Professor Karla Hemming PhD

Professor Karla Hemming

Institute of Applied Health Research
Professor of Biostatistics

Contact details

Public Health, Epidemiology and Biostatistics
Institute of Applied Health Research
College of Medical and Dental Sciences
University of Birmingham
Birmingham, B15 2TT

Karla Hemming leads a research programme related to stepped wedge trials, this includes both theoretical and applied research. Karla has close links with the West Midlands CLAHRC (Collaborations for Leadership in Applied Health Research and Care) and through this collaboration has helped establish and complete three stepped-wedge studies. Karla is affiliated with the Birmingham Clinical Trials Unit (BCTU) and provides methodological support for the design of cluster and stepped wedge trials. Karla is known internationally as an expert in stepped-wedge trials, has been invited to speak at international conferences, sits on international data monitoring committees and receives frequent requests for advise on stepped wedge trials from around the world.

Karla sits on the NIHR program grants panel, the West Midlands Research for patient benefit funding panel; and is a statistical editor for the BJOG. 


Postgraduate supervision

Karla Hemming's research interests include perinatal epidemiology, meta-analysis, missing data and cluster trials. She has conducted and published research in a number of areas, including:

Prescribing errors in electronic prescribing
Large-scale organisational intervention to improve patient safety
Bayesian sensitivity models for missing covariates in the analysis of survival data
Meta-regression with partial information


Recent publications


Hemming, K, Melo, P, Luo, R, Taljaard, M & Coomarasamy, A 2023, 'A re‐analysis of 150 women's health trials to investigate how the Bayesian approach may offer a solution to the misinterpretation of statistical findings', BJOG: An International Journal of Obstetrics & Gynaecology.

Al-Khudairy, L, Akram, Y, Watson, SI, Kudrna, L, Hofman, J, Nightingale, M, Alidu, L, Rudge, A, Rawdin, C, Ghosh, I, Mason, F, Perera, C, Wright, J, Boachie, J, Hemming, K, Vlaev, I, Russell, S & Lilford, RJ 2023, 'Evaluation of an organisational-level monetary incentive to promote the health and wellbeing of workers in small and medium-sized enterprises: a mixed-methods cluster randomised controlled trial', PLOS Global Public Health, vol. 3, no. 7, e0001381.

Dickinson-Craig, E, Badarch, J, Bartington, S, Hemming, K, Thayakaran, R, Day, R, Pope, F, Chuluunbaatar, B, Boldbaatar, D, Ochir, C, Warburton, D, Thomas, GN & Manaseki-Holland, S 2023, 'Impact assessment of a raw coal ban on maternal and child health outcomes in Ulaanbaatar: a protocol for an interrupted time series study', BMJ open, vol. 13, no. 4, e061723.

Hemming, K & Taljaard, M 2023, 'Key considerations for designing, conducting and analysing a cluster randomized trial', International Journal of Epidemiology, pp. 1-11.

Martin, J, Middleton, L & Hemming, K 2023, 'Minimisation for the design of parallel cluster-randomised trials: An evaluation of balance in cluster-level covariates and numbers of clusters allocated to each arm', Clinical Trials, vol. 20, no. 2, pp. 111–120.

Watson, S, Girling, A & Hemming, K 2023, 'Optimal Study Designs for Cluster Randomised Trials: An Overview of Methods and Results', Statistical methods in medical research. . <>

Watson, SI, Akinyemi, JO & Hemming, K 2023, 'Permutation-based multiple testing corrections for p-values and confidence intervals for cluster randomised trials', Statistics in Medicine.

Prevention Workplace Collaboration West Midlands 2023, 'Protocol for a cluster randomised waitlist-controlled trial of a goal-based behaviour change intervention for employees in workplaces enrolled in health and wellbeing initiatives', PLoS ONE, vol. 18, no. 9, e0282848.

Asamane, EA, Quinn, L, Watson, SI, Lilford, RJ, Hemming, K, Sidibe, C, Rego, RT, Bensassi, S, Diarra, Y, Diop, S, Gautam, OP, Islam, MS, Jackson, L, Jolly, K, Kayentao, K, Koita, O, Manjang, B, Tebbs, S, Gale, N, Griffiths, PL, Cairncross, S, Toure, O & Manaseki-Holland, S 2023, 'Protocol for a parallel group, two-arm, superiority cluster randomised trial to evaluate a community-level complementary-food safety and hygiene and nutrition intervention in Mali: the MaaCiwara study (version 1.3; 10 November 2022)', Trials, vol. 24, no. 1, 68.

Gallos, I, Devall, A, Martin, J, Middleton, L, Beeson, L, Galadanci, H, Alwy al-Beity, F, Qureshi, Z, Hofmeyr, GJ, Moran, N, Fawcus, S, Sheikh, L, Gwako, G, Osoti, A, Aswat, A, Mammoliti, K, Sindhu, KN, Podesek, M, Horne, I, Timms, R, Yunas, I, Okore, J, Singata-Madliki, M, Arends, E, Wakili, AA, Mwampashi, A, Nausheen, S, Muhammad, S, Latthe, P, Evans, C, Akter, S, Forbes, G, Lissauer, D, Meher, S, Weeks, A, Shennan, A, Ammerdorffer, A, Williams, E, Roberts, T, Widmer, M, Oladapo, OT, Lorencatto, F, Bohren, MA, Miller, S, Althabe, F, Gülmezoglu, M, Smith, JM, Hemming, K & Coomarasamy, A 2023, 'Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage', New England Journal of Medicine, vol. 389, no. 1, pp. 11-21.

Hemming, K, Taljaard, M, Gkini, E & Bishop, J 2023, 'Sample size determination for external pilot cluster randomised trials with binary feasibility outcomes: a tutorial', Pilot and Feasibility Studies, vol. 9, no. 1, 163.

Daniels, J, Dixon, EF, Gill, A, Bishop, J, D’Amico, M, Ahmed, K, Dodds, J, Tryposkiadis, K, Wilks, M, Millar, M, Husain, S, Gray, J, Whiley, A, Moore, PV, Munetsi, RL, Hemming, K, Roberts, T, Plumb, J, Deeks, J, Khan, KS & Thangaratinam, S 2022, 'A rapid intrapartum test for group B Streptococcus to reduce antibiotic usage in mothers with risk factors: the GBS2 cluster RCT', Health Technology Assessment, vol. 26, no. 12, pp. vii-76.

Hemming, K, Javid, I & Taljaard, M 2022, 'A review of high impact journals found that misinterpretation of non-statistically significant results from randomized trials was common', Journal of Clinical Epidemiology, vol. 145, pp. 112-120.

Bick, D, Bishop, J, Coleman, T, Dean, S, Edwards, E, Frawley, H, Gkini, E, Hay-Smith, J, Hemming, K, Jones, E, Oborn, E, Pearson, M, Salmon, V, Webb, S & MacArthur, C 2022, 'Antenatal preventative pelvic floor muscle exercise intervention led by midwives to reduce postnatal urinary incontinence (APPEAL): protocol for a feasibility and pilot cluster randomised controlled trial', Pilot and Feasibility Studies, vol. 8, no. 1, 231.

Review article

Quinn, L, Veenith, T, Bion, J, Hemming, K, Whitehouse, T & Lilford, R 2022, 'Bayesian analysis of a systematic review of early versus late tracheostomy in ICU patients', British Journal of Anaesthesia, vol. 129, no. 5, pp. 693-702.

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