/jimmunol.1800455

Najdekr, L, Blanco, GR & Dunn, WB 2019, 'Collection of Untargeted Metabolomic Data for Mammalian Urine Applying HILIC and Reversed Phase Ultra Performance Liquid Chromatography Methods Coupled to a Q Exactive Mass Spectrometer', Methods in molecular biology, vol. 1996, pp. 1-15. https://doi.org/10.1007/978-1-4939-9488-5_1

Thompson, JW, Adams, KJ, Adamski, J, Asad, Y, Borts, D, Bowden, JA, Byram, G, Dang, V, Dunn, W, Fernandez, F, Fiehn, O, Gaul, DA, Hühmer, AFR, Kalli, A, Koal, T, Koeniger, S, Mandal, R, Meier, F, Fuad J., N, O'Neil, D, Pal, A, Patti, GJ, Pham-Tuan, H, Prehn, C, Raynaud, FI, Shen, T, Southam, A, St. John-Williams, L, Sulek, K, Vasilopoulou, CG, Viant, M, Winder, C, Wishart, D, Zhang, L, Zheng, J & Moseley, MA 2019, 'International ring trial of a high resolution targeted metabolomics and lipidomics platform for serum and plasma analysis', Analytical Chemistry, vol. 91, no. 22, 9b02908, pp. 14407-14416. https://doi.org/10.1021/acs.analchem.9b02908

Palmer, E, Cooper, H & Dunn, W 2019, 'Investigation of the 12-month stability and detectable metabolomes of dried blood and urine spots applying untargeted UHPLC-MS metabolomic assays', Analytical Chemistry, vol. 91, no. 22, pp. 14306−14313. https://doi.org/10.1021/acs.analchem.9b02577

D’Elia, R, Goodchild, S, Winder, CL, Southam, A, Weber, R, Stahl, F, Docx, C, Patel, V, Green, AC, Viant, M, Lukaszewski, R & Dunn, W 2019, 'Multiple metabolic pathways are predictive of ricin intoxication in a rat model', Metabolomics, vol. 15, no. 7, 102. https://doi.org/10.1007/s11306-019-1547-9

Attard, JA, Dunn, WB, Mergental, H, Mirza, DF, Afford, SC & Perera, MTPR 2019, 'Systematic Review: Clinical Metabolomics to Forecast Outcomes in Liver Transplantation Surgery', OMICS: A Journal of Integrative Biology, vol. 23, no. 10, pp. 463-476. https://doi.org/10.1089/omi.2019.0086

Beger, RD, Dunn, WB, Bandukwala, A, Bethan, B, Broadhurst, D, Clish, CB, Dasari, S, Derr, L, Evans, A, Fischer, S, Flynn, T, Hartung, T, Herrington, D, Higashi, R, Hsu, P, Jones, C, Kachman, M, Karuso, H, Kruppa, G, Lippa, K, Maruvada, P, Mosley, J, Ntai, I, O’donovan, C, Playdon, M, Raftery, D, Shaughnessy, D, Souza, A, Spaeder, T, Spalholz, B, Tayyari, F, Ubhi, B, Verma, M, Walk, T, Wilson, I, Witkin, K, Bearden, DW & Zanetti, KA 2019, 'Towards quality assurance and quality control in untargeted metabolomics studies', Metabolomics, vol. 15, no. 1. https://doi.org/10.1007/s11306-018-1460-7

Sostare, J, Di Guida, R, Kirwan, J, Chalal, K, Palmer, E, Dunn, WB & Viant, MR 2018, 'Comparison of modified Matyash method to conventional solvent systems for polar metabolite and lipid extractions', Analytica Chimica Acta. https://doi.org/10.1016/j.aca.2018.03.019

Comment/debate

Sostare, E, Di Guida, R, Kirwan, J, Chalal, K, Palmer, E, Dunn, WB & Viant, MR 2019, 'Erratum for “Comparison of modified Matyash method to conventional solvent systems for polar metabolite and lipid extractions” (Anal. Chim. Acta 1037 (2018), (301–315), (S0003267018303982), (10.1016/j.aca.2018.03.019))', Analytica Chimica Acta, vol. 1091. https://doi.org/10.1016/j.aca.2019.09.069

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