Mr Lee Middleton BSc, MSc

Mr Lee Middleton

Institute of Applied Health Research
Statistics Lead, BCTU

Contact details

Address
Birmingham Clinical Trials Unit
Robert Aitken Institute
Institute of Applied Health Research
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Lee Middleton is a Senior Medical Statistician at the Birmingham Clinical Trials Unit.

He is currently involved with numerous randomised controlled trials, diagnostic accuracy studies and systematic reviews. The majority of this work is focused on obstetric and gynaecological health issues in collaboration with the Birmingham Women’s Hospital.

Qualifications

  • MSc Statistics, University of Kent, 2001
  • BSc Mathematics, University of Manchester, 1998

Teaching

  • MBChB Cancer ‘causes to cures’ tutor, School of Cancer Sciences 
  • MBChB statistics tutor, School of Health and Population Sciences 
  • Research Methods Course, Birmingham Clinical Trials Unit

Publications

Recent publications

Article

Ahmed, A, Williams, D, Cheed, V, Middleton, L, Ahmad, S, Wang, K, Vince, A, Hewett, P, Spencer, K, Khan, K & Daniels, J 2019, 'Pravastatin for early-onset preeclampsia: a randomized, blinded, placebo-controlled trial', BJOG: An International Journal of Obstetrics & Gynaecology.

Goranitis, I, Lissauer, D, Coomarasamy, A, Wilson, A, Daniels, J, Middleton, L, Bishop, J, Hewitt, C, Weeks, AD, Mhango, C, Mataya, R, Ahmed, I, Oladapo, OT, Zamora, J & Roberts, T 2019, 'Antibiotic prophylaxis in the surgical management of miscarriage in low income countries: a cost-effectiveness analysis of the AIMS trial', Lancet Global Health, vol. 7, no. 9, pp. e1280-e1286. https://doi.org/10.1016/S2214-109X(19)30336-5

Yeung, J, Middleton, L, Tryposkiadis, K, Kerr, A, Daniels, J, Naidu, B, Melody, T, Goebel, A, Wilson, M, Kumar, S, Szentgyorgyi, L, Flanagan, S, Shah, R, Worrall, A & Gao, F 2019, 'Randomised controlled trial to investigate the effectiveness of thoracic epidural and paravertebral blockade in reducing chronic post-thoracotomy pain (TOPIC): a pilot study to assess feasibility of a large multicentre trial', BMJ open, vol. 9, no. 7, e023679. https://doi.org/10.1136/bmjopen-2018-023679

Coomarasamy, A, Devall, AJ, Cheed, V, Harb, H, Middleton, LJ, Gallos, ID, Williams, H, Eapen, AK, Roberts, T, Ogwulu, CC, Goranitis, I, Daniels, JP, Ahmed, A, Bender-Atik, R, Bhatia, K, Bottomley, C, Brewin, J, Choudhary, M, Crosfill, F, Deb, S, Duncan, WC, Ewer, A, Hinshaw, K, Holland, T, Izzat, F, Johns, J, Kriedt, K, Lumsden, M-A, Manda, P, Norman, JE, Nunes, N, Overton, CE, Quenby, S, Rao, S, Ross, J, Shahid, A, Underwood, M, Vaithilingam, N, Watkins, L, Wykes, C, Horne, A & Jurkovic, D 2019, 'A randomized trial of progesterone in women with bleeding in early pregnancy', The New England Journal of Medicine, vol. 380, no. 19, pp. 1815-1824. https://doi.org/10.1056/NEJMoa1813730

Dhillon-smith, R, Middleton, L, Sunner, K, Cheed, V, Baker, K, Farrell-Carver, S, Bender Atik, R, Agrawal, R, Bhatia, K, Edi-Osagie, E, Ghobara, T, Gupta, P, Jurkovic, D, Khalaf, Y, MacLean, M, McCabe, C, Mulbagal, K, Nunes, N, Overton, C, Quenby, S, Rai, R, Raine-Fenning, N, Robinson, L, Ross, J, Sizer, A, Small, R, Tan, A, Underwood, M, Kilby, M, Boelaert, K, Daniels, J, Thangaratinam, S, Chan, SY & Coomarasamy, A 2019, 'Levothyroxine in Women with Thyroid Peroxidase Antibodies before Conception', The New England Journal of Medicine, vol. 380, pp. 1316-1325. https://doi.org/DOI: 10.1056/NEJMoa1812537

Lissauer, D, Wilson, A, Hewitt, C, Middleton, L, Bishop, J, Daniels, J, Merriel, A, Weeks, A, Mhango, C, Mataya, R, Taulo, F, Ngalawesa, T, Chirwa, A, Mphasa, C, Tambala, T, Chiudzu, G, Mwalwanda, C, Mboma, A, Qureshi, R, Ahmed, I, Ismail, H, Oladapo, OT, Mbaruku, G, Chibwana, J, Watts, G, Simon, B, Ditai, J, Tom, CO, Acam, J, Ekunait, J, Unzia, H, Iyaku, M, Malilka, J, Zamora, J, Roberts, T, Goranitis, I, Bar-Zeev, S, Desmond, N, Arulkumaran, S, Bhutta, Z, Gülmezoglu, AM & Coomarasamy, A 2019, 'A randomized trial of prophylactic antibiotics for miscarriage surgery', The New England Journal of Medicine, vol. 380, no. 11, pp. 1012-1021. https://doi.org/10.1056/NEJMoa1808817

