Professor Karla Hemming PhD

Professor Karla Hemming

Institute of Applied Health Research
Professor of Biostatistics

Contact details

Public Health, Epidemiology and Biostatistics
Institute of Applied Health Research
College of Medical and Dental Sciences
University of Birmingham
Birmingham, B15 2TT

Karla Hemming leads a research programme related to stepped wedge trials, this includes both theoretical and applied research. Karla has close links with the West Midlands CLAHRC (Collaborations for Leadership in Applied Health Research and Care) and through this collaboration has helped establish and complete three stepped-wedge studies. Karla is affiliated with the Birmingham Clinical Trials Unit (BCTU) and provides methodological support for the design of cluster and stepped wedge trials. Karla is known internationally as an expert in stepped-wedge trials, has been invited to speak at international conferences, sits on international data monitoring committees and receives frequent requests for advise on stepped wedge trials from around the world.

Karla sits on the NIHR program grants panel, the West Midlands Research for patient benefit funding panel; and is a statistical editor for the BJOG. 


Postgraduate supervision

Karla Hemming's research interests include perinatal epidemiology, meta-analysis, missing data and cluster trials. She has conducted and published research in a number of areas, including:

Prescribing errors in electronic prescribing
Large-scale organisational intervention to improve patient safety
Bayesian sensitivity models for missing covariates in the analysis of survival data
Meta-regression with partial information


Recent publications


Daniels, J, Dixon, EF, Gill, A, Bishop, J, D’Amico, M, Ahmed, K, Dodds, J, Tryposkiadis, K, Wilks, M, Millar, M, Husain, S, Gray, J, Whiley, A, Moore, PV, Munetsi, RL, Hemming, K, Roberts, T, Plumb, J, Deeks, J, Khan, KS & Thangaratinam, S 2022, 'A rapid intrapartum test for group B Streptococcus to reduce antibiotic usage in mothers with risk factors: the GBS2 cluster RCT', Health Technology Assessment, vol. 26, no. 12, pp. 1-82.

Kristunas, C, Grayling, M, Gray, LJ & Hemming, K 2022, 'Mind the gap: covariate constrained randomisation can protect against substantial power loss in parallel cluster randomised trials', BMC Medical Research Methodology, vol. 22, no. 1, 111.

Osuh, ME, Oke, GA, Lilford, RJ, Owoaje, E, Harris, B, Taiwo, OJ, Yeboah, G, Abiona, T, Watson, SI, Hemming, K, Quinn, L, Chen, Y & Trevisan, M (ed.) 2022, 'Prevalence and determinants of oral health conditions and treatment needs among slum and non-slum urban residents: Evidence from Nigeria', PLOS Global Public Health, vol. 2, no. 4, pp. e0000297.

Kudhail, K, Thompson, J, Mathews, V, Morrison, B & Hemming, K 2022, 'Randomized controlled trials in patients with COVID-19: a systematic review and critical appraisal', International Journal of Infectious Diseases, vol. 122, pp. 72-80.

GBS2 Collaborative Group 2022, 'Rapid intrapartum test for maternal group B streptococcal colonisation and its effect on antibiotic use in labouring women with risk factors for early-onset neonatal infection (GBS2): cluster randomised trial with nested test accuracy study', BMC Medicine, vol. 20, no. 1, 9.

Sheppard, D, Clarke, E, Hemming, K, Martin, J & Lilford, R 2021, 'An opportunistic evaluation of a routine service improvement project to reduce falls in hospital', BMC Health Services Research, vol. 21, no. 1, 79.

Hemming, K, Taljaard, M, Moerbeek, M & Forbes, A 2021, 'Contamination: How much can an individually randomized trial tolerate?', Statistics in Medicine, vol. 40, no. 14, pp. 3329-3351.

Zanganeh, M, Adab, P, Li, B, Pallan, M, Liu, WJ, Hemming, K, Lin, R, Liu, W, Martin, J, Cheng, KK & Frew, E 2021, 'Cost-effectiveness of a school-and family-based childhood obesity prevention programme in China: the 'CHIRPY DRAGON' cluster-randomised controlled trial', International Journal of Public Health, vol. 66, 1604025.

Watson, S, Girling, A & Hemming, K 2021, 'Design and analysis of three-arm parallel cluster randomized trials with small numbers of clusters', Statistics in Medicine, vol. 40, no. 5, pp. 1133-1146.

Manaseki-Holland, S, Manjang, B, Hemming, K, Martin, J, Bradley, C, Jackson, L, Taal, M, Gautam, OP, Crowe, F, Sanneh, B, Ensink, J, Stokes, T & Cairncross, S 2021, 'Effects on childhood infections of promoting safe and hygienic complementary-food handling practices through a community based programme: A cluster randomised controlled trial in a rural area of The Gambia', PLoS Medicine, vol. 18, no. 1, e1003260.

Hemming, K, Martin, J, Gallos, I, Coomarasamy, A, Middleton, L & E-MOTIVE study group 2021, 'Interim data monitoring in cluster randomised trials: practical issues and a case study', Clinical Trials, vol. 18, no. 5, pp. 552-561.

Hamilton, FW, Lee, T, Arnold, DT, Lilford, R & Hemming, K 2021, 'Is convalescent plasma futile in COVID-19? A Bayesian re-analysis of the RECOVERY randomized controlled trial', International Journal of Infectious Diseases, vol. 109, pp. 114-117.

Easter, C & Hemming, K 2021, 'Looking at knock-on effects: univariable, multivariable linear regression', BJOG: An International Journal of Obstetrics & Gynaecology.

Easter, C & Hemming, K 2021, 'What are the odds? Interpretation of odds ratios from a logistic regression model', BJOG: An International Journal of Obstetrics & Gynaecology.


Watson, S, Asamane, E, Lilford, R, Hemming, K, Sidibe, C, Rego, R, Bensassi, S, Diarra, A, Gautam, OP, Islam, MS, Jackson, L, Jolly, K, Kayentao, K, Koita, O, Manjang, B, Tebbs, S, Griffiths, P, Cairncross, S, Toure, O & Manaseki-Holland, S 2021 'Protocol for a cluster randomised trial to evaluate a community-level complementary-food safety and hygiene and nutrition intervention in Mali: the MaaCiwara study' medRxiv, pp. 1-26.

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