May, J, Duncan, C, Mol, B, Bhattacharya, S, Daniels, J, Middleton, L, Hewitt, C, Coomarasamy, A, Jurkovic, D, Bourne, T, Bottomley, C, Peace-Gadsby, A, Doust, A, Tong, S & Horne, AW 2018, 'A multi-centre, double-blind, placebo-controlled, randomised trial of combination methotrexate and gefitinib versus methotrexate alone to treat tubal ectopic pregnancies (GEM3): Trial protocol', Trials, vol. 19, no. 1, 643. https://doi.org/10.1186/s13063-018-3008-6

Khan, KS, Tryposkiadis, K, Tirlapur, SA, Middleton, LJ, Sutton, AJ, Priest, L, Ball, E, Balogun, M, Sahdev, A, Roberts, T, Birch, J, Daniels, JP & Deeks, JJ 2018, 'MRI versus laparoscopy to diagnose the main causes of chronic pelvic pain in women: a test-accuracy study and economic evaluation', Health Technology Assessment, vol. 22, no. 40, pp. 1-92. https://doi.org/10.3310/hta22400

Thangaratinam, S, Marlin, N, Newton, S, Weckesser, A, Bagary, M, Greenhill, L, Rikunenko, R, D’Amico, M, Rogozińska, E, Kelso, A, Hard, K, Coleman, J, Moss, N, Roberts, T, Middleton, L, Dodds, J, Pullen, A, Eldridge, S, Pirie, A, Denny, E, McCorry, D & Khan, KS 2018, 'AntiEpileptic drug Monitoring in PREgnancy (EMPiRE): a double-blind randomised trial on effectiveness and acceptability of monitoring strategies', Health Technology Assessment, vol. 22, no. 23. https://doi.org/10.3310/hta22230

Lissauer, D, Wilson, A, Daniels, J, Middleton, L, Bishop, J, Hewitt, C, Merriel, A, Weeks, A, Mhango, C, Mataya, R, Taulo, F, Ngalawesa, T, Chirwa, A, Mphasa, C, Tambala, T, Chiudzu, G, Mwalwanda, C, Mboma, A, Qureshi, R, Ahmed, I, Ismail, H, Gulmezoglu, M, Oladapo, OT, Mbaruku, G, Chibwana, J, Watts, G, Simon, B, Ditai, J, Tom, CO, Acam, J, Ekunait, J, Uniza, H, Iyaku, M, Anyango, M, Zamora, J, Roberts, T, Goranitis, I, Desmond, N & Coomarasamy, A 2018, 'Prophylactic antibiotics to reduce pelvic infection in women having miscarriage surgery – The AIMS (Antibiotics in Miscarriage Surgery) trial: study protocol for a randomized controlled trial', Trials, vol. 19, 245. https://doi.org/10.1186/s13063-018-2598-3

Sitch, A & Middleton, L 2018, 'Statistical testing for continuous data', BJOG: An International Journal of Obstetrics & Gynaecology.

Middleton, L & Sitch, A 2018, 'Good practice for subgroup analyses in randomised controlled trials', BJOG: An International Journal of Obstetrics & Gynaecology.

Vincent, K, Baranowski, A, Bhattacharya, S, Birch, J, Cheong, Y, Cregg, R, Daniels, J, Hewitt, CA, Macfarlane, GJ, Middleton, L, Szubert, W, Tracey, I, Williams, ACDC & Horne, AW 2018, 'GaPP2, a multicentre randomised controlled trial of the efficacy of gabapentin for the management of chronic pelvic pain in women: study protocol', BMJ open, vol. 8, no. 1, e014924. https://doi.org/10.1136/bmjopen-2016-014924

Rachaneni, S, Middleton, L, Sajja, A, Balogun, M, Daniels, J, Latthe, P & Deeks, J 2018, 'Reproducibility of the transvaginal sonographic assessment of bladder wall thickness', European Journal of Obstetrics and Gynecology and Reproductive Biology, vol. 220, pp. 88-95. https://doi.org/10.1016/j.ejogrb.2017.11.011

Latthe, P, Middleton, L, Rachaneni, S, Mccooty, S, Daniels, J, Coomarasamy, A, Balogun, M, Duckett, J, Thakar, R, Goranitis, I, Roberts, T & Deeks, J 2017, 'Ultrasound bladder wall thickness and detrusor overactivity: A multicentre test accuracy study', BJOG: An International Journal of Obstetrics & Gynaecology, vol. 124, no. 9, pp. 1422–1429. https://doi.org/10.1111/1471-0528.14503

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